| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,655,922 | 6,601,830 | +945,908 | 0.02 | 0.02 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,048,725 | 1,671,917 | +623,192 | 0.10 | 0.14 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 891,149 | 1,426,339 | +535,190 | 0.03 | 0.04 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 416,736 | +416,736 | 0.00 | 0.05 | +0.05 | buy |
| FEDERATED HERMES, INC. | 346,596 | 734,900 | +388,304 | 0.04 | 0.07 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 460,000 | 837,387 | +377,387 | 4.22 | 5.86 | +1.64 | buy |
| Paradigm Biocapital Advisors LP | 2,127,400 | 2,484,874 | +357,474 | 4.59 | 3.77 | -0.83 | buy |
| Invesco Ltd. | 719,718 | 1,049,526 | +329,808 | 0.01 | 0.01 | +0.00 | buy |
| Artal Group S.A. | 0 | 253,387 | +253,387 | 0.00 | 0.28 | +0.28 | buy |
| FRANKLIN RESOURCES INC | 293,825 | 542,289 | +248,464 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 238,843 | +238,843 | 0.00 | 0.06 | +0.06 | buy |
| Vestal Point Capital, LP | 175,000 | 400,000 | +225,000 | 0.85 | 1.42 | +0.57 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 15,851 | 201,274 | +185,423 | 0.00 | 0.02 | +0.02 | buy |
| LORD, ABBETT & CO. LLC | 717,972 | 895,196 | +177,224 | 0.12 | 0.12 | +0.01 | buy |
| Laurion Capital Management LP | 75,000 | 239,126 | +164,126 | 0.12 | 0.29 | +0.16 | buy |
| MORGAN STANLEY | 225,147 | 386,199 | +161,052 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 84,153 | 198,526 | +114,373 | 0.01 | 0.01 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 237,495 | 347,351 | +109,856 | 0.06 | 0.08 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 107,187 | +107,187 | 0.00 | 1.26 | +1.26 | buy |
| TWINBEECH CAPITAL LP | 0 | 98,042 | +98,042 | 0.00 | 0.09 | +0.09 | buy |
| Assenagon Asset Management S.A. | 99,731 | 186,606 | +86,875 | 0.01 | 0.02 | +0.01 | buy |
| Nicholas Investment Partners, LP | 87,752 | 167,926 | +80,174 | 0.47 | 0.74 | +0.27 | buy |
| Ally Bridge Group (NY) LLC | 241,961 | 309,369 | +67,408 | 6.64 | 7.40 | +0.76 | buy |
| Altium Capital Management LLC | 290,535 | 348,000 | +57,465 | 9.22 | 6.69 | -2.53 | buy |
| LMR Partners LLP | 958 | 48,668 | +47,710 | 0.00 | 0.05 | +0.05 | buy |
| Trexquant Investment LP | 0 | 46,874 | +46,874 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 0 | 45,286 | +45,286 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 40,000 | +40,000 | 0.00 | 0.42 | +0.42 | buy |
| DEUTSCHE BANK AG\ | 2,495 | 38,711 | +36,216 | 0.00 | 0.00 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 255,432 | 291,403 | +35,971 | 2.75 | 2.54 | -0.21 | buy |
| Candriam S.C.A. | 530,884 | 560,884 | +30,000 | 0.17 | 0.15 | -0.01 | buy |
| Atika Capital Management LLC | 93,234 | 122,000 | +28,766 | 0.61 | 0.59 | -0.02 | buy |
| Engineers Gate Manager LP | 0 | 26,513 | +26,513 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 32,600 | 56,400 | +23,800 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 133,412 | 157,104 | +23,692 | 0.00 | 0.00 | -0.00 | buy |
| Fiera Capital Corp | 553,030 | 576,542 | +23,512 | 0.08 | 0.07 | -0.01 | buy |
| Jump Financial, LLC | 24,000 | 46,079 | +22,079 | 0.04 | 0.05 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 21,614 | +21,614 | 0.00 | 0.07 | +0.07 | buy |
| HighVista Strategies LLC | 51,801 | 72,715 | +20,914 | 0.87 | 1.12 | +0.25 | buy |
| CITADEL ADVISORS LLC | 1,266,844 | 1,287,075 | +20,231 | 0.06 | 0.05 | -0.01 | buy |
| Capital International Investors | 2,455,683 | 2,475,859 | +20,176 | 0.03 | 0.02 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 18,305 | +18,305 | 0.00 | 0.06 | +0.06 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,584 | 31,280 | +15,696 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 227,040 | 242,640 | +15,600 | 0.00 | 0.00 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 15,092 | +15,092 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 323,495 | 335,635 | +12,140 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 0 | 9,700 | +9,700 | 0.00 | 0.04 | +0.04 | buy |
| Entropy Technologies, LP | 0 | 9,649 | +9,649 | 0.00 | 0.04 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 402,668 | 410,207 | +7,539 | 0.01 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 6,900 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 76,965 | 83,661 | +6,696 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 6,661 | +6,661 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 8,546 | 14,520 | +5,974 | 0.08 | 0.08 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 8,217 | 13,698 | +5,481 | 0.00 | 0.01 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 9,123 | 14,451 | +5,328 | 0.08 | 0.11 | +0.03 | buy |
| UBS Group AG | 30,943 | 36,246 | +5,303 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 19,500 | 24,700 | +5,200 | 0.02 | 0.03 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 5,105 | +5,105 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 0 | 5,000 | +5,000 | 0.00 | 0.13 | +0.13 | buy |
| NEOS Investment Management LLC | 0 | 4,972 | +4,972 | 0.00 | 0.01 | +0.01 | buy |
| Corton Capital Inc. | 0 | 4,864 | +4,864 | 0.00 | 0.08 | +0.08 | buy |
| CANADA LIFE ASSURANCE Co | 5,341 | 10,032 | +4,691 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 4,541 | +4,541 | 0.00 | 0.18 | +0.18 | buy |
| TD ASSET MANAGEMENT INC | 16,230 | 20,430 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 27,600 | 31,770 | +4,170 | 0.09 | 0.07 | -0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,390 | 8,321 | +3,931 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 174,286 | 178,099 | +3,813 | 0.01 | 0.01 | -0.00 | buy |
| Advisors Asset Management, Inc. | 10,416 | 13,717 | +3,301 | 0.01 | 0.01 | +0.00 | buy |
| ASSETMARK, INC | 9,938 | 13,185 | +3,247 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 3,225 | +3,225 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 58,423 | 61,457 | +3,034 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 45,229 | 48,177 | +2,948 | 0.00 | 0.00 | -0.00 | buy |
| 17 CAPITAL PARTNERS, LLC | 0 | 2,840 | +2,840 | 0.00 | 0.29 | +0.29 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 8,861 | 11,402 | +2,541 | 0.01 | 0.01 | +0.00 | buy |
| Vident Advisory, LLC | 5,292 | 7,801 | +2,509 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 7,199 | 9,655 | +2,456 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 190,312 | 192,752 | +2,440 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 50,780 | 53,200 | +2,420 | 0.02 | 0.02 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 62,073 | 64,229 | +2,156 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 9,529 | 11,388 | +1,859 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 18,606 | 20,366 | +1,760 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 53,649 | 55,010 | +1,361 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 20,881 | 22,175 | +1,294 | 0.00 | 0.00 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 4,428 | 5,374 | +946 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 909 | +909 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,980 | 2,680 | +700 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 933 | 1,564 | +631 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 4,721 | 5,286 | +565 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,987 | 56,477 | +490 | 0.00 | 0.00 | -0.00 | buy |
| Avior Wealth Management, LLC | 0 | 302 | +302 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,000 | 1,300 | +300 | 0.02 | 0.02 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 276 | +276 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 66,659 | 66,910 | +251 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,014 | 1,226 | +212 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 46 | 164 | +118 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 187,821 | 187,872 | +51 | 0.03 | 0.02 | -0.00 | buy |
| Parallel Advisors, LLC | 1,125 | 1,157 | +32 | 0.00 | 0.00 | -0.00 | buy |
| Bell Investment Advisors, Inc | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |