| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 5,753,798 | 5,356,622 | -397,176 | 1.51 | 1.86 | +0.35 | sell |
| TANG CAPITAL MANAGEMENT LLC | 4,847,399 | 4,847,399 | 0 | 5.36 | 5.61 | +0.25 | hold |
| VANGUARD GROUP INC | 2,985,215 | 3,195,331 | +210,116 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 2,910,849 | 2,824,849 | -86,000 | 3.17 | 3.85 | +0.68 | sell |
| Caligan Partners LP | 2,167,790 | 2,193,488 | +25,698 | 5.50 | 11.26 | +5.77 | buy |
| Stonepine Capital Management, LLC | 1,657,611 | 1,369,821 | -287,790 | 16.41 | 14.02 | -2.39 | sell |
| STATE STREET CORP | 1,339,077 | 1,277,841 | -61,236 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,199,594 | 1,210,621 | +11,027 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 2,451,772 | 1,170,000 | -1,281,772 | 5.10 | 5.72 | +0.62 | sell |
| Soleus Capital Management, L.P. | 1,152,000 | 1,037,680 | -114,320 | 1.10 | 1.40 | +0.30 | sell |
| MILLENNIUM MANAGEMENT LLC | 899,377 | 1,029,670 | +130,293 | 0.01 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 977,629 | 1,014,960 | +37,331 | 0.01 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 1,480,713 | 1,000,549 | -480,164 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 806,764 | 995,449 | +188,685 | 0.03 | 0.05 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 996,510 | 983,702 | -12,808 | 0.33 | 0.47 | +0.15 | sell |
| D. E. Shaw & Co., Inc. | 871,098 | 970,270 | +99,172 | 0.01 | 0.02 | +0.01 | buy |
| Assenagon Asset Management S.A. | 947,103 | 955,555 | +8,452 | 0.03 | 0.03 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 851,295 | 904,900 | +53,605 | 0.55 | 0.79 | +0.24 | buy |
| SOROS FUND MANAGEMENT LLC | 850,000 | 850,000 | 0 | 0.21 | 0.27 | +0.07 | hold |
| AWH Capital, L.P. | 675,000 | 657,500 | -17,500 | 7.56 | 9.50 | +1.95 | sell |
| UBS Group AG | 652,871 | 645,301 | -7,570 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 526,617 | 567,048 | +40,431 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 1,541,293 | 545,589 | -995,704 | 0.01 | 0.00 | -0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 514,900 | 514,900 | 0 | 0.34 | 0.43 | +0.08 | hold |
| NORTHERN TRUST CORP | 382,423 | 485,783 | +103,360 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 574,462 | 453,061 | -121,401 | 0.48 | 0.56 | +0.09 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 152,941 | 418,576 | +265,635 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 360,000 | 360,000 | 0 | 0.10 | 0.15 | +0.05 | hold |
| Altium Capital Management LLC | 0 | 355,000 | +355,000 | 0.00 | 1.71 | +1.71 | buy |
| Alyeska Investment Group, L.P. | 173,586 | 325,000 | +151,414 | 0.01 | 0.03 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 154,158 | 310,582 | +156,424 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 294,442 | 295,553 | +1,111 | 0.60 | 0.83 | +0.24 | buy |
| Ikarian Capital, LLC | 0 | 258,279 | +258,279 | 0.00 | 1.30 | +1.30 | buy |
| Zimmer Partners, LP | 501,629 | 250,000 | -251,629 | 0.10 | 0.08 | -0.03 | sell |
| Trexquant Investment LP | 142,403 | 247,560 | +105,157 | 0.02 | 0.05 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 338,254 | 242,042 | -96,212 | 0.06 | 0.06 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 238,809 | 222,690 | -16,119 | 0.01 | 0.01 | +0.00 | sell |
| Walleye Capital LLC | 0 | 212,209 | +212,209 | 0.00 | 0.04 | +0.04 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 181,380 | +181,380 | 0.00 | 0.04 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 134,324 | 175,039 | +40,715 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 213,954 | 169,926 | -44,028 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 64,116 | 151,049 | +86,933 | 0.00 | 0.00 | +0.00 | buy |
| Soviero Asset Management, LP | 0 | 150,000 | +150,000 | 0.00 | 2.45 | +2.45 | buy |
| CM Management, LLC | 150,000 | 150,000 | 0 | 1.49 | 1.94 | +0.45 | hold |
| AQR CAPITAL MANAGEMENT LLC | 72,007 | 149,562 | +77,555 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 70,853 | 149,231 | +78,378 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 143,822 | 144,024 | +202 | 0.00 | 0.00 | +0.00 | buy |
| FORMULA GROWTH LTD | 0 | 138,000 | +138,000 | 0.00 | 0.77 | +0.77 | buy |
| Bank of New York Mellon Corp | 181,093 | 136,586 | -44,507 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 27,788 | 120,964 | +93,176 | 0.02 | 0.15 | +0.13 | buy |
| Russell Investments Group, Ltd. | 111,819 | 111,892 | +73 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 108,219 | 108,547 | +328 | 0.16 | 0.22 | +0.06 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 116,532 | 108,231 | -8,301 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 17,278 | 101,398 | +84,120 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 25,449 | 93,662 | +68,213 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 131,603 | 91,899 | -39,704 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 102,600 | 91,700 | -10,900 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 70,498 | 90,359 | +19,861 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 47,872 | 80,316 | +32,444 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 91,010 | 78,440 | -12,570 | 0.00 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 81,439 | 78,387 | -3,052 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 63,951 | 74,787 | +10,836 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 83,224 | 72,232 | -10,992 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 31,448 | 62,748 | +31,300 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 62,440 | 62,440 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 25,780 | 59,485 | +33,705 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 58,046 | +58,046 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 108,682 | 57,570 | -51,112 | 0.47 | 0.33 | -0.14 | sell |
| Semanteon Capital Management, LP | 0 | 56,313 | +56,313 | 0.00 | 0.62 | +0.62 | buy |
| TWO SIGMA INVESTMENTS, LP | 40,700 | 51,999 | +11,299 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 50,011 | 51,416 | +1,405 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 51,100 | +51,100 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,868 | 49,829 | +33,961 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 33,802 | 48,786 | +14,984 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 45,614 | 46,261 | +647 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,114 | 45,588 | +26,474 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,140 | 45,000 | -6,140 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 43,815 | +43,815 | 0.00 | 0.00 | +0.00 | buy |
| Numerai GP LLC | 51,001 | 43,698 | -7,303 | 0.20 | 0.19 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 40,813 | 40,908 | +95 | 0.02 | 0.04 | +0.02 | buy |
| FIRST MANHATTAN CO. LLC. | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 0 | 38,447 | +38,447 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 36,537 | +36,537 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,480 | 34,841 | +11,361 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 32,228 | 32,228 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 33,174 | 30,381 | -2,793 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,151 | 30,357 | +9,206 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 29,734 | 29,552 | -182 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 19,600 | 29,300 | +9,700 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 19,368 | 24,570 | +5,202 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 15,016 | 21,337 | +6,321 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,825 | 21,178 | -647 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 21,770 | 21,071 | -699 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 18,897 | 18,346 | -551 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 17,642 | 17,642 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 12,488 | 15,451 | +2,963 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 14,171 | +14,171 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,154 | 14,154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,061 | +14,061 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,010 | 13,984 | -26 | 0.00 | 0.00 | +0.00 | sell |