| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 421,220 | 2,910,849 | +2,489,629 | 0.49 | 3.07 | +2.58 | buy |
| PERCEPTIVE ADVISORS LLC | 1,485,801 | 3,963,424 | +2,477,623 | 0.46 | 0.93 | +0.48 | buy |
| MORGAN STANLEY | 526,575 | 2,582,711 | +2,056,136 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,918 | 1,414,526 | +1,393,608 | 0.00 | 0.01 | +0.01 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 550,000 | +550,000 | 0.00 | 0.11 | +0.11 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 371,400 | +371,400 | 0.00 | 0.36 | +0.36 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 16,900 | 265,700 | +248,800 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,698,647 | 2,943,512 | +244,865 | 0.00 | 0.00 | +0.00 | buy |
| Divisadero Street Capital Management, LP | 0 | 230,700 | +230,700 | 0.00 | 0.55 | +0.55 | buy |
| D. E. Shaw & Co., Inc. | 493,681 | 708,538 | +214,857 | 0.01 | 0.01 | +0.00 | buy |
| Stonepine Capital Management, LLC | 5,179,004 | 5,333,004 | +154,000 | 15.72 | 24.29 | +8.56 | buy |
| CITADEL ADVISORS LLC | 35,075 | 171,216 | +136,141 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 92,858 | 220,399 | +127,541 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 118,880 | 222,751 | +103,871 | 0.01 | 0.03 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 28,720 | 130,726 | +102,006 | 0.03 | 0.12 | +0.09 | buy |
| Trexquant Investment LP | 90,397 | 158,075 | +67,678 | 0.02 | 0.04 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 65,024 | +65,024 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 869,493 | 934,276 | +64,783 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 74,572 | 126,454 | +51,882 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 50,459 | +50,459 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 19,794 | 69,457 | +49,663 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 984,543 | 1,026,374 | +41,831 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 39,453 | +39,453 | 0.00 | 0.09 | +0.09 | buy |
| Qube Research & Technologies Ltd | 9,832 | 46,092 | +36,260 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 39,006 | 69,803 | +30,797 | 0.01 | 0.02 | +0.01 | buy |
| SG Americas Securities, LLC | 18,744 | 43,978 | +25,234 | 0.00 | 0.01 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 29,783 | 51,221 | +21,438 | 0.05 | 0.10 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 0 | 21,206 | +21,206 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 600 | 20,200 | +19,600 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 18,996 | +18,996 | 0.00 | 0.05 | +0.05 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 18,204 | +18,204 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,411 | +14,411 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 14,279 | +14,279 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 13,697 | +13,697 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 12,196 | +12,196 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Middle East FZE | 5,219 | 17,210 | +11,991 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 10,507 | +10,507 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,970 | 13,958 | +7,988 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 141,160 | 148,246 | +7,086 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 24,329 | 31,040 | +6,711 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 61,214 | 66,747 | +5,533 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 63,836 | 69,146 | +5,310 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,459 | 6,614 | +5,155 | 0.00 | 0.01 | +0.01 | buy |
| Knott David M Jr | 68,066 | 73,066 | +5,000 | 0.24 | 0.29 | +0.06 | buy |
| JANE STREET GROUP, LLC | 66,924 | 71,769 | +4,845 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 15,253 | 20,056 | +4,803 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 4,800 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 386,743 | 390,616 | +3,873 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 34,363 | 37,931 | +3,568 | 0.00 | 0.00 | +0.00 | buy |
| Tradition Wealth Management, LLC | 5,525 | 8,000 | +2,475 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 20,835 | 22,115 | +1,280 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,393 | 38,245 | +852 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,155 | 12,742 | +587 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,891 | 47,370 | +479 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 254 | +254 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 114,606 | 114,779 | +173 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,831 | 1,972 | +141 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 42 | +42 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 1,731 | 1,731 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,084 | 4,084 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 17,401 | 17,401 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WASHINGTON TRUST Co | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 3,097,399 | 3,097,399 | 0 | 3.99 | 3.01 | -0.98 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,622 | 12,622 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GHP Investment Advisors, Inc. | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Plante Moran Financial Advisors, LLC | 1,220 | 1,220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 162 | 162 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 19,614 | 19,614 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PDT Partners, LLC | 64,334 | 64,334 | 0 | 0.07 | 0.07 | +0.00 | hold |
| Global Retirement Partners, LLC | 8,650 | 8,650 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IAG Wealth Partners, LLC | 927 | 927 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CM Management, LLC | 150,000 | 150,000 | 0 | 1.45 | 1.27 | -0.19 | hold |
| Covestor Ltd | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Stephens Consulting, LLC | 290 | 290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 688 | 688 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,418 | 2,418 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 154 | 154 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BENDER ROBERT & ASSOCIATES | 25,070 | 25,070 | 0 | 0.07 | 0.07 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 5,767 | 5,767 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,859 | 11,859 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 17,897 | 17,859 | -38 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,335 | 12,261 | -74 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 20,665 | 20,582 | -83 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 10,800 | 10,700 | -100 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 533 | 409 | -124 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 36,467 | 36,329 | -138 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 14,553 | 14,394 | -159 | 0.00 | 0.00 | +0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 228 | 0 | -228 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 5,966 | 5,622 | -344 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 13,926 | 13,472 | -454 | 0.00 | 0.00 | +0.00 | sell |
| Federation des caisses Desjardins du Quebec | 850 | 100 | -750 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,625 | 16,836 | -789 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,329 | 28,466 | -863 | 0.00 | 0.00 | +0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,084 | 10,398 | -1,686 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 11,608 | 9,876 | -1,732 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 164,020 | 162,083 | -1,937 | 0.00 | 0.00 | +0.00 | sell |
| Legato Capital Management LLC | 110,329 | 108,210 | -2,119 | 0.15 | 0.15 | +0.00 | sell |
| Kestra Advisory Services, LLC | 16,356 | 13,806 | -2,550 | 0.00 | 0.00 | -0.00 | sell |