| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 1,079,158 | 2,119,000 | +1,039,842 | 1.02 | 1.35 | +0.33 | buy |
| Tri Locum Partners LP | 321,802 | 1,239,031 | +917,229 | 1.99 | 3.46 | +1.48 | buy |
| Caligan Partners LP | 2,731,154 | 3,341,970 | +610,816 | 6.86 | 5.98 | -0.88 | buy |
| Nantahala Capital Management, LLC | 3,651,343 | 4,197,926 | +546,583 | 1.75 | 1.51 | -0.23 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,207,295 | 1,664,828 | +457,533 | 0.16 | 0.14 | -0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 37,361 | 259,487 | +222,126 | 0.03 | 0.06 | 0.00 | buy |
| Zimmer Partners, LP | 505,000 | 630,000 | +125,000 | 0.11 | 0.13 | +0.01 | buy |
| FIRST MANHATTAN CO. LLC. | 40,000 | 150,000 | +110,000 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 225,000 | 325,000 | +100,000 | 0.01 | 0.01 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 921,394 | 996,040 | +74,646 | 0.65 | 0.49 | -0.16 | buy |
| ExodusPoint Capital Management, LP | 71,322 | 138,927 | +67,605 | 0.01 | 0.02 | 0.00 | buy |
| Dynamic Technology Lab Private Ltd | 34,037 | 80,020 | +45,983 | 0.06 | 0.10 | +0.04 | buy |
| CM Management, LLC | 150,000 | 175,000 | +25,000 | 1.81 | 1.47 | -0.35 | buy |
| AWH Capital, L.P. | 600,600 | 625,000 | +24,400 | 10.47 | 6.71 | -3.76 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 52,213 | 43,248 | +8,965 | 0.00 | 0.00 | 0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,049,405 | 1,056,773 | +7,368 | 0.01 | 0.01 | -0.00 | buy |
| NATIXIS | 4,499 | 3,252 | +1,247 | 0.00 | 0.00 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,701 | 12,950 | +249 | 0.01 | 0.01 | -0.00 | buy |
| Tradition Wealth Management, LLC | 13,500 | 13,600 | +100 | 0.01 | 0.01 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 139,145 | 120,899 | -18,246 | 0.02 | 0.01 | -0.01 | sell |
| Legato Capital Management LLC | 63,429 | 10,583 | -52,846 | 0.10 | 0.01 | -0.09 | sell |
| Stonepine Capital Management, LLC | 1,134,574 | 916,500 | -218,074 | 13.28 | 8.28 | -5.00 | sell |
| GREAT POINT PARTNERS LLC | 944,743 | 720,118 | -224,625 | 6.02 | 4.31 | -1.71 | sell |
| Allostery Investments LP | 412,754 | 60,000 | -352,754 | 7.16 | 7.04 | -0.12 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 486,400 | 128,400 | -358,000 | 0.01 | 0.00 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 4,129,142 | 2,474,843 | -1,654,299 | 1.75 | 0.85 | -0.91 | sell |