| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 346,712 | 938,714 | +592,002 | 0.43 | 1.29 | +0.86 | buy |
| Deep Track Capital, LP | 1,304,721 | 1,852,784 | +548,063 | 2.99 | 4.45 | +1.46 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 515,000 | 730,000 | +215,000 | 0.08 | 0.11 | +0.03 | buy |
| Tri Locum Partners LP | 102,711 | 306,513 | +203,802 | 2.84 | 6.24 | +3.40 | buy |
| Checkpoint Capital L.P. | 132,437 | 290,772 | +158,335 | 7.06 | 14.11 | +7.05 | buy |
| RTW INVESTMENTS, LP | 4,492,679 | 4,634,331 | +141,652 | 5.29 | 5.78 | +0.48 | buy |
| NATIXIS | 1,235 | 33,652 | +32,417 | 0.00 | 0.02 | +0.01 | buy |
| Hood River Capital Management LLC | 520,750 | 549,066 | +28,316 | 0.93 | 0.92 | -0.01 | buy |
| MPM BioImpact LLC | 114,127 | 132,312 | +18,185 | 1.46 | 1.66 | +0.19 | buy |
| Clearbridge Investments, LLC | 89,370 | 106,767 | +17,397 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 48,527 | 62,192 | +13,665 | 1.38 | 1.83 | +0.45 | buy |
| Knights of Columbus Asset Advisors LLC | 22,553 | 32,510 | +9,957 | 0.13 | 0.17 | +0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 8,918 | 15,118 | +6,200 | 0.05 | 0.08 | 0.00 | buy |
| CWM, LLC | 29,595 | 23,920 | +5,675 | 0.01 | 0.01 | -0.00 | sell |
| WINTON GROUP Ltd | 3,438 | 8,823 | +5,385 | 0.02 | 0.05 | +0.03 | buy |
| WESBANCO BANK INC | 8,300 | 13,300 | +5,000 | 0.02 | 0.04 | +0.01 | buy |
| WEDBUSH SECURITIES INC | 8,297 | 4,818 | +3,479 | 0.03 | 0.01 | 0.00 | sell |
| PROFUND ADVISORS LLC | 9,015 | 6,871 | +2,144 | 0.03 | 0.02 | 0.00 | sell |
| ProShare Advisors LLC | 9,724 | 7,707 | +2,017 | 0.00 | 0.00 | 0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 111,590 | 113,345 | +1,755 | 0.02 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 741,518 | 739,819 | +1,699 | 0.06 | 0.06 | 0.00 | sell |
| DnB Asset Management AS | 4,426 | 6,072 | +1,646 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,800 | 3,200 | +1,400 | 0.06 | 0.11 | 0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 86,135 | 87,373 | +1,238 | 0.20 | 0.21 | +0.01 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 10,538 | 11,747 | +1,209 | 0.13 | 0.14 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 19,483 | 20,615 | +1,132 | 0.03 | 0.04 | +0.00 | buy |
| BALDWIN WEALTH PARTNERS LLC/MA | 48,995 | 49,695 | +700 | 0.31 | 0.31 | 0.00 | buy |
| Dana Investment Advisors, Inc. | 19,027 | 19,724 | +697 | 0.05 | 0.05 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 9,040 | 9,415 | +375 | 0.01 | 0.01 | +0.00 | buy |
| PITCAIRN CO | 4,674 | 4,975 | +301 | 0.02 | 0.02 | +0.00 | buy |
| CI INVESTMENTS INC. | 1,111 | 878 | +233 | 0.00 | 0.00 | 0.00 | sell |
| CIBC Private Wealth Group LLC | 16,394 | 16,214 | +180 | 0.00 | 0.00 | 0.00 | sell |
| SYNOVUS FINANCIAL CORP | 15,654 | 15,832 | +178 | 0.02 | 0.02 | +0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 740,791 | 740,888 | +97 | 48.02 | 45.25 | -2.76 | buy |
| INTRUST BANK NA | 2,940 | 2,682 | -258 | 0.03 | 0.02 | -0.00 | sell |
| EntryPoint Capital, LLC | 437 | 171 | -266 | 0.03 | 0.02 | -0.01 | sell |
| Phocas Financial Corp. | 19,154 | 18,799 | -355 | 0.01 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 8,896 | 8,336 | -560 | 0.02 | 0.02 | -0.00 | sell |
| Cannell & Spears LLC | 82,730 | 82,092 | -638 | 0.14 | 0.14 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,200 | 4,542 | -658 | 0.22 | 0.18 | -0.04 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 6,300 | 5,200 | -1,100 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 6,862 | 5,477 | -1,385 | 0.00 | 0.00 | -0.00 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 128,842 | 126,905 | -1,937 | 2.02 | 2.31 | +0.29 | sell |
| OAK RIDGE INVESTMENTS LLC | 15,930 | 13,936 | -1,994 | 0.13 | 0.11 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 9,103 | 5,580 | -3,523 | 0.09 | 0.06 | -0.03 | sell |
| Lion Street Advisors, LLC | 11,932 | 8,315 | -3,617 | 0.39 | 0.25 | -0.14 | sell |
| MOODY ALDRICH PARTNERS LLC | 65,659 | 61,751 | -3,908 | 0.89 | 0.97 | +0.08 | sell |
| Hennion & Walsh Asset Management, Inc. | 69,483 | 64,685 | -4,798 | 0.30 | 0.27 | -0.03 | sell |
| First Turn Management, LLC | 342,173 | 337,246 | -4,927 | 4.08 | 4.42 | +0.33 | sell |
| Privium Fund Management B.V. | 82,032 | 74,332 | -7,700 | 1.75 | 1.50 | -0.25 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 105,344 | 96,027 | -9,317 | 0.08 | 0.08 | -0.00 | sell |
| LOOMIS SAYLES & CO L P | 279,791 | 269,089 | -10,702 | 0.03 | 0.03 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 143,600 | 127,600 | -16,000 | 1.09 | 0.99 | -0.10 | sell |
| Atika Capital Management LLC | 68,000 | 49,000 | -19,000 | 0.53 | 0.39 | -0.15 | sell |
| Woodline Partners LP | 360,128 | 318,011 | -42,117 | 0.27 | 0.25 | -0.02 | sell |
| Avidity Partners Management LP | 431,000 | 376,000 | -55,000 | 1.22 | 1.29 | +0.06 | sell |
| Affinity Asset Advisors, LLC | 139,758 | 80,000 | -59,758 | 1.81 | 1.01 | -0.80 | sell |
| Altium Capital Management LLC | 138,000 | 50,000 | -88,000 | 4.92 | 1.66 | -3.26 | sell |
| Bellevue Group AG | 685,476 | 516,533 | -168,943 | 0.83 | 0.68 | -0.16 | sell |
| PERCEPTIVE ADVISORS LLC | 1,105,341 | 459,111 | -646,230 | 1.54 | 0.89 | -0.65 | sell |