| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 1,096,733 | 2,721,881 | +1,625,148 | 0.06 | 0.16 | 0.00 | buy |
| ARK Investment Management LLC | 1,409,116 | 2,823,497 | +1,414,381 | 0.60 | 1.08 | +0.48 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 629,508 | 1,765,576 | +1,136,068 | 0.00 | 0.01 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 1,356,990 | 2,030,428 | +673,438 | 0.74 | 1.05 | +0.31 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,933,086 | 2,475,613 | +542,527 | 0.79 | 1.03 | +0.24 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 838,992 | 564,348 | +274,644 | 0.10 | 0.07 | 0.00 | sell |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,965,721 | 2,197,829 | +232,108 | 0.33 | 0.42 | +0.09 | buy |
| EMERALD ADVISERS, LLC | 531,424 | 699,922 | +168,498 | 1.02 | 1.34 | +0.32 | buy |
| TD ASSET MANAGEMENT INC | 43,714 | 162,600 | +118,886 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 327,283 | 415,774 | +88,491 | 0.99 | 1.32 | +0.33 | buy |
| VANGUARD GROUP INC | 12,081,377 | 12,168,020 | +86,643 | 0.01 | 0.01 | 0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 616,500 | 675,200 | +58,700 | 0.04 | 0.05 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 525,702 | 577,846 | +52,144 | 0.52 | 0.47 | -0.05 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 31,660 | 75,621 | +43,961 | 0.12 | 0.31 | +0.19 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,236 | 111,445 | +40,209 | 0.01 | 0.01 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 9,004 | 45,324 | +36,320 | 0.05 | 0.21 | +0.16 | buy |
| Edgestream Partners, L.P. | 20,425 | 50,519 | +30,094 | 0.03 | 0.07 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,825,863 | 1,854,611 | +28,748 | 0.18 | 0.19 | 0.00 | buy |
| Sicart Associates LLC | 137,593 | 165,455 | +27,862 | 2.03 | 3.01 | +0.99 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 43,686 | 65,990 | +22,304 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 23,669 | 39,313 | +15,644 | 0.01 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 144,676 | 159,348 | +14,672 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 119,256 | 105,922 | +13,334 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,907,626 | 2,920,714 | +13,088 | 0.01 | 0.01 | 0.00 | buy |
| Hood River Capital Management LLC | 236,064 | 245,701 | +9,637 | 0.17 | 0.18 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 254,410 | 245,560 | +8,850 | 0.02 | 0.02 | 0.00 | sell |
| ALGERT GLOBAL LLC | 52,940 | 44,640 | +8,300 | 0.06 | 0.05 | 0.00 | sell |
| Entropy Technologies, LP | 5,047 | 11,134 | +6,087 | 0.02 | 0.05 | +0.03 | buy |
| Investors Towarzystwo Funduszy Inwestycyjnych Spolka Akcyjna | 6,000 | 10,200 | +4,200 | 0.12 | 0.21 | +0.09 | buy |
| Rathbones Group PLC | 202,127 | 205,965 | +3,838 | 0.04 | 0.05 | +0.00 | buy |
| Atika Capital Management LLC | 85,500 | 89,200 | +3,700 | 0.51 | 0.46 | -0.05 | buy |
| Values First Advisors, Inc. | 29,597 | 32,539 | +2,942 | 0.74 | 0.92 | +0.19 | buy |
| ProShare Advisors LLC | 31,975 | 29,648 | +2,327 | 0.00 | 0.00 | 0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 60,187 | 62,441 | +2,254 | 0.03 | 0.03 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 85,159 | 87,270 | +2,111 | 0.03 | 0.04 | 0.00 | buy |
| STRS OHIO | 19,000 | 20,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 10,160 | 11,350 | +1,190 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 10,160 | 11,350 | +1,190 | 0.13 | 0.16 | +0.03 | buy |
| MRA Advisory Group | 15,275 | 16,353 | +1,078 | 0.35 | 0.40 | +0.05 | buy |
| SHELL ASSET MANAGEMENT CO | 2,726 | 2,082 | +644 | 0.01 | 0.00 | 0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 33,129 | 33,741 | +612 | 0.00 | 0.00 | 0.00 | buy |
| Canton Hathaway, LLC | 8,280 | 8,870 | +590 | 0.07 | 0.09 | +0.02 | buy |
| F/m Investments LLC | 38,628 | 39,099 | +471 | 0.07 | 0.07 | +0.01 | buy |
| Main Management ETF Advisors, LLC | 20,909 | 21,257 | +348 | 0.04 | 0.05 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 12,034 | 12,196 | +162 | 0.02 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 24,756 | 24,882 | +126 | 0.10 | 0.12 | +0.02 | buy |
| CURIO WEALTH, LLC | 1 | 14 | +13 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 25,009 | 25,016 | +7 | 0.08 | 0.13 | +0.05 | buy |
| Wealthcare Advisory Partners LLC | 8,225 | 8,232 | +7 | 0.01 | 0.01 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 44 | 46 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SouthState Corp | 130 | 100 | -30 | 0.00 | 0.00 | -0.00 | sell |
| IMA Advisory Services, Inc. | 1,402 | 1,312 | -90 | 0.01 | 0.01 | +0.00 | sell |
| Banque Cantonale Vaudoise | 8,582 | 8,334 | -248 | 0.02 | 0.02 | +0.00 | sell |
| Adalta Capital Management LLC | 63,663 | 63,363 | -300 | 1.44 | 1.65 | +0.21 | sell |
| OAK RIDGE INVESTMENTS LLC | 14,921 | 14,178 | -743 | 0.05 | 0.05 | +0.00 | sell |
| Bridgewater Associates, LP | 5,070 | 3,870 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| Green Alpha Advisors, LLC | 6,930 | 5,494 | -1,436 | 0.32 | 0.27 | -0.04 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 8,747 | 6,958 | -1,789 | 0.10 | 0.06 | -0.03 | sell |
| SIG BROKERAGE, LP | 8,504 | 6,557 | -1,947 | 0.02 | 0.01 | -0.01 | sell |
| MSH Capital Advisors LLC | 15,123 | 12,853 | -2,270 | 0.20 | 0.19 | -0.01 | sell |
| Candriam S.C.A. | 172,874 | 170,522 | -2,352 | 0.05 | 0.05 | +0.01 | sell |
| Fiduciary Alliance LLC | 10,284 | 7,769 | -2,515 | 0.04 | 0.03 | -0.01 | sell |
| Capital International, Inc./CA/ | 11,858 | 8,836 | -3,022 | 0.01 | 0.00 | -0.00 | sell |
| SWS Partners | 104,817 | 93,077 | -11,740 | 1.47 | 1.31 | -0.16 | sell |
| CIBC WORLD MARKETS CORP | 27,253 | 15,115 | -12,138 | 0.01 | 0.01 | -0.01 | sell |
| First Turn Management, LLC | 315,737 | 302,307 | -13,430 | 2.71 | 2.93 | +0.22 | sell |
| HighVista Strategies LLC | 51,718 | 28,265 | -23,453 | 0.85 | 0.54 | -0.31 | sell |
| Swiss National Bank | 239,300 | 212,100 | -27,200 | 0.01 | 0.01 | -0.00 | sell |
| Exome Asset Management LLC | 127,182 | 98,182 | -29,000 | 4.85 | 4.21 | -0.64 | sell |
| Nicholas Investment Partners, LP | 234,637 | 203,030 | -31,607 | 1.03 | 0.94 | -0.09 | sell |
| Granite Investment Partners, LLC | 419,004 | 386,866 | -32,138 | 0.91 | 0.98 | +0.08 | sell |
| Aristotle Atlantic Partners, LLC | 964,521 | 931,956 | -32,565 | 1.39 | 1.48 | +0.09 | sell |
| Pier Capital, LLC | 122,957 | 72,402 | -50,555 | 0.88 | 0.57 | -0.30 | sell |
| OSTERWEIS CAPITAL MANAGEMENT INC | 296,571 | 240,316 | -56,255 | 0.62 | 0.60 | -0.03 | sell |
| LORD, ABBETT & CO. LLC | 954,493 | 887,716 | -66,777 | 0.14 | 0.15 | +0.00 | sell |
| Aberdeen Group plc | 252,963 | 173,261 | -79,702 | 0.02 | 0.02 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 457,617 | 373,679 | -83,938 | 0.11 | 0.09 | -0.02 | sell |
| PDT Partners, LLC | 207,713 | 102,374 | -105,339 | 0.63 | 0.30 | -0.33 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,566,738 | 3,458,963 | -107,775 | 3.03 | 3.15 | +0.13 | sell |
| First Light Asset Management, LLC | 271,115 | 128,868 | -142,247 | 1.32 | 0.87 | -0.45 | sell |
| Casdin Capital, LLC | 250,000 | 100,000 | -150,000 | 0.87 | 0.47 | -0.40 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 476,499 | 305,567 | -170,932 | 0.01 | 0.01 | -0.00 | sell |
| Capital International Investors | 5,147,724 | 4,976,458 | -171,266 | 0.04 | 0.04 | +0.00 | sell |
| BAILLIE GIFFORD & CO | 5,061,011 | 4,809,786 | -251,225 | 0.19 | 0.19 | -0.00 | sell |
| Blue Water Life Science Advisors, LP | 694,047 | 439,047 | -255,000 | 29.30 | 18.09 | -11.21 | sell |
| Iron Triangle Partners LP | 600,867 | 300,000 | -300,867 | 4.03 | 2.47 | -1.56 | sell |
| BRAIDWELL LP | 1,327,327 | 837,800 | -489,527 | 1.99 | 1.49 | -0.50 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 846,749 | 307,305 | -539,444 | 0.07 | 0.03 | -0.04 | sell |
| CITADEL ADVISORS LLC | 3,596,913 | 2,938,553 | -658,360 | 0.21 | 0.19 | -0.02 | sell |
| Deep Track Capital, LP | 5,443,721 | 4,250,000 | -1,193,721 | 7.51 | 7.11 | -0.40 | sell |
| CADIAN CAPITAL MANAGEMENT, LP | 4,595,087 | 3,179,217 | -1,415,870 | 8.38 | 9.27 | +0.89 | sell |