| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 3,912,844 | 3,103,708 | -809,136 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 1,297,678 | 1,671,684 | +374,006 | 0.03 | 0.03 | +0.00 | buy |
| FMR LLC | 1,566,995 | 1,539,163 | -27,832 | 0.01 | 0.02 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,162,981 | 967,172 | -195,809 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 476,701 | 804,082 | +327,381 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 986,809 | 785,661 | -201,148 | 0.01 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 1,100,000 | 700,000 | -400,000 | 3.84 | 2.52 | -1.31 | sell |
| TWO SIGMA INVESTMENTS, LP | 322,778 | 669,478 | +346,700 | 0.05 | 0.12 | +0.08 | buy |
| FRANKLIN RESOURCES INC | 438,490 | 668,373 | +229,883 | 0.02 | 0.04 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,145,306 | 653,920 | -491,386 | 0.04 | 0.03 | -0.01 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 649,114 | 648,756 | -358 | 58.94 | 65.78 | +6.84 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,317,059 | 642,893 | -674,166 | 0.03 | 0.02 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 603,465 | 604,753 | +1,288 | 0.08 | 0.09 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,758 | 556,088 | +535,330 | 0.00 | 0.09 | +0.09 | buy |
| NORGES BANK | 0 | 514,266 | +514,266 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 577,479 | 482,061 | -95,418 | 0.07 | 0.07 | -0.00 | sell |
| Assenagon Asset Management S.A. | 865,958 | 454,682 | -411,276 | 0.23 | 0.14 | -0.09 | sell |
| BANK OF AMERICA CORP /DE/ | 598,091 | 452,491 | -145,600 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 176,314 | 428,079 | +251,765 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 415,983 | 426,527 | +10,544 | 0.07 | 0.10 | +0.03 | buy |
| Qube Research & Technologies Ltd | 335,334 | 426,336 | +91,002 | 0.08 | 0.12 | +0.04 | buy |
| Point72 Asset Management, L.P. | 424,750 | 416,516 | -8,234 | 0.12 | 0.16 | +0.03 | sell |
| JANE STREET GROUP, LLC | 4,078 | 403,995 | +399,917 | 0.00 | 0.06 | +0.06 | buy |
| Hood River Capital Management LLC | 371,503 | 402,678 | +31,175 | 0.63 | 0.71 | +0.09 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 97,550 | 373,067 | +275,517 | 0.03 | 0.13 | +0.10 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 292,370 | 372,474 | +80,104 | 0.36 | 0.53 | +0.17 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 350,488 | 332,642 | -17,846 | 0.03 | 0.04 | +0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 519,558 | 316,820 | -202,738 | 1.45 | 1.04 | -0.42 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 316,104 | +316,104 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 395,118 | 316,104 | -79,014 | 0.01 | 0.01 | +0.00 | sell |
| Integral Health Asset Management, LLC | 35,000 | 300,000 | +265,000 | 0.31 | 3.01 | +2.70 | buy |
| NORTHERN TRUST CORP | 401,459 | 270,189 | -131,270 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 164,300 | 262,000 | +97,700 | 0.04 | 0.09 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 737,578 | 259,034 | -478,544 | 0.19 | 0.09 | -0.10 | sell |
| CITADEL ADVISORS LLC | 281,503 | 255,878 | -25,625 | 0.03 | 0.04 | +0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 203,066 | 254,280 | +51,214 | 0.35 | 0.58 | +0.23 | buy |
| SAMLYN CAPITAL, LLC | 0 | 246,015 | +246,015 | 0.00 | 1.00 | +1.00 | buy |
| Clearbridge Investments, LLC | 45,020 | 245,574 | +200,554 | 0.01 | 0.05 | +0.04 | buy |
| LOOMIS SAYLES & CO L P | 256,625 | 239,490 | -17,135 | 0.06 | 0.07 | +0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 188,146 | 230,954 | +42,808 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 421,447 | 229,668 | -191,779 | 0.01 | 0.01 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 91,400 | 225,400 | +134,000 | 0.01 | 0.03 | +0.02 | buy |
| MARSHALL WACE, LLP | 141,236 | 223,386 | +82,150 | 0.03 | 0.05 | +0.02 | buy |
| PFM Health Sciences, LP | 264,304 | 219,596 | -44,708 | 4.70 | 4.67 | -0.03 | sell |
| Tri Locum Partners LP | 62,116 | 219,308 | +157,192 | 1.47 | 6.60 | +5.13 | buy |
| First Turn Management, LLC | 188,772 | 218,415 | +29,643 | 3.56 | 5.72 | +2.15 | buy |
| Bank of New York Mellon Corp | 206,644 | 197,226 | -9,418 | 0.01 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 335,737 | 190,080 | -145,657 | 0.02 | 0.01 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 178,491 | +178,491 | 0.00 | 0.08 | +0.08 | buy |
| FEDERATED HERMES, INC. | 108,571 | 177,842 | +69,271 | 0.03 | 0.06 | +0.03 | buy |
| Woodline Partners LP | 162,221 | 162,221 | 0 | 0.10 | 0.12 | +0.02 | hold |
| JPMORGAN CHASE & CO | 270,160 | 162,065 | -108,095 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 212,747 | 160,429 | -52,318 | 1.80 | 2.10 | +0.30 | sell |
| Neuberger Berman Group LLC | 60,759 | 156,523 | +95,764 | 0.01 | 0.03 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 147,766 | 155,855 | +8,089 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 114,102 | 154,605 | +40,503 | 0.04 | 0.07 | +0.03 | buy |
| UBS Group AG | 547,195 | 151,903 | -395,292 | 0.02 | 0.01 | -0.01 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 145,145 | +145,145 | 0.00 | 0.12 | +0.12 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 183,967 | 142,051 | -41,916 | 0.03 | 0.03 | -0.00 | sell |
| CITIGROUP INC | 185,658 | 136,858 | -48,800 | 0.02 | 0.02 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 135,195 | +135,195 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 94,937 | 127,178 | +32,241 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 117,093 | 118,999 | +1,906 | 0.02 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 149,950 | 118,450 | -31,500 | 0.50 | 0.45 | -0.05 | sell |
| ORBIMED ADVISORS LLC | 213,921 | 117,578 | -96,343 | 0.79 | 0.55 | -0.24 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 116,000 | +116,000 | 0.00 | 0.07 | +0.07 | buy |
| AQR CAPITAL MANAGEMENT LLC | 104,059 | 114,025 | +9,966 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 107,610 | 104,237 | -3,373 | 0.58 | 0.60 | +0.02 | sell |
| Nicholas Investment Partners, LP | 81,478 | 98,974 | +17,496 | 0.99 | 1.36 | +0.37 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 134,792 | 97,698 | -37,094 | 0.05 | 0.05 | -0.01 | sell |
| ALGERT GLOBAL LLC | 135,460 | 95,335 | -40,125 | 0.34 | 0.28 | -0.07 | sell |
| ROYCE & ASSOCIATES LP | 94,017 | 91,041 | -2,976 | 0.16 | 0.18 | +0.02 | sell |
| MetLife Investment Management, LLC | 152,645 | 89,662 | -62,983 | 0.13 | 0.10 | -0.03 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,198 | 87,815 | +40,617 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 104,266 | 86,466 | -17,800 | 0.01 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 62,822 | 85,716 | +22,894 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 147,867 | 84,433 | -63,434 | 0.54 | 0.38 | -0.16 | sell |
| Cannell & Spears LLC | 84,154 | 84,154 | 0 | 0.28 | 0.37 | +0.09 | hold |
| Trexquant Investment LP | 5,935 | 83,679 | +77,744 | 0.01 | 0.13 | +0.12 | buy |
| Man Group plc | 142,271 | 82,526 | -59,745 | 0.05 | 0.04 | -0.01 | sell |
| Granite Investment Partners, LLC | 80,299 | 80,124 | -175 | 0.83 | 1.00 | +0.17 | sell |
| Weiss Asset Management LP | 0 | 80,000 | +80,000 | 0.00 | 0.22 | +0.22 | buy |
| Swiss National Bank | 69,100 | 79,500 | +10,400 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 149,688 | 78,236 | -71,452 | 0.04 | 0.03 | -0.01 | sell |
| SEI INVESTMENTS CO | 70,064 | 76,462 | +6,398 | 0.01 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 76,250 | +76,250 | 0.00 | 0.03 | +0.03 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 107,817 | 75,713 | -32,104 | 0.04 | 0.03 | -0.01 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 50,879 | 74,778 | +23,899 | 0.01 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 73,978 | +73,978 | 0.00 | 0.05 | +0.05 | buy |
| Science & Technology Partners, L.P. | 0 | 73,040 | +73,040 | 0.00 | 3.01 | +3.01 | buy |
| TimesSquare Capital Management, LLC | 0 | 71,510 | +71,510 | 0.00 | 0.26 | +0.26 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 67,054 | 67,195 | +141 | 0.55 | 0.58 | +0.03 | buy |
| US BANCORP \DE\ | 131,414 | 66,580 | -64,834 | 0.03 | 0.02 | -0.01 | sell |
| DnB Asset Management AS | 90,088 | 65,199 | -24,889 | 0.05 | 0.04 | -0.01 | sell |
| Eagle Health Investments LP | 0 | 65,051 | +65,051 | 0.00 | 2.64 | +2.64 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,725 | 63,551 | -7,174 | 0.02 | 0.02 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 63,800 | 63,050 | -750 | 1.33 | 1.46 | +0.13 | sell |
| Atika Capital Management LLC | 0 | 63,000 | +63,000 | 0.00 | 1.53 | +1.53 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 62,528 | +62,528 | 0.00 | 0.02 | +0.02 | buy |
| IFP Advisors, Inc | 60,994 | 62,273 | +1,279 | 0.21 | 0.28 | +0.06 | buy |