| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILDER GAGNON HOWE & CO LLC | 181,380 | 702,239 | +520,859 | 0.04 | 0.08 | +0.05 | buy |
| Caligan Partners LP | 2,193,488 | 2,692,388 | +498,900 | 11.26 | 7.53 | -3.74 | buy |
| Altium Capital Management LLC | 355,000 | 685,000 | +330,000 | 1.71 | 2.36 | +0.64 | buy |
| Nantahala Capital Management, LLC | 2,824,849 | 3,130,149 | +305,300 | 2.32 | 1.48 | -0.83 | buy |
| SOROS FUND MANAGEMENT LLC | 850,000 | 1,100,000 | +250,000 | 0.20 | 0.18 | -0.02 | buy |
| Zimmer Partners, LP | 250,000 | 416,500 | +166,500 | 0.07 | 0.08 | +0.01 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 514,900 | 677,600 | +162,700 | 0.43 | 0.35 | -0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 4,847,399 | 4,997,399 | +150,000 | 5.61 | 3.65 | -1.96 | buy |
| Ikarian Capital, LLC | 258,279 | 373,265 | +114,986 | 1.30 | 1.18 | -0.12 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 904,900 | 948,281 | +43,381 | 0.79 | 0.57 | -0.22 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,014,960 | 1,040,440 | +25,480 | 0.02 | 0.01 | -0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 78,440 | 59,623 | +18,817 | 0.01 | 0.00 | 0.00 | sell |
| Dynamic Technology Lab Private Ltd | 11,783 | 18,886 | +7,103 | 0.02 | 0.03 | +0.01 | buy |
| Tradition Wealth Management, LLC | 11,000 | 13,000 | +2,000 | 0.02 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,135 | 13,426 | +1,291 | 0.02 | 0.01 | -0.01 | buy |
| NATIXIS | 5,293 | 4,499 | +794 | 0.00 | 0.00 | 0.00 | sell |
| AWH Capital, L.P. | 657,500 | 635,000 | -22,500 | 9.50 | 8.34 | -1.16 | sell |
| Legato Capital Management LLC | 108,547 | 64,778 | -43,769 | 0.22 | 0.09 | -0.12 | sell |
| FORMULA GROWTH LTD | 138,000 | 90,830 | -47,170 | 0.77 | 0.34 | -0.43 | sell |
| Eversept Partners, LP | 453,061 | 383,045 | -70,016 | 0.50 | 0.38 | -0.13 | sell |
| Stonepine Capital Management, LLC | 1,369,821 | 1,264,651 | -105,170 | 14.02 | 11.27 | -2.75 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 295,553 | 182,503 | -113,050 | 0.83 | 0.36 | -0.47 | sell |
| PERCEPTIVE ADVISORS LLC | 5,356,622 | 5,145,846 | -210,776 | 1.84 | 1.57 | -0.27 | sell |
| GREAT POINT PARTNERS LLC | 1,170,000 | 895,524 | -274,476 | 5.58 | 4.66 | -0.92 | sell |
| Soleus Capital Management, L.P. | 1,037,680 | 697,158 | -340,522 | 1.40 | 0.58 | -0.82 | sell |
| LORD, ABBETT & CO. LLC | 995,449 | 497,849 | -497,600 | 0.05 | 0.02 | -0.03 | sell |