| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 6,376,857 | 5,602,021 | -774,836 | 1.64 | 2.35 | +0.71 | sell |
| BlackRock, Inc. | 4,290,383 | 4,840,828 | +550,445 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 3,105,209 | 3,155,209 | +50,000 | 0.43 | 0.81 | +0.38 | buy |
| Frazier Life Sciences Management, L.P. | 2,630,665 | 2,630,665 | 0 | 0.28 | 0.40 | +0.12 | hold |
| PERCEPTIVE ADVISORS LLC | 1,286,862 | 2,459,285 | +1,172,423 | 0.10 | 0.27 | +0.16 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,461,159 | 1,787,929 | +326,770 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,320,790 | 1,697,294 | +376,504 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,381,338 | 1,608,394 | +227,056 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 1,759,091 | 1,590,162 | -168,929 | 6.36 | 8.40 | +2.04 | sell |
| Point72 Asset Management, L.P. | 0 | 1,508,518 | +1,508,518 | 0.00 | 0.02 | +0.02 | buy |
| PINNACLE ASSOCIATES LTD | 1,158,895 | 1,487,264 | +328,369 | 0.06 | 0.11 | +0.05 | buy |
| ARMISTICE CAPITAL, LLC | 1,396,000 | 1,436,000 | +40,000 | 0.19 | 0.28 | +0.09 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,254,819 | 1,289,888 | +35,069 | 0.29 | 0.44 | +0.15 | buy |
| GOLDMAN SACHS GROUP INC | 1,086,398 | 1,219,419 | +133,021 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 598,145 | 908,180 | +310,035 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 2,245,360 | 822,428 | -1,422,932 | 0.37 | 0.20 | -0.18 | sell |
| Soviero Asset Management, LP | 680,373 | 770,000 | +89,627 | 1.57 | 2.59 | +1.02 | buy |
| UBS Group AG | 752,881 | 752,679 | -202 | 0.00 | 0.00 | +0.00 | sell |
| AWH Capital, L.P. | 625,000 | 625,000 | 0 | 2.33 | 2.98 | +0.64 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 530,843 | +530,843 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 515,516 | 530,843 | +15,327 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 696,629 | 506,354 | -190,275 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 472,343 | 497,018 | +24,675 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 441,655 | 454,930 | +13,275 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 458,396 | 423,174 | -35,222 | 0.00 | 0.00 | +0.00 | sell |
| CM Management, LLC | 400,000 | 400,000 | 0 | 1.37 | 1.76 | +0.39 | hold |
| D. E. Shaw & Co., Inc. | 559,050 | 336,901 | -222,149 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 339,025 | 302,569 | -36,456 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 0 | 253,817 | +253,817 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 237,559 | +237,559 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 111,602 | 233,614 | +122,012 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 216,316 | 216,316 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Squarepoint Ops LLC | 158,392 | 197,708 | +39,316 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 169,934 | +169,934 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 143,164 | 162,849 | +19,685 | 0.00 | 0.00 | +0.00 | buy |
| Krensavage Asset Management, LLC | 157,985 | 157,985 | 0 | 0.25 | 0.42 | +0.16 | hold |
| Trexquant Investment LP | 375,210 | 146,325 | -228,885 | 0.01 | 0.01 | -0.00 | sell |
| NATIXIS | 141,437 | 141,437 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 97,964 | 137,761 | +39,797 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 124,761 | 128,078 | +3,317 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 110,885 | +110,885 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 69,110 | 106,501 | +37,391 | 0.00 | 0.01 | +0.00 | buy |
| ANGELES WEALTH MANAGEMENT, LLC | 0 | 105,545 | +105,545 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 55,859 | 100,000 | +44,141 | 0.01 | 0.03 | +0.02 | buy |
| BARCLAYS PLC | 27,878 | 98,179 | +70,301 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 25,677 | 97,563 | +71,886 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 91,741 | +91,741 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 74,497 | 84,748 | +10,251 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 98,285 | 81,768 | -16,517 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 76,997 | +76,997 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 67,366 | 75,676 | +8,310 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 155,248 | 73,232 | -82,016 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 62,340 | 69,440 | +7,100 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 68,726 | 68,376 | -350 | 0.00 | 0.00 | +0.00 | sell |
| Corient Private Wealth LLC | 79,939 | 63,003 | -16,936 | 0.00 | 0.00 | +0.00 | sell |
| Pathstone Holdings, LLC | 45,259 | 61,448 | +16,189 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 59,796 | 60,906 | +1,110 | 0.01 | 0.01 | +0.01 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 55,513 | 55,048 | -465 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 51,303 | 51,267 | -36 | 0.02 | 0.03 | +0.01 | sell |
| CITIGROUP INC | 6,406 | 42,998 | +36,592 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 28,737 | 41,083 | +12,346 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 39,435 | +39,435 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 31,016 | 39,052 | +8,036 | 0.02 | 0.03 | +0.01 | buy |
| Global Retirement Partners, LLC | 16,200 | 36,100 | +19,900 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 36,335 | 35,493 | -842 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 18,307 | 35,080 | +16,773 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 31,476 | 33,349 | +1,873 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 30,635 | 32,545 | +1,910 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 34,288 | 32,423 | -1,865 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 31,547 | +31,547 | 0.00 | 0.00 | +0.00 | buy |
| Concurrent Investment Advisors, LLC | 0 | 27,829 | +27,829 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,324 | 27,346 | +1,022 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 25,947 | 26,438 | +491 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 19,291 | 22,248 | +2,957 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 20,448 | +20,448 | 0.00 | 0.02 | +0.02 | buy |
| Pure Financial Advisors, LLC | 17,995 | 17,800 | -195 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 15,449 | 17,533 | +2,084 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 16,213 | +16,213 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,219 | 16,021 | -198 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 15,833 | 15,833 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OneDigital Investment Advisors LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,154 | 14,154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PROFUND ADVISORS LLC | 0 | 13,810 | +13,810 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 47,670 | 13,382 | -34,288 | 0.03 | 0.01 | -0.02 | sell |
| Tradition Wealth Management, LLC | 12,700 | 12,700 | 0 | 0.00 | 0.01 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 12,310 | 12,386 | +76 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 12,336 | +12,336 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,921 | +11,921 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,859 | 11,859 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Krilogy Financial LLC | 0 | 11,587 | +11,587 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 14,185 | 11,574 | -2,611 | 0.00 | 0.00 | +0.00 | sell |
| WINTON GROUP Ltd | 0 | 11,100 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 11,009 | +11,009 | 0.00 | 0.00 | +0.00 | buy |
| Accelerate Investment Advisors LLC | 10,670 | 10,670 | 0 | 0.03 | 0.04 | +0.01 | hold |
| China Universal Asset Management Co., Ltd. | 11,503 | 10,481 | -1,022 | 0.00 | 0.00 | +0.00 | sell |
| Sequoia Financial Advisors, LLC | 0 | 10,218 | +10,218 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 16,763 | 10,164 | -6,599 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 16,680 | 9,080 | -7,600 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 8,881 | 8,505 | -376 | 0.00 | 0.00 | +0.00 | sell |