| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LAZARD ASSET MANAGEMENT LLC | 85,932 | 537,669 | +451,737 | 0.01 | 0.07 | 0.00 | buy |
| BVF INC/IL | 1,046,000 | 1,388,064 | +342,064 | 2.75 | 3.98 | +1.23 | buy |
| Tri Locum Partners LP | 91,721 | 249,769 | +158,048 | 1.97 | 4.38 | +2.40 | buy |
| Sofinnova Investments, Inc. | 379,527 | 491,726 | +112,199 | 2.71 | 3.03 | +0.32 | buy |
| Woodline Partners LP | 298,569 | 408,441 | +109,872 | 0.23 | 0.23 | +0.01 | buy |
| DnB Asset Management AS | 6,144 | 73,770 | +67,626 | 0.00 | 0.03 | +0.02 | buy |
| Aberdeen Group plc | 11,048 | 72,179 | +61,131 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 58,300 | 24,142 | +34,158 | 0.01 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 8,279 | 40,323 | +32,044 | 0.02 | 0.09 | +0.07 | buy |
| Brevan Howard Capital Management LP | 14,355 | 38,748 | +24,393 | 0.01 | 0.02 | +0.01 | buy |
| Hood River Capital Management LLC | 625,084 | 644,785 | +19,701 | 0.91 | 0.81 | -0.10 | buy |
| ADAR1 Capital Management, LLC | 600 | 19,661 | +19,061 | 0.01 | 0.34 | +0.33 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 19,431 | 37,941 | +18,510 | 0.04 | 0.07 | +0.03 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 71,929 | 87,187 | +15,258 | 0.20 | 0.22 | +0.02 | buy |
| ROYCE & ASSOCIATES LP | 22,500 | 37,000 | +14,500 | 0.02 | 0.03 | +0.01 | buy |
| Point72 Europe (London) LLP | 34,570 | 41,734 | +7,164 | 0.20 | 0.20 | +0.01 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 11,823 | 17,174 | +5,351 | 0.15 | 0.21 | +0.06 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,941 | 16,028 | +5,087 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 9,722 | 12,664 | +2,942 | 0.00 | 0.00 | 0.00 | buy |
| CWM, LLC | 20,793 | 18,705 | +2,088 | 0.01 | 0.01 | -0.00 | sell |
| Lion Street Advisors, LLC | 8,255 | 9,599 | +1,344 | 0.26 | 0.26 | +0.00 | buy |
| Quarry LP | 2,000 | 750 | +1,250 | 0.06 | 0.01 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,232 | 10,276 | +1,044 | 0.09 | 0.08 | -0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 827,887 | 828,711 | +824 | 1.28 | 1.28 | -0.01 | buy |
| SHERBROOKE PARK ADVISERS LLC | 3,348 | 4,082 | +734 | 0.07 | 0.11 | +0.04 | buy |
| PROFUND ADVISORS LLC | 5,616 | 4,886 | +730 | 0.02 | 0.02 | 0.00 | sell |
| SYNOVUS FINANCIAL CORP | 15,850 | 16,128 | +278 | 0.02 | 0.02 | +0.00 | buy |
| INTRUST BANK NA | 2,640 | 2,823 | +183 | 0.02 | 0.02 | +0.00 | buy |
| Meridian Wealth Management, LLC | 21,021 | 21,171 | +150 | 0.09 | 0.08 | -0.01 | buy |
| PITCAIRN CO | 4,414 | 4,562 | +148 | 0.02 | 0.02 | -0.00 | buy |
| NATIXIS | 890 | 748 | +142 | 0.00 | 0.00 | 0.00 | sell |
| D.A. DAVIDSON & CO. | 8,160 | 8,230 | +70 | 0.01 | 0.01 | -0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 20,885 | 20,937 | +52 | 0.12 | 0.12 | -0.01 | buy |
| MONECO Advisors, LLC | 7,465 | 7,513 | +48 | 0.08 | 0.07 | -0.02 | buy |
| BALDWIN WEALTH PARTNERS LLC/MA | 49,695 | 49,570 | -125 | 0.30 | 0.29 | -0.01 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 5,100 | 4,950 | -150 | 0.01 | 0.01 | -0.00 | sell |
| Phocas Financial Corp. | 17,701 | 17,546 | -155 | 0.01 | 0.20 | +0.19 | sell |
| Hennion & Walsh Asset Management, Inc. | 58,148 | 57,836 | -312 | 0.24 | 0.22 | -0.02 | sell |
| OAK RIDGE INVESTMENTS LLC | 13,417 | 12,945 | -472 | 0.11 | 0.09 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 4,542 | 3,705 | -837 | 0.19 | 0.13 | -0.06 | sell |
| Clearbridge Investments, LLC | 114,236 | 113,077 | -1,159 | 0.01 | 0.01 | -0.00 | sell |
| Dana Investment Advisors, Inc. | 17,577 | 16,394 | -1,183 | 0.05 | 0.05 | -0.01 | sell |
| Values First Advisors, Inc. | 6,322 | 5,070 | -1,252 | 0.31 | 0.24 | -0.07 | sell |
| Cynosure Group, LLC | 7,930 | 6,547 | -1,383 | 0.10 | 0.08 | -0.02 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 113,692 | 111,996 | -1,696 | 0.02 | 0.02 | -0.00 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 126,803 | 125,079 | -1,724 | 2.44 | 2.82 | +0.38 | sell |
| GREAT LAKES ADVISORS, LLC | 16,728 | 13,508 | -3,220 | 0.01 | 0.01 | -0.00 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 738,503 | 734,317 | -4,186 | 47.94 | 53.19 | +5.25 | sell |
| Affinity Asset Advisors, LLC | 80,000 | 75,000 | -5,000 | 1.12 | 0.99 | -0.12 | sell |
| PDT Partners, LLC | 11,701 | 4,195 | -7,506 | 0.09 | 0.03 | -0.06 | sell |
| LOOMIS SAYLES & CO L P | 298,586 | 290,111 | -8,475 | 0.04 | 0.03 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 60,644 | 45,138 | -15,506 | 0.99 | 0.71 | -0.28 | sell |
| Privium Fund Management B.V. | 80,232 | 62,232 | -18,000 | 1.79 | 1.19 | -0.60 | sell |
| HighVista Strategies LLC | 41,542 | 17,124 | -24,418 | 1.29 | 0.54 | -0.75 | sell |
| Checkpoint Capital L.P. | 209,632 | 174,769 | -34,863 | 9.35 | 7.53 | -1.82 | sell |
| Atika Capital Management LLC | 57,000 | 22,000 | -35,000 | 0.53 | 0.20 | -0.33 | sell |
| First Turn Management, LLC | 255,294 | 192,146 | -63,148 | 3.63 | 2.91 | -0.72 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 120,540 | 52,768 | -67,772 | 0.10 | 0.04 | -0.06 | sell |
| Cormorant Asset Management, LP | 400,000 | 325,000 | -75,000 | 1.91 | 1.51 | -0.40 | sell |
| Avidity Partners Management LP | 296,100 | 188,000 | -108,100 | 1.36 | 1.59 | +0.23 | sell |
| PERCEPTIVE ADVISORS LLC | 782,844 | 664,074 | -118,770 | 1.49 | 1.55 | +0.06 | sell |
| RTW INVESTMENTS, LP | 4,189,557 | 4,051,365 | -138,192 | 5.45 | 5.18 | -0.26 | sell |
| Bellevue Group AG | 367,181 | 118,930 | -248,251 | 0.53 | 0.19 | -0.34 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 525,000 | 60,000 | -465,000 | 0.08 | 0.01 | -0.07 | sell |
| Fairmount Funds Management LLC | 2,360,077 | 1,468,983 | -891,094 | 17.20 | 12.36 | -4.84 | sell |