| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TWO SIGMA INVESTMENTS, LP | 1,365,346 | 1,890,714 | +525,368 | 0.08 | 0.14 | 0.00 | buy |
| Polar Asset Management Partners Inc. | 22,700 | 454,500 | +431,800 | 0.01 | 0.16 | +0.15 | buy |
| Deep Track Capital, LP | 6,000,560 | 6,419,566 | +419,006 | 4.39 | 7.35 | +2.96 | buy |
| Blue Water Life Science Advisors, LP | 451,047 | 694,047 | +243,000 | 9.10 | 18.77 | +9.67 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 56,800 | 279,800 | +223,000 | 0.00 | 0.01 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 1,266,484 | 1,464,213 | +197,729 | 0.33 | 0.48 | +0.16 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 100,200 | 177,500 | +77,300 | 0.00 | 0.01 | 0.00 | buy |
| Pier Capital, LLC | 158,429 | 230,280 | +71,851 | 0.51 | 1.00 | +0.49 | buy |
| LAZARD ASSET MANAGEMENT LLC | 119,251 | 49,631 | +69,620 | 0.00 | 0.00 | 0.00 | sell |
| Exome Asset Management LLC | 89,800 | 147,800 | +58,000 | 1.39 | 3.40 | +2.00 | buy |
| SWS Partners | 83,762 | 120,888 | +37,126 | 0.61 | 1.12 | +0.51 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,023,217 | 992,538 | +30,679 | 0.06 | 0.07 | 0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,100 | 42,200 | +24,100 | 0.03 | 0.11 | +0.08 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 30,962 | 8,585 | +22,377 | 0.01 | 0.00 | 0.00 | sell |
| PDT Partners, LLC | 219,542 | 240,473 | +20,931 | 0.45 | 0.65 | +0.20 | buy |
| OMERS ADMINISTRATION Corp | 39,000 | 20,800 | +18,200 | 0.01 | 0.01 | -0.01 | sell |
| D.A. DAVIDSON & CO. | 24,625 | 42,380 | +17,755 | 0.00 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 38,361 | 51,845 | +13,484 | 0.11 | 0.19 | +0.08 | buy |
| Rathbones Group PLC | 186,586 | 198,961 | +12,375 | 0.02 | 0.03 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 125,680 | 113,850 | +11,830 | 0.02 | 0.03 | 0.00 | sell |
| Hood River Capital Management LLC | 189,878 | 200,957 | +11,079 | 0.07 | 0.09 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 32,848 | 43,824 | +10,976 | 0.01 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 30,326 | 39,594 | +9,268 | 0.00 | 0.00 | 0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 19,103 | 25,957 | +6,854 | 0.09 | 0.14 | +0.05 | buy |
| Scientech Research LLC | 25,419 | 29,733 | +4,314 | 0.12 | 0.26 | +0.14 | buy |
| NEOS Investment Management LLC | 32,567 | 36,120 | +3,553 | 0.02 | 0.03 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 23,661 | 26,198 | +2,537 | 0.06 | 0.07 | +0.02 | buy |
| Fiduciary Alliance LLC | 11,043 | 11,879 | +836 | 0.03 | 0.04 | +0.00 | buy |
| Financial Network Wealth Advisors LLC | 24 | 69 | +45 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 155,429 | 155,472 | +43 | 0.02 | 0.02 | +0.01 | buy |
| Tidemark, LLC | 65 | 50 | -15 | 0.00 | 0.00 | -0.00 | sell |
| Elequin Capital, LP | 29 | 9 | -20 | 0.00 | 0.00 | -0.00 | sell |
| IMA Advisory Services, Inc. | 16,124 | 15,648 | -476 | 0.08 | 0.06 | -0.02 | sell |
| OAK RIDGE INVESTMENTS LLC | 15,552 | 14,331 | -1,221 | 0.03 | 0.03 | +0.00 | sell |
| Green Alpha Advisors, LLC | 8,782 | 7,085 | -1,697 | 0.16 | 0.17 | +0.02 | sell |
| WEXFORD CAPITAL LP | 10,081 | 7,739 | -2,342 | 0.06 | 0.04 | -0.02 | sell |
| Adalta Capital Management LLC | 70,963 | 68,263 | -2,700 | 0.84 | 1.09 | +0.25 | sell |
| Values First Advisors, Inc. | 32,025 | 28,059 | -3,966 | 0.40 | 0.47 | +0.07 | sell |
| Bridgewater Associates, LP | 18,140 | 12,544 | -5,596 | 0.00 | 0.00 | -0.00 | sell |
| Sicart Associates LLC | 146,303 | 140,333 | -5,970 | 1.18 | 1.53 | +0.35 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 31,448 | 22,711 | -8,737 | 0.07 | 0.07 | +0.00 | sell |
| Candriam S.C.A. | 366,145 | 352,492 | -13,653 | 0.06 | 0.06 | -0.00 | sell |
| EntryPoint Capital, LLC | 31,633 | 16,337 | -15,296 | 0.41 | 0.21 | -0.20 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 66,176 | 43,686 | -22,490 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,837,300 | 3,807,937 | -29,363 | 1.52 | 2.12 | +0.60 | sell |
| Aristotle Atlantic Partners, LLC | 893,508 | 851,995 | -41,513 | 0.64 | 0.82 | +0.18 | sell |
| MPM BioImpact LLC | 499,170 | 452,739 | -46,431 | 1.72 | 1.96 | +0.25 | sell |
| ARK Investment Management LLC | 1,512,694 | 1,439,852 | -72,842 | 0.32 | 0.37 | +0.05 | sell |
| Aberdeen Group plc | 552,473 | 442,951 | -109,522 | 0.02 | 0.03 | +0.00 | sell |
| FIL Ltd | 2,073,825 | 1,943,061 | -130,764 | 0.04 | 0.06 | +0.01 | sell |
| FULLER & THALER ASSET MANAGEMENT, INC. | 2,174,717 | 1,984,586 | -190,131 | 0.20 | 0.23 | +0.03 | sell |
| Erste Asset Management GmbH | 932,600 | 692,600 | -240,000 | 0.26 | 0.26 | +0.00 | sell |
| First Light Asset Management, LLC | 648,993 | 309,389 | -339,604 | 1.24 | 0.90 | -0.33 | sell |
| BAILLIE GIFFORD & CO | 5,872,024 | 5,449,100 | -422,924 | 0.10 | 0.13 | +0.03 | sell |
| BRAIDWELL LP | 3,342,124 | 2,847,931 | -494,193 | 2.17 | 2.58 | +0.41 | sell |
| Temasek Holdings (Private) Ltd | 2,088,194 | 1,561,979 | -526,215 | 0.19 | 0.19 | -0.01 | sell |
| CADIAN CAPITAL MANAGEMENT, LP | 6,930,474 | 5,221,565 | -1,708,909 | 8.14 | 9.19 | +1.05 | sell |