| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Beutel, Goodman & Co Ltd. | 3,709,373 | 3,666,465 | -42,908 | 0.17 | 0.18 | +0.01 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 1,589,005 | +1,289,005 | 0.16 | 0.67 | +0.51 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,350,000 | 1,350,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Vivo Capital, LLC | 1,350,000 | 1,350,000 | 0 | 0.66 | 0.81 | +0.15 | hold |
| SCOTIA CAPITAL INC. | 1,286,183 | 1,342,178 | +55,995 | 0.04 | 0.03 | -0.01 | buy |
| Ikarian Capital, LLC | 610,000 | 1,214,741 | +604,741 | 0.60 | 1.26 | +0.66 | buy |
| GREAT POINT PARTNERS LLC | 1,200,000 | 1,200,000 | 0 | 2.94 | 2.13 | -0.81 | hold |
| Point72 Asset Management, L.P. | 712,104 | 967,575 | +255,471 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 220,024 | 762,635 | +542,611 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 0 | 700,000 | +700,000 | 0.00 | 0.34 | +0.34 | buy |
| Rubric Capital Management LP | 0 | 691,170 | +691,170 | 0.00 | 0.06 | +0.06 | buy |
| Ally Bridge Group (NY) LLC | 397,895 | 660,375 | +262,480 | 4.77 | 4.75 | -0.02 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 649,074 | +649,074 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 540,871 | +540,871 | 0.00 | 0.41 | +0.41 | buy |
| Woodline Partners LP | 0 | 440,551 | +440,551 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 375,000 | +375,000 | 0.00 | 0.01 | +0.01 | buy |
| Velan Capital Investment Management LP | 352,000 | 352,000 | 0 | 1.55 | 1.60 | +0.05 | hold |
| SummitTX Capital, L.P. | 175,948 | 327,997 | +152,049 | 0.04 | 0.08 | +0.04 | buy |
| Aisling Capital Management LP | 0 | 325,000 | +325,000 | 0.00 | 0.49 | +0.49 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 156,331 | 323,843 | +167,512 | 0.03 | 0.05 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 253,321 | 268,221 | +14,900 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 196,277 | 261,376 | +65,099 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 230,176 | +230,176 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 158,133 | 158,133 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC WORLD MARKET INC. | 58,050 | 150,950 | +92,900 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 155,766 | 93,600 | -62,166 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 92,347 | +92,347 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 9,600 | 81,725 | +72,125 | 0.00 | 0.00 | +0.00 | buy |
| INGALLS & SNYDER LLC | 77,400 | 75,650 | -1,750 | 0.02 | 0.02 | -0.00 | sell |
| 1832 Asset Management L.P. | 32,138 | 60,000 | +27,862 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 58,058 | 53,080 | -4,978 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 52,972 | 50,560 | -2,412 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 0 | 40,000 | +40,000 | 0.00 | 0.12 | +0.12 | buy |
| BANK OF MONTREAL /CAN/ | 37,250 | 38,250 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 37,926 | +37,926 | 0.00 | 0.11 | +0.11 | buy |
| TORONTO DOMINION BANK | 0 | 32,898 | +32,898 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,899 | 25,613 | +11,714 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 15,760 | +15,760 | 0.00 | 0.01 | +0.01 | buy |
| Integrated Wealth Concepts LLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| TCI Wealth Advisors, Inc. | 11,000 | 11,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| Aptus Capital Advisors, LLC | 10,000 | 10,500 | +500 | 0.00 | 0.00 | -0.00 | buy |
| GUARDIAN WEALTH ADVISORS, LLC / NC | 10,000 | 10,500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Federation des caisses Desjardins du Quebec | 9,091 | 9,091 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,429 | +6,429 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 586 | 359 | -227 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 278,064 | 0 | -278,064 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 43,186 | 0 | -43,186 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 16,180 | 0 | -16,180 | 0.00 | 0.00 | -0.00 | sell |