| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 5,726,857 | 5,820,649 | +93,792 | 2.17 | 2.31 | +0.14 | buy |
| BlackRock, Inc. | 4,476,691 | 4,095,300 | -381,391 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 3,428,943 | 3,341,804 | -87,139 | 0.00 | 0.00 | +0.00 | sell |
| BRAIDWELL LP | 0 | 3,105,209 | +3,105,209 | 0.00 | 0.66 | +0.66 | buy |
| Frazier Life Sciences Management, L.P. | 2,630,665 | 2,630,665 | 0 | 0.48 | 0.47 | -0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,859,003 | 2,093,037 | +234,034 | 0.01 | 0.01 | +0.00 | buy |
| Stonepine Capital Management, LLC | 1,536,391 | 1,631,588 | +95,197 | 7.67 | 8.58 | +0.91 | buy |
| STATE STREET CORP | 1,515,217 | 1,574,851 | +59,634 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,354,395 | 1,541,096 | +186,701 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,417,192 | 1,386,248 | -30,944 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 588,409 | 1,379,131 | +790,722 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 5,488,299 | 1,245,692 | -4,242,607 | 1.30 | 0.41 | -0.89 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,168,886 | 1,153,444 | -15,442 | 0.39 | 0.42 | +0.03 | sell |
| Soleus Capital Management, L.P. | 1,450,000 | 1,070,000 | -380,000 | 0.48 | 0.30 | -0.17 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,014,473 | 986,466 | -28,007 | 0.00 | 0.00 | +0.00 | sell |
| ARMISTICE CAPITAL, LLC | 0 | 976,000 | +976,000 | 0.00 | 0.16 | +0.16 | buy |
| UBS Group AG | 1,030,116 | 881,369 | -148,747 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 626,000 | 799,900 | +173,900 | 0.01 | 0.01 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 674,875 | 782,365 | +107,490 | 0.05 | 0.07 | +0.01 | buy |
| MORGAN STANLEY | 265,728 | 730,665 | +464,937 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 675,000 | +675,000 | 0.00 | 0.20 | +0.20 | buy |
| Soviero Asset Management, LP | 330,000 | 655,000 | +325,000 | 1.25 | 2.28 | +1.02 | buy |
| AWH Capital, L.P. | 625,000 | 625,000 | 0 | 4.00 | 3.83 | -0.17 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 71,536 | 564,988 | +493,452 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 490,303 | 517,129 | +26,826 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 552,410 | 445,166 | -107,244 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 436,414 | 436,747 | +333 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 428,647 | +428,647 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 273,232 | 417,278 | +144,046 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 266,115 | 358,046 | +91,931 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 457,697 | 350,742 | -106,955 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 1,475,109 | 344,104 | -1,131,005 | 0.69 | 0.13 | -0.57 | sell |
| Campbell & CO Investment Adviser LLC | 19,533 | 340,188 | +320,655 | 0.01 | 0.11 | +0.10 | buy |
| Assenagon Asset Management S.A. | 285,782 | 270,219 | -15,563 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 277,915 | 263,129 | -14,786 | 0.00 | 0.00 | +0.00 | sell |
| CM Management, LLC | 250,000 | 250,000 | 0 | 1.28 | 1.40 | +0.12 | hold |
| JPMORGAN CHASE & CO | 446,311 | 225,602 | -220,709 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 184,310 | 195,160 | +10,850 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 41,213 | 174,346 | +133,133 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 142,820 | 137,797 | -5,023 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 12,227 | 132,970 | +120,743 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 105,893 | 130,738 | +24,845 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN ASSETS INC | 125,000 | 125,000 | 0 | 0.25 | 0.26 | +0.02 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 118,139 | +118,139 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,769 | 102,094 | +82,325 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,029,701 | 101,812 | -927,889 | 0.16 | 0.02 | -0.14 | sell |
| Krensavage Asset Management, LLC | 100,000 | 100,000 | 0 | 0.26 | 0.23 | -0.03 | hold |
| Knott David M Jr | 0 | 99,338 | +99,338 | 0.00 | 0.31 | +0.31 | buy |
| Quantinno Capital Management LP | 32,528 | 88,988 | +56,460 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 1,071,367 | 88,369 | -982,998 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 63,335 | 85,364 | +22,029 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,828 | 80,151 | +3,323 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 46,850 | 76,850 | +30,000 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 48,157 | 75,968 | +27,811 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 82,726 | 70,049 | -12,677 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 140,773 | 67,991 | -72,782 | 0.04 | 0.01 | -0.03 | sell |
| Russell Investments Group, Ltd. | 66,239 | 65,571 | -668 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 88,167 | 65,096 | -23,071 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 62,340 | 62,340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brooklyn Investment Group | 0 | 61,735 | +61,735 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 74,912 | 60,975 | -13,937 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 57,332 | 54,270 | -3,062 | 0.00 | 0.00 | +0.00 | sell |
| GWN SECURITIES INC. | 0 | 48,913 | +48,913 | 0.00 | 0.07 | +0.07 | buy |
| SEI INVESTMENTS CO | 48,332 | 45,501 | -2,831 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 82,954 | 43,404 | -39,550 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Quantitative Investments LLC | 0 | 41,972 | +41,972 | 0.00 | 0.06 | +0.06 | buy |
| Pathstone Holdings, LLC | 27,260 | 41,059 | +13,799 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 35,267 | 39,303 | +4,036 | 0.02 | 0.02 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 35,859 | +35,859 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 21,879 | 35,470 | +13,591 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 33,668 | 34,119 | +451 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 30,390 | 32,689 | +2,299 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 27,205 | 32,664 | +5,459 | 0.03 | 0.03 | +0.01 | buy |
| Atom Investors LP | 0 | 32,498 | +32,498 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 26,132 | 28,388 | +2,256 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 7,895 | 28,383 | +20,488 | 0.00 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 27,827 | +27,827 | 0.00 | 0.00 | +0.00 | buy |
| Versor Investments LP | 0 | 26,700 | +26,700 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 34,070 | 26,206 | -7,864 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 0 | 26,085 | +26,085 | 0.00 | 0.04 | +0.04 | buy |
| SIMPLEX TRADING, LLC | 5,389 | 24,684 | +19,295 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,238 | 24,126 | -3,112 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 22,549 | 24,060 | +1,511 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 58,343 | 22,977 | -35,366 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 0 | 22,919 | +22,919 | 0.00 | 0.05 | +0.05 | buy |
| Virtu Financial LLC | 0 | 22,701 | +22,701 | 0.00 | 0.01 | +0.01 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 21,661 | +21,661 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 18,121 | 20,418 | +2,297 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 26,500 | 19,400 | -7,100 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 18,838 | +18,838 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 12,502 | 18,181 | +5,679 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 13,927 | 18,095 | +4,168 | 0.00 | 0.00 | +0.00 | buy |
| Pure Financial Advisors, LLC | 17,834 | 17,800 | -34 | 0.00 | 0.00 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 16,705 | +16,705 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 16,413 | 16,413 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,275 | 16,232 | -2,043 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 15,200 | 16,200 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,833 | 15,833 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legato Capital Management LLC | 13,891 | 15,130 | +1,239 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,154 | 14,154 | 0 | 0.00 | 0.00 | +0.00 | hold |