| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 955,000 | +955,000 | 0.00 | 2.15 | +2.15 | buy |
| BANK OF AMERICA CORP /DE/ | 185,713 | 890,985 | +705,272 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 346,712 | 938,714 | +592,002 | 0.43 | 1.29 | +0.86 | buy |
| Deep Track Capital, LP | 1,304,721 | 1,852,784 | +548,063 | 2.99 | 4.45 | +1.46 | buy |
| Cormorant Asset Management, LP | 0 | 400,000 | +400,000 | 0.00 | 1.87 | +1.87 | buy |
| MACQUARIE GROUP LTD | 700,410 | 1,073,242 | +372,832 | 0.06 | 0.10 | +0.04 | buy |
| Invesco Ltd. | 245,653 | 557,861 | +312,208 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 0 | 310,198 | +310,198 | 0.00 | 1.57 | +1.57 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 1.80 | +1.80 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 515,000 | 730,000 | +215,000 | 0.08 | 0.11 | +0.03 | buy |
| Tri Locum Partners LP | 102,711 | 306,513 | +203,802 | 2.84 | 6.24 | +3.40 | buy |
| Checkpoint Capital L.P. | 132,437 | 290,772 | +158,335 | 7.06 | 14.11 | +7.05 | buy |
| RTW INVESTMENTS, LP | 4,492,679 | 4,634,331 | +141,652 | 5.29 | 5.78 | +0.48 | buy |
| GOLDMAN SACHS GROUP INC | 291,612 | 401,327 | +109,715 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 27,042 | 135,855 | +108,813 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 378,864 | 479,044 | +100,180 | 0.09 | 0.12 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 80,154 | 168,762 | +88,608 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 828,550 | 902,136 | +73,586 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,287 | 91,804 | +72,517 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 676,646 | 734,620 | +57,974 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 0 | 39,675 | +39,675 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 845,407 | 884,895 | +39,488 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 33,969 | +33,969 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 12,587 | 45,315 | +32,728 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 1,235 | 33,652 | +32,417 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Europe (London) LLP | 0 | 30,741 | +30,741 | 0.00 | 0.21 | +0.21 | buy |
| Hood River Capital Management LLC | 520,750 | 549,066 | +28,316 | 0.93 | 0.92 | -0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 28,841 | 56,193 | +27,352 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 27,119 | +27,119 | 0.00 | 0.04 | +0.04 | buy |
| Strategic Financial Concepts, LLC | 0 | 26,010 | +26,010 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Management, LLC | 0 | 21,056 | +21,056 | 0.00 | 0.20 | +0.20 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 18,983 | +18,983 | 0.00 | 0.02 | +0.02 | buy |
| NORGES BANK | 385,551 | 404,217 | +18,666 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 114,127 | 132,312 | +18,185 | 1.46 | 1.66 | +0.19 | buy |
| Clearbridge Investments, LLC | 89,370 | 106,767 | +17,397 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 48,527 | 62,192 | +13,665 | 1.38 | 1.83 | +0.45 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 12,141 | +12,141 | 0.00 | 0.01 | +0.01 | buy |
| Quantitative Investment Management, LLC | 0 | 11,799 | +11,799 | 0.00 | 0.10 | +0.10 | buy |
| Bank of New York Mellon Corp | 153,771 | 165,564 | +11,793 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,575 | +11,575 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 10,531 | +10,531 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 22,553 | 32,510 | +9,957 | 0.13 | 0.17 | +0.04 | buy |
| NOMURA HOLDINGS INC | 0 | 9,077 | +9,077 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 301,074 | 309,818 | +8,744 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 4,032 | 11,205 | +7,173 | 0.04 | 0.08 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 8,918 | 15,118 | +6,200 | 0.02 | 0.03 | +0.01 | buy |
| WINTON GROUP Ltd | 3,438 | 8,823 | +5,385 | 0.02 | 0.05 | +0.03 | buy |
| Aquatic Capital Management LLC | 0 | 5,200 | +5,200 | 0.00 | 0.02 | +0.02 | buy |
| WESBANCO BANK INC | 8,300 | 13,300 | +5,000 | 0.02 | 0.04 | +0.01 | buy |
| SEI INVESTMENTS CO | 35,654 | 40,624 | +4,970 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 4,892 | +4,892 | 0.00 | 0.09 | +0.09 | buy |
| Brevan Howard Capital Management LP | 0 | 4,782 | +4,782 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 880 | 4,583 | +3,703 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 3,105 | +3,105 | 0.00 | 0.01 | +0.01 | buy |
| Flower City Capital | 0 | 3,000 | +3,000 | 0.00 | 0.16 | +0.16 | buy |
| RHUMBLINE ADVISERS | 52,257 | 54,931 | +2,674 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,503 | 21,045 | +2,542 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,274 | 27,175 | +1,901 | 0.00 | 0.00 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 111,590 | 113,345 | +1,755 | 0.02 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 3,740,278 | 3,742,002 | +1,724 | 0.01 | 0.01 | -0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 9,698 | 11,354 | +1,656 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 4,426 | 6,072 | +1,646 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,800 | 3,200 | +1,400 | 0.06 | 0.11 | +0.05 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 86,135 | 87,373 | +1,238 | 0.20 | 0.21 | +0.01 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 10,538 | 11,747 | +1,209 | 0.13 | 0.14 | +0.02 | buy |
| Creative Planning | 7,216 | 8,365 | +1,149 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 19,483 | 20,615 | +1,132 | 0.03 | 0.04 | +0.00 | buy |
| Russell Investments Group, Ltd. | 791 | 1,834 | +1,043 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,341 | 23,358 | +1,017 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,902 | 22,901 | +999 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 107,871 | 108,838 | +967 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 19,855 | 20,668 | +813 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 32,867 | 33,649 | +782 | 0.00 | 0.00 | +0.00 | buy |
| OneDigital Investment Advisors LLC | 8,097 | 8,819 | +722 | 0.01 | 0.01 | -0.00 | buy |
| Dana Investment Advisors, Inc. | 19,027 | 19,724 | +697 | 0.05 | 0.05 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 584 | +584 | 0.00 | 0.01 | +0.01 | buy |
| Mariner, LLC | 2,614 | 3,137 | +523 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 5,675 | 6,132 | +457 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 9,040 | 9,415 | +375 | 0.01 | 0.01 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 335 | +335 | 0.00 | 0.00 | +0.00 | buy |
| PITCAIRN CO | 4,674 | 4,975 | +301 | 0.02 | 0.02 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 7,370 | 7,599 | +229 | 0.00 | 0.00 | -0.00 | buy |
| SYNOVUS FINANCIAL CORP | 15,654 | 15,832 | +178 | 0.02 | 0.02 | +0.00 | buy |
| Arizona State Retirement System | 8,453 | 8,630 | +177 | 0.00 | 0.00 | -0.00 | buy |
| Global Retirement Partners, LLC | 23 | 177 | +154 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 144 | +144 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 16,013 | 16,144 | +131 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 2,763 | 2,880 | +117 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 19 | 118 | +99 | 0.00 | 0.00 | +0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 740,791 | 740,888 | +97 | 48.02 | 45.25 | -2.76 | buy |
| Smartleaf Asset Management LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 947 | 986 | +39 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,216 | 1,252 | +36 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 10 | 42 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 1,300 | 1,332 | +32 | 0.00 | 0.00 | -0.00 | buy |
| Stephens Consulting, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 20 | 37 | +17 | 0.00 | 0.00 | +0.00 | buy |