| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 11,436,026 | 11,636,732 | +200,706 | 0.00 | 0.01 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 6,232,104 | 6,093,286 | -138,818 | 0.10 | 0.14 | +0.04 | sell |
| Deep Track Capital, LP | 6,000,000 | 4,500,000 | -1,500,000 | 3.56 | 3.88 | +0.32 | sell |
| Capital International Investors | 3,822,939 | 4,468,723 | +645,784 | 0.02 | 0.03 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 4,179,432 | 3,760,538 | -418,894 | 1.35 | 1.86 | +0.51 | sell |
| Temasek Holdings (Private) Ltd | 4,111,172 | 3,749,102 | -362,070 | 0.47 | 0.50 | +0.03 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 3,508,743 | +3,508,743 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 2,790,538 | 3,290,897 | +500,359 | 0.06 | 0.09 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 902,033 | 3,233,044 | +2,331,011 | 0.01 | 0.03 | +0.02 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 5,792,779 | 3,131,808 | -2,660,971 | 4.25 | 4.50 | +0.25 | sell |
| FMR LLC | 3,026,510 | 3,118,623 | +92,113 | 0.00 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 2,476,804 | 2,807,968 | +331,164 | 1.65 | 2.54 | +0.90 | buy |
| Parkwood LLC | 2,800,000 | 2,800,000 | 0 | 0.20 | 0.27 | +0.07 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,641,810 | 2,792,534 | +150,724 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,628,037 | 2,754,977 | +126,940 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,189,983 | 2,135,311 | +945,328 | 0.02 | 0.05 | +0.03 | buy |
| FIL Ltd | 1,919,888 | 2,068,481 | +148,593 | 0.04 | 0.06 | +0.02 | buy |
| MORGAN STANLEY | 1,101,592 | 2,021,706 | +920,114 | 0.00 | 0.00 | +0.00 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 0 | 1,938,515 | +1,938,515 | 0.00 | 0.24 | +0.24 | buy |
| Point72 Asset Management, L.P. | 1,426,450 | 1,815,053 | +388,603 | 0.09 | 0.17 | +0.08 | buy |
| NORGES BANK | 1,169,699 | 1,383,768 | +214,069 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,545,114 | 1,375,674 | -169,440 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,277,099 | 1,309,431 | +32,332 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 971,064 | 1,280,221 | +309,157 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,200,800 | 1,248,050 | +47,250 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 1,334,270 | 1,207,469 | -126,801 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 1,015,012 | 1,073,077 | +58,065 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,067,261 | 1,069,963 | +2,702 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,047,123 | 1,032,907 | -14,216 | 0.00 | 0.01 | +0.00 | sell |
| Erste Asset Management GmbH | 652,600 | 932,600 | +280,000 | 0.18 | 0.36 | +0.18 | buy |
| FEDERATED HERMES, INC. | 906,900 | 862,100 | -44,800 | 0.04 | 0.06 | +0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 250,928 | 814,523 | +563,595 | 0.01 | 0.06 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 793,900 | 770,800 | -23,100 | 0.04 | 0.05 | +0.01 | sell |
| Aristotle Atlantic Partners, LLC | 806,895 | 749,197 | -57,698 | 0.54 | 0.70 | +0.16 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 670,200 | +670,200 | 0.00 | 2.99 | +2.99 | buy |
| Pictet Asset Management Holding SA | 1,149,621 | 664,108 | -485,513 | 0.02 | 0.02 | -0.00 | sell |
| Eagle Health Investments LP | 730,209 | 626,909 | -103,300 | 2.87 | 3.24 | +0.37 | sell |
| Railway Pension Investments Ltd | 379,078 | 620,878 | +241,800 | 0.08 | 0.21 | +0.14 | buy |
| Trexquant Investment LP | 272,496 | 584,914 | +312,418 | 0.11 | 0.26 | +0.15 | buy |
| Blue Water Life Science Advisors, LP | 571,047 | 571,047 | 0 | 11.08 | 16.04 | +4.96 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,160,803 | 541,953 | -618,850 | 0.09 | 0.06 | -0.03 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 532,502 | 513,283 | -19,219 | 0.01 | 0.01 | +0.00 | sell |
| MPM BioImpact LLC | 0 | 500,000 | +500,000 | 0.00 | 2.24 | +2.24 | buy |
| JENNISON ASSOCIATES LLC | 489,657 | 497,088 | +7,431 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 894,840 | 477,372 | -417,468 | 0.01 | 0.01 | -0.00 | sell |
| ARK Investment Management LLC | 361,166 | 453,590 | +92,424 | 0.05 | 0.12 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 20,286 | 440,379 | +420,093 | 0.01 | 0.14 | +0.13 | buy |
| BANK OF AMERICA CORP /DE/ | 529,604 | 430,500 | -99,104 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 160,251 | 429,385 | +269,134 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 189,765 | 416,967 | +227,202 | 0.30 | 1.06 | +0.76 | buy |
| Cubist Systematic Strategies, LLC | 65,509 | 374,130 | +308,621 | 0.02 | 0.19 | +0.17 | buy |
| Aberdeen Group plc | 457,791 | 373,591 | -84,200 | 0.02 | 0.02 | +0.00 | sell |
| Candriam S.C.A. | 466,137 | 366,145 | -99,992 | 0.06 | 0.06 | +0.00 | sell |
| Mitsubishi UFJ Trust & Banking Corp | 402,310 | 339,090 | -63,220 | 0.02 | 0.02 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 316,800 | 299,800 | -17,000 | 0.01 | 0.02 | +0.00 | sell |
| Beck Bode, LLC | 203,596 | 269,390 | +65,794 | 0.86 | 1.56 | +0.71 | buy |
| Swiss National Bank | 227,700 | 239,400 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 239,223 | +239,223 | 0.00 | 0.08 | +0.08 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 103,351 | 216,234 | +112,883 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 209,312 | 203,976 | -5,336 | 0.01 | 0.01 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 134,262 | 198,468 | +64,206 | 0.01 | 0.03 | +0.01 | buy |
| Granahan Investment Management, LLC | 198,434 | 181,167 | -17,267 | 0.14 | 0.21 | +0.07 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 312,031 | 178,219 | -133,812 | 0.08 | 0.06 | -0.02 | sell |
| RHUMBLINE ADVISERS | 163,136 | 173,298 | +10,162 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 182,231 | 171,051 | -11,180 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 141,648 | 159,601 | +17,953 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 166,476 | 153,809 | -12,667 | 0.00 | 0.00 | +0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 152,986 | 152,986 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Hood River Capital Management LLC | 0 | 146,726 | +146,726 | 0.00 | 0.09 | +0.09 | buy |
| Sicart Associates LLC | 146,592 | 145,983 | -609 | 1.11 | 1.62 | +0.51 | sell |
| PDT Partners, LLC | 68,666 | 144,585 | +75,919 | 0.13 | 0.40 | +0.26 | buy |
| ALLIANCEBERNSTEIN L.P. | 131,358 | 143,720 | +12,362 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 155,183 | 137,811 | -17,372 | 0.02 | 0.03 | +0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 137,767 | 136,269 | -1,498 | 0.00 | 0.00 | +0.00 | sell |
| Polar Asset Management Partners Inc. | 181,800 | 134,000 | -47,800 | 0.10 | 0.10 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 130,234 | 131,802 | +1,568 | 0.01 | 0.01 | +0.00 | buy |
| Cerity Partners LLC | 188,459 | 126,125 | -62,334 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 115,054 | 118,547 | +3,493 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 0 | 115,854 | +115,854 | 0.00 | 0.50 | +0.50 | buy |
| Rathbones Group PLC | 103,728 | 108,395 | +4,667 | 0.01 | 0.02 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 106,885 | 106,620 | -265 | 0.00 | 0.00 | +0.00 | sell |
| Holocene Advisors, LP | 204,469 | 102,944 | -101,525 | 0.02 | 0.01 | -0.00 | sell |
| Casdin Capital, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.22 | +0.22 | buy |
| Eversept Partners, LP | 449,586 | 99,377 | -350,209 | 0.69 | 0.22 | -0.47 | sell |
| Edgestream Partners, L.P. | 46,939 | 96,513 | +49,574 | 0.05 | 0.13 | +0.09 | buy |
| Engineers Gate Manager LP | 158,236 | 95,685 | -62,551 | 0.09 | 0.06 | -0.02 | sell |
| ALGERT GLOBAL LLC | 73,220 | 90,220 | +17,000 | 0.06 | 0.09 | +0.03 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 317,694 | 88,694 | -229,000 | 0.00 | 0.00 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 84,046 | 88,694 | +4,648 | 0.02 | 0.03 | +0.01 | buy |
| Gotham Asset Management, LLC | 0 | 84,748 | +84,748 | 0.00 | 0.03 | +0.03 | buy |
| Exome Asset Management LLC | 79,000 | 79,000 | 0 | 1.40 | 2.03 | +0.64 | hold |
| SWS Partners | 45,411 | 78,857 | +33,446 | 0.28 | 0.68 | +0.40 | buy |
| AMERIPRISE FINANCIAL INC | 23,842 | 72,029 | +48,187 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 13,316 | 72,000 | +58,684 | 0.00 | 0.03 | +0.03 | buy |
| State of New Jersey Common Pension Fund D | 138,437 | 71,286 | -67,151 | 0.01 | 0.01 | +0.00 | sell |
| Adalta Capital Management LLC | 71,023 | 71,023 | 0 | 0.81 | 1.12 | +0.31 | hold |
| HSBC HOLDINGS PLC | 92,167 | 69,746 | -22,421 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 58,605 | 68,147 | +9,542 | 0.01 | 0.01 | +0.00 | buy |
| COMERICA BANK | 1,601 | 68,128 | +66,527 | 0.00 | 0.01 | +0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 66,176 | 66,176 | 0 | 0.00 | 0.00 | +0.00 | hold |