| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 11,701,945 | 12,052,551 | +350,606 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 11,435,564 | 11,701,587 | +266,023 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 6,000,560 | 6,419,566 | +419,006 | 4.39 | 7.35 | +2.96 | buy |
| BAILLIE GIFFORD & CO | 5,872,024 | 5,449,100 | -422,924 | 0.10 | 0.13 | +0.03 | sell |
| CADIAN CAPITAL MANAGEMENT, LP | 6,930,474 | 5,221,565 | -1,708,909 | 8.14 | 9.19 | +1.04 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 10,127,528 | 4,850,271 | -5,277,257 | 0.04 | 0.03 | -0.01 | sell |
| Capital International Investors | 4,473,242 | 4,473,242 | 0 | 0.02 | 0.03 | +0.01 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,837,300 | 3,807,937 | -29,363 | 1.52 | 2.12 | +0.60 | sell |
| STATE STREET CORP | 2,794,375 | 2,849,113 | +54,738 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 3,342,124 | 2,847,931 | -494,193 | 2.17 | 2.58 | +0.41 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,822,220 | 2,823,088 | +868 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,344,037 | 2,612,777 | -731,260 | 0.02 | 0.02 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,177,300 | 2,315,600 | +1,138,300 | 0.06 | 0.16 | +0.10 | buy |
| FULLER & THALER ASSET MANAGEMENT, INC. | 2,174,717 | 1,984,586 | -190,131 | 0.20 | 0.23 | +0.03 | sell |
| FIL Ltd | 2,073,825 | 1,943,061 | -130,764 | 0.04 | 0.06 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,365,346 | 1,890,714 | +525,368 | 0.07 | 0.13 | +0.06 | buy |
| UBS Group AG | 361,067 | 1,755,391 | +1,394,324 | 0.00 | 0.01 | +0.01 | buy |
| Temasek Holdings (Private) Ltd | 2,088,194 | 1,561,979 | -526,215 | 0.19 | 0.19 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,226,892 | 1,490,725 | +263,833 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 330,401 | 1,481,889 | +1,151,488 | 0.01 | 0.04 | +0.03 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,226,176 | 1,464,213 | +238,037 | 0.02 | 0.03 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 1,266,484 | 1,464,213 | +197,729 | 0.33 | 0.48 | +0.16 | buy |
| ARK Investment Management LLC | 1,512,694 | 1,439,852 | -72,842 | 0.32 | 0.37 | +0.05 | sell |
| MORGAN STANLEY | 1,716,216 | 1,432,416 | -283,800 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 2,902,074 | 1,390,997 | -1,511,077 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 653,975 | 1,226,810 | +572,835 | 0.01 | 0.03 | +0.02 | buy |
| NORGES BANK | 1,179,501 | 1,192,742 | +13,241 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 1,179,000 | +1,179,000 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,471,802 | 1,159,611 | -312,191 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,064,579 | 1,141,992 | +77,413 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,003,138 | 1,016,533 | +13,395 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,023,217 | 992,538 | -30,679 | 0.06 | 0.07 | +0.01 | sell |
| FEDERATED HERMES, INC. | 863,650 | 962,722 | +99,072 | 0.04 | 0.06 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 946,025 | 940,046 | -5,979 | 0.01 | 0.01 | +0.00 | sell |
| Man Group plc | 1,020,710 | 925,308 | -95,402 | 0.07 | 0.09 | +0.02 | sell |
| Bank of New York Mellon Corp | 949,211 | 899,902 | -49,309 | 0.00 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 873,082 | +873,082 | 0.00 | 0.07 | +0.07 | buy |
| Aristotle Atlantic Partners, LLC | 893,508 | 851,995 | -41,513 | 0.64 | 0.82 | +0.18 | sell |
| DEUTSCHE BANK AG\ | 1,303,727 | 777,170 | -526,557 | 0.01 | 0.01 | -0.00 | sell |
| Blue Water Life Science Advisors, LP | 451,047 | 694,047 | +243,000 | 9.10 | 18.77 | +9.67 | buy |
| Erste Asset Management GmbH | 932,600 | 692,600 | -240,000 | 0.26 | 0.26 | +0.00 | sell |
| JPMORGAN CHASE & CO | 199,544 | 677,126 | +477,582 | 0.00 | 0.00 | +0.00 | buy |
| Railway Pension Investments Ltd | 620,878 | 620,878 | 0 | 0.17 | 0.25 | +0.08 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 662,267 | 596,682 | -65,585 | 0.06 | 0.06 | +0.01 | sell |
| Pictet Asset Management Holding SA | 623,071 | 593,516 | -29,555 | 0.02 | 0.02 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 526,536 | +526,536 | 0.00 | 0.26 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 438,400 | 503,100 | +64,700 | 0.02 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 484,537 | 482,888 | -1,649 | 0.01 | 0.01 | +0.00 | sell |
| Trexquant Investment LP | 455,710 | 474,171 | +18,461 | 0.13 | 0.17 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 766,284 | 459,611 | -306,673 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 22,700 | 454,500 | +431,800 | 0.01 | 0.21 | +0.19 | buy |
| MPM BioImpact LLC | 499,170 | 452,739 | -46,431 | 1.72 | 1.96 | +0.25 | sell |
| Aberdeen Group plc | 552,473 | 442,951 | -109,522 | 0.02 | 0.03 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 66,907 | 441,326 | +374,419 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 282,349 | 417,839 | +135,490 | 0.13 | 0.22 | +0.10 | buy |
| Qube Research & Technologies Ltd | 60,130 | 398,387 | +338,257 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 887,031 | 370,894 | -516,137 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 366,145 | 352,492 | -13,653 | 0.05 | 0.06 | +0.01 | sell |
| Casdin Capital, LLC | 350,000 | 350,000 | 0 | 0.54 | 0.71 | +0.18 | hold |
| First Light Asset Management, LLC | 648,993 | 309,389 | -339,604 | 1.24 | 0.90 | -0.33 | sell |
| Mitsubishi UFJ Trust & Banking Corp | 330,072 | 292,972 | -37,100 | 0.02 | 0.02 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 56,800 | 279,800 | +223,000 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 0 | 276,036 | +276,036 | 0.00 | 0.87 | +0.87 | buy |
| Swiss National Bank | 239,400 | 241,900 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 219,542 | 240,473 | +20,931 | 0.45 | 0.65 | +0.20 | buy |
| Pier Capital, LLC | 158,429 | 230,280 | +71,851 | 0.51 | 1.00 | +0.49 | buy |
| PRUDENTIAL FINANCIAL INC | 9,842 | 229,870 | +220,028 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 189,878 | 200,957 | +11,079 | 0.07 | 0.09 | +0.02 | buy |
| Rathbones Group PLC | 186,586 | 198,961 | +12,375 | 0.02 | 0.03 | +0.01 | buy |
| Walleye Capital LLC | 5,429 | 192,196 | +186,767 | 0.00 | 0.06 | +0.05 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 156,796 | 178,470 | +21,674 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 100,200 | 177,500 | +77,300 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 183,561 | 177,187 | -6,374 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 163,701 | 167,230 | +3,529 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 98,482 | 165,835 | +67,353 | 0.00 | 0.01 | +0.00 | buy |
| Aquatic Capital Management LLC | 207,200 | 164,842 | -42,358 | 0.12 | 0.14 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 38,407 | 163,645 | +125,238 | 0.00 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 36,372 | 162,065 | +125,693 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 155,429 | 155,472 | +43 | 0.02 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 79,041 | 155,165 | +76,124 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 152,986 | 152,986 | 0 | 0.03 | 0.04 | +0.01 | hold |
| WELLS FARGO & COMPANY/MN | 58,989 | 149,229 | +90,240 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 89,800 | 147,800 | +58,000 | 1.39 | 3.40 | +2.00 | buy |
| Sicart Associates LLC | 146,303 | 140,333 | -5,970 | 1.18 | 1.53 | +0.35 | sell |
| Cerity Partners LLC | 195,008 | 136,750 | -58,258 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 126,925 | 129,424 | +2,499 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 143,720 | 125,720 | -18,000 | 0.00 | 0.00 | +0.00 | sell |
| SWS Partners | 83,762 | 120,888 | +37,126 | 0.61 | 1.12 | +0.51 | buy |
| ROYAL BANK OF CANADA | 134,270 | 118,919 | -15,351 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 115,436 | 114,687 | -749 | 0.00 | 0.00 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 125,680 | 113,850 | -11,830 | 0.02 | 0.03 | +0.01 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 171,582 | 107,141 | -64,441 | 0.04 | 0.03 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 106,620 | 103,924 | -2,696 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 114,641 | 103,203 | -11,438 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 842,508 | 96,404 | -746,104 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 37,641 | 94,283 | +56,642 | 0.01 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 94,118 | +94,118 | 0.00 | 1.07 | +1.07 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 85,267 | +85,267 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 68,147 | 72,149 | +4,002 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 67,004 | 71,977 | +4,973 | 0.01 | 0.01 | +0.00 | buy |