| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 12,168,020 | 11,908,829 | -259,191 | 0.01 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 10,979,470 | 11,429,315 | +449,845 | 0.01 | 0.01 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 4,809,786 | 5,127,692 | +317,906 | 0.19 | 0.24 | +0.05 | buy |
| Invesco Ltd. | 3,558,501 | 4,929,543 | +1,371,042 | 0.03 | 0.05 | +0.02 | buy |
| Capital International Investors | 4,976,458 | 4,689,241 | -287,217 | 0.04 | 0.05 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,765,576 | 4,221,637 | +2,456,061 | 0.01 | 0.03 | +0.02 | buy |
| Deep Track Capital, LP | 4,250,000 | 4,154,086 | -95,914 | 7.11 | 7.24 | +0.13 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,458,963 | 3,321,338 | -137,625 | 3.15 | 3.41 | +0.26 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,922,969 | 3,249,085 | +1,326,116 | 0.02 | 0.04 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,920,714 | 2,936,656 | +15,942 | 0.01 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,319,947 | 2,926,315 | +606,368 | 0.03 | 0.05 | +0.01 | buy |
| STATE STREET CORP | 2,839,665 | 2,787,777 | -51,888 | 0.01 | 0.01 | +0.00 | sell |
| FULLER & THALER ASSET MANAGEMENT, INC. | 2,197,829 | 2,369,568 | +171,739 | 0.42 | 0.50 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,933,988 | 2,261,869 | -672,119 | 0.03 | 0.03 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,475,613 | 2,152,315 | -323,298 | 1.03 | 0.96 | -0.07 | sell |
| CADIAN CAPITAL MANAGEMENT, LP | 3,179,217 | 2,141,191 | -1,038,026 | 9.27 | 7.95 | -1.32 | sell |
| TWO SIGMA ADVISERS, LP | 2,381,800 | 2,112,800 | -269,000 | 0.25 | 0.26 | +0.01 | sell |
| Alyeska Investment Group, L.P. | 0 | 1,831,318 | +1,831,318 | 0.00 | 0.35 | +0.35 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,854,611 | 1,803,331 | -51,280 | 0.17 | 0.17 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,465,438 | 1,776,369 | +310,931 | 0.14 | 0.20 | +0.05 | buy |
| LORD, ABBETT & CO. LLC | 887,716 | 1,523,635 | +635,919 | 0.15 | 0.28 | +0.13 | buy |
| GOLDMAN SACHS GROUP INC | 1,146,705 | 1,506,210 | +359,505 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 856,501 | 1,481,033 | +624,532 | 0.63 | 1.14 | +0.51 | buy |
| JENNISON ASSOCIATES LLC | 715,467 | 1,471,294 | +755,827 | 0.02 | 0.05 | +0.03 | buy |
| UBS Group AG | 1,183,819 | 1,457,051 | +273,232 | 0.01 | 0.02 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,013,272 | 1,415,884 | +402,612 | 0.01 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,183,803 | 1,154,761 | -29,042 | 0.01 | 0.01 | +0.00 | sell |
| Temasek Holdings (Private) Ltd | 1,044,097 | 1,044,097 | 0 | 0.21 | 0.23 | +0.02 | hold |
| MORGAN STANLEY | 886,626 | 982,544 | +95,918 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 906,225 | 953,051 | +46,826 | 0.01 | 0.01 | +0.00 | buy |
| Aristotle Atlantic Partners, LLC | 931,956 | 923,734 | -8,222 | 1.48 | 1.67 | +0.20 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,721,881 | 878,576 | -1,843,305 | 0.13 | 0.04 | -0.08 | sell |
| BANK OF AMERICA CORP /DE/ | 707,404 | 873,858 | +166,454 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 699,922 | 873,203 | +173,281 | 1.34 | 1.75 | +0.41 | buy |
| FMR LLC | 987,675 | 824,265 | -163,410 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 2,823,497 | 795,234 | -2,028,263 | 1.08 | 0.30 | -0.78 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 2,030,638 | 754,154 | -1,276,484 | 0.07 | 0.03 | -0.04 | sell |
| Nikko Asset Management Americas, Inc. | 2,030,428 | 753,944 | -1,276,484 | 1.05 | 0.46 | -0.60 | sell |
| Man Group plc | 806,072 | 751,533 | -54,539 | 0.09 | 0.09 | +0.00 | sell |
| Erste Asset Management GmbH | 638,600 | 705,217 | +66,617 | 0.28 | 0.42 | +0.14 | buy |
| FRED ALGER MANAGEMENT, LLC | 373,679 | 638,487 | +264,808 | 0.09 | 0.16 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 632,630 | 634,451 | +1,821 | 0.03 | 0.03 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 630,855 | +630,855 | 0.00 | 0.06 | +0.06 | buy |
| ROYAL BANK OF CANADA | 893,411 | 572,791 | -320,620 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 254,199 | 570,095 | +315,896 | 0.02 | 0.05 | +0.03 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 415,774 | 556,009 | +140,235 | 1.32 | 1.79 | +0.48 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 564,348 | 533,377 | -30,971 | 0.07 | 0.07 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 675,200 | 531,847 | -143,353 | 0.05 | 0.04 | -0.00 | sell |
| Engineers Gate Manager LP | 277,551 | 506,950 | +229,399 | 0.18 | 0.36 | +0.18 | buy |
| JPMORGAN CHASE & CO | 193,302 | 493,821 | +300,519 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 566,405 | 474,033 | -92,372 | 0.02 | 0.02 | -0.00 | sell |
| Nuveen, LLC | 446,609 | 454,959 | +8,350 | 0.01 | 0.01 | +0.00 | buy |
| Blue Water Life Science Advisors, LP | 439,047 | 405,647 | -33,400 | 18.09 | 23.12 | +5.04 | sell |
| Bank of New York Mellon Corp | 200,000 | 400,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| Iron Triangle Partners LP | 300,000 | 400,000 | +100,000 | 2.47 | 3.55 | +1.08 | buy |
| Northwest & Ethical Investments L.P. | 0 | 400,000 | +400,000 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 376,705 | 384,730 | +8,025 | 0.22 | 0.25 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 549,578 | 356,421 | -193,157 | 0.03 | 0.02 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 318,119 | 335,852 | +17,733 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 232,599 | 329,893 | +97,294 | 0.00 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 123,459 | 328,049 | +204,590 | 0.01 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 494,872 | 307,481 | -187,391 | 0.01 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 193,325 | 305,147 | +111,822 | 0.14 | 0.25 | +0.11 | buy |
| CITADEL ADVISORS LLC | 2,938,553 | 304,520 | -2,634,033 | 0.13 | 0.02 | -0.12 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 305,567 | 303,322 | -2,245 | 0.01 | 0.01 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 195,186 | 301,449 | +106,263 | 0.02 | 0.03 | +0.01 | buy |
| Eagle Health Investments LP | 212,000 | 284,100 | +72,100 | 2.72 | 4.66 | +1.94 | buy |
| First Light Asset Management, LLC | 128,868 | 280,001 | +151,133 | 0.87 | 1.65 | +0.78 | buy |
| BARCLAYS PLC | 395,980 | 277,436 | -118,544 | 0.01 | 0.01 | -0.00 | sell |
| Hood River Capital Management LLC | 245,701 | 256,893 | +11,192 | 0.18 | 0.19 | +0.01 | buy |
| Pictet Asset Management Holding SA | 318,418 | 255,770 | -62,648 | 0.02 | 0.02 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 241,306 | +241,306 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 43,425 | 240,423 | +196,998 | 0.00 | 0.02 | +0.02 | buy |
| Sicart Associates LLC | 165,455 | 230,083 | +64,628 | 3.01 | 3.89 | +0.88 | buy |
| Swiss National Bank | 212,100 | 216,100 | +4,000 | 0.01 | 0.01 | +0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 240,316 | 215,011 | -25,305 | 0.60 | 0.61 | +0.01 | sell |
| JUPITER ASSET MANAGEMENT LTD | 0 | 207,816 | +207,816 | 0.00 | 0.11 | +0.11 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 151,701 | 206,824 | +55,123 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 77,308 | 201,327 | +124,019 | 0.00 | 0.01 | +0.01 | buy |
| Rathbones Group PLC | 205,965 | 200,088 | -5,877 | 0.05 | 0.05 | +0.00 | sell |
| Russell Investments Group, Ltd. | 104,304 | 195,235 | +90,931 | 0.01 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 162,600 | 188,810 | +26,210 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 202,245 | 186,193 | -16,052 | 0.01 | 0.01 | +0.00 | sell |
| Granite Investment Partners, LLC | 386,866 | 185,301 | -201,565 | 0.98 | 0.66 | -0.33 | sell |
| Aquatic Capital Management LLC | 155,964 | 183,576 | +27,612 | 0.16 | 0.21 | +0.05 | buy |
| RHUMBLINE ADVISERS | 184,724 | 180,167 | -4,557 | 0.01 | 0.01 | +0.00 | sell |
| Mitsubishi UFJ Trust & Banking Corp | 183,443 | 178,309 | -5,134 | 0.02 | 0.02 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 7,600 | 177,300 | +169,700 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 262,522 | 176,516 | -86,006 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 170,522 | 171,753 | +1,231 | 0.05 | 0.06 | +0.01 | buy |
| CASTLEARK MANAGEMENT LLC | 121,560 | 160,073 | +38,513 | 0.19 | 0.28 | +0.09 | buy |
| Allianz Asset Management GmbH | 159,348 | 158,781 | -567 | 0.01 | 0.01 | +0.00 | sell |
| Hillsdale Investment Management Inc. | 136,100 | 155,900 | +19,800 | 0.26 | 0.29 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 307,305 | 152,122 | -155,183 | 0.03 | 0.02 | -0.01 | sell |
| Legal & General Group Plc | 158,069 | 151,605 | -6,464 | 0.00 | 0.00 | +0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 148,317 | 151,117 | +2,800 | 0.06 | 0.07 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 145,360 | +145,360 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 140,308 | 139,523 | -785 | 0.00 | 0.00 | +0.00 | sell |
| Atika Capital Management LLC | 89,200 | 133,000 | +43,800 | 0.48 | 0.71 | +0.22 | buy |