| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LAZARD ASSET MANAGEMENT LLC | 537,669 | 29,249 | +508,420 | 0.07 | 0.01 | 0.00 | sell |
| BVF INC/IL | 1,388,064 | 1,690,221 | +302,157 | 3.98 | 8.03 | +4.05 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 33,719 | 285,494 | +251,775 | 0.35 | 6.87 | +6.53 | buy |
| Qube Research & Technologies Ltd | 155,911 | 282,376 | +126,465 | 0.02 | 0.06 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 73,497 | 175,942 | +102,445 | 0.03 | 0.09 | +0.06 | buy |
| PFM Health Sciences, LP | 467,427 | 556,545 | +89,118 | 2.45 | 4.71 | +2.26 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 207,065 | 295,671 | +88,606 | 0.01 | 0.02 | 0.00 | buy |
| Atika Capital Management LLC | 22,000 | 73,700 | +51,700 | 0.20 | 1.21 | +1.01 | buy |
| Granite Investment Partners, LLC | 91,649 | 138,719 | +47,070 | 0.34 | 0.82 | +0.49 | buy |
| PDT Partners, LLC | 4,195 | 51,199 | +47,004 | 0.03 | 0.42 | +0.39 | buy |
| Nicholas Investment Partners, LP | 10,135 | 43,572 | +33,437 | 0.08 | 0.52 | +0.45 | buy |
| Affinity Asset Advisors, LLC | 75,000 | 100,000 | +25,000 | 0.85 | 1.11 | +0.26 | buy |
| MOODY ALDRICH PARTNERS LLC | 45,138 | 62,339 | +17,201 | 0.71 | 1.52 | +0.81 | buy |
| Pallas Capital Advisors LLC | 26,435 | 35,280 | +8,845 | 0.10 | 0.17 | +0.08 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 6,119 | 13,584 | +7,465 | 0.09 | 0.25 | +0.15 | buy |
| Ally Bridge Group (NY) LLC | 66,661 | 72,113 | +5,452 | 4.84 | 7.58 | +2.75 | buy |
| SYNOVUS FINANCIAL CORP | 16,128 | 21,553 | +5,425 | 0.02 | 0.03 | +0.02 | buy |
| CIBC WORLD MARKETS CORP | 3,445 | 8,170 | +4,725 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 17,124 | 21,503 | +4,379 | 0.54 | 0.97 | +0.43 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,028 | 20,298 | +4,270 | 0.01 | 0.03 | +0.01 | buy |
| CIBC Private Wealth Group LLC | 16,214 | 13,715 | +2,499 | 0.00 | 0.00 | 0.00 | sell |
| ProShare Advisors LLC | 12,664 | 10,170 | +2,494 | 0.00 | 0.00 | 0.00 | sell |
| Cannell & Spears LLC | 82,087 | 84,264 | +2,177 | 0.14 | 0.21 | +0.07 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 4,663 | 6,734 | +2,071 | 0.07 | 0.13 | +0.06 | buy |
| Birchview Capital, LP | 4,000 | 6,000 | +2,000 | 0.28 | 0.61 | +0.33 | buy |
| Hennion & Walsh Asset Management, Inc. | 57,836 | 59,273 | +1,437 | 0.22 | 0.31 | +0.09 | buy |
| GUGGENHEIM CAPITAL LLC | 11,606 | 10,203 | +1,403 | 0.01 | 0.01 | 0.00 | sell |
| Quarry LP | 750 | 1,400 | +650 | 0.01 | 0.04 | 0.00 | buy |
| INTRUST BANK NA | 2,823 | 3,093 | +270 | 0.02 | 0.04 | +0.01 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 4,950 | 5,200 | +250 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,018 | 1,241 | +223 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 820 | 1,020 | +200 | 0.05 | 0.09 | +0.05 | buy |
| TRUST CO OF VERMONT | 500 | 400 | +100 | 0.00 | 0.00 | 0.00 | sell |
| MONECO Advisors, LLC | 7,513 | 7,505 | -8 | 0.07 | 0.09 | +0.02 | sell |
| OAK RIDGE INVESTMENTS LLC | 12,945 | 12,922 | -23 | 0.09 | 0.13 | +0.04 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 111,996 | 111,948 | -48 | 0.02 | 0.03 | +0.01 | sell |
| Lion Street Advisors, LLC | 9,599 | 9,547 | -52 | 0.26 | 0.35 | +0.09 | sell |
| TORRAY INVESTMENT PARTNERS LLC | 17,174 | 17,116 | -58 | 0.21 | 0.30 | +0.09 | sell |
| Washington Trust Advisors, Inc. | 330 | 250 | -80 | 0.00 | 0.00 | +0.00 | sell |
| Meridian Wealth Management, LLC | 21,171 | 21,021 | -150 | 0.08 | 0.12 | +0.03 | sell |
| PITCAIRN CO | 4,562 | 4,271 | -291 | 0.02 | 0.03 | +0.01 | sell |
| Values First Advisors, Inc. | 5,070 | 4,764 | -306 | 0.24 | 0.32 | +0.09 | sell |
| China Universal Asset Management Co., Ltd. | 10,276 | 9,782 | -494 | 0.08 | 0.11 | +0.02 | sell |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC | 2,632 | 1,832 | -800 | 0.01 | 0.01 | +0.00 | sell |
| Phocas Financial Corp. | 17,546 | 16,588 | -958 | 0.20 | 0.30 | +0.10 | sell |
| PROFUND ADVISORS LLC | 4,886 | 3,883 | -1,003 | 0.02 | 0.02 | +0.00 | sell |
| Cynosure Group, LLC | 6,547 | 5,405 | -1,142 | 0.08 | 0.09 | +0.00 | sell |
| D.A. DAVIDSON & CO. | 8,230 | 6,755 | -1,475 | 0.01 | 0.01 | +0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 20,937 | 15,980 | -4,957 | 0.12 | 0.13 | +0.01 | sell |
| Dana Investment Advisors, Inc. | 16,394 | 11,313 | -5,081 | 0.05 | 0.05 | +0.00 | sell |
| LOOMIS SAYLES & CO L P | 290,111 | 284,170 | -5,941 | 0.03 | 0.05 | +0.02 | sell |
| GREAT LAKES ADVISORS, LLC | 13,508 | 7,193 | -6,315 | 0.01 | 0.01 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 37,000 | 30,257 | -6,743 | 0.03 | 0.04 | +0.01 | sell |
| ALPS ADVISORS INC | 39,190 | 32,364 | -6,826 | 0.02 | 0.02 | +0.00 | sell |
| TFG Asset Management GP Ltd | 41,250 | 33,806 | -7,444 | 0.89 | 0.90 | +0.01 | sell |
| Aberdeen Group plc | 72,179 | 63,954 | -8,225 | 0.01 | 0.01 | +0.00 | sell |
| Privium Fund Management B.V. | 62,232 | 52,732 | -9,500 | 1.19 | 1.60 | +0.41 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 52,768 | 43,261 | -9,507 | 0.04 | 0.06 | +0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 60,000 | 48,000 | -12,000 | 0.01 | 0.01 | +0.00 | sell |
| DnB Asset Management AS | 73,770 | 61,528 | -12,242 | 0.03 | 0.03 | +0.01 | sell |
| Rhenman & Partners Asset Management AB | 122,600 | 109,600 | -13,000 | 1.07 | 1.47 | +0.40 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 125,079 | 106,312 | -18,767 | 2.82 | 3.89 | +1.07 | sell |
| Bellevue Group AG | 118,930 | 96,407 | -22,523 | 0.19 | 0.25 | +0.06 | sell |
| Point72 Europe (London) LLP | 41,734 | 15,050 | -26,684 | 0.20 | 0.12 | -0.08 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 87,187 | 59,721 | -27,466 | 0.22 | 0.23 | +0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 37,941 | 5,822 | -32,119 | 0.07 | 0.02 | -0.06 | sell |
| J. Goldman & Co LP | 40,323 | 2,296 | -38,027 | 0.09 | 0.01 | -0.08 | sell |
| Clearbridge Investments, LLC | 113,077 | 68,164 | -44,913 | 0.01 | 0.01 | -0.00 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 734,317 | 667,368 | -66,949 | 53.19 | 58.07 | +4.89 | sell |
| First Turn Management, LLC | 192,146 | 118,179 | -73,967 | 2.91 | 2.78 | -0.13 | sell |
| Cormorant Asset Management, LP | 325,000 | 250,000 | -75,000 | 1.51 | 2.19 | +0.68 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 828,711 | 744,850 | -83,861 | 1.28 | 1.73 | +0.45 | sell |
| Woodline Partners LP | 408,441 | 304,084 | -104,357 | 0.23 | 0.23 | -0.00 | sell |
| Avidity Partners Management LP | 188,000 | 77,000 | -111,000 | 1.56 | 1.71 | +0.15 | sell |
| Tri Locum Partners LP | 249,769 | 101,240 | -148,529 | 4.38 | 6.06 | +1.68 | sell |
| PERCEPTIVE ADVISORS LLC | 664,074 | 355,107 | -308,967 | 1.55 | 1.46 | -0.09 | sell |
| Sofinnova Investments, Inc. | 491,726 | 175,317 | -316,409 | 3.03 | 1.34 | -1.70 | sell |
| Fairmount Funds Management LLC | 1,468,983 | 815,176 | -653,807 | 12.36 | 14.75 | +2.39 | sell |
| RTW INVESTMENTS, LP | 4,051,365 | 2,922,729 | -1,128,636 | 5.18 | 5.21 | +0.03 | sell |