| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 3,822,939 | 4,468,723 | +645,784 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 250,928 | 814,523 | +563,595 | 0.01 | 0.06 | 0.00 | buy |
| Temasek Holdings (Private) Ltd | 4,111,172 | 3,749,102 | +362,070 | 0.47 | 0.50 | 0.00 | sell |
| BRAIDWELL LP | 2,476,804 | 2,807,968 | +331,164 | 1.65 | 2.54 | +0.90 | buy |
| Erste Asset Management GmbH | 652,600 | 932,600 | +280,000 | 0.18 | 0.36 | +0.18 | buy |
| Railway Pension Investments Ltd | 379,078 | 620,878 | +241,800 | 0.08 | 0.21 | +0.14 | buy |
| First Light Asset Management, LLC | 189,765 | 416,967 | +227,202 | 0.30 | 1.06 | +0.76 | buy |
| FIL Ltd | 1,919,888 | 2,068,481 | +148,593 | 0.04 | 0.06 | +0.02 | buy |
| ARK Investment Management LLC | 361,166 | 453,590 | +92,424 | 0.05 | 0.12 | +0.06 | buy |
| PDT Partners, LLC | 68,666 | 144,585 | +75,919 | 0.13 | 0.40 | +0.26 | buy |
| Beck Bode, LLC | 203,596 | 269,390 | +65,794 | 0.86 | 1.56 | +0.71 | buy |
| FRED ALGER MANAGEMENT, LLC | 134,262 | 198,468 | +64,206 | 0.01 | 0.03 | +0.01 | buy |
| Edgestream Partners, L.P. | 46,939 | 96,513 | +49,574 | 0.05 | 0.13 | +0.09 | buy |
| SWS Partners | 45,411 | 78,857 | +33,446 | 0.28 | 0.68 | +0.40 | buy |
| Y-Intercept (Hong Kong) Ltd | 24,633 | 50,873 | +26,240 | 0.04 | 0.08 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 155,183 | 137,811 | +17,372 | 0.02 | 0.03 | 0.00 | sell |
| ALGERT GLOBAL LLC | 73,220 | 90,220 | +17,000 | 0.06 | 0.09 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 17,000 | 34,000 | +17,000 | 0.10 | 0.20 | +0.10 | buy |
| GSA CAPITAL PARTNERS LLP | 31,291 | 18,999 | +12,292 | 0.06 | 0.04 | 0.00 | sell |
| NEOS Investment Management LLC | 21,996 | 30,402 | +8,406 | 0.03 | 0.04 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 489,657 | 497,088 | +7,431 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 29,317 | 23,441 | +5,876 | 0.00 | 0.00 | 0.00 | sell |
| Rathbones Group PLC | 103,728 | 108,395 | +4,667 | 0.01 | 0.02 | +0.00 | buy |
| Nikko Asset Management Americas, Inc. | 84,046 | 88,694 | +4,648 | 0.02 | 0.03 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 137,767 | 136,269 | +1,498 | 0.00 | 0.00 | 0.00 | sell |
| Tidemark, LLC | 206 | 15 | -191 | 0.00 | 0.00 | -0.00 | sell |
| Silicon Valley Community Foundation | 13,599 | 13,399 | -200 | 0.01 | 0.02 | +0.01 | sell |
| IMA Advisory Services, Inc. | 15,970 | 15,754 | -216 | 0.16 | 0.20 | +0.05 | sell |
| Harel Insurance Investments & Financial Services Ltd. | 754 | 491 | -263 | 0.00 | 0.00 | -0.00 | sell |
| Sicart Associates LLC | 146,592 | 145,983 | -609 | 1.11 | 1.62 | +0.51 | sell |
| D.A. DAVIDSON & CO. | 27,695 | 26,545 | -1,150 | 0.01 | 0.01 | +0.00 | sell |
| Alpine Global Management, LLC | 4,500 | 3,000 | -1,500 | 0.60 | 0.40 | -0.20 | sell |
| OAK RIDGE INVESTMENTS LLC | 18,540 | 16,184 | -2,356 | 0.04 | 0.04 | +0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,816 | 19,713 | -4,103 | 0.03 | 0.05 | +0.01 | sell |
| BRANDYWINE MANAGERS, LLC | 14,303 | 7,152 | -7,151 | 0.29 | 0.22 | -0.07 | sell |
| Values First Advisors, Inc. | 36,111 | 28,248 | -7,863 | 0.44 | 0.49 | +0.05 | sell |
| China Universal Asset Management Co., Ltd. | 23,406 | 14,378 | -9,028 | 0.06 | 0.06 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 316,800 | 299,800 | -17,000 | 0.01 | 0.02 | +0.00 | sell |
| Granahan Investment Management, LLC | 198,434 | 181,167 | -17,267 | 0.14 | 0.21 | +0.07 | sell |
| TCW GROUP INC | 90,174 | 52,084 | -38,090 | 0.02 | 0.01 | -0.01 | sell |
| Polar Asset Management Partners Inc. | 181,800 | 134,000 | -47,800 | 0.06 | 0.08 | +0.02 | sell |
| Aristotle Atlantic Partners, LLC | 806,895 | 749,197 | -57,698 | 0.54 | 0.70 | +0.16 | sell |
| Aberdeen Group plc | 457,791 | 373,591 | -84,200 | 0.02 | 0.02 | +0.00 | sell |
| Bridgewater Associates, LP | 107,816 | 20,201 | -87,615 | 0.01 | 0.00 | -0.01 | sell |
| Candriam S.C.A. | 466,137 | 366,145 | -99,992 | 0.06 | 0.06 | +0.00 | sell |
| Holocene Advisors, LP | 204,469 | 102,944 | -101,525 | 0.02 | 0.01 | -0.00 | sell |
| Eagle Health Investments LP | 730,209 | 626,909 | -103,300 | 2.87 | 3.24 | +0.37 | sell |
| BAILLIE GIFFORD & CO | 6,232,104 | 6,093,286 | -138,818 | 0.10 | 0.14 | +0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,545,114 | 1,375,674 | -169,440 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 449,586 | 99,377 | -350,209 | 0.62 | 0.20 | -0.42 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 4,179,432 | 3,760,538 | -418,894 | 1.35 | 1.86 | +0.51 | sell |
| Deep Track Capital, LP | 6,000,000 | 4,500,000 | -1,500,000 | 3.56 | 3.88 | +0.32 | sell |
| CADIAN CAPITAL MANAGEMENT, LP | 5,792,779 | 3,131,808 | -2,660,971 | 4.25 | 4.50 | +0.25 | sell |
| Opti Capital Management, LP | 10,000,000 | 0 | -10,000,000 | 0.52 | 0.58 | +0.06 | sell |