| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 11,130,654 | 11,436,026 | +305,372 | 0.01 | 0.00 | -0.00 | buy |
| Opti Capital Management, LP | 0 | 10,000,000 | +10,000,000 | 0.00 | 0.52 | +0.52 | buy |
| BAILLIE GIFFORD & CO | 6,178,812 | 6,232,104 | +53,292 | 0.13 | 0.10 | -0.03 | buy |
| Deep Track Capital, LP | 5,000,000 | 6,000,000 | +1,000,000 | 4.74 | 3.56 | -1.18 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 710,000 | 5,792,779 | +5,082,779 | 0.77 | 4.25 | +3.48 | buy |
| JANE STREET GROUP, LLC | 2,575,000 | 4,226,000 | +1,651,000 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,888,146 | 4,179,432 | +291,286 | 1.72 | 1.35 | -0.36 | buy |
| Temasek Holdings (Private) Ltd | 3,673,243 | 4,111,172 | +437,929 | 0.56 | 0.47 | -0.09 | buy |
| Capital International Investors | 4,001,803 | 3,822,939 | -178,864 | 0.02 | 0.02 | -0.01 | sell |
| FMR LLC | 5,251,349 | 3,026,510 | -2,224,839 | 0.01 | 0.00 | -0.01 | sell |
| Parkwood LLC | 2,800,000 | 2,800,000 | 0 | 0.31 | 0.20 | -0.12 | hold |
| CITADEL ADVISORS LLC | 27,870 | 2,790,538 | +2,762,668 | 0.00 | 0.06 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,513,703 | 2,641,810 | +128,107 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 2,572,324 | 2,628,037 | +55,713 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 758,928 | 2,476,804 | +1,717,876 | 0.75 | 1.65 | +0.89 | buy |
| FIL Ltd | 1,970,988 | 1,919,888 | -51,100 | 0.06 | 0.04 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,819,584 | 1,545,114 | -274,470 | 0.01 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 1,426,450 | +1,426,450 | 0.00 | 0.09 | +0.09 | buy |
| Invesco Ltd. | 1,089,642 | 1,334,270 | +244,628 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,232,117 | 1,277,099 | +44,982 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 909,770 | 1,200,800 | +291,030 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 720,015 | 1,189,983 | +469,968 | 0.02 | 0.02 | +0.00 | buy |
| NORGES BANK | 943,433 | 1,169,699 | +226,266 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 893,547 | 1,160,803 | +267,256 | 0.10 | 0.09 | -0.01 | buy |
| Pictet Asset Management Holding SA | 950,793 | 1,149,621 | +198,828 | 0.03 | 0.02 | -0.00 | buy |
| MORGAN STANLEY | 2,458,282 | 1,101,592 | -1,356,690 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,369,009 | 1,067,261 | -301,748 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 1,079,580 | 1,047,123 | -32,457 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 1,159,846 | 1,015,012 | -144,834 | 0.02 | 0.01 | -0.01 | sell |
| Man Group plc | 1,008,046 | 971,353 | -36,693 | 0.08 | 0.05 | -0.02 | sell |
| Bank of New York Mellon Corp | 1,103,892 | 971,064 | -132,828 | 0.01 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 907,200 | 906,900 | -300 | 0.06 | 0.04 | -0.02 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 636,092 | 902,033 | +265,941 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 430,755 | 894,840 | +464,085 | 0.01 | 0.01 | +0.00 | buy |
| Aristotle Atlantic Partners, LLC | 836,945 | 806,895 | -30,050 | 0.80 | 0.54 | -0.25 | sell |
| TWO SIGMA ADVISERS, LP | 807,300 | 793,900 | -13,400 | 0.05 | 0.04 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 791,735 | 791,735 | 0 | 0.40 | 0.28 | -0.11 | hold |
| Eagle Health Investments LP | 120,109 | 730,209 | +610,100 | 0.66 | 2.87 | +2.21 | buy |
| Squarepoint Ops LLC | 373,043 | 715,312 | +342,269 | 0.04 | 0.06 | +0.02 | buy |
| Erste Asset Management GmbH | 692,600 | 652,600 | -40,000 | 0.28 | 0.18 | -0.10 | sell |
| Blue Water Life Science Advisors, LP | 571,047 | 571,047 | 0 | 13.53 | 11.08 | -2.45 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 529,716 | 532,502 | +2,786 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 606,518 | 529,604 | -76,914 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 479,846 | 489,657 | +9,811 | 0.01 | 0.01 | -0.00 | buy |
| Prosight Management, LP | 0 | 470,000 | +470,000 | 0.00 | 2.70 | +2.70 | buy |
| Candriam S.C.A. | 466,137 | 466,137 | 0 | 0.09 | 0.06 | -0.03 | hold |
| Aberdeen Group plc | 346,084 | 457,791 | +111,707 | 0.02 | 0.02 | -0.00 | buy |
| Eversept Partners, LP | 0 | 449,586 | +449,586 | 0.00 | 0.69 | +0.69 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 402,310 | +402,310 | 0.00 | 0.02 | +0.02 | buy |
| Railway Pension Investments Ltd | 379,078 | 379,078 | 0 | 0.11 | 0.08 | -0.03 | hold |
| ARK Investment Management LLC | 438,100 | 361,166 | -76,934 | 0.07 | 0.05 | -0.02 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 343,745 | 317,694 | -26,051 | 0.01 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 316,800 | +316,800 | 0.00 | 0.01 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 208,329 | 312,031 | +103,702 | 0.07 | 0.08 | +0.01 | buy |
| Trexquant Investment LP | 223,647 | 272,496 | +48,849 | 0.14 | 0.11 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 584,557 | 250,928 | -333,629 | 0.04 | 0.01 | -0.03 | sell |
| Handelsbanken Fonder AB | 161,341 | 232,341 | +71,000 | 0.02 | 0.02 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 13,045 | 228,215 | +215,170 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 220,400 | 227,700 | +7,300 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 154,845 | 223,585 | +68,740 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 181,914 | 209,312 | +27,398 | 0.01 | 0.01 | -0.00 | buy |
| Holocene Advisors, LP | 40,511 | 204,469 | +163,958 | 0.00 | 0.02 | +0.01 | buy |
| Beck Bode, LLC | 142,745 | 203,596 | +60,851 | 0.87 | 0.86 | -0.01 | buy |
| Granite Investment Partners, LLC | 208,187 | 202,450 | -5,737 | 0.22 | 0.16 | -0.06 | sell |
| Granahan Investment Management, LLC | 0 | 198,434 | +198,434 | 0.00 | 0.14 | +0.14 | buy |
| First Light Asset Management, LLC | 144,049 | 189,765 | +45,716 | 0.31 | 0.30 | -0.01 | buy |
| Cerity Partners LLC | 49,642 | 188,459 | +138,817 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 159,695 | 182,231 | +22,536 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 181,800 | +181,800 | 0.00 | 0.10 | +0.10 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 166,476 | 166,476 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 159,246 | 163,136 | +3,890 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 482,813 | 160,251 | -322,562 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 58,259 | 158,236 | +99,977 | 0.04 | 0.09 | +0.04 | buy |
| GUGGENHEIM CAPITAL LLC | 161,809 | 155,183 | -6,626 | 0.03 | 0.02 | -0.01 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 142,986 | 152,986 | +10,000 | 0.04 | 0.03 | -0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.30 | +0.30 | buy |
| Sicart Associates LLC | 92,953 | 146,592 | +53,639 | 0.96 | 1.11 | +0.15 | buy |
| ROYAL BANK OF CANADA | 252,131 | 141,648 | -110,483 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 100,948 | 138,437 | +37,489 | 0.01 | 0.01 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 150,137 | 137,767 | -12,370 | 0.01 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 51,316 | 134,262 | +82,946 | 0.01 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 3,708,283 | 131,358 | -3,576,925 | 0.04 | 0.00 | -0.04 | sell |
| UBS Group AG | 151,191 | 130,257 | -20,934 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 146,193 | 130,234 | -15,959 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 48,894 | 128,430 | +79,536 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 119,878 | +119,878 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 118,181 | 115,054 | -3,127 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 32,238 | 114,125 | +81,887 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 138,644 | 112,924 | -25,720 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 136,029 | 109,943 | -26,086 | 0.01 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 35,117 | 107,816 | +72,699 | 0.01 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 106,885 | 106,885 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 95,678 | 103,728 | +8,050 | 0.02 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 323,453 | 103,351 | -220,102 | 0.02 | 0.00 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 400,898 | 100,519 | -300,379 | 0.03 | 0.01 | -0.02 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.06 | +0.06 | buy |
| PURA VIDA INVESTMENTS, LLC | 15,000 | 100,000 | +85,000 | 0.10 | 1.40 | +1.31 | buy |
| HSBC HOLDINGS PLC | 43,532 | 92,167 | +48,635 | 0.00 | 0.00 | +0.00 | buy |
| TCW GROUP INC | 133,660 | 90,174 | -43,486 | 0.04 | 0.02 | -0.02 | sell |
| Nikko Asset Management Americas, Inc. | 93,745 | 84,046 | -9,699 | 0.02 | 0.02 | -0.01 | sell |