| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artisan Partners Limited Partnership | 5,830,205 | 6,367,777 | +537,572 | 0.28 | 0.49 | +0.21 | buy |
| ARK Investment Management LLC | 7,559,495 | 6,342,733 | -1,216,762 | 1.59 | 2.34 | +0.75 | sell |
| BlackRock, Inc. | 5,894,972 | 5,554,362 | -340,610 | 0.00 | 0.00 | +0.00 | sell |
| EdgePoint Investment Group Inc. | 5,377,991 | 5,382,521 | +4,530 | 1.40 | 2.05 | +0.65 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 5,954,429 | 5,269,718 | -684,711 | 0.53 | 0.83 | +0.30 | sell |
| STATE STREET CORP | 3,627,818 | 3,670,682 | +42,864 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 1,290,271 | 2,171,898 | +881,627 | 0.01 | 0.01 | +0.01 | buy |
| FMR LLC | 68,937 | 1,889,945 | +1,821,008 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,696,594 | 1,705,546 | +8,952 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,459,274 | 1,519,713 | +60,439 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,902,829 | 1,496,099 | -406,730 | 0.04 | 0.05 | +0.01 | sell |
| Nikko Asset Management Americas, Inc. | 1,902,829 | 1,496,099 | -406,730 | 0.70 | 1.01 | +0.31 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 7,650 | 1,427,650 | +1,420,000 | 0.00 | 0.40 | +0.40 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 1,361,355 | 1,312,544 | -48,811 | 0.08 | 0.12 | +0.04 | sell |
| Soleus Capital Management, L.P. | 1,861,802 | 1,226,629 | -635,173 | 2.51 | 2.36 | -0.14 | sell |
| CITADEL ADVISORS LLC | 32,049 | 1,220,400 | +1,188,351 | 0.00 | 0.04 | +0.04 | buy |
| BAILLIE GIFFORD & CO | 1,276,195 | 1,215,151 | -61,044 | 0.03 | 0.06 | +0.03 | sell |
| First Light Asset Management, LLC | 1,140,771 | 878,848 | -261,923 | 2.77 | 3.74 | +0.98 | sell |
| Tao Capital Management LP | 828,815 | 828,815 | 0 | 22.63 | 33.14 | +10.52 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,173,100 | 823,976 | -349,124 | 0.01 | 0.01 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 815,369 | 781,618 | -33,751 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 813,122 | 738,629 | -74,493 | 0.00 | 0.01 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 579,370 | 726,288 | +146,918 | 0.03 | 0.07 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 591,180 | 673,987 | +82,807 | 0.03 | 0.04 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 669,732 | +669,732 | 0.00 | 0.06 | +0.06 | buy |
| JENNISON ASSOCIATES LLC | 618,933 | 605,188 | -13,745 | 0.01 | 0.02 | +0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 415,609 | 604,047 | +188,438 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 601,163 | +601,163 | 0.00 | 0.03 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 584,696 | +584,696 | 0.00 | 0.20 | +0.20 | buy |
| BANK OF AMERICA CORP /DE/ | 399,354 | 584,261 | +184,907 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 866,356 | 546,845 | -319,511 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 548,392 | 537,111 | -11,281 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 504,838 | 527,966 | +23,128 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 492,290 | +492,290 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 401,282 | 460,287 | +59,005 | 0.01 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 455,446 | +455,446 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 662,317 | 452,526 | -209,791 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 270,099 | 354,420 | +84,321 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,497,746 | 350,604 | -1,147,142 | 0.03 | 0.01 | -0.02 | sell |
| Holocene Advisors, LP | 0 | 344,758 | +344,758 | 0.00 | 0.04 | +0.04 | buy |
| Nuveen, LLC | 290,556 | 293,655 | +3,099 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 371,552 | 284,589 | -86,963 | 0.81 | 1.03 | +0.21 | sell |
| Blue Water Life Science Advisors, LP | 383,000 | 276,000 | -107,000 | 7.63 | 10.52 | +2.89 | sell |
| Freshford Capital Management, LLC | 420,171 | 258,982 | -161,189 | 5.35 | 6.15 | +0.80 | sell |
| Schonfeld Strategic Advisors LLC | 139,893 | 258,604 | +118,711 | 0.02 | 0.10 | +0.08 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 269,093 | 244,025 | -25,068 | 0.06 | 0.08 | +0.03 | sell |
| Meridiem Capital Partners LP | 21,205 | 239,669 | +218,464 | 0.04 | 0.75 | +0.71 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 288,283 | 220,079 | -68,204 | 0.28 | 0.39 | +0.11 | sell |
| OSTERWEIS CAPITAL MANAGEMENT INC | 256,878 | 211,158 | -45,720 | 0.34 | 0.52 | +0.17 | sell |
| Duquesne Family Office LLC | 0 | 206,000 | +206,000 | 0.00 | 0.33 | +0.33 | buy |
| JPMORGAN CHASE & CO | 215,147 | 205,767 | -9,380 | 0.00 | 0.00 | +0.00 | sell |
| Pictet Asset Management Holding SA | 222,647 | 185,992 | -36,655 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 182,941 | 180,817 | -2,124 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 198,473 | 170,107 | -28,366 | 0.06 | 0.06 | +0.00 | sell |
| Squarepoint Ops LLC | 35,717 | 153,526 | +117,809 | 0.00 | 0.02 | +0.01 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 153,172 | 153,172 | 0 | 0.02 | 0.04 | +0.01 | hold |
| PERCEPTIVE ADVISORS LLC | 0 | 150,000 | +150,000 | 0.00 | 0.14 | +0.14 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 135,650 | 145,960 | +10,310 | 0.16 | 0.27 | +0.11 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 65,122 | 131,265 | +66,143 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 171,206 | 128,075 | -43,131 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 129,552 | 124,753 | -4,799 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 119,000 | 119,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vestmark Advisory Solutions, Inc. | 129,990 | 109,266 | -20,724 | 0.06 | 0.06 | +0.00 | sell |
| Neuberger Berman Group LLC | 135,622 | 108,300 | -27,322 | 0.00 | 0.00 | +0.00 | sell |
| Clearstead Advisors, LLC | 8,013 | 107,303 | +99,290 | 0.00 | 0.05 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 106,712 | +106,712 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 104,650 | +104,650 | 0.00 | 0.00 | +0.00 | buy |
| Metavasi Capital LP | 0 | 100,000 | +100,000 | 0.00 | 2.83 | +2.83 | buy |
| LORD, ABBETT & CO. LLC | 0 | 99,630 | +99,630 | 0.00 | 0.02 | +0.02 | buy |
| Man Group plc | 0 | 96,470 | +96,470 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 114,258 | 96,255 | -18,003 | 0.01 | 0.02 | +0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 94,111 | 95,783 | +1,672 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,753 | 90,319 | +19,566 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 91,122 | 90,044 | -1,078 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,318 | 79,078 | +2,760 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 212,593 | 75,012 | -137,581 | 0.01 | 0.01 | -0.01 | sell |
| Aberdeen Group plc | 308,116 | 73,619 | -234,497 | 0.02 | 0.01 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,337 | 70,348 | +12,011 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,985 | 70,305 | +11,320 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 66,524 | 67,437 | +913 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 22,444 | 66,565 | +44,121 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 38,649 | 65,556 | +26,907 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 55,671 | 64,536 | +8,865 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 66,027 | 57,628 | -8,399 | 0.00 | 0.00 | +0.00 | sell |
| BLAIR WILLIAM & CO/IL | 81,561 | 57,417 | -24,144 | 0.01 | 0.01 | +0.00 | sell |
| LPL Financial LLC | 53,043 | 56,890 | +3,847 | 0.00 | 0.00 | +0.00 | buy |
| Conestoga Capital Advisors, LLC | 56,785 | 56,785 | 0 | 0.03 | 0.05 | +0.02 | hold |
| Baird Financial Group, Inc. | 0 | 53,867 | +53,867 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 53,881 | 51,960 | -1,921 | 0.00 | 0.00 | +0.00 | sell |
| IEQ CAPITAL, LLC | 51,335 | 51,184 | -151 | 0.00 | 0.01 | +0.01 | sell |
| D. E. Shaw & Co., Inc. | 27,581 | 46,644 | +19,063 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 37,555 | 45,411 | +7,856 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 518,355 | 43,110 | -475,245 | 2.82 | 0.39 | -2.43 | sell |
| PROFUND ADVISORS LLC | 42,355 | 43,039 | +684 | 0.04 | 0.08 | +0.03 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 44,668 | 42,418 | -2,250 | 0.00 | 0.00 | +0.00 | sell |
| HighMark Wealth Management LLC | 39,462 | 39,290 | -172 | 0.51 | 0.76 | +0.25 | sell |
| AMERICAN CENTURY COMPANIES INC | 865,634 | 37,838 | -827,796 | 0.01 | 0.00 | -0.01 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 37,399 | +37,399 | 0.00 | 0.14 | +0.14 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 37,200 | +37,200 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,547 | 34,401 | -146 | 0.00 | 0.00 | +0.00 | sell |