| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FRONTIER CAPITAL MANAGEMENT CO LLC | 239,811 | 1,207,295 | +967,484 | 0.03 | 0.16 | +0.13 | buy |
| Divisadero Street Capital Management, LP | 0 | 720,721 | +720,721 | 0.00 | 1.00 | +1.00 | buy |
| JPMORGAN CHASE & CO | 138,149 | 727,891 | +589,742 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 3,130,149 | 3,651,343 | +521,194 | 2.42 | 3.63 | +1.22 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 486,400 | +486,400 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 697,158 | 1,079,158 | +382,000 | 0.58 | 1.02 | +0.44 | buy |
| Assenagon Asset Management S.A. | 435,453 | 710,713 | +275,260 | 0.01 | 0.02 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 244,129 | +244,129 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 163,937 | 365,375 | +201,438 | 0.02 | 0.05 | +0.03 | buy |
| CITADEL ADVISORS LLC | 61,971 | 247,473 | +185,502 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 160,632 | +160,632 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 33,944 | 191,858 | +157,914 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 148,001 | +148,001 | 0.00 | 0.08 | +0.08 | buy |
| COMERICA BANK | 28,301 | 169,068 | +140,767 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 52,035 | 151,549 | +99,514 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 10,931 | 101,827 | +90,896 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 416,500 | 505,000 | +88,500 | 0.08 | 0.12 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 81,600 | +81,600 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 75,700 | +75,700 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 43,100 | 116,982 | +73,882 | 0.01 | 0.02 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 72,608 | +72,608 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 69,947 | +69,947 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,171,404 | 3,234,068 | +62,664 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 61,682 | +61,682 | 0.00 | 0.04 | +0.04 | buy |
| PDT Partners, LLC | 0 | 60,651 | +60,651 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,192 | 140,332 | +59,140 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 13,525 | 71,322 | +57,797 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 24,387 | 77,757 | +53,370 | 0.01 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 0 | 51,641 | +51,641 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 895,524 | 944,743 | +49,219 | 4.66 | 6.18 | +1.52 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,214,590 | 1,262,041 | +47,451 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 115,052 | 156,565 | +41,513 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 2,692,388 | 2,731,154 | +38,766 | 7.53 | 6.86 | -0.67 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 37,840 | +37,840 | 0.00 | 0.04 | +0.04 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 37,361 | +37,361 | 0.00 | 0.03 | +0.03 | buy |
| LORD, ABBETT & CO. LLC | 497,849 | 533,599 | +35,750 | 0.02 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 805,240 | 839,142 | +33,902 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 31,562 | +31,562 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 848,176 | 877,061 | +28,885 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 36,213 | 63,720 | +27,507 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 754,079 | 781,548 | +27,469 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,368,423 | 1,392,028 | +23,605 | 0.01 | 0.02 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 197,697 | 215,694 | +17,997 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 18,886 | 34,037 | +15,151 | 0.03 | 0.06 | +0.03 | buy |
| Quantbot Technologies LP | 10,665 | 25,760 | +15,095 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 13,979 | +13,979 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 18,326 | 31,900 | +13,574 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 12,700 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 12,544 | +12,544 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 12,406 | +12,406 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,674 | 29,804 | +11,130 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 46,963 | 57,694 | +10,731 | 0.02 | 0.02 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 1,678 | 11,598 | +9,920 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,040,440 | 1,049,405 | +8,965 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 112,070 | 118,085 | +6,015 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 4,736 | 9,427 | +4,691 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 345 | 3,754 | +3,409 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 80,149 | 83,436 | +3,287 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 3,247 | +3,247 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52,593 | 54,629 | +2,036 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,451 | 33,289 | +1,838 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 21,071 | 22,594 | +1,523 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 3,436 | 4,600 | +1,164 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 802 | +802 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 998 | 1,548 | +550 | 0.00 | 0.00 | +0.00 | buy |
| Tradition Wealth Management, LLC | 13,000 | 13,500 | +500 | 0.01 | 0.01 | +0.00 | buy |
| AMALGAMATED BANK | 1,426 | 1,907 | +481 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 390 | +390 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 100 | 400 | +300 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,330 | 1,621 | +291 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 282 | +282 | 0.00 | 0.00 | +0.00 | buy |
| SouthState Corp | 0 | 217 | +217 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 110 | +100 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 99 | +99 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 6,558 | 6,643 | +85 | 0.01 | 0.01 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 43 | +43 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 33,370 | 33,409 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 290 | 320 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Geneos Wealth Management Inc. | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,910 | 5,927 | +17 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 13 | 27 | +14 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 251 | 256 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 96 | 100 | +4 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 3,200 | 3,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 7,749 | 7,749 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,415 | 5,415 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,777 | 44,777 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 62,440 | 62,440 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 53 | 53 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 4,997,399 | 4,997,399 | 0 | 3.65 | 3.33 | -0.32 | hold |
| JANUS HENDERSON GROUP PLC | 17,642 | 17,642 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIXIS | 4,499 | 4,499 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 750 | 750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 57 | 57 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GHP Investment Advisors, Inc. | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KBC Group NV | 4,451 | 4,451 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Plante Moran Financial Advisors, LLC | 1,220 | 1,220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 262 | 262 | 0 | 0.00 | 0.00 | -0.00 | hold |