| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 160,000 | 1,152,000 | +992,000 | 0.20 | 1.10 | +0.91 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,147,399 | 4,847,399 | +700,000 | 6.05 | 5.36 | -0.69 | buy |
| Caligan Partners LP | 1,888,881 | 2,167,790 | +278,909 | 6.99 | 5.50 | -1.49 | buy |
| Zimmer Partners, LP | 300,000 | 501,629 | +201,629 | 0.09 | 0.10 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 832,798 | 977,629 | +144,831 | 0.01 | 0.01 | -0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 397,300 | 514,900 | +117,600 | 0.40 | 0.34 | -0.06 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 136,226 | 91,010 | +45,216 | 0.01 | 0.00 | 0.00 | sell |
| AWH Capital, L.P. | 630,500 | 675,000 | +44,500 | 8.13 | 7.56 | -0.58 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 254,811 | 294,442 | +39,631 | 0.70 | 0.60 | -0.11 | buy |
| Numerai GP LLC | 13,005 | 51,001 | +37,996 | 0.08 | 0.20 | +0.12 | buy |
| SHERBROOKE PARK ADVISERS LLC | 16,618 | 36,732 | +20,114 | 0.05 | 0.07 | +0.02 | buy |
| SOROS FUND MANAGEMENT LLC | 840,100 | 850,000 | +9,900 | 0.20 | 0.17 | -0.03 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 13,852 | 18,388 | +4,536 | 0.04 | 0.04 | -0.00 | buy |
| EntryPoint Capital, LLC | 1,889 | 5,401 | +3,512 | 0.02 | 0.09 | +0.06 | buy |
| GREAT POINT PARTNERS LLC | 2,450,000 | 2,451,772 | +1,772 | 5.35 | 5.10 | -0.25 | buy |
| Legato Capital Management LLC | 108,210 | 108,219 | +9 | 0.18 | 0.16 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 10,969 | 7,355 | -3,614 | 0.02 | 0.01 | -0.01 | sell |
| LORD, ABBETT & CO. LLC | 830,532 | 806,764 | -23,768 | 0.04 | 0.03 | -0.01 | sell |
| NATIXIS | 34,946 | 6,275 | -28,671 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 880,744 | 851,295 | -29,449 | 0.70 | 0.55 | -0.15 | sell |
| HAP Trading, LLC | 74,167 | 20,209 | -53,958 | 0.12 | 0.03 | -0.09 | sell |
| Stonepine Capital Management, LLC | 2,674,356 | 1,657,611 | -1,016,745 | 29.70 | 16.41 | -13.29 | sell |