| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,048,725 | 1,671,917 | +623,192 | 0.10 | 0.14 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 891,149 | 1,426,339 | +535,190 | 0.03 | 0.04 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 460,000 | 837,387 | +377,387 | 4.22 | 5.86 | +1.64 | buy |
| Paradigm Biocapital Advisors LP | 2,127,400 | 2,484,874 | +357,474 | 4.59 | 3.77 | -0.83 | buy |
| Vestal Point Capital, LP | 175,000 | 400,000 | +225,000 | 0.85 | 1.42 | +0.57 | buy |
| LORD, ABBETT & CO. LLC | 717,972 | 895,196 | +177,224 | 0.12 | 0.12 | +0.01 | buy |
| Laurion Capital Management LP | 75,000 | 239,126 | +164,126 | 0.03 | 0.09 | +0.06 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 237,495 | 347,351 | +109,856 | 0.06 | 0.08 | +0.01 | buy |
| Nicholas Investment Partners, LP | 87,752 | 167,926 | +80,174 | 0.47 | 0.74 | +0.27 | buy |
| Ally Bridge Group (NY) LLC | 241,961 | 309,369 | +67,408 | 6.64 | 7.40 | +0.76 | buy |
| TWO SIGMA INVESTMENTS, LP | 340,015 | 274,626 | +65,389 | 0.04 | 0.03 | 0.00 | sell |
| Altium Capital Management LLC | 290,535 | 348,000 | +57,465 | 9.22 | 6.69 | -2.53 | buy |
| LMR Partners LLP | 958 | 48,668 | +47,710 | 0.00 | 0.05 | +0.05 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 255,432 | 291,403 | +35,971 | 2.75 | 2.54 | -0.21 | buy |
| ALGERT GLOBAL LLC | 217,320 | 184,015 | +33,305 | 0.41 | 0.31 | 0.00 | sell |
| Candriam S.C.A. | 530,884 | 560,884 | +30,000 | 0.17 | 0.15 | -0.01 | buy |
| Atika Capital Management LLC | 93,234 | 122,000 | +28,766 | 0.58 | 0.52 | -0.06 | buy |
| JANUS HENDERSON GROUP PLC | 966,065 | 941,569 | +24,496 | 0.03 | 0.02 | 0.00 | sell |
| Fiera Capital Corp | 553,030 | 576,542 | +23,512 | 0.08 | 0.07 | -0.01 | buy |
| HighVista Strategies LLC | 51,801 | 72,715 | +20,914 | 0.87 | 1.12 | +0.25 | buy |
| Capital International Investors | 2,455,683 | 2,475,859 | +20,176 | 0.03 | 0.02 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 165,267 | 154,038 | +11,229 | 0.10 | 0.08 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 14,676 | 7,987 | +6,689 | 0.05 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,546 | 14,520 | +5,974 | 0.08 | 0.08 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 9,123 | 14,451 | +5,328 | 0.08 | 0.11 | +0.03 | buy |
| Cinctive Capital Management LP | 27,600 | 31,770 | +4,170 | 0.09 | 0.07 | -0.02 | buy |
| Advisors Asset Management, Inc. | 10,416 | 13,717 | +3,301 | 0.01 | 0.01 | 0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 190,312 | 192,752 | +2,440 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 50,780 | 53,200 | +2,420 | 0.02 | 0.02 | -0.00 | buy |
| Quarry LP | 1,000 | 1,300 | +300 | 0.02 | 0.02 | 0.00 | buy |
| DnB Asset Management AS | 126,375 | 126,250 | -125 | 0.03 | 0.03 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,245 | 2,103 | -142 | 0.07 | 0.05 | -0.02 | sell |
| CIBC WORLD MARKET INC. | 37,892 | 37,320 | -572 | 0.00 | 0.00 | -0.00 | sell |
| AXQ CAPITAL, LP | 7,006 | 5,662 | -1,344 | 0.09 | 0.06 | -0.03 | sell |
| Elmwood Wealth Management, Inc. | 10,069 | 7,943 | -2,126 | 0.33 | 0.15 | -0.18 | sell |
| JENNISON ASSOCIATES LLC | 566,396 | 563,952 | -2,444 | 0.02 | 0.02 | -0.00 | sell |
| DAFNA Capital Management LLC | 276,739 | 273,739 | -3,000 | 3.05 | 2.68 | -0.37 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 8,043 | 4,863 | -3,180 | 0.07 | 0.05 | -0.02 | sell |
| Atom Investors LP | 15,247 | 9,603 | -5,644 | 0.12 | 0.05 | -0.07 | sell |
| Bellevue Group AG | 22,000 | 14,100 | -7,900 | 0.02 | 0.01 | -0.01 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 65,000 | 55,000 | -10,000 | 0.05 | 0.04 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 32,196 | 18,311 | -13,885 | 0.13 | 0.06 | -0.07 | sell |
| Tri Locum Partners LP | 225,564 | 207,465 | -18,099 | 5.10 | 3.10 | -2.00 | sell |
| LOOMIS SAYLES & CO L P | 708,295 | 686,510 | -21,785 | 0.05 | 0.04 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,345,180 | 4,321,740 | -23,440 | 2.41 | 1.85 | -0.56 | sell |
| SAMLYN CAPITAL, LLC | 421,155 | 396,196 | -24,959 | 0.39 | 0.29 | -0.10 | sell |
| PFM Health Sciences, LP | 192,856 | 150,554 | -42,302 | 0.53 | 0.30 | -0.23 | sell |
| TimesSquare Capital Management, LLC | 793,954 | 737,173 | -56,781 | 0.54 | 0.46 | -0.08 | sell |
| Granahan Investment Management, LLC | 302,581 | 244,080 | -58,501 | 0.46 | 0.37 | -0.09 | sell |
| Parkman Healthcare Partners LLC | 294,788 | 223,942 | -70,846 | 1.92 | 1.18 | -0.74 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 163,168 | 66,090 | -97,078 | 2.32 | 0.80 | -1.52 | sell |
| Avidity Partners Management LP | 815,993 | 710,000 | -105,993 | 1.44 | 1.09 | -0.35 | sell |
| GREAT POINT PARTNERS LLC | 600,000 | 456,148 | -143,852 | 4.71 | 3.06 | -1.65 | sell |
| PERCEPTIVE ADVISORS LLC | 1,100,748 | 892,208 | -208,540 | 1.13 | 0.67 | -0.46 | sell |
| First Light Asset Management, LLC | 1,645,490 | 1,320,172 | -325,318 | 6.10 | 4.35 | -1.75 | sell |
| BRAIDWELL LP | 1,647,311 | 1,308,011 | -339,300 | 2.79 | 1.81 | -0.97 | sell |
| Polar Capital Holdings Plc | 3,066,628 | 2,612,108 | -454,520 | 0.87 | 0.59 | -0.28 | sell |