| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 5,356,622 | 5,145,846 | -210,776 | 1.86 | 1.58 | -0.28 | sell |
| TANG CAPITAL MANAGEMENT LLC | 4,847,399 | 4,997,399 | +150,000 | 5.61 | 3.65 | -1.96 | buy |
| BlackRock, Inc. | 4,230,149 | 4,364,896 | +134,747 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 3,195,331 | 3,171,404 | -23,927 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 2,824,849 | 3,130,149 | +305,300 | 3.85 | 2.42 | -1.43 | buy |
| Caligan Partners LP | 2,193,488 | 2,692,388 | +498,900 | 11.26 | 7.53 | -3.74 | buy |
| STATE STREET CORP | 1,277,841 | 1,422,369 | +144,528 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,029,670 | 1,368,423 | +338,753 | 0.01 | 0.01 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 983,702 | 1,287,767 | +304,065 | 0.47 | 0.42 | -0.05 | buy |
| Stonepine Capital Management, LLC | 1,369,821 | 1,264,651 | -105,170 | 14.02 | 11.27 | -2.75 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,210,621 | 1,214,590 | +3,969 | 0.00 | 0.00 | -0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 850,000 | 1,100,000 | +250,000 | 0.27 | 0.21 | -0.06 | buy |
| UBS Group AG | 645,301 | 1,093,405 | +448,104 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,014,960 | 1,040,440 | +25,480 | 0.02 | 0.01 | -0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 904,900 | 948,281 | +43,381 | 0.79 | 0.57 | -0.22 | buy |
| GREAT POINT PARTNERS LLC | 1,170,000 | 895,524 | -274,476 | 5.72 | 4.66 | -1.06 | sell |
| D. E. Shaw & Co., Inc. | 970,270 | 848,176 | -122,094 | 0.02 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 1,000,549 | 805,240 | -195,309 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 567,048 | 754,079 | +187,031 | 0.02 | 0.01 | -0.00 | buy |
| Tri Locum Partners LP | 0 | 742,574 | +742,574 | 0.00 | 1.70 | +1.70 | buy |
| GILDER GAGNON HOWE & CO LLC | 181,380 | 702,239 | +520,859 | 0.04 | 0.08 | +0.05 | buy |
| Soleus Capital Management, L.P. | 1,037,680 | 697,158 | -340,522 | 1.40 | 0.58 | -0.82 | sell |
| Altium Capital Management LLC | 355,000 | 685,000 | +330,000 | 1.71 | 2.36 | +0.64 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 514,900 | 677,600 | +162,700 | 0.43 | 0.35 | -0.07 | buy |
| AWH Capital, L.P. | 657,500 | 635,000 | -22,500 | 9.50 | 8.34 | -1.16 | sell |
| NORTHERN TRUST CORP | 485,783 | 531,167 | +45,384 | 0.00 | 0.00 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 995,449 | 497,849 | -497,600 | 0.05 | 0.02 | -0.03 | sell |
| Assenagon Asset Management S.A. | 955,555 | 435,453 | -520,102 | 0.03 | 0.01 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 418,576 | 421,481 | +2,905 | 0.00 | 0.00 | -0.00 | buy |
| Zimmer Partners, LP | 250,000 | 416,500 | +166,500 | 0.08 | 0.08 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 310,582 | 415,677 | +105,095 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 453,061 | 383,045 | -70,016 | 0.56 | 0.44 | -0.13 | sell |
| Ikarian Capital, LLC | 258,279 | 373,265 | +114,986 | 1.30 | 1.18 | -0.12 | buy |
| Alyeska Investment Group, L.P. | 325,000 | 325,000 | 0 | 0.03 | 0.01 | -0.01 | hold |
| DEUTSCHE BANK AG\ | 545,589 | 307,769 | -237,820 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 212,209 | 272,248 | +60,039 | 0.04 | 0.03 | -0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 239,811 | +239,811 | 0.00 | 0.03 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 144,024 | 197,697 | +53,673 | 0.00 | 0.00 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 295,553 | 182,503 | -113,050 | 0.83 | 0.36 | -0.47 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 222,690 | 173,521 | -49,169 | 0.01 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 247,560 | 163,937 | -83,623 | 0.05 | 0.02 | -0.03 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 175,039 | 162,239 | -12,800 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 149,231 | 158,671 | +9,440 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 149,562 | 157,044 | +7,482 | 0.00 | 0.00 | -0.00 | buy |
| CM Management, LLC | 150,000 | 150,000 | 0 | 1.94 | 1.48 | -0.46 | hold |
| JPMORGAN CHASE & CO | 169,926 | 138,149 | -31,777 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 136,586 | 136,599 | +13 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 108,231 | 115,052 | +6,821 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 111,892 | 112,070 | +178 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 80,316 | 111,649 | +31,333 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 93,662 | 105,786 | +12,124 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 91,700 | 91,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FORMULA GROWTH LTD | 138,000 | 90,830 | -47,170 | 0.77 | 0.34 | -0.43 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,829 | 81,192 | +31,363 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 72,232 | 80,446 | +8,214 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 78,387 | 80,149 | +1,762 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 68,181 | +68,181 | 0.00 | 0.01 | +0.01 | buy |
| Legato Capital Management LLC | 108,547 | 64,778 | -43,769 | 0.22 | 0.09 | -0.12 | sell |
| ALLIANCEBERNSTEIN L.P. | 62,440 | 62,440 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITADEL ADVISORS LLC | 151,049 | 61,971 | -89,078 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 78,440 | 59,623 | -18,817 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 45,588 | 58,090 | +12,502 | 0.00 | 0.00 | -0.00 | buy |
| Knott David M Jr | 57,570 | 57,570 | 0 | 0.33 | 0.23 | -0.10 | hold |
| Legal & General Group Plc | 51,416 | 52,656 | +1,240 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,261 | 52,593 | +6,332 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,841 | 49,347 | +14,506 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 48,786 | 48,727 | -59 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 242,042 | 47,438 | -194,604 | 0.06 | 0.01 | -0.05 | sell |
| Graham Capital Management, L.P. | 12,056 | 46,963 | +34,907 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,000 | 44,777 | -223 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 74,787 | 43,100 | -31,687 | 0.02 | 0.01 | -0.01 | sell |
| FIRST MANHATTAN CO. LLC. | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 62,748 | 36,213 | -26,535 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 21,337 | 34,700 | +13,363 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 32,228 | 34,272 | +2,044 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 51,999 | 33,944 | -18,055 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 30,381 | 33,370 | +2,989 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,357 | 31,451 | +1,094 | 0.00 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 51,100 | 29,300 | -21,800 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 0 | 28,301 | +28,301 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 29,552 | 27,477 | -2,075 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 38,447 | 27,173 | -11,274 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 90,359 | 26,179 | -64,180 | 0.00 | 0.00 | -0.00 | sell |
| BENDER ROBERT & ASSOCIATES | 0 | 25,070 | +25,070 | 0.00 | 0.07 | +0.07 | buy |
| ALGERT GLOBAL LLC | 24,570 | 24,387 | -183 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 24,206 | +24,206 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 36,537 | 23,531 | -13,006 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,503 | 21,496 | +17,993 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 21,071 | 21,071 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,178 | 20,677 | -501 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 11,783 | 18,886 | +7,103 | 0.02 | 0.03 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,061 | 18,674 | +4,613 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 14,171 | 18,563 | +4,392 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 101,398 | 18,326 | -83,072 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 17,642 | 17,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 18,346 | 16,846 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,154 | 14,154 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,782 | 14,084 | +2,302 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 15,451 | 13,733 | -1,718 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 13,522 | 13,700 | +178 | 0.00 | 0.00 | -0.00 | buy |