| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 459,111 | 782,844 | +323,733 | 0.89 | 1.49 | +0.60 | buy |
| BVF INC/IL | 955,000 | 1,046,000 | +91,000 | 2.15 | 2.75 | +0.60 | buy |
| Hood River Capital Management LLC | 549,066 | 625,084 | +76,018 | 0.92 | 0.91 | -0.01 | buy |
| Sofinnova Investments, Inc. | 310,198 | 379,527 | +69,329 | 1.30 | 2.71 | +1.41 | buy |
| LOOMIS SAYLES & CO L P | 269,089 | 298,586 | +29,497 | 0.03 | 0.04 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 96,027 | 120,540 | +24,513 | 0.08 | 0.10 | +0.03 | buy |
| ROYCE & ASSOCIATES LP | 13,000 | 22,500 | +9,500 | 0.01 | 0.02 | +0.01 | buy |
| Altium Capital Management LLC | 50,000 | 58,000 | +8,000 | 1.66 | 1.55 | -0.11 | buy |
| Atika Capital Management LLC | 49,000 | 57,000 | +8,000 | 0.39 | 0.53 | +0.14 | buy |
| Clearbridge Investments, LLC | 106,767 | 114,236 | +7,469 | 0.01 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 74,332 | 80,232 | +5,900 | 1.50 | 1.79 | +0.30 | buy |
| EntryPoint Capital, LLC | 171 | 5,156 | +4,985 | 0.02 | 0.26 | +0.24 | buy |
| GREAT LAKES ADVISORS, LLC | 12,141 | 16,728 | +4,587 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Europe (London) LLP | 30,741 | 34,570 | +3,829 | 0.20 | 0.20 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 5,580 | 9,232 | +3,652 | 0.06 | 0.09 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,575 | 7,958 | +3,617 | 0.05 | 0.05 | 0.00 | sell |
| CWM, LLC | 23,920 | 20,793 | +3,127 | 0.01 | 0.01 | -0.00 | sell |
| ProShare Advisors LLC | 7,707 | 9,722 | +2,015 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 6,871 | 5,616 | +1,255 | 0.02 | 0.02 | 0.00 | sell |
| Quarry LP | 3,200 | 2,000 | +1,200 | 0.11 | 0.06 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 15,118 | 15,666 | +548 | 0.08 | 0.11 | 0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 113,345 | 113,692 | +347 | 0.02 | 0.02 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 300 | 600 | +300 | 0.00 | 0.01 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 11,747 | 11,823 | +76 | 0.14 | 0.15 | +0.01 | buy |
| DnB Asset Management AS | 6,072 | 6,144 | +72 | 0.00 | 0.00 | +0.00 | buy |
| SYNOVUS FINANCIAL CORP | 15,832 | 15,850 | +18 | 0.02 | 0.02 | -0.00 | buy |
| CI INVESTMENTS INC. | 878 | 885 | +7 | 0.00 | 0.00 | 0.00 | buy |
| Cannell & Spears LLC | 82,092 | 82,087 | -5 | 0.14 | 0.15 | +0.01 | sell |
| MONECO Advisors, LLC | 7,485 | 7,465 | -20 | 0.09 | 0.08 | -0.01 | sell |
| Meridian Wealth Management, LLC | 21,056 | 21,021 | -35 | 0.20 | 0.09 | -0.11 | sell |
| INTRUST BANK NA | 2,682 | 2,640 | -42 | 0.02 | 0.02 | +0.00 | sell |
| J. Goldman & Co LP | 8,336 | 8,279 | -57 | 0.02 | 0.02 | +0.00 | sell |
| Lion Street Advisors, LLC | 8,315 | 8,255 | -60 | 0.25 | 0.26 | +0.01 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 5,200 | 5,100 | -100 | 0.01 | 0.01 | +0.00 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 126,905 | 126,803 | -102 | 2.31 | 2.44 | +0.13 | sell |
| Old North State Wealth Management, LLC | 3,750 | 3,450 | -300 | 0.20 | 0.17 | -0.03 | sell |
| OAK RIDGE INVESTMENTS LLC | 13,936 | 13,417 | -519 | 0.11 | 0.11 | -0.00 | sell |
| PITCAIRN CO | 4,975 | 4,414 | -561 | 0.02 | 0.02 | -0.00 | sell |
| Rafferty Asset Management, LLC | 5,477 | 4,684 | -793 | 0.00 | 0.00 | -0.00 | sell |
| Phocas Financial Corp. | 18,799 | 17,701 | -1,098 | 0.01 | 0.01 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 61,751 | 60,644 | -1,107 | 0.97 | 0.99 | +0.02 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 20,615 | 19,431 | -1,184 | 0.04 | 0.04 | +0.00 | sell |
| D.A. DAVIDSON & CO. | 9,415 | 8,160 | -1,255 | 0.01 | 0.01 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 19,724 | 17,577 | -2,147 | 0.05 | 0.05 | -0.00 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 740,888 | 738,503 | -2,385 | 45.25 | 47.94 | +2.68 | sell |
| Quantitative Investment Management, LLC | 11,799 | 8,231 | -3,568 | 0.10 | 0.07 | -0.03 | sell |
| Rhenman & Partners Asset Management AB | 127,600 | 122,600 | -5,000 | 0.99 | 0.89 | -0.09 | sell |
| Hennion & Walsh Asset Management, Inc. | 64,685 | 58,148 | -6,537 | 0.27 | 0.24 | -0.02 | sell |
| Knights of Columbus Asset Advisors LLC | 32,510 | 20,885 | -11,625 | 0.17 | 0.12 | -0.05 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 87,373 | 71,929 | -15,444 | 0.21 | 0.20 | -0.01 | sell |
| Woodline Partners LP | 318,011 | 298,569 | -19,442 | 0.24 | 0.23 | -0.02 | sell |
| HighVista Strategies LLC | 62,192 | 41,542 | -20,650 | 1.83 | 1.29 | -0.54 | sell |
| Aberdeen Group plc | 39,675 | 11,048 | -28,627 | 0.01 | 0.00 | -0.00 | sell |
| NATIXIS | 33,652 | 890 | -32,762 | 0.02 | 0.00 | -0.02 | sell |
| Avidity Partners Management LP | 376,000 | 296,100 | -79,900 | 1.29 | 1.36 | +0.07 | sell |
| Checkpoint Capital L.P. | 290,772 | 209,632 | -81,140 | 14.11 | 9.35 | -4.76 | sell |
| First Turn Management, LLC | 337,246 | 255,294 | -81,952 | 4.42 | 3.63 | -0.78 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 938,714 | 827,887 | -110,827 | 1.29 | 1.28 | -0.01 | sell |
| Bellevue Group AG | 516,533 | 367,181 | -149,352 | 0.68 | 0.53 | -0.14 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 730,000 | 525,000 | -205,000 | 0.11 | 0.08 | -0.03 | sell |
| Tri Locum Partners LP | 306,513 | 91,721 | -214,792 | 6.24 | 1.97 | -4.26 | sell |
| RTW INVESTMENTS, LP | 4,634,331 | 4,189,557 | -444,774 | 5.78 | 5.45 | -0.33 | sell |
| Deep Track Capital, LP | 1,852,784 | 857,219 | -995,565 | 4.45 | 2.46 | -1.99 | sell |