| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PFM Health Sciences, LP | 540,871 | 1,210,661 | +669,790 | 0.41 | 0.69 | +0.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 441,586 | +441,586 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 360,878 | +360,878 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 329,053 | +329,053 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 440,551 | 746,864 | +306,313 | 0.01 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 230,176 | 502,011 | +271,835 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 269,000 | +269,000 | 0.00 | 0.03 | +0.03 | buy |
| DAFNA Capital Management LLC | 0 | 225,600 | +225,600 | 0.00 | 0.28 | +0.28 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,800 | 221,084 | +210,284 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 691,170 | 867,424 | +176,254 | 0.06 | 0.05 | -0.01 | buy |
| CIBC WORLD MARKET INC. | 150,950 | 234,673 | +83,723 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 70,265 | +70,265 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 649,074 | 711,024 | +61,950 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 1,589,005 | 1,650,000 | +60,995 | 0.67 | 0.53 | -0.14 | buy |
| Annis Gardner Whiting Capital Advisors, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.06 | +0.06 | buy |
| ROYAL BANK OF CANADA | 261,376 | 311,435 | +50,059 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 43,491 | +43,491 | 0.00 | 0.22 | +0.22 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,429 | 46,145 | +39,716 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 34,767 | +34,767 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 34,237 | +34,237 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 19,800 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 17,644 | +17,644 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 25,613 | 36,211 | +10,598 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Lynx1 Capital Management LP | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Northwest & Ethical Investments L.P. | 0 | 6,237 | +6,237 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 15,760 | 21,150 | +5,390 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 53,080 | 58,058 | +4,978 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 50,560 | 53,503 | +2,943 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,000 | 12,500 | +2,500 | 0.01 | 0.00 | -0.00 | buy |
| SCOTIA CAPITAL INC. | 1,342,178 | 1,343,726 | +1,548 | 0.03 | 0.03 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 38,250 | 38,457 | +207 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1 | 52 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,350,000 | 1,350,015 | +15 | 0.02 | 0.02 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,200,000 | 1,200,000 | 0 | 2.13 | 1.87 | -0.26 | hold |
| MARSHALL WACE, LLP | 158,133 | 158,133 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 375,000 | 375,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TCI Wealth Advisors, Inc. | 11,000 | 11,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aptus Capital Advisors, LLC | 10,500 | 10,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 1,350,000 | 1,350,000 | 0 | 0.81 | 0.81 | +0.00 | hold |
| Aisling Capital Management LP | 325,000 | 325,000 | 0 | 0.49 | 0.46 | -0.04 | hold |
| Velan Capital Investment Management LP | 352,000 | 352,000 | 0 | 1.60 | 1.43 | -0.17 | hold |
| GUARDIAN WEALTH ADVISORS, LLC / NC | 10,500 | 10,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 9,091 | 9,091 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 359 | 8 | -351 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 32,898 | 30,920 | -1,978 | 0.00 | 0.00 | -0.00 | sell |
| TD Waterhouse Canada Inc. | 81,725 | 79,607 | -2,118 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Wealth Concepts LLC | 12,000 | 9,875 | -2,125 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 268,221 | 264,721 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| INGALLS & SNYDER LLC | 75,650 | 68,450 | -7,200 | 0.02 | 0.01 | -0.01 | sell |
| SummitTX Capital, L.P. | 327,997 | 318,784 | -9,213 | 0.08 | 0.06 | -0.02 | sell |
| 1832 Asset Management L.P. | 60,000 | 50,432 | -9,568 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 37,926 | 3,791 | -34,135 | 0.11 | 0.01 | -0.10 | sell |
| Beutel, Goodman & Co Ltd. | 3,666,465 | 3,627,864 | -38,601 | 0.18 | 0.18 | -0.00 | sell |
| DIADEMA PARTNERS LP | 40,000 | 0 | -40,000 | 0.12 | 0.00 | -0.12 | sell |
| Redmile Group, LLC | 700,000 | 611,400 | -88,600 | 0.34 | 0.27 | -0.06 | sell |
| Hudson Bay Capital Management LP | 92,347 | 0 | -92,347 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 93,600 | 0 | -93,600 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 323,843 | 212,653 | -111,190 | 0.05 | 0.03 | -0.03 | sell |
| Point72 Asset Management, L.P. | 967,575 | 730,284 | -237,291 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 762,635 | 519,211 | -243,424 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 1,214,741 | 809,741 | -405,000 | 1.26 | 0.88 | -0.38 | sell |
| Ally Bridge Group (NY) LLC | 660,375 | 252,175 | -408,200 | 4.75 | 2.15 | -2.60 | sell |