| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 169,132 | 1,000,000 | +830,868 | 0.25 | 1.09 | +0.84 | buy |
| Capital International Investors | 2,547,210 | 3,088,730 | +541,520 | 0.02 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 810,000 | 1,300,000 | +490,000 | 1.88 | 3.11 | +1.23 | buy |
| JANUS HENDERSON GROUP PLC | 2,866,755 | 3,325,093 | +458,338 | 0.06 | 0.06 | 0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,157,189 | 1,391,370 | +234,181 | 0.20 | 0.23 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 1,161,237 | 1,328,175 | +166,938 | 7.11 | 6.98 | -0.14 | buy |
| Aberdeen Group plc | 283,899 | 404,154 | +120,255 | 0.02 | 0.03 | +0.01 | buy |
| ALGERT GLOBAL LLC | 241,417 | 123,415 | +118,002 | 0.22 | 0.10 | 0.00 | sell |
| MPM BioImpact LLC | 197,212 | 303,398 | +106,186 | 1.10 | 1.75 | +0.65 | buy |
| Saturn V Capital Management LP | 322,470 | 413,711 | +91,241 | 4.95 | 7.00 | +2.05 | buy |
| Alyeska Investment Group, L.P. | 288,843 | 367,233 | +78,390 | 0.04 | 0.05 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 50,547 | 127,548 | +77,001 | 0.41 | 0.82 | +0.42 | buy |
| Avoro Capital Advisors LLC | 5,666,666 | 5,741,666 | +75,000 | 3.14 | 3.01 | -0.14 | buy |
| Nicholas Investment Partners, LP | 14,658 | 86,968 | +72,310 | 0.05 | 0.30 | +0.25 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,520,595 | 4,584,859 | +64,264 | 1.46 | 1.48 | +0.02 | buy |
| Nan Fung Group Holdings Ltd | 106,680 | 158,605 | +51,925 | 3.58 | 4.34 | +0.76 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,863,473 | 1,914,749 | +51,276 | 0.13 | 0.12 | -0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 663,704 | 703,795 | +40,091 | 0.06 | 0.06 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 176,674 | 137,221 | +39,453 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 273,352 | 236,983 | +36,369 | 0.03 | 0.02 | 0.00 | sell |
| ExodusPoint Capital Management, LP | 68,884 | 42,000 | +26,884 | 0.03 | 0.02 | 0.00 | sell |
| DnB Asset Management AS | 203,243 | 229,482 | +26,239 | 0.03 | 0.04 | +0.00 | buy |
| Nebula Research & Development LLC | 20,360 | 46,561 | +26,201 | 0.09 | 0.14 | +0.05 | buy |
| J. Safra Sarasin Holding AG | 17,786 | 30,573 | +12,787 | 0.01 | 0.02 | +0.01 | buy |
| Birchview Capital, LP | 10,000 | 21,000 | +11,000 | 0.32 | 0.61 | +0.29 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 40,376 | 47,457 | +7,081 | 67.28 | 1.12 | -66.16 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 49,818 | 56,591 | +6,773 | 0.09 | 0.09 | 0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 11,441 | 16,975 | +5,534 | 0.08 | 0.08 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 8,621 | 11,372 | +2,751 | 0.06 | 0.06 | -0.00 | buy |
| Granahan Investment Management, LLC | 182,333 | 183,808 | +1,475 | 0.30 | 0.31 | +0.01 | buy |
| Advisors Asset Management, Inc. | 13,048 | 14,281 | +1,233 | 0.01 | 0.01 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,601 | 1,952 | +351 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 11 | 84 | +73 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,166 | 15,353 | -813 | 0.06 | 0.05 | -0.01 | sell |
| SAMLYN CAPITAL, LLC | 1,017,838 | 1,016,381 | -1,457 | 0.60 | 0.51 | -0.10 | sell |
| First Turn Management, LLC | 684,986 | 683,451 | -1,535 | 4.81 | 4.62 | -0.19 | sell |
| Knott David M Jr | 20,866 | 15,866 | -5,000 | 0.30 | 0.25 | -0.04 | sell |
| ALPS ADVISORS INC | 61,648 | 55,332 | -6,316 | 0.02 | 0.01 | -0.00 | sell |
| Fiera Capital Corp | 535,887 | 529,442 | -6,445 | 0.07 | 0.06 | -0.00 | sell |
| Siren, L.L.C. | 743,769 | 732,761 | -11,008 | 1.29 | 1.39 | +0.10 | sell |
| LOOMIS SAYLES & CO L P | 687,145 | 673,011 | -14,134 | 0.03 | 0.03 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 193,004 | 174,576 | -18,428 | 1.01 | 0.69 | -0.31 | sell |
| PFM Health Sciences, LP | 116,998 | 92,236 | -24,762 | 0.28 | 0.22 | -0.06 | sell |
| JENNISON ASSOCIATES LLC | 801,553 | 776,693 | -24,860 | 0.02 | 0.02 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 52,097 | 26,097 | -26,000 | 0.37 | 0.20 | -0.17 | sell |
| BIT Capital GmbH | 53,928 | 17,352 | -36,576 | 0.17 | 0.05 | -0.12 | sell |
| Candriam S.C.A. | 492,181 | 454,650 | -37,531 | 0.11 | 0.10 | -0.02 | sell |
| Atika Capital Management LLC | 72,600 | 24,000 | -48,600 | 0.30 | 0.11 | -0.19 | sell |
| Ally Bridge Group (NY) LLC | 129,291 | 69,603 | -59,688 | 4.35 | 2.11 | -2.24 | sell |
| Capital World Investors | 2,294,537 | 2,224,715 | -69,822 | 0.01 | 0.01 | -0.00 | sell |
| Polar Capital Holdings Plc | 2,697,657 | 2,623,039 | -74,618 | 0.59 | 0.54 | -0.06 | sell |
| STEMPOINT CAPITAL LP | 375,845 | 274,633 | -101,212 | 3.70 | 2.94 | -0.75 | sell |
| TimesSquare Capital Management, LLC | 848,850 | 745,551 | -103,299 | 100.00 | 100.00 | 0.00 | sell |
| LORD, ABBETT & CO. LLC | 194,971 | 87,981 | -106,990 | 0.02 | 0.01 | -0.01 | sell |
| BRAIDWELL LP | 2,913,964 | 2,709,875 | -204,089 | 3.39 | 3.20 | -0.19 | sell |
| Altium Capital Management LLC | 288,000 | 60,251 | -227,749 | 3.52 | 5.87 | +2.35 | sell |
| Avidity Partners Management LP | 474,000 | 229,000 | -245,000 | 1.85 | 1.58 | -0.27 | sell |
| Rock Springs Capital Management LP | 1,251,859 | 931,681 | -320,178 | 1.87 | 1.79 | -0.08 | sell |
| Commodore Capital LP | 2,740,000 | 2,325,000 | -415,000 | 7.87 | 5.75 | -2.12 | sell |
| First Light Asset Management, LLC | 1,160,580 | 627,904 | -532,676 | 4.35 | 2.41 | -1.95 | sell |
| T. Rowe Price Investment Management, Inc. | 1,437,831 | 796,986 | -640,845 | 0.03 | 0.02 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 993,679 | 347,408 | -646,271 | 0.42 | 0.13 | -0.29 | sell |