| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 160,000 | 1,152,000 | +992,000 | 0.20 | 1.10 | +0.91 | buy |
| Assenagon Asset Management S.A. | 16,537 | 947,103 | +930,566 | 0.00 | 0.03 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,147,399 | 4,847,399 | +700,000 | 6.05 | 5.36 | -0.69 | buy |
| Eversept Partners, LP | 0 | 574,462 | +574,462 | 0.00 | 0.48 | +0.48 | buy |
| Cutter Capital Management, LP | 0 | 465,300 | +465,300 | 0.00 | 1.54 | +1.54 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 360,000 | +360,000 | 0.00 | 0.10 | +0.10 | buy |
| STATE STREET CORP | 1,032,568 | 1,339,077 | +306,509 | 0.00 | 0.00 | -0.00 | buy |
| Caligan Partners LP | 1,888,881 | 2,167,790 | +278,909 | 6.99 | 5.50 | -1.49 | buy |
| Qube Research & Technologies Ltd | 267,945 | 526,617 | +258,672 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 959,559 | 1,199,594 | +240,035 | 0.00 | 0.00 | -0.00 | buy |
| Zimmer Partners, LP | 300,000 | 501,629 | +201,629 | 0.09 | 0.10 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 173,586 | +173,586 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,831 | 238,809 | +169,978 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 832,798 | 977,629 | +144,831 | 0.01 | 0.01 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 122,200 | +122,200 | 0.00 | 0.00 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 397,300 | 514,900 | +117,600 | 0.40 | 0.34 | -0.06 | buy |
| UBS Group AG | 571,182 | 652,871 | +81,689 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 2,905,510 | 2,985,215 | +79,705 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 12,210 | 63,951 | +51,741 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 66,747 | 116,532 | +49,785 | 0.00 | 0.00 | +0.00 | buy |
| AWH Capital, L.P. | 630,500 | 675,000 | +44,500 | 8.13 | 7.56 | -0.58 | buy |
| JANE STREET GROUP, LLC | 88,381 | 131,603 | +43,222 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,686 | 152,941 | +42,255 | 0.00 | 0.00 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 254,811 | 294,442 | +39,631 | 0.70 | 0.60 | -0.11 | buy |
| Numerai GP LLC | 13,005 | 51,001 | +37,996 | 0.08 | 0.20 | +0.12 | buy |
| Bank of New York Mellon Corp | 145,333 | 181,093 | +35,760 | 0.00 | 0.00 | -0.00 | buy |
| Knott David M Jr | 80,000 | 108,682 | +28,682 | 0.40 | 0.47 | +0.07 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 27,788 | +27,788 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 973,102 | 996,510 | +23,408 | 0.38 | 0.33 | -0.05 | buy |
| Lombard Odier Asset Management (USA) Corp | 0 | 22,690 | +22,690 | 0.00 | 0.09 | +0.09 | buy |
| Y-Intercept (Hong Kong) Ltd | 18,259 | 40,813 | +22,554 | 0.02 | 0.02 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 21,118 | +21,118 | 0.00 | 0.02 | +0.02 | buy |
| SHERBROOKE PARK ADVISERS LLC | 16,618 | 36,732 | +20,114 | 0.05 | 0.07 | +0.02 | buy |
| ALGERT GLOBAL LLC | 0 | 19,368 | +19,368 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 800 | 19,600 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 320,097 | 338,254 | +18,157 | 0.05 | 0.06 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 54,036 | 72,007 | +17,971 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 63,997 | 81,439 | +17,442 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 15,016 | +15,016 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 13,809 | +13,809 | 0.00 | 0.03 | +0.03 | buy |
| Creative Planning | 0 | 12,488 | +12,488 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 11,995 | +11,995 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 11,859 | +11,859 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 20,626 | 32,228 | +11,602 | 0.00 | 0.00 | +0.00 | buy |
| Tradition Wealth Management, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| SOROS FUND MANAGEMENT LLC | 840,100 | 850,000 | +9,900 | 0.27 | 0.21 | -0.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 125,192 | 134,324 | +9,132 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,040 | 23,480 | +8,440 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 15,786 | 22,674 | +6,888 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 95,900 | 102,600 | +6,700 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 12,878 | 19,114 | +6,236 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 1,731 | 7,749 | +6,018 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,017 | 21,825 | +5,808 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 39,882 | 45,614 | +5,732 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,868 | 18,897 | +5,029 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 5,000 | +5,000 | 0.00 | 0.02 | +0.02 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 13,852 | 18,388 | +4,536 | 0.04 | 0.04 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 768 | 4,978 | +4,210 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 45,802 | 50,011 | +4,209 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 3,964 | +3,964 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 43,996 | 47,872 | +3,876 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 1,889 | 5,401 | +3,512 | 0.02 | 0.03 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 3,389 | +3,389 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,109 | 51,140 | +3,031 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 30,782 | 33,802 | +3,020 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 491 | 3,099 | +2,608 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 2,450,000 | 2,451,772 | +1,772 | 5.35 | 5.10 | -0.25 | buy |
| CITADEL ADVISORS LLC | 62,682 | 64,116 | +1,434 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,084 | 5,415 | +1,331 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,350 | 14,603 | +1,253 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 1,540,225 | 1,541,293 | +1,068 | 0.01 | 0.01 | -0.00 | buy |
| MATHER GROUP, LLC. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 16,255 | 17,194 | +939 | 0.01 | 0.01 | -0.00 | buy |
| CWM, LLC | 15 | 829 | +814 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 678 | +678 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,812 | 11,448 | +636 | 0.00 | 0.00 | -0.00 | buy |
| Olistico Wealth, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 312 | +312 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 1 | 301 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 88 | +88 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 111,769 | 111,819 | +50 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 15 | 50 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,119 | 14,154 | +35 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 20 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 108,210 | 108,219 | +9 | 0.18 | 0.16 | -0.02 | buy |
| GAMMA Investing LLC | 478 | 487 | +9 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,809 | 5,811 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 25 | 26 | +1 | 0.00 | 0.00 | 0.00 | buy |
| WASHINGTON TRUST Co | 5,000 | 5,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 62,440 | 62,440 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 5,753,798 | 5,753,798 | 0 | 1.42 | 1.51 | +0.09 | hold |
| PRIVATE TRUST CO NA | 6,558 | 6,558 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 750 | 750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GHP Investment Advisors, Inc. | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Plante Moran Financial Advisors, LLC | 1,220 | 1,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nantahala Capital Management, LLC | 2,910,849 | 2,910,849 | 0 | 3.99 | 3.17 | -0.82 | hold |
| Daiwa Securities Group Inc. | 162 | 162 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FourWorld Capital Management LLC | 153,620 | 153,620 | 0 | 1.90 | 2.08 | +0.18 | hold |
| IAG Wealth Partners, LLC | 927 | 927 | 0 | 0.00 | 0.00 | -0.00 | hold |