| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CADIAN CAPITAL MANAGEMENT, LP | 3,131,808 | 6,930,474 | +3,798,666 | 4.50 | 8.14 | +3.64 | buy |
| Temasek Holdings (Private) Ltd | 3,749,102 | 2,088,194 | +1,660,908 | 0.50 | 0.19 | 0.00 | sell |
| Deep Track Capital, LP | 4,500,000 | 6,000,560 | +1,500,560 | 3.88 | 4.39 | +0.51 | buy |
| Nikko Asset Management Americas, Inc. | 88,694 | 1,266,484 | +1,177,790 | 0.03 | 0.33 | +0.30 | buy |
| ARK Investment Management LLC | 453,590 | 1,512,694 | +1,059,104 | 0.12 | 0.32 | +0.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 814,523 | 1,365,346 | +550,823 | 0.06 | 0.08 | 0.00 | buy |
| BRAIDWELL LP | 2,807,968 | 3,342,124 | +534,156 | 2.54 | 2.17 | -0.37 | buy |
| Casdin Capital, LLC | 100,000 | 350,000 | +250,000 | 0.22 | 0.54 | +0.31 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,938,515 | 2,174,717 | +236,202 | 0.24 | 0.20 | -0.04 | buy |
| First Light Asset Management, LLC | 416,967 | 648,993 | +232,026 | 1.06 | 1.24 | +0.18 | buy |
| Aberdeen Group plc | 373,591 | 552,473 | +178,882 | 0.02 | 0.02 | +0.00 | buy |
| Aristotle Atlantic Partners, LLC | 749,197 | 893,508 | +144,311 | 0.70 | 0.64 | -0.06 | buy |
| Rathbones Group PLC | 108,395 | 186,586 | +78,191 | 0.02 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,760,538 | 3,837,300 | +76,762 | 1.86 | 1.52 | -0.34 | buy |
| PDT Partners, LLC | 144,585 | 219,542 | +74,957 | 0.40 | 0.45 | +0.05 | buy |
| Hood River Capital Management LLC | 146,726 | 189,878 | +43,152 | 0.09 | 0.07 | -0.02 | buy |
| Pier Capital, LLC | 115,854 | 158,429 | +42,575 | 0.50 | 0.51 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 136,269 | 119,251 | +17,018 | 0.00 | 0.00 | 0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 137,811 | 125,680 | +12,131 | 0.03 | 0.02 | 0.00 | sell |
| Exome Asset Management LLC | 79,000 | 89,800 | +10,800 | 2.03 | 1.39 | -0.64 | buy |
| China Universal Asset Management Co., Ltd. | 14,378 | 23,661 | +9,283 | 0.06 | 0.06 | +0.00 | buy |
| FULLCIRCLE WEALTH LLC | 6,642 | 13,642 | +7,000 | 0.10 | 0.14 | +0.03 | buy |
| ProShare Advisors LLC | 23,441 | 30,326 | +6,885 | 0.00 | 0.00 | 0.00 | buy |
| FIL Ltd | 2,068,481 | 2,073,825 | +5,344 | 0.06 | 0.04 | -0.02 | buy |
| SWS Partners | 78,857 | 83,762 | +4,905 | 0.68 | 0.61 | -0.07 | buy |
| Capital International Investors | 4,468,723 | 4,473,242 | +4,519 | 0.03 | 0.02 | -0.01 | buy |
| Values First Advisors, Inc. | 28,248 | 32,025 | +3,777 | 0.49 | 0.40 | -0.09 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 15,420 | 19,103 | +3,683 | 0.09 | 0.09 | -0.00 | buy |
| BRANDYWINE MANAGERS, LLC | 7,152 | 10,233 | +3,081 | 0.22 | 0.25 | +0.03 | buy |
| NEOS Investment Management LLC | 30,402 | 32,567 | +2,165 | 0.04 | 0.02 | -0.01 | buy |
| Green Alpha Advisors, LLC | 7,108 | 8,782 | +1,674 | 0.16 | 0.16 | -0.01 | buy |
| WEXFORD CAPITAL LP | 8,923 | 10,081 | +1,158 | 0.07 | 0.06 | -0.01 | buy |
| IMA Advisory Services, Inc. | 15,754 | 16,124 | +370 | 0.20 | 0.08 | -0.12 | buy |
| Sicart Associates LLC | 145,983 | 146,303 | +320 | 1.62 | 1.18 | -0.44 | buy |
| BROWN, LISLE/CUMMINGS, INC. | 85 | 285 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Tidemark, LLC | 15 | 65 | +50 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 2,382 | 2,400 | +18 | 0.00 | 0.00 | 0.00 | buy |
| Adalta Capital Management LLC | 71,023 | 70,963 | -60 | 1.12 | 0.84 | -0.28 | sell |
| Silicon Valley Community Foundation | 13,399 | 13,228 | -171 | 0.02 | 0.01 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 16,184 | 15,552 | -632 | 0.04 | 0.03 | -0.01 | sell |
| MPM BioImpact LLC | 500,000 | 499,170 | -830 | 2.24 | 1.72 | -0.53 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,713 | 18,100 | -1,613 | 0.05 | 0.03 | -0.02 | sell |
| Byrne Asset Management LLC | 2,660 | 780 | -1,880 | 0.06 | 0.01 | -0.04 | sell |
| D.A. DAVIDSON & CO. | 26,545 | 24,625 | -1,920 | 0.01 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 20,201 | 18,140 | -2,061 | 0.00 | 0.00 | -0.00 | sell |
| TCW GROUP INC | 52,084 | 43,799 | -8,285 | 0.01 | 0.01 | -0.00 | sell |
| Beck Bode, LLC | 269,390 | 248,859 | -20,531 | 1.56 | 1.07 | -0.49 | sell |
| Scientech Research LLC | 59,023 | 25,419 | -33,604 | 0.35 | 0.12 | -0.24 | sell |
| FRED ALGER MANAGEMENT, LLC | 198,468 | 155,429 | -43,039 | 0.03 | 0.02 | -0.01 | sell |
| Polar Asset Management Partners Inc. | 134,000 | 22,700 | -111,300 | 0.08 | 0.01 | -0.07 | sell |
| Blue Water Life Science Advisors, LP | 571,047 | 451,047 | -120,000 | 16.04 | 9.10 | -6.94 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 670,200 | 485,000 | -185,200 | 2.99 | 1.63 | -1.36 | sell |
| BAILLIE GIFFORD & CO | 6,093,286 | 5,872,024 | -221,262 | 0.14 | 0.10 | -0.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 299,800 | 56,800 | -243,000 | 0.02 | 0.00 | -0.01 | sell |