| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Tri Locum Partners LP | 0 | 742,574 | +742,574 | 0.00 | 1.70 | +1.70 | buy |
| GILDER GAGNON HOWE & CO LLC | 181,380 | 702,239 | +520,859 | 0.04 | 0.08 | +0.05 | buy |
| Caligan Partners LP | 2,193,488 | 2,692,388 | +498,900 | 11.26 | 7.53 | -3.74 | buy |
| UBS Group AG | 645,301 | 1,093,405 | +448,104 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,029,670 | 1,368,423 | +338,753 | 0.01 | 0.01 | -0.00 | buy |
| Altium Capital Management LLC | 355,000 | 685,000 | +330,000 | 1.71 | 2.36 | +0.64 | buy |
| Nantahala Capital Management, LLC | 2,824,849 | 3,130,149 | +305,300 | 3.85 | 2.42 | -1.43 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 983,702 | 1,287,767 | +304,065 | 0.47 | 0.42 | -0.05 | buy |
| SOROS FUND MANAGEMENT LLC | 850,000 | 1,100,000 | +250,000 | 0.27 | 0.21 | -0.06 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 239,811 | +239,811 | 0.00 | 0.03 | +0.03 | buy |
| Qube Research & Technologies Ltd | 567,048 | 754,079 | +187,031 | 0.02 | 0.01 | -0.00 | buy |
| Zimmer Partners, LP | 250,000 | 416,500 | +166,500 | 0.08 | 0.08 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 514,900 | 677,600 | +162,700 | 0.43 | 0.35 | -0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,847,399 | 4,997,399 | +150,000 | 5.61 | 3.65 | -1.96 | buy |
| STATE STREET CORP | 1,277,841 | 1,422,369 | +144,528 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 4,230,149 | 4,364,896 | +134,747 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 258,279 | 373,265 | +114,986 | 1.30 | 1.18 | -0.12 | buy |
| GOLDMAN SACHS GROUP INC | 310,582 | 415,677 | +105,095 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 68,181 | +68,181 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 212,209 | 272,248 | +60,039 | 0.04 | 0.03 | -0.01 | buy |
| STIFEL FINANCIAL CORP | 144,024 | 197,697 | +53,673 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 485,783 | 531,167 | +45,384 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 904,900 | 948,281 | +43,381 | 0.79 | 0.57 | -0.22 | buy |
| Graham Capital Management, L.P. | 12,056 | 46,963 | +34,907 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,829 | 81,192 | +31,363 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 80,316 | 111,649 | +31,333 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 0 | 28,301 | +28,301 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,014,960 | 1,040,440 | +25,480 | 0.02 | 0.01 | -0.01 | buy |
| BENDER ROBERT & ASSOCIATES | 0 | 25,070 | +25,070 | 0.00 | 0.07 | +0.07 | buy |
| Engineers Gate Manager LP | 0 | 24,206 | +24,206 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,503 | 21,496 | +17,993 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,841 | 49,347 | +14,506 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 13,525 | +13,525 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 21,337 | 34,700 | +13,363 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 12,907 | +12,907 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 45,588 | 58,090 | +12,502 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 93,662 | 105,786 | +12,124 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 10,931 | +10,931 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 10,665 | +10,665 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 10,432 | +10,432 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 149,231 | 158,671 | +9,440 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 72,232 | 80,446 | +8,214 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 149,562 | 157,044 | +7,482 | 0.00 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 11,783 | 18,886 | +7,103 | 0.02 | 0.03 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 108,231 | 115,052 | +6,821 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,261 | 52,593 | +6,332 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 27 | 4,736 | +4,709 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,061 | 18,674 | +4,613 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 0 | 4,451 | +4,451 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 14,171 | 18,563 | +4,392 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,210,621 | 1,214,590 | +3,969 | 0.00 | 0.00 | -0.00 | buy |
| MAI Capital Management | 0 | 3,200 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 30,381 | 33,370 | +2,989 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 418,576 | 421,481 | +2,905 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,782 | 14,084 | +2,302 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 32,228 | 34,272 | +2,044 | 0.00 | 0.00 | -0.00 | buy |
| Tradition Wealth Management, LLC | 11,000 | 13,000 | +2,000 | 0.02 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 78,387 | 80,149 | +1,762 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,678 | +1,678 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,135 | 13,426 | +1,291 | 0.02 | 0.01 | -0.01 | buy |
| Legal & General Group Plc | 51,416 | 52,656 | +1,240 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,357 | 31,451 | +1,094 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 678 | 1,678 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 2,487 | 3,436 | +949 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 345 | +345 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,522 | 13,700 | +178 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 111,892 | 112,070 | +178 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 26 | 96 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 136,586 | 136,599 | +13 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 7,749 | 7,749 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BESSEMER GROUP INC | 145 | 145 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,415 | 5,415 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WASHINGTON TRUST Co | 5,000 | 5,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 62,440 | 62,440 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 53 | 53 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 17,642 | 17,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRIVATE TRUST CO NA | 6,558 | 6,558 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 750 | 750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 57 | 57 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GHP Investment Advisors, Inc. | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LPL Financial LLC | 21,071 | 21,071 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Plante Moran Financial Advisors, LLC | 1,220 | 1,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 325,000 | 325,000 | 0 | 0.03 | 0.01 | -0.01 | hold |
| Daiwa Securities Group Inc. | 262 | 262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 91,700 | 91,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IAG Wealth Partners, LLC | 927 | 927 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CM Management, LLC | 150,000 | 150,000 | 0 | 1.94 | 1.48 | -0.46 | hold |
| Knott David M Jr | 57,570 | 57,570 | 0 | 0.33 | 0.23 | -0.10 | hold |
| POM Investment Strategies, LLC | 2,000 | 2,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Fortitude Family Office, LLC | 118 | 118 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stephens Consulting, LLC | 290 | 290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Olistico Wealth, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Glass Jacobson Investment Advisors llc | 2,665 | 2,665 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Farther Finance Advisors, LLC | 15 | 15 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 301 | 301 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |