| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 5,820,649 | 6,376,857 | +556,208 | 2.31 | 1.64 | -0.67 | buy |
| BlackRock, Inc. | 4,095,300 | 4,290,383 | +195,083 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 3,105,209 | 3,105,209 | 0 | 0.66 | 0.43 | -0.23 | hold |
| Frazier Life Sciences Management, L.P. | 2,630,665 | 2,630,665 | 0 | 0.47 | 0.28 | -0.19 | hold |
| Soleus Capital Management, L.P. | 1,070,000 | 2,245,360 | +1,175,360 | 0.30 | 0.37 | +0.07 | buy |
| Stonepine Capital Management, LLC | 1,631,588 | 1,759,091 | +127,503 | 8.58 | 6.36 | -2.22 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,093,037 | 1,461,159 | -631,878 | 0.01 | 0.00 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 976,000 | 1,396,000 | +420,000 | 0.16 | 0.19 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,386,248 | 1,381,338 | -4,910 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,574,851 | 1,320,790 | -254,061 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 0 | 1,286,862 | +1,286,862 | 0.00 | 0.10 | +0.10 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,153,444 | 1,254,819 | +101,375 | 0.42 | 0.29 | -0.14 | buy |
| PINNACLE ASSOCIATES LTD | 782,365 | 1,158,895 | +376,530 | 0.07 | 0.06 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 350,742 | 1,086,398 | +735,656 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 881,369 | 752,881 | -128,488 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,379,131 | 696,629 | -682,502 | 0.01 | 0.00 | -0.00 | sell |
| Soviero Asset Management, LP | 655,000 | 680,373 | +25,373 | 2.28 | 1.57 | -0.71 | buy |
| AWH Capital, L.P. | 625,000 | 625,000 | 0 | 3.83 | 2.33 | -1.50 | hold |
| Assenagon Asset Management S.A. | 270,219 | 598,145 | +327,926 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,541,096 | 559,050 | -982,046 | 0.01 | 0.00 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 517,129 | 515,516 | -1,613 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,245,692 | 483,021 | -762,671 | 0.41 | 0.10 | -0.31 | sell |
| NORTHERN TRUST CORP | 445,166 | 472,343 | +27,177 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 263,129 | 458,396 | +195,267 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 436,747 | 441,655 | +4,908 | 0.00 | 0.00 | -0.00 | buy |
| CM Management, LLC | 250,000 | 400,000 | +150,000 | 1.40 | 1.37 | -0.03 | buy |
| Trexquant Investment LP | 18,838 | 375,210 | +356,372 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 799,900 | 339,025 | -460,875 | 0.01 | 0.00 | -0.01 | sell |
| Caption Management, LLC | 0 | 216,316 | +216,316 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 174,346 | 158,392 | -15,954 | 0.00 | 0.00 | -0.00 | sell |
| Krensavage Asset Management, LLC | 100,000 | 157,985 | +57,985 | 0.23 | 0.25 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 358,046 | 155,248 | -202,798 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 137,797 | 143,164 | +5,367 | 0.00 | 0.00 | -0.00 | buy |
| NATIXIS | 1,437 | 141,437 | +140,000 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 88,988 | 124,761 | +35,773 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 88,369 | 111,602 | +23,233 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN ASSETS INC | 125,000 | 110,000 | -15,000 | 0.26 | 0.30 | +0.03 | sell |
| Campbell & CO Investment Adviser LLC | 340,188 | 101,867 | -238,321 | 0.11 | 0.02 | -0.08 | sell |
| Knott David M Jr | 99,338 | 99,338 | 0 | 0.31 | 0.24 | -0.06 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,096 | 98,285 | +33,189 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 85,364 | 97,964 | +12,600 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,151 | 91,509 | +11,358 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 0 | 79,939 | +79,939 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 75,968 | 74,497 | -1,471 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 67,991 | 69,110 | +1,119 | 0.01 | 0.00 | -0.01 | buy |
| RHUMBLINE ADVISERS | 70,049 | 68,726 | -1,323 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 65,571 | 67,366 | +1,795 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 43,404 | 66,243 | +22,839 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 62,340 | 62,340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aquatic Capital Management LLC | 28,383 | 59,796 | +31,413 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 35,859 | 55,859 | +20,000 | 0.02 | 0.01 | -0.00 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 0 | 55,513 | +55,513 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 39,303 | 51,303 | +12,000 | 0.02 | 0.02 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 48,823 | +48,823 | 0.00 | 0.02 | +0.02 | buy |
| AXQ CAPITAL, LP | 0 | 47,670 | +47,670 | 0.00 | 0.03 | +0.03 | buy |
| Pathstone Holdings, LLC | 41,059 | 45,259 | +4,200 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 34,119 | 36,335 | +2,216 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 34,288 | +34,288 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 225,602 | 31,476 | -194,126 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 9,497 | 31,016 | +21,519 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 54,270 | 30,635 | -23,635 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 24,060 | 28,737 | +4,677 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 130,738 | 27,878 | -102,860 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,126 | 26,324 | +2,198 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 45,501 | 25,947 | -19,554 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 22,977 | 25,677 | +2,700 | 0.00 | 0.00 | -0.00 | buy |
| BENDER ROBERT & ASSOCIATES | 0 | 25,070 | +25,070 | 0.00 | 0.02 | +0.02 | buy |
| Quadrature Capital Ltd | 18,095 | 24,068 | +5,973 | 0.00 | 0.00 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 0 | 19,291 | +19,291 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 28,388 | 18,307 | -10,081 | 0.00 | 0.00 | -0.00 | sell |
| Pure Financial Advisors, LLC | 17,800 | 17,995 | +195 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 17,900 | +17,900 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 27,827 | 16,763 | -11,064 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 6,197 | 16,680 | +10,483 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,232 | 16,219 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 15,833 | 15,833 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 32,689 | 15,449 | -17,240 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 564,988 | 14,185 | -550,803 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,154 | 14,154 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legato Capital Management LLC | 15,130 | 13,907 | -1,223 | 0.01 | 0.01 | -0.00 | sell |
| Tradition Wealth Management, LLC | 12,500 | 12,700 | +200 | 0.01 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 6,823 | 12,310 | +5,487 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,859 | 11,859 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 10,562 | 11,503 | +941 | 0.01 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 11,125 | +11,125 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 12,329 | 11,032 | -1,297 | 0.00 | 0.00 | -0.00 | sell |
| Accelerate Investment Advisors LLC | 0 | 10,670 | +10,670 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 2,735 | 10,216 | +7,481 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 316 | 9,837 | +9,521 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,155 | 8,881 | +5,726 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 24,684 | 7,557 | -17,127 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 35,470 | 6,406 | -29,064 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 5,415 | 5,415 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 5,454 | 4,682 | -772 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 37 | 4,404 | +4,367 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 4,330 | 4,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUMMIT SECURITIES GROUP LLC | 455 | 3,429 | +2,974 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,150 | 3,381 | +231 | 0.00 | 0.00 | -0.00 | buy |
| MAI Capital Management | 3,200 | 3,200 | 0 | 0.00 | 0.00 | -0.00 | hold |