| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Assenagon Asset Management S.A. | 3,701 | 627,418 | +623,717 | 0.00 | 0.13 | +0.13 | buy |
| D. E. Shaw & Co., Inc. | 20,346 | 547,665 | +527,319 | 0.00 | 0.08 | +0.07 | buy |
| ORBIMED ADVISORS LLC | 0 | 386,700 | +386,700 | 0.00 | 1.08 | +1.08 | buy |
| 1832 Asset Management L.P. | 0 | 363,200 | +363,200 | 0.00 | 0.08 | +0.08 | buy |
| Man Group plc | 163,388 | 513,221 | +349,833 | 0.04 | 0.18 | +0.14 | buy |
| BANK OF AMERICA CORP /DE/ | 204,587 | 533,902 | +329,315 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 4,678 | 333,205 | +328,527 | 0.00 | 0.04 | +0.04 | buy |
| BVF INC/IL | 1,388,064 | 1,690,221 | +302,157 | 3.98 | 8.03 | +4.05 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 266,997 | +266,997 | 0.00 | 0.02 | +0.02 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 33,719 | 285,494 | +251,775 | 0.35 | 6.87 | +6.53 | buy |
| FMR LLC | 1,000,446 | 1,247,231 | +246,785 | 0.01 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 235,383 | +235,383 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 4,246 | 235,311 | +231,065 | 0.00 | 0.03 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 214,139 | +214,139 | 0.00 | 0.24 | +0.24 | buy |
| Invesco Ltd. | 692,464 | 857,001 | +164,537 | 0.01 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 22,277 | 178,955 | +156,678 | 0.01 | 0.11 | +0.10 | buy |
| TWO SIGMA ADVISERS, LP | 6,300 | 149,600 | +143,300 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 147,347 | 288,647 | +141,300 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 134,400 | +134,400 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 155,911 | 282,376 | +126,465 | 0.02 | 0.05 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 73,497 | 175,942 | +102,445 | 0.03 | 0.09 | +0.06 | buy |
| Jump Financial, LLC | 0 | 92,640 | +92,640 | 0.00 | 0.17 | +0.17 | buy |
| PFM Health Sciences, LP | 467,427 | 556,545 | +89,118 | 3.01 | 4.98 | +1.97 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 207,065 | 295,671 | +88,606 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 217,567 | 301,718 | +84,151 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 0 | 79,930 | +79,930 | 0.00 | 0.06 | +0.06 | buy |
| Edgestream Partners, L.P. | 0 | 70,086 | +70,086 | 0.00 | 0.28 | +0.28 | buy |
| VAN ECK ASSOCIATES CORP | 0 | 62,995 | +62,995 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 116,937 | 177,814 | +60,877 | 0.16 | 0.27 | +0.11 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 59,553 | +59,553 | 0.00 | 0.35 | +0.35 | buy |
| HB Wealth Management, LLC | 0 | 55,030 | +55,030 | 0.00 | 0.05 | +0.05 | buy |
| ExodusPoint Capital Management, LP | 0 | 52,683 | +52,683 | 0.00 | 0.08 | +0.08 | buy |
| Squarepoint Ops LLC | 89,430 | 141,597 | +52,167 | 0.02 | 0.04 | +0.02 | buy |
| Atika Capital Management LLC | 22,000 | 73,700 | +51,700 | 0.24 | 1.32 | +1.08 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 50,096 | +50,096 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 50,000 | +50,000 | 0.00 | 5.26 | +5.26 | buy |
| Granite Investment Partners, LLC | 91,649 | 138,719 | +47,070 | 0.34 | 0.82 | +0.49 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 47,005 | +47,005 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 4,195 | 51,199 | +47,004 | 0.03 | 0.42 | +0.39 | buy |
| Aquatic Capital Management LLC | 903 | 47,446 | +46,543 | 0.00 | 0.14 | +0.14 | buy |
| FRANKLIN RESOURCES INC | 182,290 | 226,515 | +44,225 | 0.00 | 0.01 | +0.00 | buy |
| Bridgewater Associates, LP | 0 | 42,825 | +42,825 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 42,222 | +42,222 | 0.00 | 0.85 | +0.85 | buy |
| Global IMC LLC | 0 | 41,922 | +41,922 | 0.00 | 1.33 | +1.33 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 41,200 | +41,200 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 40,866 | +40,866 | 0.00 | 0.04 | +0.04 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 4,100 | 44,500 | +40,400 | 0.00 | 0.01 | +0.00 | buy |
| NORGES BANK | 403,026 | 437,497 | +34,471 | 0.00 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 10,135 | 43,572 | +33,437 | 0.08 | 0.52 | +0.45 | buy |
| Lisanti Capital Growth, LLC | 0 | 33,280 | +33,280 | 0.00 | 1.15 | +1.15 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,770 | 51,726 | +32,956 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 673,157 | 703,279 | +30,122 | 0.01 | 0.02 | +0.01 | buy |
| Trek Financial, LLC | 0 | 29,544 | +29,544 | 0.00 | 0.25 | +0.25 | buy |
| PRUDENTIAL FINANCIAL INC | 2,673 | 29,413 | +26,740 | 0.00 | 0.00 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 26,307 | +26,307 | 0.00 | 0.03 | +0.03 | buy |
| FEDERATED HERMES, INC. | 0 | 25,990 | +25,990 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 25,940 | +25,940 | 0.00 | 0.07 | +0.07 | buy |
| Affinity Asset Advisors, LLC | 75,000 | 100,000 | +25,000 | 0.99 | 1.83 | +0.83 | buy |
| Verition Fund Management LLC | 5,348 | 28,998 | +23,650 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 912,538 | 934,853 | +22,315 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 38,211 | 58,363 | +20,152 | 0.00 | 0.01 | +0.00 | buy |
| Versor Investments LP | 0 | 19,615 | +19,615 | 0.00 | 0.37 | +0.37 | buy |
| Penserra Capital Management LLC | 0 | 19,112 | +19,112 | 0.00 | 0.04 | +0.04 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 18,790 | +18,790 | 0.00 | 0.08 | +0.08 | buy |
| Engineers Gate Manager LP | 6,690 | 24,289 | +17,599 | 0.01 | 0.05 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 57,642 | 74,892 | +17,250 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 45,138 | 62,339 | +17,201 | 0.71 | 1.52 | +0.81 | buy |
| Soleus Capital Management, L.P. | 0 | 17,000 | +17,000 | 0.00 | 0.16 | +0.16 | buy |
| ALLIANCEBERNSTEIN L.P. | 46,590 | 61,471 | +14,881 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 14,153 | +14,153 | 0.00 | 0.04 | +0.04 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 13,025 | +13,025 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,745 | +12,745 | 0.00 | 0.10 | +0.10 | buy |
| MACQUARIE GROUP LTD | 964,047 | 976,260 | +12,213 | 0.10 | 0.14 | +0.04 | buy |
| JANE STREET GROUP, LLC | 78,449 | 90,141 | +11,692 | 0.01 | 0.02 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,491 | 33,581 | +11,090 | 0.00 | 0.01 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 9,981 | +9,981 | 0.00 | 0.16 | +0.16 | buy |
| Scientech Research LLC | 0 | 9,759 | +9,759 | 0.00 | 0.30 | +0.30 | buy |
| J. Safra Sarasin Holding AG | 0 | 9,660 | +9,660 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 328,034 | 337,246 | +9,212 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 8,984 | +8,984 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 26,435 | 35,280 | +8,845 | 0.10 | 0.17 | +0.08 | buy |
| NORTHERN TRUST CORP | 402,500 | 410,969 | +8,469 | 0.00 | 0.01 | +0.00 | buy |
| Virtu Financial LLC | 0 | 7,986 | +7,986 | 0.00 | 0.05 | +0.05 | buy |
| FORA Capital, LLC | 0 | 7,633 | +7,633 | 0.00 | 0.09 | +0.09 | buy |
| Virtue Capital Management, LLC | 0 | 7,545 | +7,545 | 0.00 | 0.10 | +0.10 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 7,478 | +7,478 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 6,119 | 13,584 | +7,465 | 0.09 | 0.25 | +0.15 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 7,373 | +7,373 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 6,544 | +6,544 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 4,600 | 10,400 | +5,800 | 0.00 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 66,661 | 72,113 | +5,452 | 4.84 | 7.58 | +2.75 | buy |
| SYNOVUS FINANCIAL CORP | 16,128 | 21,553 | +5,425 | 0.02 | 0.03 | +0.02 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 5,417 | +5,417 | 0.00 | 0.06 | +0.06 | buy |
| Quantitative Investment Management, LLC | 0 | 5,259 | +5,259 | 0.00 | 0.06 | +0.06 | buy |
| Creative Planning | 12,267 | 17,416 | +5,149 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 4,816 | +4,816 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 3,445 | 8,170 | +4,725 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 17,124 | 21,503 | +4,379 | 0.54 | 0.97 | +0.43 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,028 | 20,298 | +4,270 | 0.01 | 0.02 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 3,873 | +3,873 | 0.00 | 0.04 | +0.04 | buy |