| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FRONTIER CAPITAL MANAGEMENT CO LLC | 239,811 | 1,207,295 | +967,484 | 0.03 | 0.16 | +0.13 | buy |
| Nantahala Capital Management, LLC | 3,130,149 | 3,651,343 | +521,194 | 1.48 | 1.75 | +0.26 | buy |
| Soleus Capital Management, L.P. | 697,158 | 1,079,158 | +382,000 | 0.58 | 1.02 | +0.44 | buy |
| Zimmer Partners, LP | 416,500 | 505,000 | +88,500 | 0.08 | 0.11 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 895,524 | 944,743 | +49,219 | 4.66 | 6.02 | +1.36 | buy |
| Caligan Partners LP | 2,692,388 | 2,731,154 | +38,766 | 7.53 | 6.86 | -0.67 | buy |
| LORD, ABBETT & CO. LLC | 497,849 | 533,599 | +35,750 | 0.02 | 0.02 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 18,886 | 34,037 | +15,151 | 0.03 | 0.06 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,040,440 | 1,049,405 | +8,965 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 59,623 | 52,213 | +7,410 | 0.00 | 0.00 | 0.00 | sell |
| Tradition Wealth Management, LLC | 13,000 | 13,500 | +500 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,330 | 1,621 | +291 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,426 | 12,701 | -725 | 0.01 | 0.01 | +0.00 | sell |
| Freestone Grove Partners LP | 12,681 | 11,367 | -1,314 | 0.00 | 0.00 | -0.00 | sell |
| Legato Capital Management LLC | 64,778 | 63,429 | -1,349 | 0.09 | 0.10 | +0.01 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 182,503 | 181,134 | -1,369 | 0.36 | 0.45 | +0.09 | sell |
| Allostery Investments LP | 431,117 | 412,754 | -18,363 | 9.34 | 7.16 | -2.18 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 948,281 | 921,394 | -26,887 | 0.57 | 0.65 | +0.08 | sell |
| AWH Capital, L.P. | 635,000 | 600,600 | -34,400 | 8.34 | 10.47 | +2.13 | sell |
| Alyeska Investment Group, L.P. | 325,000 | 225,000 | -100,000 | 0.01 | 0.01 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 1,100,000 | 995,485 | -104,515 | 0.18 | 0.18 | -0.00 | sell |
| Stonepine Capital Management, LLC | 1,264,651 | 1,134,574 | -130,077 | 11.27 | 13.28 | +2.01 | sell |
| Ikarian Capital, LLC | 373,265 | 193,265 | -180,000 | 1.18 | 0.76 | -0.42 | sell |
| Altium Capital Management LLC | 685,000 | 296,193 | -388,807 | 2.36 | 10.35 | +7.99 | sell |
| Tri Locum Partners LP | 742,574 | 321,802 | -420,772 | 1.70 | 1.99 | +0.29 | sell |
| GILDER GAGNON HOWE & CO LLC | 702,239 | 139,145 | -563,094 | 0.08 | 0.02 | -0.06 | sell |
| PERCEPTIVE ADVISORS LLC | 5,145,846 | 4,129,142 | -1,016,704 | 1.57 | 1.75 | +0.19 | sell |