| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CADIAN CAPITAL MANAGEMENT, LP | 710,000 | 5,792,779 | +5,082,779 | 0.77 | 4.25 | +3.48 | buy |
| BRAIDWELL LP | 758,928 | 2,476,804 | +1,717,876 | 0.75 | 1.65 | +0.89 | buy |
| Deep Track Capital, LP | 5,000,000 | 6,000,000 | +1,000,000 | 4.74 | 3.56 | -1.18 | buy |
| Eagle Health Investments LP | 120,109 | 730,209 | +610,100 | 0.66 | 2.87 | +2.21 | buy |
| Temasek Holdings (Private) Ltd | 3,673,243 | 4,111,172 | +437,929 | 0.56 | 0.47 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 584,557 | 250,928 | +333,629 | 0.04 | 0.01 | 0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,888,146 | 4,179,432 | +291,286 | 1.72 | 1.35 | -0.36 | buy |
| Holocene Advisors, LP | 40,511 | 204,469 | +163,958 | 0.00 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 346,084 | 457,791 | +111,707 | 0.02 | 0.02 | -0.00 | buy |
| PURA VIDA INVESTMENTS, LLC | 15,000 | 100,000 | +85,000 | 0.06 | 0.35 | +0.29 | buy |
| FRED ALGER MANAGEMENT, LLC | 51,316 | 134,262 | +82,946 | 0.01 | 0.01 | +0.01 | buy |
| Bridgewater Associates, LP | 35,117 | 107,816 | +72,699 | 0.01 | 0.01 | +0.01 | buy |
| Beck Bode, LLC | 142,745 | 203,596 | +60,851 | 0.87 | 0.86 | -0.01 | buy |
| Sicart Associates LLC | 92,953 | 146,592 | +53,639 | 0.96 | 1.11 | +0.15 | buy |
| BAILLIE GIFFORD & CO | 6,178,812 | 6,232,104 | +53,292 | 0.13 | 0.10 | -0.03 | buy |
| Nebula Research & Development LLC | 20,073 | 70,328 | +50,255 | 0.16 | 0.31 | +0.15 | buy |
| First Light Asset Management, LLC | 144,049 | 189,765 | +45,716 | 0.31 | 0.30 | -0.01 | buy |
| Edgestream Partners, L.P. | 9,854 | 46,939 | +37,085 | 0.02 | 0.05 | +0.03 | buy |
| Employees Retirement System of Texas | 18,987 | 37,287 | +18,300 | 0.01 | 0.01 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 150,137 | 137,767 | +12,370 | 0.01 | 0.00 | 0.00 | sell |
| AlphaQuest LLC | 9,245 | 20,284 | +11,039 | 0.05 | 0.07 | 0.00 | buy |
| JENNISON ASSOCIATES LLC | 479,846 | 489,657 | +9,811 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,652 | 23,406 | +9,754 | 0.07 | 0.06 | -0.01 | buy |
| Adalta Capital Management LLC | 61,458 | 71,023 | +9,565 | 1.01 | 0.81 | -0.20 | buy |
| Rathbones Group PLC | 95,678 | 103,728 | +8,050 | 0.02 | 0.01 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 18,091 | 25,652 | +7,561 | 0.12 | 0.11 | -0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 161,809 | 155,183 | +6,626 | 0.03 | 0.02 | 0.00 | sell |
| NEOS Investment Management LLC | 15,856 | 21,996 | +6,140 | 0.04 | 0.03 | -0.01 | buy |
| ProShare Advisors LLC | 26,799 | 29,317 | +2,518 | 0.00 | 0.00 | 0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 17,089 | 18,540 | +1,451 | 0.05 | 0.04 | -0.01 | buy |
| Values First Advisors, Inc. | 35,135 | 36,111 | +976 | 0.57 | 0.44 | -0.14 | buy |
| ALGERT GLOBAL LLC | 73,848 | 73,220 | +628 | 0.08 | 0.06 | 0.00 | sell |
| Harel Insurance Investments & Financial Services Ltd. | 699 | 754 | +55 | 0.00 | 0.00 | -0.00 | buy |
| MV CAPITAL MANAGEMENT, INC. | 1 | 6 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Tidemark, LLC | 294 | 206 | -88 | 0.00 | 0.00 | -0.00 | sell |
| Silicon Valley Community Foundation | 13,821 | 13,599 | -222 | 0.04 | 0.01 | -0.03 | sell |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 360 | 96 | -264 | 0.01 | 0.00 | -0.01 | sell |
| SWS Partners | 45,971 | 45,411 | -560 | 0.41 | 0.28 | -0.13 | sell |
| IMA Advisory Services, Inc. | 17,205 | 15,970 | -1,235 | 0.23 | 0.16 | -0.08 | sell |
| D.A. DAVIDSON & CO. | 29,793 | 27,695 | -2,098 | 0.01 | 0.01 | -0.00 | sell |
| Granite Investment Partners, LLC | 208,187 | 202,450 | -5,737 | 0.22 | 0.16 | -0.06 | sell |
| Nikko Asset Management Americas, Inc. | 93,745 | 84,046 | -9,699 | 0.02 | 0.02 | -0.01 | sell |
| NATIXIS | 15,927 | 1 | -15,926 | 0.00 | 0.00 | -0.00 | sell |
| Capital Impact Advisors, LLC | 35,219 | 16,619 | -18,600 | 1.25 | 0.45 | -0.81 | sell |
| PDT Partners, LLC | 90,083 | 68,666 | -21,417 | 0.27 | 0.13 | -0.14 | sell |
| LOOMIS SAYLES & CO L P | 87,652 | 63,655 | -23,997 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 138,644 | 112,924 | -25,720 | 0.00 | 0.00 | -0.00 | sell |
| Aristotle Atlantic Partners, LLC | 836,945 | 806,895 | -30,050 | 0.80 | 0.54 | -0.25 | sell |
| Erste Asset Management GmbH | 692,600 | 652,600 | -40,000 | 0.28 | 0.18 | -0.10 | sell |
| TCW GROUP INC | 133,660 | 90,174 | -43,486 | 0.04 | 0.02 | -0.02 | sell |
| FIL Ltd | 1,970,988 | 1,919,888 | -51,100 | 0.06 | 0.04 | -0.02 | sell |
| Virtus Investment Advisers, LLC | 52,000 | 0 | -52,000 | 0.03 | 0.03 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 119,976 | 66,176 | -53,800 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 438,100 | 361,166 | -76,934 | 0.07 | 0.05 | -0.02 | sell |
| Capital International Investors | 4,001,803 | 3,822,939 | -178,864 | 0.02 | 0.02 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,819,584 | 1,545,114 | -274,470 | 0.01 | 0.00 | -0.00 | sell |