| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 2,927,351 | 4,001,803 | +1,074,452 | 0.02 | 0.02 | +0.00 | buy |
| Deep Track Capital, LP | 4,050,000 | 5,000,000 | +950,000 | 4.66 | 4.74 | +0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,101,873 | 584,557 | +517,316 | 0.10 | 0.04 | 0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 795,233 | 400,898 | +394,335 | 0.07 | 0.03 | 0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,589,530 | 3,888,146 | +298,616 | 1.91 | 1.72 | -0.20 | buy |
| Erste Asset Management GmbH | 612,600 | 692,600 | +80,000 | 0.31 | 0.28 | -0.04 | buy |
| BRAIDWELL LP | 689,000 | 758,928 | +69,928 | 0.65 | 0.75 | +0.11 | buy |
| ALGERT GLOBAL LLC | 21,240 | 73,848 | +52,608 | 0.03 | 0.08 | 0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 37,967 | 79,026 | +41,059 | 0.10 | 0.14 | +0.03 | buy |
| TCW GROUP INC | 108,429 | 133,660 | +25,231 | 0.04 | 0.04 | -0.00 | buy |
| Capital Impact Advisors, LLC | 10,422 | 35,219 | +24,797 | 0.52 | 1.25 | +0.74 | buy |
| GUGGENHEIM CAPITAL LLC | 150,329 | 161,809 | +11,480 | 0.04 | 0.03 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,421 | 13,652 | +9,231 | 0.04 | 0.07 | +0.03 | buy |
| Graham Capital Management, L.P. | 34,221 | 42,149 | +7,928 | 0.02 | 0.03 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 156,291 | 150,137 | +6,154 | 0.01 | 0.01 | 0.00 | sell |
| Nebula Research & Development LLC | 14,375 | 20,073 | +5,698 | 0.22 | 0.16 | -0.06 | buy |
| D.A. DAVIDSON & CO. | 24,225 | 29,793 | +5,568 | 0.01 | 0.01 | +0.00 | buy |
| Values First Advisors, Inc. | 30,531 | 35,135 | +4,604 | 0.58 | 0.57 | -0.01 | buy |
| LOOMIS SAYLES & CO L P | 83,253 | 87,652 | +4,399 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 22,638 | 26,799 | +4,161 | 0.00 | 0.00 | 0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,575 | 14,793 | +3,218 | 0.00 | 0.00 | 0.00 | buy |
| Aristotle Atlantic Partners, LLC | 834,096 | 836,945 | +2,849 | 0.99 | 0.80 | -0.19 | buy |
| Headlands Technologies LLC | 509 | 2,353 | +1,844 | 0.01 | 0.02 | +0.01 | buy |
| Wealthcare Advisory Partners LLC | 7,288 | 8,596 | +1,308 | 0.01 | 0.01 | -0.00 | buy |
| Itau Unibanco Holding S.A. | 1,722 | 2,861 | +1,139 | 0.00 | 0.00 | +0.00 | buy |
| CI INVESTMENTS INC. | 2,107 | 2,606 | +499 | 0.00 | 0.00 | 0.00 | buy |
| Pacific Capital Partners Ltd | 10,142 | 10,329 | +187 | 0.18 | 0.21 | +0.03 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 256 | 360 | +104 | 0.01 | 0.01 | +0.00 | buy |
| Cornerstone Planning Group LLC | 29 | 95 | +66 | 0.00 | 0.00 | +0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 237 | 232 | +5 | 0.00 | 0.00 | 0.00 | sell |
| Silicon Valley Community Foundation | 14,056 | 13,821 | -235 | 0.05 | 0.04 | -0.01 | sell |
| STEPHENS INC /AR/ | 11,746 | 11,285 | -461 | 0.01 | 0.01 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 51,824 | 51,316 | -508 | 0.01 | 0.01 | -0.00 | sell |
| SWS Partners | 46,695 | 45,971 | -724 | 0.51 | 0.41 | -0.11 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 291,446 | 290,571 | -875 | 0.01 | 0.01 | -0.00 | sell |
| Rathbones Group PLC | 96,784 | 95,678 | -1,106 | 0.02 | 0.02 | -0.00 | sell |
| Harel Insurance Investments & Financial Services Ltd. | 1,884 | 699 | -1,185 | 0.00 | 0.00 | -0.00 | sell |
| BRANDYWINE MANAGERS, LLC | 15,933 | 14,303 | -1,630 | 0.80 | 0.42 | -0.37 | sell |
| Bridgewater Associates, LP | 37,024 | 35,117 | -1,907 | 0.01 | 0.01 | -0.00 | sell |
| Green Alpha Advisors, LLC | 10,110 | 7,712 | -2,398 | 0.23 | 0.15 | -0.08 | sell |
| Mach-1 Financial Group, LLC | 19,076 | 16,160 | -2,916 | 0.24 | 0.17 | -0.07 | sell |
| Sicart Associates LLC | 95,925 | 92,953 | -2,972 | 1.12 | 0.96 | -0.15 | sell |
| Alpha DNA Investment Management LLC | 21,566 | 18,364 | -3,202 | 0.41 | 0.30 | -0.12 | sell |
| OAK RIDGE INVESTMENTS LLC | 21,030 | 17,089 | -3,941 | 0.08 | 0.05 | -0.03 | sell |
| FIRST FOUNDATION ADVISORS | 7,873 | 1,121 | -6,752 | 0.01 | 0.00 | -0.01 | sell |
| RTW INVESTMENTS, LP | 500,887 | 492,977 | -7,910 | 0.31 | 0.21 | -0.10 | sell |
| PURA VIDA INVESTMENTS, LLC | 22,943 | 15,000 | -7,943 | 0.13 | 0.06 | -0.07 | sell |
| Hillsdale Investment Management Inc. | 146,100 | 136,380 | -9,720 | 0.40 | 0.30 | -0.10 | sell |
| IMA Advisory Services, Inc. | 31,102 | 17,205 | -13,897 | 0.24 | 0.23 | -0.01 | sell |
| Fiera Capital Corp | 911,694 | 897,587 | -14,107 | 0.09 | 0.07 | -0.01 | sell |
| Dynamic Technology Lab Private Ltd | 31,653 | 17,089 | -14,564 | 0.09 | 0.05 | -0.04 | sell |
| Citizens Business Bank | 62,596 | 45,424 | -17,172 | 0.44 | 0.27 | -0.17 | sell |
| Nikko Asset Management Americas, Inc. | 111,841 | 93,745 | -18,096 | 0.04 | 0.02 | -0.02 | sell |
| Adalta Capital Management LLC | 81,220 | 61,458 | -19,762 | 1.64 | 1.01 | -0.64 | sell |
| FIL Ltd | 1,990,886 | 1,970,988 | -19,898 | 0.07 | 0.06 | -0.01 | sell |
| Bayesian Capital Management, LP | 38,700 | 18,300 | -20,400 | 0.13 | 0.05 | -0.08 | sell |
| Granite Investment Partners, LLC | 232,378 | 208,187 | -24,191 | 0.29 | 0.22 | -0.07 | sell |
| Candriam S.C.A. | 491,137 | 466,137 | -25,000 | 0.10 | 0.09 | -0.02 | sell |
| Portman Square Capital LLP | 41,221 | 9,474 | -31,747 | 0.17 | 0.04 | -0.12 | sell |
| Holocene Advisors, LP | 72,828 | 40,511 | -32,317 | 0.01 | 0.00 | -0.01 | sell |
| PDT Partners, LLC | 144,629 | 90,083 | -54,546 | 0.54 | 0.27 | -0.27 | sell |
| First Light Asset Management, LLC | 198,783 | 144,049 | -54,734 | 0.56 | 0.31 | -0.25 | sell |
| Eagle Health Investments LP | 204,861 | 120,109 | -84,752 | 1.34 | 0.66 | -0.68 | sell |
| Blue Water Life Science Advisors, LP | 676,047 | 571,047 | -105,000 | 18.92 | 13.53 | -5.39 | sell |
| ARK Investment Management LLC | 573,323 | 438,100 | -135,223 | 0.13 | 0.07 | -0.06 | sell |
| TD ASSET MANAGEMENT INC | 284,844 | 138,644 | -146,200 | 0.01 | 0.00 | -0.01 | sell |
| Clearbridge Investments, LLC | 1,824,558 | 1,466,362 | -358,196 | 0.05 | 0.03 | -0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 1,493,100 | 1,010,326 | -482,774 | 0.03 | 0.02 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,329,935 | 791,735 | -538,200 | 0.87 | 0.40 | -0.47 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,745,962 | 1,819,584 | -926,378 | 0.01 | 0.01 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 1,890,884 | 479,846 | -1,411,038 | 0.05 | 0.01 | -0.04 | sell |
| LORD, ABBETT & CO. LLC | 38,218,000 | 22,240,000 | -15,978,000 | 0.10 | 0.05 | -0.04 | sell |