| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 4,197,926 | 5,726,857 | +1,528,931 | 2.74 | 2.17 | -0.56 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,997,399 | 5,488,299 | +490,900 | 2.33 | 1.30 | -1.03 | buy |
| BlackRock, Inc. | 4,184,056 | 4,476,691 | +292,635 | 0.00 | 0.00 | -0.00 | buy |
| Caligan Partners LP | 3,341,970 | 4,138,943 | +796,973 | 5.98 | 3.53 | -2.45 | buy |
| VANGUARD GROUP INC | 3,318,250 | 3,428,943 | +110,693 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 2,435,550 | 2,630,665 | +195,115 | 0.90 | 0.48 | -0.41 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,483,426 | 1,859,003 | +375,577 | 0.01 | 0.01 | -0.00 | buy |
| Stonepine Capital Management, LLC | 916,500 | 1,536,391 | +619,891 | 8.32 | 7.67 | -0.65 | buy |
| STATE STREET CORP | 1,406,594 | 1,515,217 | +108,623 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 1,170,311 | 1,475,109 | +304,798 | 1.09 | 0.69 | -0.39 | buy |
| Soleus Capital Management, L.P. | 2,119,000 | 1,450,000 | -669,000 | 1.35 | 0.48 | -0.87 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,231,841 | 1,417,192 | +185,351 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 957,741 | 1,354,395 | +396,654 | 0.01 | 0.01 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 996,040 | 1,168,886 | +172,846 | 0.49 | 0.39 | -0.10 | buy |
| Nuveen, LLC | 896,472 | 1,071,367 | +174,895 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 1,076,584 | 1,030,116 | -46,468 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,171,093 | 1,029,701 | -141,392 | 0.33 | 0.16 | -0.17 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,056,773 | 1,014,473 | -42,300 | 0.01 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 685,960 | 674,875 | -11,085 | 0.09 | 0.05 | -0.04 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 341,400 | 626,000 | +284,600 | 0.00 | 0.01 | +0.00 | buy |
| AWH Capital, L.P. | 625,000 | 625,000 | 0 | 6.71 | 4.00 | -2.71 | hold |
| CITADEL ADVISORS LLC | 581,859 | 588,409 | +6,550 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 499,470 | 552,410 | +52,940 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 419,768 | 490,303 | +70,535 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 296,704 | 457,697 | +160,993 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 692,486 | 446,311 | -246,175 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 290,039 | 436,414 | +146,375 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 204,562 | 393,222 | +188,660 | 0.01 | 0.01 | +0.00 | buy |
| Divisadero Street Capital Management, LP | 0 | 388,231 | +388,231 | 0.00 | 0.11 | +0.11 | buy |
| Zimmer Partners, LP | 630,000 | 330,000 | -300,000 | 0.13 | 0.05 | -0.08 | sell |
| Soviero Asset Management, LP | 0 | 330,000 | +330,000 | 0.00 | 1.25 | +1.25 | buy |
| Assenagon Asset Management S.A. | 612,388 | 285,782 | -326,606 | 0.01 | 0.00 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 257,454 | 277,915 | +20,461 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 82,594 | 273,232 | +190,638 | 0.00 | 0.00 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,664,828 | 270,506 | -1,394,322 | 0.14 | 0.01 | -0.13 | sell |
| BANK OF AMERICA CORP /DE/ | 120,569 | 266,115 | +145,546 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 961,153 | 265,728 | -695,425 | 0.00 | 0.00 | -0.00 | sell |
| CM Management, LLC | 175,000 | 250,000 | +75,000 | 1.47 | 1.28 | -0.19 | buy |
| Caption Management, LLC | 0 | 247,601 | +247,601 | 0.00 | 0.09 | +0.09 | buy |
| HighVista Strategies LLC | 58,042 | 226,025 | +167,983 | 0.20 | 0.34 | +0.14 | buy |
| ROYAL BANK OF CANADA | 87,020 | 224,189 | +137,169 | 0.00 | 0.00 | +0.00 | buy |
| Prospect Capital Advisors, LLC | 0 | 208,100 | +208,100 | 0.00 | 0.66 | +0.66 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 164,020 | 184,310 | +20,290 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 726,198 | 177,693 | -548,505 | 0.01 | 0.00 | -0.01 | sell |
| Bank of New York Mellon Corp | 141,005 | 142,820 | +1,815 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 82,347 | 140,773 | +58,426 | 0.03 | 0.04 | +0.01 | buy |
| AMERICAN ASSETS INC | 0 | 125,000 | +125,000 | 0.00 | 0.25 | +0.25 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 119,240 | 119,240 | 0 | 0.04 | 0.03 | -0.01 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 175,559 | 112,966 | -62,593 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 118,889 | 105,893 | -12,996 | 0.00 | 0.00 | -0.00 | sell |
| Krensavage Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.26 | +0.26 | buy |
| Y-Intercept (Hong Kong) Ltd | 259,487 | 96,068 | -163,419 | 0.06 | 0.01 | -0.04 | sell |
| Swiss National Bank | 91,700 | 91,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 148,362 | 88,167 | -60,195 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 125,749 | 82,954 | -42,795 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 85,093 | 82,726 | -2,367 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,634 | 76,828 | -80,806 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 25,152 | 74,912 | +49,760 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 51,890 | 71,536 | +19,646 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 117,960 | 66,239 | -51,721 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 56,323 | 63,335 | +7,012 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 62,440 | 62,340 | -100 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 71,265 | 58,343 | -12,922 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 57,838 | 57,332 | -506 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 67,846 | 56,588 | -11,258 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 51,692 | 49,608 | -2,084 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 48,676 | 48,332 | -344 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 41,821 | 48,157 | +6,336 | 0.00 | 0.00 | -0.00 | buy |
| Marex Group plc | 0 | 46,850 | +46,850 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,777 | 44,097 | -680 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 105,797 | 41,213 | -64,584 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 39,786 | +39,786 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 35,267 | +35,267 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 138,927 | 34,070 | -104,857 | 0.02 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 34,283 | 33,668 | -615 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 29,731 | 32,692 | +2,961 | 0.01 | 0.01 | -0.00 | buy |
| Quantinno Capital Management LP | 16,342 | 32,528 | +16,186 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,687 | 30,390 | +4,703 | 0.00 | 0.00 | -0.00 | buy |
| Pathstone Holdings, LLC | 28,050 | 27,260 | -790 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,249 | 27,238 | -2,011 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 27,205 | +27,205 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 76,200 | 26,500 | -49,700 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 33,598 | 26,132 | -7,466 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 158,325 | 25,546 | -132,779 | 0.01 | 0.00 | -0.01 | sell |
| BENDER ROBERT & ASSOCIATES | 25,070 | 25,070 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Creative Planning | 0 | 22,549 | +22,549 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 28,293 | 21,879 | -6,414 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 123,860 | 19,769 | -104,091 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 47,157 | 19,533 | -27,624 | 0.03 | 0.01 | -0.02 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,557 | 18,275 | -1,282 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 10,833 | 18,121 | +7,288 | 0.00 | 0.00 | +0.00 | buy |
| Pure Financial Advisors, LLC | 0 | 17,834 | +17,834 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 17,642 | 17,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 10,706 | 16,413 | +5,707 | 0.01 | 0.01 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,270 | 15,833 | +3,563 | 0.00 | 0.00 | -0.00 | buy |
| Global Retirement Partners, LLC | 2,650 | 15,200 | +12,550 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,918 | 14,309 | +391 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,154 | 14,154 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 0 | 13,927 | +13,927 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 10,583 | 13,891 | +3,308 | 0.01 | 0.01 | -0.00 | buy |