| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 4,492,679 | 4,634,331 | +141,652 | 5.29 | 5.78 | +0.48 | buy |
| VANGUARD GROUP INC | 3,740,278 | 3,742,002 | +1,724 | 0.01 | 0.01 | -0.00 | buy |
| Fairmount Funds Management LLC | 2,360,077 | 2,360,077 | 0 | 20.53 | 21.46 | +0.93 | hold |
| Deep Track Capital, LP | 1,304,721 | 1,852,784 | +548,063 | 2.99 | 4.45 | +1.46 | buy |
| MACQUARIE GROUP LTD | 700,410 | 1,073,242 | +372,832 | 0.06 | 0.10 | +0.04 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,000,000 | 1,000,000 | 0 | 1.02 | 1.06 | +0.05 | hold |
| BVF INC/IL | 0 | 955,000 | +955,000 | 0.00 | 2.15 | +2.15 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 346,712 | 938,714 | +592,002 | 0.43 | 1.29 | +0.86 | buy |
| STATE STREET CORP | 938,716 | 938,503 | -213 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 828,550 | 902,136 | +73,586 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 185,713 | 890,985 | +705,272 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 845,407 | 884,895 | +39,488 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,143,644 | 753,237 | -390,407 | 0.09 | 0.06 | -0.03 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 740,791 | 740,888 | +97 | 48.02 | 45.25 | -2.76 | buy |
| MILLENNIUM MANAGEMENT LLC | 741,518 | 739,819 | -1,699 | 0.05 | 0.05 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 676,646 | 734,620 | +57,974 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 515,000 | 730,000 | +215,000 | 0.08 | 0.11 | +0.03 | buy |
| Invesco Ltd. | 245,653 | 557,861 | +312,208 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 520,750 | 549,066 | +28,316 | 0.93 | 0.92 | -0.01 | buy |
| Bellevue Group AG | 685,476 | 516,533 | -168,943 | 0.83 | 0.68 | -0.16 | sell |
| Point72 Asset Management, L.P. | 378,864 | 479,044 | +100,180 | 0.09 | 0.12 | +0.04 | buy |
| PFM Health Sciences, LP | 467,427 | 467,427 | 0 | 1.86 | 2.05 | +0.20 | hold |
| PERCEPTIVE ADVISORS LLC | 1,105,341 | 459,111 | -646,230 | 1.55 | 0.89 | -0.66 | sell |
| NORGES BANK | 385,551 | 404,217 | +18,666 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 291,612 | 401,327 | +109,715 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 400,000 | +400,000 | 0.00 | 1.87 | +1.87 | buy |
| Avidity Partners Management LP | 431,000 | 376,000 | -55,000 | 1.22 | 1.29 | +0.06 | sell |
| First Turn Management, LLC | 342,173 | 337,246 | -4,927 | 4.08 | 4.42 | +0.33 | sell |
| NORTHERN TRUST CORP | 336,085 | 324,493 | -11,592 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 943,883 | 321,981 | -621,902 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 360,128 | 318,011 | -42,117 | 0.27 | 0.25 | -0.02 | sell |
| Sofinnova Investments, Inc. | 0 | 310,198 | +310,198 | 0.00 | 1.57 | +1.57 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 301,074 | 309,818 | +8,744 | 0.01 | 0.00 | -0.00 | buy |
| Tri Locum Partners LP | 102,711 | 306,513 | +203,802 | 2.84 | 6.24 | +3.40 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 1.80 | +1.80 | buy |
| Checkpoint Capital L.P. | 132,437 | 290,772 | +158,335 | 7.06 | 14.11 | +7.05 | buy |
| LOOMIS SAYLES & CO L P | 279,791 | 269,089 | -10,702 | 0.03 | 0.03 | -0.00 | sell |
| JPMORGAN CHASE & CO | 195,261 | 184,576 | -10,685 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 80,154 | 168,762 | +88,608 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 199,079 | 168,434 | -30,645 | 0.02 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 153,771 | 165,564 | +11,793 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 27,042 | 135,855 | +108,813 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 133,505 | 132,705 | -800 | 0.01 | 0.01 | -0.00 | sell |
| MPM BioImpact LLC | 114,127 | 132,312 | +18,185 | 1.46 | 1.66 | +0.19 | buy |
| Rhenman & Partners Asset Management AB | 143,600 | 127,600 | -16,000 | 1.09 | 0.99 | -0.10 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 128,842 | 126,905 | -1,937 | 2.02 | 2.31 | +0.29 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 111,590 | 113,345 | +1,755 | 0.02 | 0.02 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 107,871 | 108,838 | +967 | 0.00 | 0.00 | -0.00 | buy |
| Clearbridge Investments, LLC | 89,370 | 106,767 | +17,397 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 105,344 | 96,027 | -9,317 | 0.08 | 0.08 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 19,287 | 91,804 | +72,517 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 87,848 | 87,848 | 0 | 1.72 | 1.81 | +0.09 | hold |
| PEREGRINE CAPITAL MANAGEMENT LLC | 86,135 | 87,373 | +1,238 | 0.20 | 0.21 | +0.01 | buy |
| Cannell & Spears LLC | 82,730 | 82,092 | -638 | 0.14 | 0.14 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 83,124 | 80,203 | -2,921 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 139,758 | 80,000 | -59,758 | 1.81 | 1.01 | -0.80 | sell |
| Walleye Capital LLC | 97,120 | 76,023 | -21,097 | 0.08 | 0.06 | -0.02 | sell |
| Neuberger Berman Group LLC | 91,656 | 74,767 | -16,889 | 0.01 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 82,032 | 74,332 | -7,700 | 1.75 | 1.50 | -0.25 | sell |
| Hennion & Walsh Asset Management, Inc. | 69,483 | 64,685 | -4,798 | 0.30 | 0.27 | -0.03 | sell |
| HighVista Strategies LLC | 48,527 | 62,192 | +13,665 | 1.38 | 1.83 | +0.45 | buy |
| MOODY ALDRICH PARTNERS LLC | 65,659 | 61,751 | -3,908 | 0.89 | 0.97 | +0.08 | sell |
| Swiss National Bank | 60,500 | 60,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BLAIR WILLIAM & CO/IL | 63,547 | 59,151 | -4,396 | 0.02 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 60,182 | 58,909 | -1,273 | 0.04 | 0.04 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 58,300 | 58,300 | 0 | 0.01 | 0.01 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 28,841 | 56,193 | +27,352 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 52,257 | 54,931 | +2,674 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 138,000 | 50,000 | -88,000 | 4.92 | 1.66 | -3.26 | sell |
| BALDWIN WEALTH PARTNERS LLC/MA | 49,695 | 49,695 | 0 | 0.30 | 0.31 | +0.01 | hold |
| Atika Capital Management LLC | 68,000 | 49,000 | -19,000 | 0.61 | 0.46 | -0.15 | sell |
| AMERIPRISE FINANCIAL INC | 12,587 | 45,315 | +32,728 | 0.00 | 0.00 | +0.00 | buy |
| WMS Partners, LLC | 40,711 | 40,711 | 0 | 0.22 | 0.21 | -0.01 | hold |
| SEI INVESTMENTS CO | 35,654 | 40,624 | +4,970 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 41,620 | 39,893 | -1,727 | 0.04 | 0.04 | -0.00 | sell |
| UBS Group AG | 61,320 | 39,704 | -21,616 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 0 | 39,675 | +39,675 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 0 | 33,969 | +33,969 | 0.00 | 0.01 | +0.01 | buy |
| SVB FINANCIAL GROUP | 33,849 | 33,849 | 0 | 1.49 | 1.91 | +0.42 | hold |
| NATIXIS | 1,235 | 33,652 | +32,417 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 32,867 | 33,649 | +782 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 22,553 | 32,510 | +9,957 | 0.13 | 0.17 | +0.04 | buy |
| Point72 Europe (London) LLP | 0 | 30,741 | +30,741 | 0.00 | 0.21 | +0.21 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,251 | 30,551 | -700 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,274 | 27,175 | +1,901 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 27,119 | +27,119 | 0.00 | 0.04 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 65,512 | 26,591 | -38,921 | 0.01 | 0.00 | -0.00 | sell |
| Strategic Financial Concepts, LLC | 0 | 26,010 | +26,010 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,321 | 25,616 | -13,705 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 33,877 | 24,729 | -9,148 | 0.01 | 0.01 | +0.00 | sell |
| CWM, LLC | 29,595 | 23,920 | -5,675 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,341 | 23,358 | +1,017 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,902 | 22,901 | +999 | 0.00 | 0.00 | +0.00 | buy |
| TRUIST FINANCIAL CORP | 21,083 | 21,083 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Meridian Wealth Management, LLC | 0 | 21,056 | +21,056 | 0.00 | 0.20 | +0.20 | buy |
| MetLife Investment Management, LLC | 18,503 | 21,045 | +2,542 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 19,855 | 20,668 | +813 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 19,483 | 20,615 | +1,132 | 0.03 | 0.04 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 19,027 | 19,724 | +697 | 0.05 | 0.05 | +0.00 | buy |