| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 169,132 | 1,000,000 | +830,868 | 0.25 | 1.09 | +0.84 | buy |
| FMR LLC | 7,525,290 | 8,287,499 | +762,209 | 0.02 | 0.02 | +0.00 | buy |
| Logos Global Management LP | 0 | 650,000 | +650,000 | 0.00 | 3.88 | +3.88 | buy |
| Capital International Investors | 2,547,210 | 3,088,730 | +541,520 | 0.02 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 810,000 | 1,300,000 | +490,000 | 1.88 | 3.11 | +1.23 | buy |
| JANUS HENDERSON GROUP PLC | 2,866,755 | 3,325,093 | +458,338 | 0.06 | 0.06 | +0.01 | buy |
| CITADEL ADVISORS LLC | 327,303 | 687,088 | +359,785 | 0.01 | 0.02 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,157,189 | 1,391,370 | +234,181 | 0.20 | 0.23 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 209,759 | +209,759 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 46,597 | 251,147 | +204,550 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,161,237 | 1,328,175 | +166,938 | 7.11 | 6.98 | -0.14 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 13,700 | 154,700 | +141,000 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 283,899 | 404,154 | +120,255 | 0.02 | 0.03 | +0.01 | buy |
| MPM BioImpact LLC | 197,212 | 303,398 | +106,186 | 1.10 | 1.75 | +0.65 | buy |
| UBS Group AG | 0 | 105,333 | +105,333 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 322,470 | 413,711 | +91,241 | 4.95 | 7.00 | +2.05 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 184,580 | 267,142 | +82,562 | 0.02 | 0.02 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 288,843 | 367,233 | +78,390 | 0.04 | 0.05 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 50,547 | 127,548 | +77,001 | 0.41 | 0.82 | +0.42 | buy |
| Avoro Capital Advisors LLC | 5,666,666 | 5,741,666 | +75,000 | 3.14 | 3.01 | -0.14 | buy |
| Nicholas Investment Partners, LP | 14,658 | 86,968 | +72,310 | 0.05 | 0.30 | +0.25 | buy |
| D. E. Shaw & Co., Inc. | 86,973 | 152,188 | +65,215 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,520,595 | 4,584,859 | +64,264 | 1.46 | 1.48 | +0.02 | buy |
| MORGAN STANLEY | 68,062 | 129,491 | +61,429 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 106,680 | 158,605 | +51,925 | 3.58 | 4.34 | +0.76 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,863,473 | 1,914,749 | +51,276 | 0.13 | 0.12 | -0.01 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 48,763 | +48,763 | 0.00 | 0.02 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 20,331 | 63,385 | +43,054 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 663,704 | 703,795 | +40,091 | 0.06 | 0.06 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 410,246 | 442,732 | +32,486 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 106,906 | 136,569 | +29,663 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 203,243 | 229,482 | +26,239 | 0.03 | 0.04 | +0.00 | buy |
| Nebula Research & Development LLC | 20,360 | 46,561 | +26,201 | 0.09 | 0.14 | +0.05 | buy |
| CenterBook Partners LP | 0 | 22,211 | +22,211 | 0.00 | 0.05 | +0.05 | buy |
| STATE STREET CORP | 288,722 | 305,620 | +16,898 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 65,783 | 81,024 | +15,241 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 17,786 | 30,573 | +12,787 | 0.01 | 0.02 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,949 | +11,949 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,777,611 | 3,789,197 | +11,586 | 0.03 | 0.02 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 92,350 | 103,624 | +11,274 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 10,000 | 21,000 | +11,000 | 0.32 | 0.61 | +0.29 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 10,121 | +10,121 | 0.00 | 0.07 | +0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 132,521 | 142,372 | +9,851 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 9,404 | +9,404 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 8,872 | +8,872 | 0.00 | 0.14 | +0.14 | buy |
| Schonfeld Strategic Advisors LLC | 15,150 | 22,954 | +7,804 | 0.00 | 0.01 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 40,376 | 47,457 | +7,081 | 0.01 | 0.01 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 49,818 | 56,591 | +6,773 | 0.09 | 0.09 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 6,445 | +6,445 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,520 | 65,912 | +6,392 | 0.00 | 0.00 | -0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 6,174 | +6,174 | 0.00 | 0.10 | +0.10 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 11,441 | 16,975 | +5,534 | 0.08 | 0.08 | -0.00 | buy |
| Verition Fund Management LLC | 8,297 | 12,508 | +4,211 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 4,161 | +4,161 | 0.00 | 0.04 | +0.04 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 8,621 | 11,372 | +2,751 | 0.06 | 0.06 | -0.00 | buy |
| Assenagon Asset Management S.A. | 238,522 | 241,206 | +2,684 | 0.02 | 0.01 | -0.00 | buy |
| Aquatic Capital Management LLC | 8,260 | 10,511 | +2,251 | 0.01 | 0.01 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 13,436 | 15,531 | +2,095 | 0.01 | 0.01 | -0.00 | buy |
| Granahan Investment Management, LLC | 182,333 | 183,808 | +1,475 | 0.30 | 0.31 | +0.01 | buy |
| Advisors Asset Management, Inc. | 13,048 | 14,281 | +1,233 | 0.01 | 0.01 | -0.00 | buy |
| Vident Advisory, LLC | 5,413 | 6,574 | +1,161 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 18,127 | 19,270 | +1,143 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 905 | +905 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 1,356,895 | 1,357,602 | +707 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 648 | +648 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,448 | 7,029 | +581 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 96,584 | 97,149 | +565 | 0.01 | 0.01 | -0.00 | buy |
| NATIXIS ADVISORS, LLC | 23,554 | 24,010 | +456 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,601 | 1,952 | +351 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 329 | +329 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 466 | 688 | +222 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 58 | 239 | +181 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 298,700 | 298,800 | +100 | 0.03 | 0.02 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,140 | 5,220 | +80 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 11 | 84 | +73 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 69,529 | 69,597 | +68 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 544 | 574 | +30 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 30 | 58 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 89 | 114 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 248 | 270 | +22 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,541 | 2,561 | +20 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 2,742 | 2,761 | +19 | 0.00 | 0.00 | -0.00 | buy |
| Park Place Capital Corp | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 100,100 | 100,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 21,500 | 21,500 | 0 | 0.13 | 0.10 | -0.02 | hold |
| ORBIMED ADVISORS LLC | 947,877 | 947,877 | 0 | 0.77 | 0.76 | -0.01 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,492 | 55,492 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 39,000 | 39,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 146,800 | 146,800 | 0 | 3.09 | 2.45 | -0.64 | hold |
| PERCEPTIVE ADVISORS LLC | 325,324 | 325,324 | 0 | 0.36 | 0.39 | +0.03 | hold |
| PRINCIPAL SECURITIES, INC. | 58 | 58 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GREAT POINT PARTNERS LLC | 245,272 | 245,272 | 0 | 4.53 | 4.47 | -0.06 | hold |
| HighVista Strategies LLC | 66,788 | 66,788 | 0 | 0.97 | 0.86 | -0.11 | hold |
| Rathbones Group PLC | 23,666 | 23,666 | 0 | 0.00 | 0.00 | -0.00 | hold |