| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 11,636,732 | 11,701,945 | +65,213 | 0.01 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,508,743 | 10,127,528 | +6,618,785 | 0.02 | 0.04 | +0.02 | buy |
| CADIAN CAPITAL MANAGEMENT, LP | 3,131,808 | 6,930,474 | +3,798,666 | 4.50 | 8.14 | +3.64 | buy |
| Deep Track Capital, LP | 4,500,000 | 6,000,560 | +1,500,560 | 3.88 | 4.39 | +0.51 | buy |
| BAILLIE GIFFORD & CO | 6,093,286 | 5,872,024 | -221,262 | 0.14 | 0.10 | -0.04 | sell |
| Capital International Investors | 4,468,723 | 4,473,242 | +4,519 | 0.03 | 0.02 | -0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,760,538 | 3,837,300 | +76,762 | 1.86 | 1.52 | -0.34 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,233,044 | 3,344,037 | +110,993 | 0.03 | 0.02 | -0.01 | buy |
| BRAIDWELL LP | 2,807,968 | 3,342,124 | +534,156 | 2.54 | 2.17 | -0.37 | buy |
| Invesco Ltd. | 1,207,469 | 2,902,074 | +1,694,605 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,792,534 | 2,822,220 | +29,686 | 0.01 | 0.01 | -0.00 | buy |
| Parkwood LLC | 2,800,000 | 2,800,000 | 0 | 0.27 | 0.27 | +0.00 | hold |
| STATE STREET CORP | 2,754,977 | 2,794,375 | +39,398 | 0.00 | 0.00 | -0.00 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,938,515 | 2,174,717 | +236,202 | 0.24 | 0.20 | -0.04 | buy |
| Temasek Holdings (Private) Ltd | 3,749,102 | 2,088,194 | -1,660,908 | 0.50 | 0.19 | -0.31 | sell |
| FIL Ltd | 2,068,481 | 2,073,825 | +5,344 | 0.06 | 0.04 | -0.02 | buy |
| MORGAN STANLEY | 2,021,706 | 1,716,216 | -305,490 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 453,590 | 1,512,694 | +1,059,104 | 0.12 | 0.32 | +0.20 | buy |
| FMR LLC | 3,118,623 | 1,471,802 | -1,646,821 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 814,523 | 1,365,346 | +550,823 | 0.06 | 0.07 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 1,073,077 | 1,303,727 | +230,650 | 0.01 | 0.01 | -0.00 | buy |
| Nikko Asset Management Americas, Inc. | 88,694 | 1,266,484 | +1,177,790 | 0.03 | 0.33 | +0.30 | buy |
| GOLDMAN SACHS GROUP INC | 1,248,050 | 1,226,892 | -21,158 | 0.01 | 0.01 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 88,694 | 1,226,176 | +1,137,482 | 0.00 | 0.02 | +0.02 | buy |
| NORGES BANK | 1,383,768 | 1,179,501 | -204,267 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 770,800 | 1,177,300 | +406,500 | 0.05 | 0.06 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,032,907 | 1,064,579 | +31,672 | 0.01 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,023,217 | +1,023,217 | 0.00 | 0.06 | +0.06 | buy |
| Man Group plc | 0 | 1,020,710 | +1,020,710 | 0.00 | 0.07 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,309,431 | 1,003,138 | -306,293 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 1,280,221 | 949,211 | -331,010 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,069,963 | 946,025 | -123,938 | 0.01 | 0.01 | -0.00 | sell |
| Erste Asset Management GmbH | 932,600 | 932,600 | 0 | 0.36 | 0.26 | -0.10 | hold |
| Aristotle Atlantic Partners, LLC | 749,197 | 893,508 | +144,311 | 0.70 | 0.64 | -0.06 | buy |
| BARCLAYS PLC | 477,372 | 887,031 | +409,659 | 0.01 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 862,100 | 863,650 | +1,550 | 0.06 | 0.04 | -0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,375,674 | 842,508 | -533,166 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 430,500 | 766,284 | +335,784 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 681,074 | +681,074 | 0.00 | 0.05 | +0.05 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 541,953 | 662,267 | +120,314 | 0.06 | 0.06 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,135,311 | 653,975 | -1,481,336 | 0.05 | 0.01 | -0.04 | sell |
| First Light Asset Management, LLC | 416,967 | 648,993 | +232,026 | 1.06 | 1.24 | +0.18 | buy |
| Pictet Asset Management Holding SA | 664,108 | 623,071 | -41,037 | 0.02 | 0.02 | -0.01 | sell |
| Railway Pension Investments Ltd | 620,878 | 620,878 | 0 | 0.21 | 0.17 | -0.04 | hold |
| Aberdeen Group plc | 373,591 | 552,473 | +178,882 | 0.02 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 500,000 | 499,170 | -830 | 2.24 | 1.72 | -0.53 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 670,200 | 485,000 | -185,200 | 2.99 | 1.63 | -1.36 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 513,283 | 484,537 | -28,746 | 0.01 | 0.01 | -0.00 | sell |
| Trexquant Investment LP | 584,914 | 455,710 | -129,204 | 0.26 | 0.13 | -0.13 | sell |
| Blue Water Life Science Advisors, LP | 571,047 | 451,047 | -120,000 | 16.04 | 9.10 | -6.94 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 438,400 | +438,400 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 0 | 406,645 | +406,645 | 0.00 | 0.77 | +0.77 | buy |
| TUDOR INVESTMENT CORP ET AL | 239,223 | 397,875 | +158,652 | 0.08 | 0.10 | +0.02 | buy |
| Candriam S.C.A. | 366,145 | 366,145 | 0 | 0.06 | 0.05 | -0.02 | hold |
| UBS Group AG | 60,444 | 361,067 | +300,623 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 100,000 | 350,000 | +250,000 | 0.22 | 0.54 | +0.31 | buy |
| CITADEL ADVISORS LLC | 3,290,897 | 330,401 | -2,960,496 | 0.09 | 0.01 | -0.09 | sell |
| Mitsubishi UFJ Trust & Banking Corp | 339,090 | 330,072 | -9,018 | 0.02 | 0.02 | -0.01 | sell |
| Engineers Gate Manager LP | 95,685 | 282,349 | +186,664 | 0.06 | 0.13 | +0.06 | buy |
| Beck Bode, LLC | 269,390 | 248,859 | -20,531 | 1.56 | 1.07 | -0.49 | sell |
| Swiss National Bank | 239,400 | 239,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDT Partners, LLC | 144,585 | 219,542 | +74,957 | 0.40 | 0.45 | +0.05 | buy |
| Aquatic Capital Management LLC | 0 | 207,200 | +207,200 | 0.00 | 0.12 | +0.12 | buy |
| JPMORGAN CHASE & CO | 429,385 | 199,544 | -229,841 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 126,125 | 195,008 | +68,883 | 0.01 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 146,726 | 189,878 | +43,152 | 0.09 | 0.07 | -0.02 | buy |
| Rathbones Group PLC | 108,395 | 186,586 | +78,191 | 0.02 | 0.02 | +0.00 | buy |
| Legal & General Group Plc | 171,051 | 183,561 | +12,510 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 178,219 | 171,582 | -6,637 | 0.06 | 0.04 | -0.01 | sell |
| RHUMBLINE ADVISERS | 173,298 | 163,701 | -9,597 | 0.00 | 0.00 | -0.00 | sell |
| Pier Capital, LLC | 115,854 | 158,429 | +42,575 | 0.50 | 0.51 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 153,809 | 156,796 | +2,987 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 198,468 | 155,429 | -43,039 | 0.03 | 0.02 | -0.01 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 152,986 | 152,986 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Sicart Associates LLC | 145,983 | 146,303 | +320 | 1.62 | 1.18 | -0.44 | buy |
| ALLIANCEBERNSTEIN L.P. | 143,720 | 143,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 159,601 | 134,270 | -25,331 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 131,802 | 126,925 | -4,877 | 0.01 | 0.01 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 137,811 | 125,680 | -12,131 | 0.03 | 0.02 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 136,269 | 119,251 | -17,018 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 118,547 | 115,436 | -3,111 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 31,276 | 114,641 | +83,365 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 107,674 | +107,674 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 106,620 | 106,620 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,500 | 100,200 | +89,700 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 203,976 | 98,482 | -105,494 | 0.01 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 79,000 | 89,800 | +10,800 | 2.03 | 1.39 | -0.64 | buy |
| SWS Partners | 78,857 | 83,762 | +4,905 | 0.68 | 0.61 | -0.07 | buy |
| AMERIPRISE FINANCIAL INC | 72,029 | 79,041 | +7,012 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 71,286 | 74,180 | +2,894 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 74,054 | +74,054 | 0.00 | 0.00 | +0.00 | buy |
| Adalta Capital Management LLC | 71,023 | 70,963 | -60 | 1.12 | 0.84 | -0.28 | sell |
| MetLife Investment Management, LLC | 68,147 | 68,147 | 0 | 0.01 | 0.01 | -0.00 | hold |
| COMERICA BANK | 68,128 | 67,836 | -292 | 0.01 | 0.01 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 67,004 | +67,004 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 216,234 | 66,907 | -149,327 | 0.01 | 0.00 | -0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 66,176 | 66,176 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 56,945 | 64,618 | +7,673 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 63,489 | 63,100 | -389 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 28,769 | 62,984 | +34,215 | 0.00 | 0.00 | +0.00 | buy |