| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 3,913,543 | 3,912,844 | -699 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 1,181,622 | 1,566,995 | +385,373 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,509,870 | 1,317,059 | -192,811 | 0.03 | 0.03 | -0.00 | sell |
| Invesco Ltd. | 1,273,494 | 1,297,678 | +24,184 | 0.03 | 0.03 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,010,249 | 1,162,981 | +152,732 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,221,656 | 1,145,306 | -76,350 | 0.04 | 0.04 | -0.00 | sell |
| Deep Track Capital, LP | 1,150,000 | 1,100,000 | -50,000 | 4.79 | 3.84 | -0.95 | sell |
| STATE STREET CORP | 958,150 | 986,809 | +28,659 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 467,982 | 865,958 | +397,976 | 0.13 | 0.23 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 367,578 | 737,578 | +370,000 | 0.10 | 0.19 | +0.09 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 668,710 | 649,114 | -19,596 | 59.30 | 58.94 | -0.36 | sell |
| D. E. Shaw & Co., Inc. | 549,113 | 603,465 | +54,352 | 0.08 | 0.08 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 618,033 | 598,091 | -19,942 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 43,413 | 577,479 | +534,066 | 0.01 | 0.07 | +0.06 | buy |
| UBS Group AG | 355,318 | 547,195 | +191,877 | 0.01 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 571,226 | 519,558 | -51,668 | 1.63 | 1.45 | -0.18 | sell |
| MORGAN STANLEY | 491,201 | 476,701 | -14,500 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 342,573 | 438,490 | +95,917 | 0.02 | 0.02 | +0.00 | buy |
| Point72 Asset Management, L.P. | 17,999 | 424,750 | +406,751 | 0.01 | 0.12 | +0.12 | buy |
| GOLDMAN SACHS GROUP INC | 300,906 | 421,447 | +120,541 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 436,063 | 415,983 | -20,080 | 0.08 | 0.07 | -0.00 | sell |
| NORTHERN TRUST CORP | 390,431 | 401,459 | +11,028 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 402,700 | 395,118 | -7,582 | 0.01 | 0.01 | -0.00 | sell |
| Hood River Capital Management LLC | 366,176 | 371,503 | +5,327 | 0.73 | 0.63 | -0.10 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 363,114 | 350,488 | -12,626 | 0.03 | 0.03 | -0.00 | sell |
| Nuveen, LLC | 349,209 | 335,737 | -13,472 | 0.02 | 0.02 | -0.00 | sell |
| Qube Research & Technologies Ltd | 325,440 | 335,334 | +9,894 | 0.09 | 0.08 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 145,597 | 322,778 | +177,181 | 0.04 | 0.05 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 220,518 | 292,370 | +71,852 | 0.27 | 0.36 | +0.09 | buy |
| CITADEL ADVISORS LLC | 138,213 | 281,503 | +143,290 | 0.02 | 0.03 | +0.02 | buy |
| JPMORGAN CHASE & CO | 233,191 | 270,160 | +36,969 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 251,562 | 264,304 | +12,742 | 4.65 | 4.70 | +0.05 | buy |
| LOOMIS SAYLES & CO L P | 315,391 | 256,625 | -58,766 | 0.07 | 0.06 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 253,121 | 213,921 | -39,200 | 0.95 | 0.79 | -0.16 | sell |
| Sofinnova Investments, Inc. | 12,266 | 212,747 | +200,481 | 0.10 | 1.80 | +1.70 | buy |
| Bank of New York Mellon Corp | 255,097 | 206,644 | -48,453 | 0.01 | 0.01 | -0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 157,691 | 203,066 | +45,375 | 0.31 | 0.35 | +0.05 | buy |
| First Turn Management, LLC | 206,921 | 188,772 | -18,149 | 4.32 | 3.56 | -0.75 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 304,388 | 188,146 | -116,242 | 0.04 | 0.02 | -0.01 | sell |
| CITIGROUP INC | 204,104 | 185,658 | -18,446 | 0.03 | 0.02 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 173,301 | 183,967 | +10,666 | 0.03 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 99,916 | 176,314 | +76,398 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 170,000 | 164,300 | -5,700 | 0.05 | 0.04 | -0.00 | sell |
| Woodline Partners LP | 150,864 | 162,221 | +11,357 | 0.11 | 0.10 | -0.00 | buy |
| MetLife Investment Management, LLC | 164,871 | 152,645 | -12,226 | 0.15 | 0.13 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 148,900 | 149,950 | +1,050 | 0.50 | 0.50 | +0.00 | buy |
| Aberdeen Group plc | 97,413 | 149,688 | +52,275 | 0.03 | 0.04 | +0.01 | buy |
| Voleon Capital Management LP | 110,179 | 147,867 | +37,688 | 0.43 | 0.54 | +0.11 | buy |
| RAYMOND JAMES FINANCIAL INC | 150,098 | 147,766 | -2,332 | 0.01 | 0.01 | -0.00 | sell |
| 1832 Asset Management L.P. | 13,700 | 143,800 | +130,100 | 0.00 | 0.03 | +0.03 | buy |
| Man Group plc | 228,641 | 142,271 | -86,370 | 0.08 | 0.05 | -0.03 | sell |
| MARSHALL WACE, LLP | 320,568 | 141,236 | -179,332 | 0.06 | 0.03 | -0.03 | sell |
| ALGERT GLOBAL LLC | 149,392 | 135,460 | -13,932 | 0.43 | 0.34 | -0.08 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 188,258 | 134,792 | -53,466 | 0.09 | 0.05 | -0.04 | sell |
| US BANCORP \DE\ | 130,985 | 131,414 | +429 | 0.03 | 0.03 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 133,884 | 117,093 | -16,791 | 0.02 | 0.02 | -0.00 | sell |
| Squarepoint Ops LLC | 155,000 | 114,102 | -40,898 | 0.06 | 0.04 | -0.02 | sell |
| FEDERATED HERMES, INC. | 87,280 | 108,571 | +21,291 | 0.03 | 0.03 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 112,058 | 107,817 | -4,241 | 0.03 | 0.04 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 108,082 | 107,610 | -472 | 0.61 | 0.58 | -0.03 | sell |
| DEUTSCHE BANK AG\ | 98,257 | 104,266 | +6,009 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 103,418 | 104,059 | +641 | 0.01 | 0.01 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 97,550 | +97,550 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 87,249 | 94,937 | +7,688 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 94,017 | 94,017 | 0 | 0.17 | 0.16 | -0.02 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 103,200 | 91,400 | -11,800 | 0.01 | 0.01 | -0.00 | sell |
| M&G Plc | 90,328 | 91,339 | +1,011 | 0.08 | 0.08 | -0.01 | buy |
| DnB Asset Management AS | 101,102 | 90,088 | -11,014 | 0.06 | 0.05 | -0.01 | sell |
| Cannell & Spears LLC | 84,154 | 84,154 | 0 | 0.29 | 0.28 | -0.01 | hold |
| Nicholas Investment Partners, LP | 91,564 | 81,478 | -10,086 | 1.22 | 0.99 | -0.22 | sell |
| Granite Investment Partners, LLC | 84,894 | 80,299 | -4,595 | 0.92 | 0.83 | -0.08 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 68,858 | 70,725 | +1,867 | 0.02 | 0.02 | +0.00 | buy |
| SEI INVESTMENTS CO | 47,600 | 70,064 | +22,464 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 68,900 | 69,100 | +200 | 0.01 | 0.01 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 68,453 | +68,453 | 0.00 | 0.01 | +0.01 | buy |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 73,783 | 67,491 | -6,292 | 4.96 | 4.62 | -0.34 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 67,608 | 67,054 | -554 | 0.60 | 0.55 | -0.05 | sell |
| Summit Financial, LLC | 70,628 | 65,249 | -5,379 | 0.19 | 0.14 | -0.05 | sell |
| Rhenman & Partners Asset Management AB | 114,800 | 63,800 | -51,000 | 1.96 | 1.33 | -0.63 | sell |
| ALLIANCEBERNSTEIN L.P. | 53,140 | 62,822 | +9,682 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 201,627 | 62,116 | -139,511 | 4.78 | 1.47 | -3.31 | sell |
| WELLS FARGO & COMPANY/MN | 89,661 | 61,405 | -28,256 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 62,448 | 60,994 | -1,454 | 0.26 | 0.21 | -0.04 | sell |
| Neuberger Berman Group LLC | 69,483 | 60,759 | -8,724 | 0.01 | 0.01 | -0.00 | sell |
| Privium Fund Management B.V. | 56,878 | 58,729 | +1,851 | 1.91 | 2.07 | +0.15 | buy |
| Bridgewater Associates, LP | 47,444 | 56,951 | +9,507 | 0.03 | 0.04 | +0.01 | buy |
| HighTower Advisors, LLC | 55,972 | 56,633 | +661 | 0.01 | 0.01 | -0.00 | buy |
| AXIOM INVESTORS LLC /DE | 63,390 | 56,529 | -6,861 | 0.10 | 0.11 | +0.00 | sell |
| Hillsdale Investment Management Inc. | 0 | 53,363 | +53,363 | 0.00 | 0.25 | +0.25 | buy |
| RHUMBLINE ADVISERS | 52,233 | 51,619 | -614 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 50,879 | +50,879 | 0.00 | 0.01 | +0.01 | buy |
| HB Wealth Management, LLC | 34,102 | 50,237 | +16,135 | 0.04 | 0.06 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 42,509 | 50,113 | +7,604 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 75,000 | 50,000 | -25,000 | 0.78 | 0.43 | -0.35 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 46,633 | 47,296 | +663 | 0.26 | 0.30 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,841 | 47,198 | +17,357 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 30,408 | 47,111 | +16,703 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 46,326 | 45,020 | -1,306 | 0.01 | 0.01 | -0.00 | sell |
| BALDWIN WEALTH PARTNERS LLC/MA | 48,570 | 42,070 | -6,500 | 0.57 | 0.52 | -0.05 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 42,040 | 41,936 | -104 | 0.08 | 0.08 | -0.00 | sell |