| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 481,649 | 1,038,019 | +556,370 | 1.12 | 1.84 | +0.72 | buy |
| MILLENNIUM MANAGEMENT LLC | 503,042 | 909,965 | +406,923 | 0.05 | 0.09 | 0.00 | buy |
| Avidity Partners Management LP | 296,800 | 459,400 | +162,600 | 0.84 | 1.40 | +0.56 | buy |
| Woodline Partners LP | 452,107 | 562,163 | +110,056 | 0.37 | 0.49 | +0.12 | buy |
| Altium Capital Management LLC | 92,000 | 138,000 | +46,000 | 3.72 | 7.57 | +3.85 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 325,000 | 365,000 | +40,000 | 0.05 | 0.06 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 40,100 | 79,100 | +39,000 | 0.30 | 0.63 | +0.33 | buy |
| Candriam S.C.A. | 50,084 | 85,084 | +35,000 | 0.02 | 0.05 | +0.02 | buy |
| Fairmount Funds Management LLC | 2,341,238 | 2,360,077 | +18,839 | 19.69 | 19.85 | +0.16 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 248,889 | 265,842 | +16,953 | 0.23 | 0.25 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 25,735 | 11,922 | +13,813 | 0.05 | 0.07 | 0.00 | sell |
| Hood River Capital Management LLC | 383,276 | 392,753 | +9,477 | 0.86 | 0.86 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 95,963 | 104,808 | +8,845 | 0.02 | 0.02 | +0.00 | buy |
| HighVista Strategies LLC | 56,964 | 62,263 | +5,299 | 1.84 | 1.80 | -0.04 | buy |
| China Universal Asset Management Co., Ltd. | 1,204 | 5,475 | +4,271 | 0.02 | 0.08 | +0.06 | buy |
| Bellevue Group AG | 631,487 | 635,372 | +3,885 | 0.71 | 0.77 | +0.06 | buy |
| CWM, LLC | 40,130 | 38,371 | +1,759 | 0.02 | 0.02 | -0.00 | sell |
| Meridian Wealth Management, LLC | 19,223 | 20,498 | +1,275 | 0.08 | 0.10 | +0.02 | buy |
| ProShare Advisors LLC | 7,656 | 8,924 | +1,268 | 0.00 | 0.00 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 12,092 | 13,347 | +1,255 | 0.02 | 0.02 | +0.00 | buy |
| WEDBUSH SECURITIES INC | 7,120 | 8,345 | +1,225 | 0.02 | 0.03 | 0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 8,185 | 9,241 | +1,056 | 0.01 | 0.01 | +0.00 | buy |
| BALDWIN WEALTH PARTNERS LLC/MA | 47,995 | 48,995 | +1,000 | 0.29 | 0.31 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 3,762 | 4,452 | +690 | 0.16 | 0.22 | +0.07 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 6,200 | 6,700 | +500 | 0.01 | 0.01 | +0.00 | buy |
| CI INVESTMENTS INC. | 800 | 1,110 | +310 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 8,133 | 8,314 | +181 | 0.03 | 0.03 | 0.00 | buy |
| CIBC Private Wealth Group LLC | 17,864 | 17,999 | +135 | 0.00 | 0.00 | 0.00 | buy |
| NATIXIS | 1,144 | 1,087 | +57 | 0.00 | 0.00 | 0.00 | sell |
| D.A. DAVIDSON & CO. | 7,430 | 7,240 | -190 | 0.01 | 0.01 | +0.00 | sell |
| MPM BioImpact LLC | 93,586 | 93,387 | -199 | 1.75 | 1.74 | -0.01 | sell |
| Headlands Technologies LLC | 390 | 78 | -312 | 0.01 | 0.00 | -0.01 | sell |
| INTRUST BANK NA | 3,196 | 2,846 | -350 | 0.03 | 0.03 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 14,148 | 13,641 | -507 | 0.05 | 0.05 | +0.00 | sell |
| ALPS ADVISORS INC | 34,828 | 32,482 | -2,346 | 0.02 | 0.02 | +0.00 | sell |
| Lion Street Advisors, LLC | 14,282 | 11,932 | -2,350 | 0.33 | 0.39 | +0.06 | sell |
| OAK RIDGE INVESTMENTS LLC | 18,041 | 15,517 | -2,524 | 0.16 | 0.14 | -0.02 | sell |
| Pearl River Capital, LLC | 9,935 | 5,806 | -4,129 | 0.11 | 0.07 | -0.03 | sell |
| Atika Capital Management LLC | 71,000 | 66,700 | -4,300 | 0.65 | 0.71 | +0.06 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 91,091 | 84,817 | -6,274 | 0.19 | 0.20 | +0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 67,046 | 60,616 | -6,430 | 0.30 | 0.28 | -0.02 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 145,033 | 138,337 | -6,696 | 2.05 | 2.00 | -0.06 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 758,794 | 752,044 | -6,750 | 65.14 | 69.06 | +3.91 | sell |
| MOODY ALDRICH PARTNERS LLC | 73,633 | 66,866 | -6,767 | 0.98 | 0.96 | -0.02 | sell |
| Ally Bridge Group (NY) LLC | 110,600 | 100,862 | -9,738 | 9.07 | 4.78 | -4.29 | sell |
| Tri Locum Partners LP | 142,510 | 130,738 | -11,772 | 3.20 | 5.11 | +1.91 | sell |
| WMS Partners, LLC | 80,711 | 50,711 | -30,000 | 0.45 | 0.30 | -0.15 | sell |
| J. Goldman & Co LP | 53,811 | 5,555 | -48,256 | 0.13 | 0.02 | -0.11 | sell |
| PFM Health Sciences, LP | 523,210 | 467,427 | -55,783 | 1.72 | 2.23 | +0.51 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 160,676 | 94,888 | -65,788 | 0.12 | 0.08 | -0.05 | sell |
| Deep Track Capital, LP | 1,140,745 | 1,000,000 | -140,745 | 3.09 | 2.79 | -0.30 | sell |
| BVF INC/IL | 2,131,100 | 1,981,100 | -150,000 | 4.02 | 3.95 | -0.07 | sell |
| CITADEL ADVISORS LLC | 1,295,624 | 1,089,085 | -206,539 | 0.14 | 0.12 | -0.01 | sell |
| Nicholas Investment Partners, LP | 394,980 | 82,645 | -312,335 | 2.06 | 0.77 | -1.29 | sell |