| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 4,997,399 | 4,997,399 | 0 | 3.33 | 2.33 | -1.00 | hold |
| Nantahala Capital Management, LLC | 3,651,343 | 4,197,926 | +546,583 | 3.63 | 2.74 | -0.90 | buy |
| BlackRock, Inc. | 4,323,532 | 4,184,056 | -139,476 | 0.00 | 0.00 | -0.00 | sell |
| Caligan Partners LP | 2,731,154 | 3,341,970 | +610,816 | 6.86 | 5.98 | -0.88 | buy |
| VANGUARD GROUP INC | 3,234,068 | 3,318,250 | +84,182 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 4,129,142 | 2,474,843 | -1,654,299 | 1.76 | 0.86 | -0.91 | sell |
| Frazier Life Sciences Management, L.P. | 0 | 2,435,550 | +2,435,550 | 0.00 | 0.90 | +0.90 | buy |
| Soleus Capital Management, L.P. | 1,079,158 | 2,119,000 | +1,039,842 | 1.02 | 1.35 | +0.33 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,207,295 | 1,664,828 | +457,533 | 0.16 | 0.14 | -0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,392,028 | 1,483,426 | +91,398 | 0.02 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 1,383,206 | 1,406,594 | +23,388 | 0.00 | 0.00 | -0.00 | buy |
| Tri Locum Partners LP | 321,802 | 1,239,031 | +917,229 | 1.99 | 3.46 | +1.48 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,262,041 | 1,231,841 | -30,200 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,141,224 | 1,171,093 | +29,869 | 0.47 | 0.33 | -0.14 | buy |
| Eversept Partners, LP | 0 | 1,170,311 | +1,170,311 | 0.00 | 1.09 | +1.09 | buy |
| UBS Group AG | 953,659 | 1,076,584 | +122,925 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,049,405 | 1,056,773 | +7,368 | 0.01 | 0.01 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 921,394 | 996,040 | +74,646 | 0.65 | 0.49 | -0.16 | buy |
| MORGAN STANLEY | 839,142 | 961,153 | +122,011 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 877,061 | 957,741 | +80,680 | 0.01 | 0.01 | -0.00 | buy |
| Stonepine Capital Management, LLC | 1,134,574 | 916,500 | -218,074 | 13.28 | 8.32 | -4.97 | sell |
| Nuveen, LLC | 1,024,937 | 896,472 | -128,465 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 781,548 | 726,198 | -55,350 | 0.01 | 0.01 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 944,743 | 720,118 | -224,625 | 6.18 | 4.31 | -1.87 | sell |
| JPMORGAN CHASE & CO | 727,891 | 692,486 | -35,405 | 0.00 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 0 | 685,960 | +685,960 | 0.00 | 0.09 | +0.09 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 677,600 | 677,600 | 0 | 0.41 | 0.27 | -0.13 | hold |
| Zimmer Partners, LP | 505,000 | 630,000 | +125,000 | 0.12 | 0.13 | +0.01 | buy |
| AWH Capital, L.P. | 600,600 | 625,000 | +24,400 | 10.47 | 6.71 | -3.76 | buy |
| Assenagon Asset Management S.A. | 710,713 | 612,388 | -98,325 | 0.02 | 0.01 | -0.01 | sell |
| CITADEL ADVISORS LLC | 247,473 | 581,859 | +334,386 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 0 | 520,631 | +520,631 | 0.00 | 0.62 | +0.62 | buy |
| NORTHERN TRUST CORP | 528,113 | 499,470 | -28,643 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 419,878 | 419,768 | -110 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 116,982 | 355,568 | +238,586 | 0.02 | 0.04 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 81,600 | 341,400 | +259,800 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 225,000 | 325,000 | +100,000 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 361,920 | 296,704 | -65,216 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 295,562 | 290,039 | -5,523 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 37,361 | 259,487 | +222,126 | 0.03 | 0.06 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 215,694 | 257,454 | +41,760 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 244,129 | 240,735 | -3,394 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 0 | 204,562 | +204,562 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 156,565 | 175,559 | +18,994 | 0.00 | 0.00 | -0.00 | buy |
| CM Management, LLC | 150,000 | 175,000 | +25,000 | 1.81 | 1.47 | -0.35 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 150,467 | 164,020 | +13,553 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 169,068 | 158,325 | -10,743 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 140,332 | 157,634 | +17,302 | 0.00 | 0.00 | -0.00 | buy |
| FIRST MANHATTAN CO. LLC. | 40,000 | 150,000 | +110,000 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 151,549 | 148,500 | -3,049 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 159,792 | 148,362 | -11,430 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 135,705 | 141,005 | +5,300 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 71,322 | 138,927 | +67,605 | 0.01 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 486,400 | 128,400 | -358,000 | 0.01 | 0.00 | -0.01 | sell |
| Man Group plc | 101,827 | 125,749 | +23,922 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 191,858 | 123,860 | -67,998 | 0.01 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 139,145 | 120,899 | -18,246 | 0.02 | 0.01 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 111,233 | 120,569 | +9,336 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 148,001 | 119,240 | -28,761 | 0.08 | 0.04 | -0.04 | sell |
| BARCLAYS PLC | 79,361 | 118,889 | +39,528 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 365,375 | 118,637 | -246,738 | 0.05 | 0.01 | -0.04 | sell |
| Russell Investments Group, Ltd. | 118,085 | 117,960 | -125 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 11,374 | 105,797 | +94,423 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 91,700 | 91,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 0 | 87,020 | +87,020 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 83,436 | 85,093 | +1,657 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 51,641 | 84,010 | +32,369 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 69,947 | 82,594 | +12,647 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 61,682 | 82,347 | +20,665 | 0.04 | 0.03 | -0.01 | buy |
| Dynamic Technology Lab Private Ltd | 34,037 | 80,020 | +45,983 | 0.06 | 0.10 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 75,700 | 76,200 | +500 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 66,738 | 71,265 | +4,527 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 67,846 | +67,846 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 62,440 | 62,440 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allostery Investments LP | 412,754 | 60,000 | -352,754 | 7.16 | 7.04 | -0.12 | sell |
| HighVista Strategies LLC | 0 | 58,042 | +58,042 | 0.00 | 0.20 | +0.20 | buy |
| AMERIPRISE FINANCIAL INC | 65,815 | 57,838 | -7,977 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 54,629 | 56,323 | +1,694 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 63,720 | 51,890 | -11,830 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 52,428 | 51,692 | -736 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 47,895 | 48,676 | +781 | 0.00 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 47,502 | +47,502 | 0.00 | 0.05 | +0.05 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 47,157 | +47,157 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,777 | 44,777 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 52,213 | 43,248 | -8,965 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 49,238 | 41,821 | -7,417 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 34,999 | +34,999 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 31,900 | 34,283 | +2,383 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 33,598 | 33,598 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtu Financial LLC | 0 | 30,521 | +30,521 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 11,598 | 29,750 | +18,152 | 0.00 | 0.01 | +0.00 | buy |
| Quantbot Technologies LP | 25,760 | 29,731 | +3,971 | 0.01 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,289 | 29,249 | -4,040 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 51,356 | 28,293 | -23,063 | 0.00 | 0.00 | -0.00 | sell |
| Pathstone Holdings, LLC | 0 | 28,050 | +28,050 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 29,804 | 25,687 | -4,117 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 22,594 | 25,152 | +2,558 | 0.00 | 0.00 | -0.00 | buy |
| BENDER ROBERT & ASSOCIATES | 0 | 25,070 | +25,070 | 0.00 | 0.05 | +0.05 | buy |
| Graham Capital Management, L.P. | 57,694 | 24,239 | -33,455 | 0.02 | 0.01 | -0.02 | sell |
| SG Americas Securities, LLC | 10,457 | 24,212 | +13,755 | 0.00 | 0.00 | +0.00 | buy |