| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 11,317,714 | 11,553,759 | +236,045 | 0.02 | 0.02 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,636,078 | 7,023,689 | +1,387,611 | 0.06 | 0.08 | +0.01 | buy |
| Invesco Ltd. | 5,315,934 | 4,946,469 | -369,465 | 0.07 | 0.06 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 2,627,709 | 4,435,839 | +1,808,130 | 0.04 | 0.05 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,171,903 | 4,229,531 | +2,057,628 | 0.33 | 0.32 | -0.01 | buy |
| FMR LLC | 2,396,433 | 4,116,081 | +1,719,648 | 0.01 | 0.02 | +0.01 | buy |
| BAILLIE GIFFORD & CO | 4,890,026 | 3,859,046 | -1,030,980 | 0.42 | 0.36 | -0.05 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,213,657 | 3,508,883 | +295,226 | 0.02 | 0.02 | -0.00 | buy |
| Capital International Investors | 3,528,656 | 3,481,318 | -47,338 | 0.06 | 0.08 | +0.02 | sell |
| FRANKLIN RESOURCES INC | 3,361,547 | 3,448,193 | +86,646 | 0.08 | 0.08 | -0.01 | buy |
| Deep Track Capital, LP | 2,800,000 | 3,338,241 | +538,241 | 6.52 | 6.36 | -0.16 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 3,000,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE STREET CORP | 2,795,727 | 2,884,620 | +88,893 | 0.01 | 0.01 | -0.00 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 2,441,730 | 2,550,314 | +108,584 | 0.84 | 0.79 | -0.05 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,511,091 | 2,362,379 | -148,712 | 4.01 | 3.61 | -0.40 | sell |
| RATIONAL ADVISORS, INC. | 0 | 2,049,000 | +2,049,000 | 0.00 | 0.21 | +0.21 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,901,308 | 1,905,637 | +4,329 | 0.06 | 0.06 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 1,988,983 | 1,899,113 | -89,870 | 0.62 | 0.57 | -0.05 | sell |
| FEDERATED HERMES, INC. | 2,031,562 | 1,887,584 | -143,978 | 0.35 | 0.28 | -0.06 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,915,581 | 1,623,511 | -292,070 | 0.04 | 0.03 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,143,193 | 1,524,282 | -618,911 | 1.49 | 1.03 | -0.45 | sell |
| Alyeska Investment Group, L.P. | 1,343,654 | 1,489,566 | +145,912 | 0.39 | 0.39 | +0.00 | buy |
| MORGAN STANLEY | 1,154,299 | 1,487,324 | +333,025 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,481,033 | 1,481,033 | 0 | 1.52 | 1.36 | -0.15 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,457,676 | 1,451,803 | -5,873 | 0.02 | 0.02 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 762,595 | 1,414,886 | +652,291 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 1,710,169 | 1,405,837 | -304,332 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 1,366,157 | 1,391,187 | +25,030 | 0.02 | 0.02 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 539,190 | 1,362,539 | +823,349 | 0.23 | 0.53 | +0.30 | buy |
| Hood River Capital Management LLC | 978,515 | 1,310,065 | +331,550 | 1.10 | 1.21 | +0.12 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 635,935 | 1,205,701 | +569,766 | 0.05 | 0.10 | +0.04 | buy |
| NORTHERN TRUST CORP | 1,102,791 | 1,112,439 | +9,648 | 0.01 | 0.01 | -0.00 | buy |
| Temasek Holdings (Private) Ltd | 1,044,097 | 985,571 | -58,526 | 0.34 | 0.31 | -0.04 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 406,519 | 972,563 | +566,044 | 0.01 | 0.02 | +0.01 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 951,114 | +951,114 | 0.00 | 0.29 | +0.29 | buy |
| MILLENNIUM MANAGEMENT LLC | 583,807 | 921,395 | +337,588 | 0.04 | 0.06 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 1,017,646 | 895,221 | -122,425 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 79,603 | 867,537 | +787,934 | 0.00 | 0.04 | +0.04 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 851,958 | 862,915 | +10,957 | 2.45 | 3.69 | +1.24 | buy |
| EMERALD ADVISERS, LLC | 861,824 | 841,917 | -19,907 | 2.71 | 2.46 | -0.25 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 464,905 | 816,095 | +351,190 | 0.07 | 0.12 | +0.04 | buy |
| Erste Asset Management GmbH | 1,045,917 | 815,917 | -230,000 | 0.90 | 0.65 | -0.25 | sell |
| Artisan Partners Limited Partnership | 290,352 | 814,571 | +524,219 | 0.05 | 0.12 | +0.08 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 922,628 | 779,648 | -142,980 | 6.81 | 8.77 | +1.96 | sell |
| CITADEL ADVISORS LLC | 564,342 | 775,941 | +211,599 | 0.04 | 0.05 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 755,707 | +755,707 | 0.00 | 0.05 | +0.05 | buy |
| Point72 Asset Management, L.P. | 1,499,169 | 695,940 | -803,229 | 0.24 | 0.11 | -0.13 | sell |
| FRED ALGER MANAGEMENT, LLC | 589,656 | 622,259 | +32,603 | 0.24 | 0.25 | +0.02 | buy |
| Allspring Global Investments Holdings, LLC | 618,599 | 608,826 | -9,773 | 0.10 | 0.09 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 624,776 | 572,650 | -52,126 | 0.04 | 0.03 | -0.01 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 523,932 | 519,545 | -4,387 | 2.61 | 2.33 | -0.28 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 330,429 | 505,034 | +174,605 | 0.03 | 0.05 | +0.02 | buy |
| BRAIDWELL LP | 0 | 499,712 | +499,712 | 0.00 | 1.54 | +1.54 | buy |
| ARK Investment Management LLC | 691,647 | 486,675 | -204,972 | 0.47 | 0.35 | -0.12 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 640,505 | 483,767 | -156,738 | 0.04 | 0.03 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 640,295 | 483,557 | -156,738 | 0.76 | 0.63 | -0.12 | sell |
| Aristotle Atlantic Partners, LLC | 494,386 | 445,530 | -48,856 | 2.31 | 1.93 | -0.38 | sell |
| Nuveen, LLC | 473,451 | 438,357 | -35,094 | 0.01 | 0.01 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 435,200 | +435,200 | 0.00 | 0.88 | +0.88 | buy |
| D. E. Shaw & Co., Inc. | 623,057 | 427,475 | -195,582 | 0.05 | 0.03 | -0.02 | sell |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 407,000 | +407,000 | 0.03 | 0.03 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 377,045 | 393,836 | +16,791 | 0.02 | 0.02 | +0.00 | buy |
| SEI INVESTMENTS CO | 261,942 | 341,013 | +79,071 | 0.03 | 0.03 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 328,632 | 338,389 | +9,757 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 602,300 | 337,600 | -264,700 | 0.10 | 0.05 | -0.05 | sell |
| BROWN ADVISORY INC | 0 | 329,564 | +329,564 | 0.00 | 0.05 | +0.05 | buy |
| Casdin Capital, LLC | 380,000 | 315,000 | -65,000 | 2.41 | 2.20 | -0.21 | sell |
| Eagle Health Investments LP | 284,100 | 310,281 | +26,181 | 6.38 | 6.02 | -0.36 | buy |
| JPMORGAN CHASE & CO | 271,039 | 304,317 | +33,278 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 160,000 | 300,000 | +140,000 | 0.30 | 0.55 | +0.25 | buy |
| Styrax Capital, LP | 281,589 | 300,000 | +18,411 | 2.20 | 1.94 | -0.27 | buy |
| Walleye Capital LLC | 254,302 | 291,926 | +37,624 | 0.15 | 0.17 | +0.02 | buy |
| First Light Asset Management, LLC | 294,751 | 280,299 | -14,452 | 2.30 | 2.32 | +0.02 | sell |
| DEUTSCHE BANK AG\ | 336,428 | 255,187 | -81,241 | 0.01 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 266,492 | 254,788 | -11,704 | 0.07 | 0.05 | -0.02 | sell |
| BARCLAYS PLC | 336,274 | 253,959 | -82,315 | 0.01 | 0.01 | -0.01 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 159,029 | 249,991 | +90,962 | 0.18 | 0.24 | +0.06 | buy |
| SAMLYN CAPITAL, LLC | 0 | 249,137 | +249,137 | 0.00 | 0.40 | +0.40 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 287,454 | 244,051 | -43,403 | 0.05 | 0.04 | -0.01 | sell |
| Blue Water Life Science Advisors, LP | 355,047 | 242,247 | -112,800 | 22.76 | 17.94 | -4.82 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 237,481 | 238,462 | +981 | 0.01 | 0.01 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 244,266 | 232,222 | -12,044 | 0.34 | 0.22 | -0.12 | sell |
| Sicart Associates LLC | 228,203 | 230,103 | +1,900 | 6.18 | 5.46 | -0.72 | buy |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 227,000 | +227,000 | 0.04 | 0.03 | -0.02 | buy |
| Swiss National Bank | 221,300 | 222,100 | +800 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 215,092 | 215,468 | +376 | 0.01 | 0.01 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,170,337 | 203,778 | -966,559 | 0.07 | 0.01 | -0.06 | sell |
| Bank of New York Mellon Corp | 300,000 | 200,000 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 181,048 | 195,300 | +14,252 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 136,894 | 191,740 | +54,846 | 0.03 | 0.04 | +0.01 | buy |
| AGF MANAGEMENT LTD | 156,256 | 189,952 | +33,696 | 0.07 | 0.08 | +0.01 | buy |
| Russell Investments Group, Ltd. | 211,392 | 188,140 | -23,252 | 0.02 | 0.02 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 153,782 | 184,846 | +31,064 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 306,553 | 182,727 | -123,826 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 188,888 | 174,072 | -14,816 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 157,485 | 173,326 | +15,841 | 0.07 | 0.07 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 107,931 | 169,731 | +61,800 | 0.02 | 0.03 | +0.01 | buy |
| Rathbones Group PLC | 205,113 | 166,507 | -38,606 | 0.08 | 0.06 | -0.02 | sell |
| CASTLEARK MANAGEMENT LLC | 165,043 | 160,283 | -4,760 | 0.49 | 0.49 | -0.00 | sell |
| RHUMBLINE ADVISERS | 155,818 | 157,909 | +2,091 | 0.01 | 0.01 | -0.00 | buy |