| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 3,876,942 | 3,945,020 | +68,078 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 3,524,411 | 3,834,990 | +310,579 | 0.01 | 0.01 | -0.00 | buy |
| BVF INC/IL | 1,690,221 | 1,690,221 | 0 | 8.03 | 6.30 | -1.73 | hold |
| RTW INVESTMENTS, LP | 2,922,729 | 1,516,903 | -1,405,826 | 5.21 | 2.26 | -2.96 | sell |
| MACQUARIE GROUP LTD | 976,260 | 1,137,748 | +161,488 | 0.14 | 0.15 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 934,853 | 989,453 | +54,600 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 1,247,231 | 976,730 | -270,501 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 906,020 | 958,503 | +52,483 | 0.00 | 0.00 | -0.00 | buy |
| Fairmount Funds Management LLC | 815,176 | 815,176 | 0 | 14.75 | 11.02 | -3.72 | hold |
| Deep Track Capital, LP | 0 | 801,371 | +801,371 | 0.00 | 2.69 | +2.69 | buy |
| BANK OF AMERICA CORP /DE/ | 533,902 | 753,429 | +219,527 | 0.01 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 744,850 | 725,672 | -19,178 | 1.73 | 1.33 | -0.40 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 703,279 | 725,044 | +21,765 | 0.02 | 0.01 | -0.00 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 667,368 | 667,368 | 0 | 58.07 | 52.72 | -5.35 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,977 | 612,743 | +580,766 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 288,647 | 595,455 | +306,808 | 0.01 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 857,001 | 571,549 | -285,452 | 0.02 | 0.01 | -0.01 | sell |
| Man Group plc | 513,221 | 525,069 | +11,848 | 0.18 | 0.12 | -0.06 | buy |
| PFM Health Sciences, LP | 556,545 | 483,105 | -73,440 | 4.98 | 4.37 | -0.61 | sell |
| NORGES BANK | 437,497 | 468,329 | +30,832 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 457,416 | 447,919 | -9,497 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 48,000 | 447,000 | +399,000 | 0.01 | 0.08 | +0.07 | buy |
| ORBIMED ADVISORS LLC | 386,700 | 427,900 | +41,200 | 1.08 | 1.12 | +0.04 | buy |
| Pictet Asset Management Holding SA | 333,205 | 411,850 | +78,645 | 0.04 | 0.04 | +0.00 | buy |
| NORTHERN TRUST CORP | 410,969 | 409,394 | -1,575 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 282,376 | 391,617 | +109,241 | 0.05 | 0.06 | +0.01 | buy |
| Hood River Capital Management LLC | 0 | 371,104 | +371,104 | 0.00 | 0.54 | +0.54 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 337,246 | 356,651 | +19,405 | 0.01 | 0.01 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 295,671 | 355,511 | +59,840 | 0.02 | 0.02 | +0.00 | buy |
| Point72 Asset Management, L.P. | 126,193 | 350,973 | +224,780 | 0.04 | 0.09 | +0.05 | buy |
| Woodline Partners LP | 304,084 | 331,131 | +27,047 | 0.23 | 0.18 | -0.05 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 285,494 | 326,318 | +40,824 | 6.87 | 4.03 | -2.85 | buy |
| Nuveen, LLC | 413,141 | 282,971 | -130,170 | 0.01 | 0.01 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 226,515 | 278,510 | +51,995 | 0.01 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 284,170 | 277,465 | -6,705 | 0.05 | 0.04 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 266,997 | 248,726 | -18,271 | 0.02 | 0.02 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 301,718 | 228,204 | -73,514 | 0.01 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 175,942 | 224,721 | +48,779 | 0.09 | 0.08 | -0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 214,139 | 223,280 | +9,141 | 0.24 | 0.19 | -0.05 | buy |
| Bank of New York Mellon Corp | 131,023 | 203,632 | +72,609 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 547,665 | 200,764 | -346,901 | 0.08 | 0.02 | -0.05 | sell |
| PERCEPTIVE ADVISORS LLC | 355,107 | 198,534 | -156,573 | 1.47 | 0.78 | -0.69 | sell |
| JPMORGAN CHASE & CO | 124,783 | 187,728 | +62,945 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 182,632 | 186,437 | +3,805 | 0.02 | 0.02 | -0.00 | buy |
| MetLife Investment Management, LLC | 178,955 | 184,164 | +5,209 | 0.11 | 0.11 | +0.00 | buy |
| Assenagon Asset Management S.A. | 627,418 | 180,960 | -446,458 | 0.13 | 0.03 | -0.10 | sell |
| Squarepoint Ops LLC | 141,597 | 163,000 | +21,403 | 0.04 | 0.04 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 155,075 | 161,412 | +6,337 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 177,814 | 159,233 | -18,581 | 0.27 | 0.18 | -0.09 | sell |
| Tri Locum Partners LP | 101,240 | 157,861 | +56,621 | 6.06 | 5.00 | -1.06 | buy |
| First Turn Management, LLC | 118,179 | 144,400 | +26,221 | 2.78 | 2.81 | +0.03 | buy |
| Blackstone Inc. | 0 | 140,000 | +140,000 | 0.00 | 0.07 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 99,000 | 139,289 | +40,289 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 134,400 | 138,700 | +4,300 | 0.02 | 0.02 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 74,892 | 134,101 | +59,209 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,851 | 133,823 | +110,972 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 130,295 | 130,847 | +552 | 0.02 | 0.02 | -0.00 | buy |
| Granite Investment Partners, LLC | 138,719 | 128,526 | -10,193 | 0.82 | 0.65 | -0.17 | sell |
| Jump Financial, LLC | 92,640 | 128,500 | +35,860 | 0.17 | 0.17 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 58,363 | 127,817 | +69,454 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 111,948 | 119,666 | +7,718 | 0.03 | 0.03 | -0.01 | buy |
| EMERALD ADVISERS, LLC | 0 | 112,469 | +112,469 | 0.00 | 0.43 | +0.43 | buy |
| Bridgewater Associates, LP | 42,825 | 107,292 | +64,467 | 0.02 | 0.05 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,726 | 106,021 | +54,295 | 0.01 | 0.02 | +0.01 | buy |
| Cormorant Asset Management, LP | 250,000 | 100,000 | -150,000 | 2.21 | 0.78 | -1.43 | sell |
| HSBC HOLDINGS PLC | 83,572 | 98,118 | +14,546 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 51,870 | 97,490 | +45,620 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 59,553 | 94,571 | +35,018 | 0.35 | 0.41 | +0.06 | buy |
| Avidity Partners Management LP | 77,000 | 94,500 | +17,500 | 1.85 | 1.98 | +0.13 | buy |
| Sofinnova Investments, Inc. | 175,317 | 93,610 | -81,707 | 1.54 | 0.66 | -0.88 | sell |
| DEUTSCHE BANK AG\ | 94,980 | 92,890 | -2,090 | 0.00 | 0.00 | -0.00 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 106,312 | 91,761 | -14,551 | 3.89 | 3.32 | -0.57 | sell |
| Rhenman & Partners Asset Management AB | 109,600 | 90,800 | -18,800 | 1.47 | 1.20 | -0.27 | sell |
| CITIGROUP INC | 39,169 | 85,011 | +45,842 | 0.00 | 0.01 | +0.00 | buy |
| Cannell & Spears LLC | 84,264 | 84,151 | -113 | 0.21 | 0.18 | -0.03 | sell |
| Aberdeen Group plc | 63,954 | 81,916 | +17,962 | 0.01 | 0.01 | -0.00 | buy |
| Candriam S.C.A. | 79,930 | 76,727 | -3,203 | 0.06 | 0.05 | -0.01 | sell |
| DnB Asset Management AS | 61,528 | 76,642 | +15,114 | 0.03 | 0.03 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 59,721 | 73,468 | +13,747 | 0.23 | 0.23 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 44,500 | 72,300 | +27,800 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 70,632 | +70,632 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 16,016 | 70,084 | +54,068 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 70,086 | 69,961 | -125 | 0.28 | 0.20 | -0.07 | sell |
| Swiss National Bank | 61,000 | 65,200 | +4,200 | 0.01 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 68,114 | 64,018 | -4,096 | 0.24 | 0.19 | -0.05 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 63,935 | +63,935 | 0.00 | 0.41 | +0.41 | buy |
| FIRST TRUST ADVISORS LP | 28,951 | 62,160 | +33,209 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 54,760 | 61,807 | +7,047 | 0.01 | 0.01 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 62,339 | 61,410 | -929 | 1.52 | 1.24 | -0.28 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 13,025 | 60,763 | +47,738 | 0.02 | 0.07 | +0.05 | buy |
| MARSHALL WACE, LLP | 68,696 | 56,716 | -11,980 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 25,990 | 56,469 | +30,479 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 68,164 | 56,316 | -11,848 | 0.01 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 96,407 | 56,253 | -40,154 | 0.25 | 0.13 | -0.12 | sell |
| WELLS FARGO & COMPANY/MN | 41,615 | 55,703 | +14,088 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 52,732 | 52,732 | 0 | 1.60 | 1.17 | -0.43 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 50,096 | 51,968 | +1,872 | 0.01 | 0.01 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 50,000 | -50,000 | 1.83 | 0.77 | -1.05 | sell |
| Hennion & Walsh Asset Management, Inc. | 59,273 | 49,900 | -9,373 | 0.31 | 0.21 | -0.10 | sell |
| BLAIR WILLIAM & CO/IL | 52,529 | 49,482 | -3,047 | 0.02 | 0.01 | -0.00 | sell |