| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,655,922 | 6,601,830 | +945,908 | 0.02 | 0.02 | -0.00 | buy |
| Avoro Capital Advisors LLC | 5,666,666 | 5,666,666 | 0 | 3.61 | 2.85 | -0.76 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,345,180 | 4,321,740 | -23,440 | 2.41 | 1.85 | -0.56 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,162,654 | 3,922,058 | -240,596 | 0.04 | 0.03 | -0.01 | sell |
| Capital World Investors | 2,681,537 | 2,681,537 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Polar Capital Holdings Plc | 3,066,628 | 2,612,108 | -454,520 | 0.87 | 0.59 | -0.28 | sell |
| Paradigm Biocapital Advisors LP | 2,127,400 | 2,484,874 | +357,474 | 4.59 | 3.77 | -0.83 | buy |
| Capital International Investors | 2,455,683 | 2,475,859 | +20,176 | 0.03 | 0.02 | -0.00 | buy |
| Commodore Capital LP | 2,167,793 | 2,167,793 | 0 | 8.72 | 6.24 | -2.48 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,048,725 | 1,671,917 | +623,192 | 0.10 | 0.14 | +0.04 | buy |
| Pictet Asset Management Holding SA | 2,040,400 | 1,515,426 | -524,974 | 0.10 | 0.07 | -0.03 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,574,568 | 1,468,446 | -106,122 | 0.03 | 0.02 | -0.01 | sell |
| MARSHALL WACE, LLP | 1,528,648 | 1,450,342 | -78,306 | 0.13 | 0.10 | -0.03 | sell |
| T. Rowe Price Investment Management, Inc. | 891,149 | 1,426,339 | +535,190 | 0.03 | 0.04 | +0.01 | buy |
| First Light Asset Management, LLC | 1,645,490 | 1,320,172 | -325,318 | 6.10 | 4.35 | -1.75 | sell |
| BRAIDWELL LP | 1,647,311 | 1,308,011 | -339,300 | 2.79 | 1.81 | -0.97 | sell |
| CITADEL ADVISORS LLC | 1,266,844 | 1,287,075 | +20,231 | 0.06 | 0.05 | -0.01 | buy |
| Rock Springs Capital Management LP | 1,255,577 | 1,255,577 | 0 | 1.43 | 1.37 | -0.05 | hold |
| Invesco Ltd. | 719,718 | 1,049,526 | +329,808 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 993,679 | 993,679 | 0 | 0.52 | 0.54 | +0.02 | hold |
| JANUS HENDERSON GROUP PLC | 966,065 | 941,569 | -24,496 | 0.03 | 0.02 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 717,972 | 895,196 | +177,224 | 0.12 | 0.12 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,100,748 | 892,208 | -208,540 | 1.13 | 0.68 | -0.46 | sell |
| Affinity Asset Advisors, LLC | 460,000 | 837,387 | +377,387 | 4.22 | 5.86 | +1.64 | buy |
| TimesSquare Capital Management, LLC | 793,954 | 737,173 | -56,781 | 0.54 | 0.46 | -0.08 | sell |
| FEDERATED HERMES, INC. | 346,596 | 734,900 | +388,304 | 0.04 | 0.07 | +0.03 | buy |
| Avidity Partners Management LP | 815,993 | 710,000 | -105,993 | 1.44 | 1.09 | -0.35 | sell |
| LOOMIS SAYLES & CO L P | 708,295 | 686,510 | -21,785 | 0.05 | 0.04 | -0.01 | sell |
| First Turn Management, LLC | 680,389 | 680,389 | 0 | 4.50 | 4.38 | -0.12 | hold |
| Fiera Capital Corp | 553,030 | 576,542 | +23,512 | 0.08 | 0.07 | -0.01 | buy |
| JENNISON ASSOCIATES LLC | 566,396 | 563,952 | -2,444 | 0.02 | 0.02 | -0.00 | sell |
| Candriam S.C.A. | 530,884 | 560,884 | +30,000 | 0.17 | 0.15 | -0.01 | buy |
| ORBIMED ADVISORS LLC | 550,000 | 550,000 | 0 | 0.51 | 0.43 | -0.07 | hold |
| FRANKLIN RESOURCES INC | 293,825 | 542,289 | +248,464 | 0.01 | 0.01 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 600,000 | 456,148 | -143,852 | 4.71 | 3.06 | -1.65 | sell |
| BNP Paribas Asset Management Holding S.A. | 0 | 416,736 | +416,736 | 0.00 | 0.05 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 402,668 | 410,207 | +7,539 | 0.01 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 175,000 | 400,000 | +225,000 | 0.85 | 1.42 | +0.57 | buy |
| SAMLYN CAPITAL, LLC | 421,155 | 396,196 | -24,959 | 0.42 | 0.30 | -0.12 | sell |
| MORGAN STANLEY | 225,147 | 386,199 | +161,052 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 290,535 | 348,000 | +57,465 | 9.22 | 6.69 | -2.53 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 237,495 | 347,351 | +109,856 | 0.06 | 0.08 | +0.01 | buy |
| VANGUARD GROUP INC | 323,495 | 335,635 | +12,140 | 0.00 | 0.00 | -0.00 | buy |
| Ally Bridge Group (NY) LLC | 241,961 | 309,369 | +67,408 | 6.64 | 7.40 | +0.76 | buy |
| GOLDMAN SACHS GROUP INC | 376,302 | 299,774 | -76,528 | 0.00 | 0.00 | -0.00 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 255,432 | 291,403 | +35,971 | 2.75 | 2.54 | -0.21 | buy |
| Point72 Asset Management, L.P. | 875,065 | 275,859 | -599,206 | 0.12 | 0.03 | -0.09 | sell |
| TWO SIGMA INVESTMENTS, LP | 340,015 | 274,626 | -65,389 | 0.04 | 0.03 | -0.01 | sell |
| DAFNA Capital Management LLC | 276,739 | 273,739 | -3,000 | 3.05 | 2.68 | -0.37 | sell |
| Artal Group S.A. | 0 | 253,387 | +253,387 | 0.00 | 0.28 | +0.28 | buy |
| Granahan Investment Management, LLC | 302,581 | 244,080 | -58,501 | 0.46 | 0.37 | -0.09 | sell |
| STATE STREET CORP | 227,040 | 242,640 | +15,600 | 0.00 | 0.00 | -0.00 | buy |
| Laurion Capital Management LP | 75,000 | 239,126 | +164,126 | 0.12 | 0.29 | +0.16 | buy |
| Alyeska Investment Group, L.P. | 0 | 238,843 | +238,843 | 0.00 | 0.06 | +0.06 | buy |
| TWO SIGMA ADVISERS, LP | 252,700 | 229,200 | -23,500 | 0.03 | 0.02 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 294,788 | 223,942 | -70,846 | 1.92 | 1.18 | -0.74 | sell |
| Tri Locum Partners LP | 225,564 | 207,465 | -18,099 | 5.10 | 3.10 | -2.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 15,851 | 201,274 | +185,423 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 84,153 | 198,526 | +114,373 | 0.01 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 190,312 | 192,752 | +2,440 | 0.01 | 0.01 | -0.00 | buy |
| AXA S.A. | 187,821 | 187,872 | +51 | 0.03 | 0.02 | -0.00 | buy |
| Assenagon Asset Management S.A. | 99,731 | 186,606 | +86,875 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 217,320 | 184,015 | -33,305 | 0.40 | 0.31 | -0.09 | sell |
| Russell Investments Group, Ltd. | 174,286 | 178,099 | +3,813 | 0.01 | 0.01 | -0.00 | buy |
| Nicholas Investment Partners, LP | 87,752 | 167,926 | +80,174 | 0.47 | 0.74 | +0.27 | buy |
| Ensign Peak Advisors, Inc | 164,380 | 163,064 | -1,316 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 133,412 | 157,104 | +23,692 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 165,267 | 154,038 | -11,229 | 0.09 | 0.08 | -0.01 | sell |
| PFM Health Sciences, LP | 192,856 | 150,554 | -42,302 | 0.53 | 0.32 | -0.21 | sell |
| BRIDGER MANAGEMENT, LLC | 146,800 | 146,800 | 0 | 2.59 | 2.85 | +0.26 | hold |
| DnB Asset Management AS | 126,375 | 126,250 | -125 | 0.03 | 0.03 | -0.00 | sell |
| Swiss National Bank | 123,800 | 123,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atika Capital Management LLC | 93,234 | 122,000 | +28,766 | 0.61 | 0.59 | -0.02 | buy |
| Ikarian Capital, LLC | 0 | 107,187 | +107,187 | 0.00 | 1.26 | +1.26 | buy |
| Nan Fung Group Holdings Ltd | 106,680 | 106,680 | 0 | 3.06 | 4.26 | +1.19 | hold |
| BAMCO INC /NY/ | 100,100 | 100,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TWINBEECH CAPITAL LP | 0 | 98,042 | +98,042 | 0.00 | 0.09 | +0.09 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 95,336 | 91,785 | -3,551 | 0.01 | 0.01 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 91,500 | 91,500 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 76,965 | 83,661 | +6,696 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 87,500 | 79,951 | -7,549 | 0.03 | 0.03 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 77,484 | 77,484 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 51,801 | 72,715 | +20,914 | 0.87 | 1.12 | +0.25 | buy |
| Bank of New York Mellon Corp | 66,659 | 66,910 | +251 | 0.00 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 163,168 | 66,090 | -97,078 | 2.32 | 0.80 | -1.52 | sell |
| Jefferies Financial Group Inc. | 66,723 | 65,637 | -1,086 | 0.05 | 0.06 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 64,940 | 64,940 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 62,073 | 64,229 | +2,156 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 58,423 | 61,457 | +3,034 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 59,000 | 59,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of New Jersey Common Pension Fund D | 71,013 | 56,750 | -14,263 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,987 | 56,477 | +490 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 32,600 | 56,400 | +23,800 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 53,649 | 55,010 | +1,361 | 0.00 | 0.00 | -0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 65,000 | 55,000 | -10,000 | 0.07 | 0.05 | -0.02 | sell |
| ALPS ADVISORS INC | 50,780 | 53,200 | +2,420 | 0.02 | 0.02 | -0.00 | buy |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| LMR Partners LLP | 958 | 48,668 | +47,710 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 61,971 | 48,470 | -13,501 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 45,229 | 48,177 | +2,948 | 0.00 | 0.00 | -0.00 | buy |