| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 1,000,000 | 1,304,721 | +304,721 | 2.79 | 2.99 | +0.20 | buy |
| MILLENNIUM MANAGEMENT LLC | 909,965 | 741,518 | +168,447 | 0.09 | 0.06 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 365,000 | 515,000 | +150,000 | 0.06 | 0.08 | +0.02 | buy |
| Hood River Capital Management LLC | 392,753 | 520,750 | +127,997 | 0.86 | 0.93 | +0.07 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 139,758 | +89,758 | 0.73 | 1.38 | +0.65 | buy |
| PERCEPTIVE ADVISORS LLC | 1,038,019 | 1,105,341 | +67,322 | 1.84 | 1.54 | -0.30 | buy |
| Rhenman & Partners Asset Management AB | 79,100 | 143,600 | +64,500 | 0.63 | 1.09 | +0.46 | buy |
| CITADEL ADVISORS LLC | 1,089,085 | 1,143,644 | +54,559 | 0.12 | 0.13 | +0.00 | buy |
| Bellevue Group AG | 635,372 | 685,476 | +50,104 | 0.77 | 0.83 | +0.06 | buy |
| First Turn Management, LLC | 295,428 | 342,173 | +46,745 | 3.38 | 4.08 | +0.71 | buy |
| MPM BioImpact LLC | 93,387 | 114,127 | +20,740 | 1.74 | 1.46 | -0.27 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 16,179 | 36,607 | +20,428 | 0.92 | 1.93 | +1.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 94,888 | 105,344 | +10,456 | 0.08 | 0.08 | +0.00 | buy |
| Privium Fund Management B.V. | 72,032 | 82,032 | +10,000 | 1.55 | 1.75 | +0.20 | buy |
| Hennion & Walsh Asset Management, Inc. | 60,616 | 69,483 | +8,867 | 0.28 | 0.30 | +0.02 | buy |
| CWM, LLC | 38,371 | 29,595 | +8,776 | 0.02 | 0.01 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 104,808 | 111,590 | +6,782 | 0.02 | 0.02 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 13,347 | 19,483 | +6,136 | 0.02 | 0.03 | +0.01 | buy |
| Dana Investment Advisors, Inc. | 13,641 | 19,027 | +5,386 | 0.05 | 0.05 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,475 | 9,103 | +3,628 | 0.08 | 0.09 | +0.01 | buy |
| J. Goldman & Co LP | 5,555 | 8,896 | +3,341 | 0.02 | 0.02 | +0.00 | buy |
| RTW INVESTMENTS, LP | 4,489,596 | 4,492,679 | +3,083 | 5.58 | 5.29 | -0.29 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 11,922 | 8,918 | +3,004 | 0.07 | 0.05 | 0.00 | sell |
| D.A. DAVIDSON & CO. | 7,240 | 9,040 | +1,800 | 0.01 | 0.01 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 17,999 | 16,394 | +1,605 | 0.00 | 0.00 | 0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 84,817 | 86,135 | +1,318 | 0.20 | 0.20 | -0.01 | buy |
| Atika Capital Management LLC | 66,700 | 68,000 | +1,300 | 0.71 | 0.53 | -0.18 | buy |
| Rafferty Asset Management, LLC | 5,837 | 6,862 | +1,025 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 32,482 | 33,417 | +935 | 0.02 | 0.02 | -0.00 | buy |
| ProShare Advisors LLC | 8,924 | 9,724 | +800 | 0.00 | 0.00 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,452 | 5,200 | +748 | 0.22 | 0.22 | -0.00 | buy |
| PROFUND ADVISORS LLC | 8,314 | 9,015 | +701 | 0.03 | 0.03 | 0.00 | buy |
| BALDWIN WEALTH PARTNERS LLC/MA | 48,995 | 49,695 | +700 | 0.31 | 0.30 | -0.01 | buy |
| OAK RIDGE INVESTMENTS LLC | 15,517 | 15,930 | +413 | 0.14 | 0.13 | -0.01 | buy |
| NATIXIS | 1,087 | 1,235 | +148 | 0.00 | 0.00 | -0.00 | buy |
| INTRUST BANK NA | 2,846 | 2,940 | +94 | 0.03 | 0.03 | -0.00 | buy |
| WEDBUSH SECURITIES INC | 8,345 | 8,297 | +48 | 0.03 | 0.03 | 0.00 | sell |
| CI INVESTMENTS INC. | 1,110 | 1,111 | +1 | 0.00 | 0.00 | 0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 6,700 | 6,300 | -400 | 0.01 | 0.01 | -0.00 | sell |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 3,037 | 2,632 | -405 | 0.01 | 0.01 | -0.00 | sell |
| HARMONY ASSET MANAGEMENT LLC | 5,057 | 4,537 | -520 | 0.17 | 0.15 | -0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 66,866 | 65,659 | -1,207 | 0.96 | 0.89 | -0.07 | sell |
| Legato Capital Management LLC | 8,622 | 4,733 | -3,889 | 0.09 | 0.05 | -0.04 | sell |
| Phocas Financial Corp. | 26,890 | 19,154 | -7,736 | 0.28 | 0.01 | -0.28 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 138,337 | 128,842 | -9,495 | 2.00 | 2.02 | +0.02 | sell |
| WMS Partners, LLC | 50,711 | 40,711 | -10,000 | 0.30 | 0.22 | -0.07 | sell |
| Candriam S.C.A. | 85,084 | 75,084 | -10,000 | 0.05 | 0.04 | -0.01 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 752,044 | 740,791 | -11,253 | 69.06 | 48.02 | -21.04 | sell |
| HighVista Strategies LLC | 62,263 | 48,527 | -13,736 | 1.80 | 1.38 | -0.42 | sell |
| Checkpoint Capital L.P. | 155,346 | 132,437 | -22,909 | 8.63 | 7.06 | -1.56 | sell |
| Tri Locum Partners LP | 130,738 | 102,711 | -28,027 | 5.11 | 2.84 | -2.27 | sell |
| Avidity Partners Management LP | 459,400 | 431,000 | -28,400 | 1.40 | 1.22 | -0.18 | sell |
| Nicholas Investment Partners, LP | 82,645 | 36,816 | -45,829 | 0.77 | 0.30 | -0.47 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 265,842 | 204,699 | -61,143 | 0.25 | 0.16 | -0.09 | sell |
| Woodline Partners LP | 562,163 | 360,128 | -202,035 | 0.49 | 0.27 | -0.22 | sell |