| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 3,945,020 | 4,180,646 | +235,626 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 3,834,990 | 3,790,929 | -44,061 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 725,044 | 1,334,560 | +609,516 | 0.01 | 0.03 | +0.01 | buy |
| RTW INVESTMENTS, LP | 1,516,903 | 1,118,883 | -398,020 | 2.26 | 1.67 | -0.58 | sell |
| MACQUARIE GROUP LTD | 1,137,748 | 1,084,536 | -53,212 | 0.15 | 0.15 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 612,743 | 1,037,448 | +424,705 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 989,453 | 997,700 | +8,247 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 571,549 | 990,557 | +419,008 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 958,503 | 942,960 | -15,543 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 976,730 | 927,883 | -48,847 | 0.01 | 0.01 | +0.00 | sell |
| Deep Track Capital, LP | 801,371 | 900,000 | +98,629 | 2.69 | 3.05 | +0.36 | buy |
| Fairmount Funds Management LLC | 815,176 | 815,176 | 0 | 11.02 | 8.91 | -2.12 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 725,672 | 746,398 | +20,726 | 1.33 | 1.49 | +0.16 | buy |
| ALETHEA CAPITAL MANAGEMENT, LLC | 667,368 | 670,883 | +3,515 | 52.72 | 52.44 | -0.28 | buy |
| ORBIMED ADVISORS LLC | 427,900 | 531,800 | +103,900 | 1.12 | 1.55 | +0.43 | buy |
| PFM Health Sciences, LP | 483,105 | 530,332 | +47,227 | 4.37 | 5.49 | +1.12 | buy |
| BVF INC/IL | 1,690,221 | 486,757 | -1,203,464 | 6.30 | 2.40 | -3.91 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 447,000 | 445,000 | -2,000 | 0.08 | 0.09 | +0.01 | sell |
| MORGAN STANLEY | 447,919 | 409,580 | -38,339 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 409,394 | 409,535 | +141 | 0.01 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 93,610 | 393,499 | +299,889 | 0.66 | 2.93 | +2.27 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 356,651 | 382,047 | +25,396 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 56,716 | 378,024 | +321,308 | 0.01 | 0.05 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 355,511 | 368,434 | +12,923 | 0.02 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 411,850 | 362,138 | -49,712 | 0.04 | 0.04 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 753,429 | 361,261 | -392,168 | 0.01 | 0.00 | -0.00 | sell |
| Hood River Capital Management LLC | 371,104 | 359,957 | -11,147 | 0.54 | 0.52 | -0.02 | sell |
| Woodline Partners LP | 331,131 | 331,864 | +733 | 0.18 | 0.19 | +0.01 | buy |
| LOOMIS SAYLES & CO L P | 277,465 | 330,125 | +52,660 | 0.04 | 0.05 | +0.01 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 326,318 | 326,318 | 0 | 4.03 | 3.06 | -0.96 | hold |
| Qube Research & Technologies Ltd | 391,617 | 325,626 | -65,991 | 0.06 | 0.06 | -0.00 | sell |
| Nuveen, LLC | 282,971 | 298,341 | +15,370 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 200,764 | 296,287 | +95,523 | 0.02 | 0.03 | +0.01 | buy |
| Assenagon Asset Management S.A. | 180,960 | 294,771 | +113,811 | 0.03 | 0.05 | +0.02 | buy |
| Tri Locum Partners LP | 157,861 | 292,137 | +134,276 | 5.00 | 8.16 | +3.15 | buy |
| Man Group plc | 525,069 | 287,908 | -237,161 | 0.12 | 0.07 | -0.05 | sell |
| FRANKLIN RESOURCES INC | 278,510 | 285,598 | +7,088 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 248,726 | 274,014 | +25,288 | 0.02 | 0.02 | +0.00 | buy |
| Bank of New York Mellon Corp | 203,632 | 253,263 | +49,631 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 187,728 | 250,513 | +62,785 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 228,204 | 224,139 | -4,065 | 0.00 | 0.00 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 223,280 | 223,408 | +128 | 0.19 | 0.19 | +0.01 | buy |
| UBS Group AG | 595,455 | 212,451 | -383,004 | 0.01 | 0.01 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 224,721 | 209,069 | -15,652 | 0.08 | 0.08 | -0.00 | sell |
| MetLife Investment Management, LLC | 184,164 | 197,318 | +13,154 | 0.11 | 0.12 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 186,437 | 190,106 | +3,669 | 0.02 | 0.02 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 90,800 | 172,800 | +82,000 | 1.20 | 2.32 | +1.12 | buy |
| RAYMOND JAMES FINANCIAL INC | 161,412 | 158,689 | -2,723 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 13,618 | 158,406 | +144,788 | 0.00 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 163,000 | 155,000 | -8,000 | 0.04 | 0.04 | +0.00 | sell |
| First Turn Management, LLC | 144,400 | 152,614 | +8,214 | 2.81 | 2.78 | -0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 138,700 | 150,000 | +11,300 | 0.02 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 150,000 | +150,000 | 0.00 | 0.83 | +0.83 | buy |
| PERCEPTIVE ADVISORS LLC | 198,534 | 148,900 | -49,634 | 0.78 | 0.52 | -0.26 | sell |
| CITIGROUP INC | 85,011 | 142,013 | +57,002 | 0.01 | 0.01 | +0.01 | buy |
| Blackstone Inc. | 140,000 | 140,000 | 0 | 0.07 | 0.07 | +0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 133,823 | 132,717 | -1,106 | 0.01 | 0.01 | +0.00 | sell |
| US BANCORP \DE\ | 130,847 | 131,533 | +686 | 0.02 | 0.02 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 130,845 | +130,845 | 0.00 | 0.02 | +0.02 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 28,842 | 126,382 | +97,540 | 0.03 | 0.14 | +0.11 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 119,666 | 119,696 | +30 | 0.03 | 0.03 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 127,817 | 118,656 | -9,161 | 0.01 | 0.01 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 139,289 | 114,050 | -25,239 | 0.01 | 0.01 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 112,469 | 108,942 | -3,527 | 0.43 | 0.42 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 70,084 | 108,236 | +38,152 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 76,642 | 101,981 | +25,339 | 0.03 | 0.05 | +0.01 | buy |
| HSBC HOLDINGS PLC | 98,118 | 101,001 | +2,883 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 100,000 | 100,000 | 0 | 0.78 | 0.84 | +0.06 | hold |
| DEUTSCHE BANK AG\ | 92,890 | 96,692 | +3,802 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 81,916 | 94,648 | +12,732 | 0.01 | 0.02 | +0.00 | buy |
| Neuberger Berman Group LLC | 70,632 | 91,178 | +20,546 | 0.01 | 0.01 | +0.00 | buy |
| Granite Investment Partners, LLC | 128,526 | 88,558 | -39,968 | 0.65 | 0.61 | -0.04 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 134,101 | 86,691 | -47,410 | 0.00 | 0.00 | -0.00 | sell |
| Cannell & Spears LLC | 84,151 | 84,151 | 0 | 0.18 | 0.19 | +0.02 | hold |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 91,761 | 83,553 | -8,208 | 3.32 | 3.99 | +0.68 | sell |
| Summit Financial, LLC | 0 | 77,540 | +77,540 | 0.00 | 0.14 | +0.14 | buy |
| BARCLAYS PLC | 97,490 | 72,067 | -25,423 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 51,968 | 67,902 | +15,934 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 65,200 | 66,800 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 63,935 | 65,505 | +1,570 | 0.41 | 0.41 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 73,468 | 64,521 | -8,947 | 0.23 | 0.24 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 72,300 | 64,400 | -7,900 | 0.01 | 0.01 | -0.00 | sell |
| IFP Advisors, Inc | 64,018 | 63,313 | -705 | 0.19 | 0.20 | +0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 45,982 | 63,065 | +17,083 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 61,807 | 60,778 | -1,029 | 0.01 | 0.01 | +0.00 | sell |
| Clearbridge Investments, LLC | 56,316 | 57,667 | +1,351 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 56,469 | 57,285 | +816 | 0.01 | 0.01 | +0.00 | buy |
| HighTower Advisors, LLC | 10,962 | 57,115 | +46,153 | 0.00 | 0.01 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 25,757 | 56,036 | +30,279 | 0.03 | 0.07 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 55,703 | 55,273 | -430 | 0.00 | 0.00 | +0.00 | sell |
| Privium Fund Management B.V. | 52,732 | 52,732 | 0 | 1.17 | 1.15 | -0.02 | hold |
| Bellevue Group AG | 56,253 | 52,335 | -3,918 | 0.13 | 0.13 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 61,410 | 51,476 | -9,934 | 1.24 | 1.19 | -0.06 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 106,021 | 50,246 | -55,775 | 0.02 | 0.01 | -0.01 | sell |
| BLAIR WILLIAM & CO/IL | 49,482 | 50,077 | +595 | 0.01 | 0.02 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 27,106 | 49,253 | +22,147 | 0.02 | 0.04 | +0.02 | buy |
| Atika Capital Management LLC | 46,121 | 49,000 | +2,879 | 0.50 | 0.51 | +0.00 | buy |
| Nicholas Investment Partners, LP | 42,154 | 48,657 | +6,503 | 0.39 | 0.45 | +0.06 | buy |
| BALDWIN WEALTH PARTNERS LLC/MA | 48,570 | 48,570 | 0 | 0.34 | 0.38 | +0.04 | hold |
| SEI INVESTMENTS CO | 43,949 | 48,127 | +4,178 | 0.01 | 0.01 | +0.00 | buy |