| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LAZARD ASSET MANAGEMENT LLC | 85,932 | 537,669 | +451,737 | 0.01 | 0.07 | +0.06 | buy |
| BVF INC/IL | 1,046,000 | 1,388,064 | +342,064 | 2.75 | 3.98 | +1.23 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 3,393 | 207,065 | +203,672 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 304,682 | 495,389 | +190,707 | 0.03 | 0.04 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,733 | 185,661 | +171,928 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 410,150 | 576,858 | +166,708 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 163,388 | +163,388 | 0.00 | 0.04 | +0.04 | buy |
| Tri Locum Partners LP | 91,721 | 249,769 | +158,048 | 1.97 | 4.38 | +2.40 | buy |
| BlackRock, Inc. | 3,398,379 | 3,533,394 | +135,015 | 0.01 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 127,097 | +127,097 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 30,370 | 155,911 | +125,541 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 62,167 | 181,213 | +119,046 | 0.01 | 0.04 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 0 | 116,937 | +116,937 | 0.00 | 0.16 | +0.16 | buy |
| Sofinnova Investments, Inc. | 379,527 | 491,726 | +112,199 | 2.82 | 3.05 | +0.23 | buy |
| Woodline Partners LP | 298,569 | 408,441 | +109,872 | 0.23 | 0.23 | +0.01 | buy |
| Caption Management, LLC | 10,000 | 115,686 | +105,686 | 0.10 | 0.40 | +0.31 | buy |
| UBS Group AG | 47,762 | 147,347 | +99,585 | 0.00 | 0.00 | +0.00 | buy |
| Granite Investment Partners, LLC | 0 | 91,649 | +91,649 | 0.00 | 0.34 | +0.34 | buy |
| Squarepoint Ops LLC | 0 | 89,430 | +89,430 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 73,497 | +73,497 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 332,582 | 402,500 | +69,918 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 6,144 | 73,770 | +67,626 | 0.00 | 0.03 | +0.02 | buy |
| Invesco Ltd. | 625,179 | 692,464 | +67,285 | 0.01 | 0.01 | -0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 66,661 | +66,661 | 0.00 | 4.84 | +4.84 | buy |
| Aberdeen Group plc | 11,048 | 72,179 | +61,131 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 0 | 50,000 | +50,000 | 0.00 | 0.60 | +0.60 | buy |
| TFG Asset Management GP Ltd | 0 | 41,250 | +41,250 | 0.00 | 1.13 | +1.13 | buy |
| Jefferies Financial Group Inc. | 0 | 40,700 | +40,700 | 0.00 | 0.04 | +0.04 | buy |
| ALPS ADVISORS INC | 0 | 39,190 | +39,190 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 61,785 | 97,988 | +36,203 | 0.00 | 0.00 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 33,719 | +33,719 | 0.00 | 0.35 | +0.35 | buy |
| DEUTSCHE BANK AG\ | 87,758 | 120,547 | +32,789 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 8,279 | 40,323 | +32,044 | 0.03 | 0.12 | +0.09 | buy |
| Strategic Financial Concepts, LLC | 0 | 30,713 | +30,713 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 916,808 | 947,251 | +30,443 | 0.00 | 0.00 | -0.00 | buy |
| Pallas Capital Advisors LLC | 0 | 26,435 | +26,435 | 0.00 | 0.10 | +0.10 | buy |
| Brevan Howard Capital Management LP | 14,355 | 38,748 | +24,393 | 0.06 | 0.08 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 160,534 | 182,290 | +21,756 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 625,084 | 644,785 | +19,701 | 0.91 | 0.81 | -0.10 | buy |
| ADAR1 Capital Management, LLC | 600 | 19,661 | +19,061 | 0.01 | 0.34 | +0.33 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 18,770 | +18,770 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 19,431 | 37,941 | +18,510 | 0.04 | 0.07 | +0.03 | buy |
| Russell Investments Group, Ltd. | 1,015 | 19,437 | +18,422 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 49,801 | 67,839 | +18,038 | 0.16 | 0.19 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 2,900 | 20,346 | +17,446 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 71,929 | 87,187 | +15,258 | 0.20 | 0.22 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 20,082 | 35,129 | +15,047 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 22,500 | 37,000 | +14,500 | 0.02 | 0.03 | +0.01 | buy |
| Trexquant Investment LP | 0 | 14,129 | +14,129 | 0.00 | 0.01 | +0.01 | buy |
| HighTower Advisors, LLC | 0 | 13,460 | +13,460 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 13,151 | +13,151 | 0.00 | 0.09 | +0.09 | buy |
| Calamos Advisors LLC | 0 | 12,808 | +12,808 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 12,500 | +12,500 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 391,316 | 403,026 | +11,710 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 43,092 | 54,580 | +11,488 | 0.00 | 0.00 | +0.00 | buy |
| 1492 Capital Management LLC | 0 | 11,385 | +11,385 | 0.00 | 0.46 | +0.46 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,162 | 38,211 | +11,049 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 10,555 | +10,555 | 0.00 | 0.30 | +0.30 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,714 | 57,642 | +9,928 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,648 | 22,491 | +8,843 | 0.00 | 0.00 | +0.00 | buy |
| Petrus Trust Company, LTA | 0 | 8,764 | +8,764 | 0.00 | 0.07 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 94,483 | 102,742 | +8,259 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 16,372 | 24,209 | +7,837 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 35,619 | 42,961 | +7,342 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 34,570 | 41,734 | +7,164 | 0.26 | 0.20 | -0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 6,731 | +6,731 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 7,199 | 13,745 | +6,546 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,119 | +6,119 | 0.00 | 0.09 | +0.09 | buy |
| Allianz Asset Management GmbH | 0 | 5,495 | +5,495 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 322,596 | 328,034 | +5,438 | 0.01 | 0.01 | -0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 11,823 | 17,174 | +5,351 | 0.15 | 0.21 | +0.06 | buy |
| Verition Fund Management LLC | 0 | 5,348 | +5,348 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 15,648 | 20,915 | +5,267 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,941 | 16,028 | +5,087 | 0.01 | 0.01 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 4,663 | +4,663 | 0.00 | 0.07 | +0.07 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 4,268 | +4,268 | 0.00 | 0.32 | +0.32 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 908,459 | 912,538 | +4,079 | 0.01 | 0.01 | -0.00 | buy |
| Seven Springs Wealth Group, LLC | 0 | 4,005 | +4,005 | 0.00 | 0.13 | +0.13 | buy |
| Tower Research Capital LLC (TRC) | 642 | 4,573 | +3,931 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 3,778 | +3,778 | 0.00 | 0.03 | +0.03 | buy |
| CIBC WORLD MARKETS CORP | 0 | 3,445 | +3,445 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 27,862 | 31,228 | +3,366 | 0.00 | 0.00 | +0.00 | buy |
| Flower City Capital | 0 | 3,000 | +3,000 | 0.00 | 0.16 | +0.16 | buy |
| ProShare Advisors LLC | 9,722 | 12,664 | +2,942 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 3,400 | 6,300 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 2,829 | +2,829 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 34,263 | 36,370 | +2,107 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,358 | 27,379 | +2,021 | 0.01 | 0.01 | +0.00 | buy |
| Mariner, LLC | 13,286 | 15,120 | +1,834 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,199 | 7,016 | +1,817 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 7,742 | 9,241 | +1,499 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 5,197 | 6,690 | +1,493 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 10,854 | 12,267 | +1,413 | 0.00 | 0.00 | +0.00 | buy |
| Lion Street Advisors, LLC | 8,255 | 9,599 | +1,344 | 0.26 | 0.26 | +0.00 | buy |
| MetLife Investment Management, LLC | 21,045 | 22,277 | +1,232 | 0.01 | 0.01 | -0.00 | buy |
| Cerity Partners LLC | 3,743 | 4,941 | +1,198 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 5,949 | 7,109 | +1,160 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,232 | 10,276 | +1,044 | 0.09 | 0.08 | -0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,935 | 20,921 | +986 | 0.00 | 0.00 | -0.00 | buy |