| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 4,180,646 | 4,164,818 | -15,828 | 0.01 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 3,790,929 | 3,913,543 | +122,614 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,037,448 | 1,509,870 | +472,422 | 0.01 | 0.03 | +0.02 | buy |
| Invesco Ltd. | 990,557 | 1,273,494 | +282,937 | 0.02 | 0.03 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,334,560 | 1,221,656 | -112,904 | 0.03 | 0.04 | +0.01 | sell |
| FMR LLC | 927,883 | 1,181,622 | +253,739 | 0.01 | 0.01 | +0.01 | buy |
| Deep Track Capital, LP | 900,000 | 1,150,000 | +250,000 | 3.05 | 4.79 | +1.74 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 997,700 | 1,010,249 | +12,549 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 942,960 | 958,150 | +15,190 | 0.00 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,118,883 | 888,001 | -230,882 | 1.67 | 1.62 | -0.05 | sell |
| ALETHEA CAPITAL MANAGEMENT, LLC | 670,883 | 668,710 | -2,173 | 52.44 | 59.30 | +6.86 | sell |
| BANK OF AMERICA CORP /DE/ | 361,261 | 618,033 | +256,772 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 746,398 | 571,226 | -175,172 | 1.49 | 1.63 | +0.14 | sell |
| D. E. Shaw & Co., Inc. | 296,287 | 549,113 | +252,826 | 0.03 | 0.08 | +0.05 | buy |
| NORGES BANK | 0 | 495,456 | +495,456 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 409,580 | 491,201 | +81,621 | 0.00 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 294,771 | 467,982 | +173,211 | 0.05 | 0.13 | +0.08 | buy |
| Pictet Asset Management Holding SA | 362,138 | 436,063 | +73,925 | 0.04 | 0.08 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 382,047 | 402,700 | +20,653 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 409,535 | 390,431 | -19,104 | 0.01 | 0.01 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 445,000 | 367,578 | -77,422 | 0.09 | 0.10 | +0.02 | sell |
| Hood River Capital Management LLC | 359,957 | 366,176 | +6,219 | 0.52 | 0.73 | +0.22 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 368,434 | 363,114 | -5,320 | 0.02 | 0.03 | +0.01 | sell |
| UBS Group AG | 212,451 | 355,318 | +142,867 | 0.01 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 298,341 | 349,209 | +50,868 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 285,598 | 342,573 | +56,975 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 325,626 | 325,440 | -186 | 0.06 | 0.09 | +0.03 | sell |
| MARSHALL WACE, LLP | 378,024 | 320,568 | -57,456 | 0.05 | 0.06 | +0.01 | sell |
| LOOMIS SAYLES & CO L P | 330,125 | 315,391 | -14,734 | 0.05 | 0.07 | +0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 190,106 | 304,388 | +114,282 | 0.02 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 224,139 | 300,906 | +76,767 | 0.00 | 0.01 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 326,318 | 278,835 | -47,483 | 3.06 | 4.52 | +1.46 | sell |
| Bank of New York Mellon Corp | 253,263 | 255,097 | +1,834 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 531,800 | 253,121 | -278,679 | 1.55 | 0.95 | -0.60 | sell |
| PFM Health Sciences, LP | 530,332 | 251,562 | -278,770 | 5.49 | 4.65 | -0.84 | sell |
| JPMORGAN CHASE & CO | 250,513 | 233,191 | -17,322 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 287,908 | 228,641 | -59,267 | 0.07 | 0.08 | +0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 223,408 | 220,518 | -2,890 | 0.19 | 0.27 | +0.08 | sell |
| Vestal Point Capital, LP | 150,000 | 210,000 | +60,000 | 0.83 | 1.41 | +0.58 | buy |
| First Turn Management, LLC | 152,614 | 206,921 | +54,307 | 2.78 | 4.32 | +1.54 | buy |
| CITIGROUP INC | 142,013 | 204,104 | +62,091 | 0.01 | 0.03 | +0.01 | buy |
| Tri Locum Partners LP | 292,137 | 201,627 | -90,510 | 8.16 | 4.78 | -3.37 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 188,500 | +188,500 | 0.00 | 0.07 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 209,069 | 188,258 | -20,811 | 0.08 | 0.09 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 114,050 | 173,301 | +59,251 | 0.01 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 150,000 | 170,000 | +20,000 | 0.02 | 0.05 | +0.02 | buy |
| MetLife Investment Management, LLC | 197,318 | 164,871 | -32,447 | 0.12 | 0.15 | +0.03 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 126,382 | 157,691 | +31,309 | 0.14 | 0.31 | +0.17 | buy |
| Squarepoint Ops LLC | 155,000 | 155,000 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Woodline Partners LP | 331,864 | 150,864 | -181,000 | 0.19 | 0.11 | -0.08 | sell |
| RAYMOND JAMES FINANCIAL INC | 158,689 | 150,098 | -8,591 | 0.01 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 44,150 | 149,392 | +105,242 | 0.09 | 0.43 | +0.34 | buy |
| PERCEPTIVE ADVISORS LLC | 148,900 | 148,900 | 0 | 0.52 | 0.50 | -0.02 | hold |
| TWO SIGMA INVESTMENTS, LP | 8,207 | 145,597 | +137,390 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 158,406 | 138,213 | -20,193 | 0.02 | 0.02 | +0.00 | sell |
| JANE STREET GROUP, LLC | 130,845 | 137,283 | +6,438 | 0.02 | 0.03 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 132,717 | 133,884 | +1,167 | 0.01 | 0.02 | +0.01 | buy |
| US BANCORP \DE\ | 131,533 | 130,985 | -548 | 0.02 | 0.03 | +0.01 | sell |
| Rhenman & Partners Asset Management AB | 172,800 | 114,800 | -58,000 | 2.32 | 1.96 | -0.36 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 119,696 | 112,058 | -7,638 | 0.03 | 0.03 | +0.01 | sell |
| Voleon Capital Management LP | 16,734 | 110,179 | +93,445 | 0.05 | 0.43 | +0.38 | buy |
| EMERALD ADVISERS, LLC | 108,942 | 108,082 | -860 | 0.42 | 0.61 | +0.18 | sell |
| AQR CAPITAL MANAGEMENT LLC | 118,656 | 103,418 | -15,238 | 0.01 | 0.01 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 64,400 | 103,200 | +38,800 | 0.01 | 0.01 | +0.01 | buy |
| DnB Asset Management AS | 101,981 | 101,102 | -879 | 0.05 | 0.06 | +0.02 | sell |
| AMERIPRISE FINANCIAL INC | 108,236 | 99,916 | -8,320 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 96,692 | 98,257 | +1,565 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 94,648 | 97,413 | +2,765 | 0.02 | 0.03 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 56,036 | 94,017 | +37,981 | 0.07 | 0.17 | +0.11 | buy |
| Nicholas Investment Partners, LP | 48,657 | 91,564 | +42,907 | 0.45 | 1.22 | +0.77 | buy |
| M&G Plc | 0 | 90,328 | +90,328 | 0.00 | 0.08 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 55,273 | 89,661 | +34,388 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 57,285 | 87,280 | +29,995 | 0.01 | 0.03 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 86,691 | 87,249 | +558 | 0.00 | 0.00 | +0.00 | buy |
| Granite Investment Partners, LLC | 88,558 | 84,894 | -3,664 | 0.61 | 0.92 | +0.31 | sell |
| Cannell & Spears LLC | 84,151 | 84,154 | +3 | 0.19 | 0.29 | +0.09 | buy |
| BARCLAYS PLC | 72,067 | 76,853 | +4,786 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 100,000 | 75,000 | -25,000 | 0.84 | 0.78 | -0.06 | sell |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 83,553 | 73,783 | -9,770 | 3.99 | 4.96 | +0.97 | sell |
| Summit Financial, LLC | 77,540 | 70,628 | -6,912 | 0.14 | 0.19 | +0.05 | sell |
| Neuberger Berman Group LLC | 91,178 | 69,483 | -21,695 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 66,800 | 68,900 | +2,100 | 0.00 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 67,902 | 68,858 | +956 | 0.01 | 0.02 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 65,505 | 67,608 | +2,103 | 0.41 | 0.60 | +0.19 | buy |
| AXIOM INVESTORS LLC /DE | 49,253 | 63,390 | +14,137 | 0.04 | 0.10 | +0.06 | buy |
| IFP Advisors, Inc | 63,313 | 62,448 | -865 | 0.20 | 0.26 | +0.06 | sell |
| Walleye Capital LLC | 500 | 60,100 | +59,600 | 0.00 | 0.06 | +0.06 | buy |
| Privium Fund Management B.V. | 52,732 | 56,878 | +4,146 | 1.15 | 1.91 | +0.76 | buy |
| Edgestream Partners, L.P. | 18,346 | 56,364 | +38,018 | 0.07 | 0.29 | +0.22 | buy |
| HighTower Advisors, LLC | 57,115 | 55,972 | -1,143 | 0.01 | 0.01 | +0.00 | sell |
| Atika Capital Management LLC | 49,000 | 55,500 | +6,500 | 0.51 | 1.41 | +0.90 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,065 | 53,140 | -9,925 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 60,778 | 52,233 | -8,545 | 0.01 | 0.01 | +0.00 | sell |
| Trexquant Investment LP | 9,521 | 49,136 | +39,615 | 0.01 | 0.08 | +0.07 | buy |
| BALDWIN WEALTH PARTNERS LLC/MA | 48,570 | 48,570 | 0 | 0.38 | 0.57 | +0.18 | hold |
| SEI INVESTMENTS CO | 48,127 | 47,600 | -527 | 0.01 | 0.01 | +0.00 | sell |
| Bridgewater Associates, LP | 0 | 47,444 | +47,444 | 0.00 | 0.03 | +0.03 | buy |
| BLAIR WILLIAM & CO/IL | 50,077 | 46,840 | -3,237 | 0.02 | 0.02 | +0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 64,521 | 46,633 | -17,888 | 0.24 | 0.26 | +0.03 | sell |
| Clearbridge Investments, LLC | 57,667 | 46,326 | -11,341 | 0.01 | 0.01 | +0.00 | sell |