| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 14,932,063 | 14,932,063 | 0 | 0.77 | 0.48 | -0.29 | hold |
| Sands Capital Alternatives, LLC | 3,417,075 | 3,417,075 | 0 | 3.34 | 2.77 | -0.57 | hold |
| FRANKLIN RESOURCES INC | 3,395,418 | 3,367,618 | -27,800 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 2,300,059 | 2,300,059 | 0 | 0.24 | 0.17 | -0.07 | hold |
| FMR LLC | 2,089,000 | 2,022,103 | -66,897 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,629,541 | 1,954,085 | -675,456 | 0.01 | 0.00 | -0.01 | sell |
| VANGUARD GROUP INC | 1,665,058 | 1,896,949 | +231,891 | 0.00 | 0.00 | -0.00 | buy |
| Knollwood Investment Advisory, LLC | 1,628,510 | 1,628,510 | 0 | 1.19 | 0.44 | -0.75 | hold |
| Laurion Capital Management LP | 1,895,023 | 1,178,338 | -716,685 | 0.21 | 0.09 | -0.12 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,098,276 | 1,046,364 | -51,912 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 939,603 | 939,603 | 0 | 0.02 | 0.01 | -0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 285,139 | 812,133 | +526,994 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 560,000 | 670,000 | +110,000 | 0.02 | 0.01 | -0.01 | buy |
| Pathstone Holdings, LLC | 480,181 | 480,223 | +42 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 81,778 | 436,565 | +354,787 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 600,255 | 427,689 | -172,566 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 217,000 | 392,100 | +175,100 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 338,100 | +338,100 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 177,901 | 310,797 | +132,896 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 266,435 | 266,435 | 0 | 0.29 | 0.20 | -0.09 | hold |
| TD ASSET MANAGEMENT INC | 148,800 | 148,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 148,400 | 148,400 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 0 | 126,422 | +126,422 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 28,037 | 125,024 | +96,987 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 80,616 | 122,725 | +42,109 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 108,743 | +108,743 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 187,585 | 105,777 | -81,808 | 0.00 | 0.00 | -0.00 | sell |
| CATALYST FINANCIAL PARTNERS LLC | 89,699 | 89,699 | 0 | 0.08 | 0.05 | -0.03 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 51,708 | 85,458 | +33,750 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 83,012 | +83,012 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 167,588 | 75,869 | -91,719 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 458,484 | 73,619 | -384,865 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 56,773 | 70,088 | +13,315 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 62,518 | 62,518 | 0 | 0.01 | 0.00 | -0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,041 | 59,996 | -45 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 61,728 | 56,548 | -5,180 | 0.00 | 0.00 | -0.00 | sell |
| Murchinson Ltd. | 0 | 56,250 | +56,250 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 0 | 55,007 | +55,007 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 265,843 | 54,080 | -211,763 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 0 | 52,323 | +52,323 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 317,904 | 51,052 | -266,852 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 23,951 | 49,367 | +25,416 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 37,000 | 46,410 | +9,410 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 34,604 | 45,444 | +10,840 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 42,400 | +42,400 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 33,649 | +33,649 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 31,900 | 30,885 | -1,015 | 0.00 | 0.00 | -0.00 | sell |
| Intrepid Financial Planning Group LLC | 30,150 | 30,150 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Tower Research Capital LLC (TRC) | 1,410 | 26,488 | +25,078 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 60,000 | 26,298 | -33,702 | 0.10 | 0.02 | -0.08 | sell |
| Virtu Financial LLC | 0 | 24,402 | +24,402 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 21,903 | 21,903 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 47,310 | 21,446 | -25,864 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 0 | 20,431 | +20,431 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 18,986 | +18,986 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 18,801 | +18,801 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Management Advisory Group, LLC | 18,020 | 18,020 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PINNACLE ASSOCIATES LTD | 18,020 | 18,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OXFORD ASSET MANAGEMENT LLP | 0 | 15,304 | +15,304 | 0.00 | 0.04 | +0.04 | buy |
| STIFEL FINANCIAL CORP | 14,650 | 13,650 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 11,479 | +11,479 | 0.00 | 0.00 | +0.00 | buy |
| Gladius Capital Management LP | 0 | 10,939 | +10,939 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 135,394 | 9,415 | -125,979 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 2,396 | 8,880 | +6,484 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 4,110 | +4,110 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 4,018 | +4,018 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 3,635 | +3,635 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 3,039 | +3,039 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 1,451 | +1,451 | 0.00 | 0.00 | +0.00 | buy |
| Kelly Financial Services LLC | 944 | 944 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Redwood Wealth Management Group, LLC | 0 | 800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 23,800 | 0 | -23,800 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 95,089 | 0 | -95,089 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 63,949 | 0 | -63,949 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 246,895 | 0 | -246,895 | 0.10 | 0.00 | -0.10 | sell |
| ALGERT GLOBAL LLC | 12,410 | 0 | -12,410 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 12,856 | 0 | -12,856 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 89,707 | 0 | -89,707 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 25,370 | 0 | -25,370 | 0.01 | 0.00 | -0.01 | sell |
| MACQUARIE GROUP LTD | 1,247 | 0 | -1,247 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 105,117 | 0 | -105,117 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 56,369 | 0 | -56,369 | 0.02 | 0.00 | -0.02 | sell |
| Chicago Partners Investment Group LLC | 13,958 | 0 | -13,958 | 0.00 | 0.00 | -0.00 | sell |
| CTC Alternative Strategies, Ltd. | 11,100 | 0 | -11,100 | 0.03 | 0.00 | -0.03 | sell |
| LMR Partners LLP | 11,503 | 0 | -11,503 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 113,232 | 0 | -113,232 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 27,556 | 0 | -27,556 | 0.03 | 0.00 | -0.03 | sell |
| OSAIC HOLDINGS, INC. | 10,400 | 0 | -10,400 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 25,620 | 0 | -25,620 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Wealth Concepts LLC | 10,100 | 0 | -10,100 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 37,191 | 0 | -37,191 | 0.01 | 0.00 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 576,657 | 0 | -576,657 | 0.29 | 0.00 | -0.29 | sell |
| JPMORGAN CHASE & CO | 71,890 | 0 | -71,890 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 112,258 | 0 | -112,258 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 19,000 | 0 | -19,000 | 0.00 | 0.00 | -0.00 | sell |