| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 12,081,377 | 12,168,020 | +86,643 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 11,173,880 | 10,979,470 | -194,410 | 0.01 | 0.01 | +0.00 | sell |
| Capital International Investors | 5,147,724 | 4,976,458 | -171,266 | 0.04 | 0.04 | +0.00 | sell |
| BAILLIE GIFFORD & CO | 5,061,011 | 4,809,786 | -251,225 | 0.19 | 0.19 | -0.00 | sell |
| Deep Track Capital, LP | 5,443,721 | 4,250,000 | -1,193,721 | 7.51 | 7.11 | -0.40 | sell |
| Invesco Ltd. | 2,794,667 | 3,558,501 | +763,834 | 0.02 | 0.03 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,566,738 | 3,458,963 | -107,775 | 3.03 | 3.15 | +0.13 | sell |
| CADIAN CAPITAL MANAGEMENT, LP | 4,595,087 | 3,179,217 | -1,415,870 | 8.38 | 9.27 | +0.89 | sell |
| CITADEL ADVISORS LLC | 3,596,913 | 2,938,553 | -658,360 | 0.15 | 0.13 | -0.02 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,777,040 | 2,933,988 | +156,948 | 0.03 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,907,626 | 2,920,714 | +13,088 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,800,039 | 2,839,665 | +39,626 | 0.00 | 0.01 | +0.00 | buy |
| ARK Investment Management LLC | 1,409,116 | 2,823,497 | +1,414,381 | 0.60 | 1.08 | +0.48 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,096,733 | 2,721,881 | +1,625,148 | 0.05 | 0.13 | +0.08 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,933,086 | 2,475,613 | +542,527 | 0.79 | 1.03 | +0.24 | buy |
| TWO SIGMA ADVISERS, LP | 2,367,800 | 2,381,800 | +14,000 | 0.23 | 0.25 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 1,301,803 | 2,319,947 | +1,018,144 | 0.02 | 0.03 | +0.02 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,965,721 | 2,197,829 | +232,108 | 0.33 | 0.42 | +0.09 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,357,227 | 2,030,638 | +673,411 | 0.04 | 0.07 | +0.02 | buy |
| Nikko Asset Management Americas, Inc. | 1,356,990 | 2,030,428 | +673,438 | 0.74 | 1.05 | +0.31 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,994,789 | 1,922,969 | -71,820 | 0.02 | 0.02 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,825,863 | 1,854,611 | +28,748 | 0.17 | 0.17 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 629,508 | 1,765,576 | +1,136,068 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 850,009 | 1,465,438 | +615,429 | 0.08 | 0.14 | +0.07 | buy |
| NORGES BANK | 1,212,766 | 1,232,428 | +19,662 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 2,281,061 | 1,183,819 | -1,097,242 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 1,277,280 | 1,183,803 | -93,477 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,167,282 | 1,146,705 | -20,577 | 0.01 | 0.01 | +0.00 | sell |
| Temasek Holdings (Private) Ltd | 1,044,097 | 1,044,097 | 0 | 0.18 | 0.21 | +0.03 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 996,506 | 1,013,272 | +16,766 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 489,929 | 987,675 | +497,746 | 0.00 | 0.00 | +0.00 | buy |
| Aristotle Atlantic Partners, LLC | 964,521 | 931,956 | -32,565 | 1.39 | 1.48 | +0.09 | sell |
| Bank of New York Mellon Corp | 852,052 | 906,225 | +54,173 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 148,748 | 893,411 | +744,663 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 954,493 | 887,716 | -66,777 | 0.14 | 0.15 | +0.00 | sell |
| MORGAN STANLEY | 940,505 | 886,626 | -53,879 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 0 | 856,501 | +856,501 | 0.00 | 0.63 | +0.63 | buy |
| BRAIDWELL LP | 1,327,327 | 837,800 | -489,527 | 1.99 | 1.49 | -0.50 | sell |
| Man Group plc | 66,272 | 806,072 | +739,800 | 0.01 | 0.09 | +0.08 | buy |
| JENNISON ASSOCIATES LLC | 0 | 715,467 | +715,467 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 486,365 | 707,404 | +221,039 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 531,424 | 699,922 | +168,498 | 1.02 | 1.34 | +0.32 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 616,500 | 675,200 | +58,700 | 0.04 | 0.05 | +0.01 | buy |
| Erste Asset Management GmbH | 638,600 | 638,600 | 0 | 0.35 | 0.28 | -0.07 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 578,346 | 632,630 | +54,284 | 0.02 | 0.03 | +0.01 | buy |
| Railway Pension Investments Ltd | 620,878 | 620,878 | 0 | 0.38 | 0.46 | +0.08 | hold |
| Polar Asset Management Partners Inc. | 525,702 | 577,846 | +52,144 | 0.74 | 0.75 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 220,124 | 566,405 | +346,281 | 0.01 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 838,992 | 564,348 | -274,644 | 0.09 | 0.07 | -0.02 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 472,899 | 549,578 | +76,679 | 0.02 | 0.03 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 163,049 | 494,872 | +331,823 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 74,826 | 446,609 | +371,783 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 442,656 | 442,656 | 0 | 3.24 | 3.99 | +0.75 | hold |
| Blue Water Life Science Advisors, LP | 694,047 | 439,047 | -255,000 | 29.30 | 18.09 | -11.21 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 327,283 | 415,774 | +88,491 | 0.99 | 1.32 | +0.33 | buy |
| BARCLAYS PLC | 243,338 | 395,980 | +152,642 | 0.00 | 0.01 | +0.00 | buy |
| Granite Investment Partners, LLC | 419,004 | 386,866 | -32,138 | 0.91 | 0.98 | +0.08 | sell |
| Trexquant Investment LP | 180,390 | 376,705 | +196,315 | 0.09 | 0.22 | +0.13 | buy |
| FRED ALGER MANAGEMENT, LLC | 457,617 | 373,679 | -83,938 | 0.11 | 0.09 | -0.02 | sell |
| Cubist Systematic Strategies, LLC | 59,747 | 329,322 | +269,575 | 0.03 | 0.19 | +0.15 | buy |
| Pictet Asset Management Holding SA | 356,670 | 318,418 | -38,252 | 0.02 | 0.02 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 746,636 | 318,119 | -428,517 | 0.01 | 0.01 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 846,749 | 307,305 | -539,444 | 0.07 | 0.03 | -0.04 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 476,499 | 305,567 | -170,932 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 315,737 | 302,307 | -13,430 | 2.71 | 2.93 | +0.22 | sell |
| Iron Triangle Partners LP | 600,867 | 300,000 | -300,867 | 4.03 | 2.47 | -1.56 | sell |
| Engineers Gate Manager LP | 244,384 | 277,551 | +33,167 | 0.18 | 0.18 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 498,129 | 262,522 | -235,607 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 319,429 | 254,199 | -65,230 | 0.02 | 0.02 | -0.00 | sell |
| Hood River Capital Management LLC | 236,064 | 245,701 | +9,637 | 0.17 | 0.18 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 254,410 | 245,560 | -8,850 | 0.02 | 0.02 | +0.00 | sell |
| OSTERWEIS CAPITAL MANAGEMENT INC | 296,571 | 240,316 | -56,255 | 0.62 | 0.60 | -0.03 | sell |
| RAYMOND JAMES FINANCIAL INC | 63,489 | 232,599 | +169,110 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 239,300 | 212,100 | -27,200 | 0.01 | 0.01 | -0.00 | sell |
| Eagle Health Investments LP | 0 | 212,000 | +212,000 | 0.00 | 2.72 | +2.72 | buy |
| Rathbones Group PLC | 202,127 | 205,965 | +3,838 | 0.04 | 0.05 | +0.00 | buy |
| Nicholas Investment Partners, LP | 234,637 | 203,030 | -31,607 | 1.03 | 0.94 | -0.09 | sell |
| FIRST TRUST ADVISORS LP | 214,291 | 202,245 | -12,046 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 200,000 | 200,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 156,148 | 195,186 | +39,038 | 0.01 | 0.02 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 193,325 | +193,325 | 0.00 | 0.14 | +0.14 | buy |
| JPMORGAN CHASE & CO | 176,223 | 193,302 | +17,079 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 175,432 | 184,724 | +9,292 | 0.01 | 0.01 | +0.00 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 270,339 | 183,443 | -86,896 | 0.03 | 0.02 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 195,544 | 183,404 | -12,140 | 0.01 | 0.01 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,050,821 | 173,441 | -877,380 | 0.17 | 0.03 | -0.13 | sell |
| Aberdeen Group plc | 252,963 | 173,261 | -79,702 | 0.02 | 0.02 | -0.01 | sell |
| Candriam S.C.A. | 172,874 | 170,522 | -2,352 | 0.05 | 0.05 | +0.01 | sell |
| Sicart Associates LLC | 137,593 | 165,455 | +27,862 | 2.03 | 3.01 | +0.99 | buy |
| TD ASSET MANAGEMENT INC | 43,714 | 162,600 | +118,886 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 144,676 | 159,348 | +14,672 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 170,134 | 158,069 | -12,065 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 142,952 | 155,964 | +13,012 | 0.16 | 0.16 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 159,669 | 151,701 | -7,968 | 0.00 | 0.01 | +0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 152,986 | 148,317 | -4,669 | 0.06 | 0.06 | +0.00 | sell |
| Cerity Partners LLC | 145,475 | 144,381 | -1,094 | 0.01 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 139,920 | 140,308 | +388 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 450,471 | 138,951 | -311,520 | 0.01 | 0.01 | -0.01 | sell |
| Hillsdale Investment Management Inc. | 0 | 136,100 | +136,100 | 0.00 | 0.26 | +0.26 | buy |
| First Light Asset Management, LLC | 271,115 | 128,868 | -142,247 | 1.32 | 0.87 | -0.45 | sell |