| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 3,963,424 | 5,753,798 | +1,790,374 | 0.93 | 1.42 | +0.49 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,097,399 | 4,147,399 | +1,050,000 | 3.01 | 6.05 | +3.03 | buy |
| MORGAN STANLEY | 2,582,711 | 3,042,803 | +460,092 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 2,910,849 | 2,910,849 | 0 | 3.07 | 3.99 | +0.92 | hold |
| VANGUARD GROUP INC | 2,943,512 | 2,905,510 | -38,002 | 0.00 | 0.00 | +0.00 | sell |
| Stonepine Capital Management, LLC | 5,333,004 | 2,674,356 | -2,658,648 | 24.29 | 29.70 | +5.42 | sell |
| GREAT POINT PARTNERS LLC | 2,000,000 | 2,450,000 | +450,000 | 3.59 | 5.35 | +1.76 | buy |
| Caligan Partners LP | 1,317,856 | 1,888,881 | +571,025 | 4.68 | 6.99 | +2.31 | buy |
| DEUTSCHE BANK AG\ | 1,414,526 | 1,540,225 | +125,699 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,026,374 | 1,032,568 | +6,194 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 708,538 | 977,578 | +269,040 | 0.01 | 0.02 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 836,925 | 973,102 | +136,177 | 0.30 | 0.38 | +0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 934,276 | 959,559 | +25,283 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,003,617 | 936,373 | -67,244 | 0.01 | 0.01 | +0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 906,195 | 880,744 | -25,451 | 0.55 | 0.70 | +0.15 | sell |
| SOROS FUND MANAGEMENT LLC | 550,000 | 840,100 | +290,100 | 0.11 | 0.27 | +0.16 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,161,738 | 832,798 | -328,940 | 0.02 | 0.01 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 0 | 830,532 | +830,532 | 0.00 | 0.04 | +0.04 | buy |
| AWH Capital, L.P. | 629,240 | 630,500 | +1,260 | 6.65 | 8.13 | +1.48 | buy |
| UBS Group AG | 666,285 | 571,182 | -95,103 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 220,399 | 405,931 | +185,532 | 0.00 | 0.01 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 371,400 | 397,300 | +25,900 | 0.36 | 0.40 | +0.04 | buy |
| NORTHERN TRUST CORP | 390,616 | 383,621 | -6,995 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 222,751 | 320,097 | +97,346 | 0.03 | 0.05 | +0.02 | buy |
| Zimmer Partners, LP | 0 | 300,000 | +300,000 | 0.00 | 0.09 | +0.09 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 298,358 | +298,358 | 0.00 | 0.01 | +0.01 | buy |
| Divisadero Street Capital Management, LP | 230,700 | 270,162 | +39,462 | 0.55 | 0.89 | +0.34 | buy |
| Qube Research & Technologies Ltd | 46,092 | 267,945 | +221,853 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 262,135 | +262,135 | 0.00 | 0.01 | +0.01 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 251,050 | 254,811 | +3,761 | 0.52 | 0.70 | +0.18 | buy |
| JPMORGAN CHASE & CO | 38,473 | 247,656 | +209,183 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 158,075 | 244,029 | +85,954 | 0.04 | 0.07 | +0.03 | buy |
| MARSHALL WACE, LLP | 553,526 | 218,300 | -335,226 | 0.01 | 0.01 | -0.01 | sell |
| Walleye Capital LLC | 233,951 | 212,889 | -21,062 | 0.03 | 0.03 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 196,200 | +196,200 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 138,313 | 186,275 | +47,962 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 160,000 | +160,000 | 0.00 | 0.20 | +0.20 | buy |
| FourWorld Capital Management LLC | 203,620 | 153,620 | -50,000 | 2.82 | 1.90 | -0.92 | sell |
| Monashee Investment Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.25 | +0.25 | buy |
| CM Management, LLC | 150,000 | 150,000 | 0 | 1.27 | 1.76 | +0.49 | hold |
| Bank of New York Mellon Corp | 162,083 | 145,333 | -16,750 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 148,246 | 144,906 | -3,340 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 136,226 | +136,226 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 126,454 | 132,751 | +6,297 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 65,024 | 125,192 | +60,168 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 111,769 | 111,769 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 114,779 | 110,686 | -4,093 | 0.00 | 0.00 | +0.00 | sell |
| Legato Capital Management LLC | 108,210 | 108,210 | 0 | 0.15 | 0.18 | +0.03 | hold |
| Invesco Ltd. | 14,363 | 98,625 | +84,262 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 89,800 | 95,900 | +6,100 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 81,519 | 93,504 | +11,985 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 111,139 | 93,391 | -17,748 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 71,769 | 88,381 | +16,612 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 73,066 | 80,000 | +6,934 | 0.29 | 0.40 | +0.10 | buy |
| Semanteon Capital Management, LP | 44,786 | 77,613 | +32,827 | 0.32 | 0.69 | +0.38 | buy |
| HAP Trading, LLC | 0 | 74,167 | +74,167 | 0.00 | 0.32 | +0.32 | buy |
| Squarepoint Ops LLC | 120,644 | 73,589 | -47,055 | 0.01 | 0.00 | -0.00 | sell |
| Brandywine Global Investment Management, LLC | 131,900 | 69,200 | -62,700 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 28,466 | 68,831 | +40,365 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66,747 | 66,747 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PDT Partners, LLC | 64,334 | 64,741 | +407 | 0.07 | 0.09 | +0.01 | buy |
| RHUMBLINE ADVISERS | 69,146 | 63,997 | -5,149 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 171,216 | 62,682 | -108,534 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 58,480 | 62,440 | +3,960 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 50,153 | 54,036 | +3,883 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,370 | 48,109 | +739 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 36,329 | 45,802 | +9,473 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,972 | 43,996 | +42,024 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 69,457 | 42,587 | -26,870 | 0.00 | 0.00 | -0.00 | sell |
| FIRST MANHATTAN CO. LLC. | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,245 | 39,882 | +1,637 | 0.00 | 0.00 | +0.00 | buy |
| Alpha DNA Investment Management LLC | 0 | 35,562 | +35,562 | 0.00 | 0.27 | +0.27 | buy |
| DIMENSIONAL FUND ADVISORS LP | 74,488 | 35,183 | -39,305 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 20,200 | 35,000 | +14,800 | 0.01 | 0.02 | +0.01 | buy |
| NATIXIS | 0 | 34,946 | +34,946 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 14,394 | 34,785 | +20,391 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 12,196 | 34,097 | +21,901 | 0.02 | 0.08 | +0.07 | buy |
| FEDERATED HERMES, INC. | 42 | 32,319 | +32,277 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 30,989 | +30,989 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 37,931 | 30,782 | -7,149 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 43,978 | 28,854 | -15,124 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 265,700 | 27,000 | -238,700 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 22,115 | 26,165 | +4,050 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 27,576 | 25,231 | -2,345 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 0 | 23,269 | +23,269 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 21,206 | 21,206 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 20,582 | 20,674 | +92 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,614 | 20,626 | +1,012 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 18,204 | 19,640 | +1,436 | 0.02 | 0.03 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 14,411 | 18,259 | +3,848 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 17,859 | 17,871 | +12 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 16,618 | +16,618 | 0.00 | 0.05 | +0.05 | buy |
| Assenagon Asset Management S.A. | 0 | 16,537 | +16,537 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 24,494 | 16,255 | -8,239 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,836 | 16,017 | -819 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 31,040 | 15,786 | -15,254 | 0.01 | 0.01 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 20,056 | 15,611 | -4,445 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 13,472 | 15,040 | +1,568 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 14,299 | +14,299 | 0.00 | 0.05 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,261 | 14,119 | +1,858 | 0.00 | 0.00 | +0.00 | buy |