| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,920,250 | 10,818,491 | +1,898,241 | 0.02 | 0.03 | +0.01 | buy |
| Avoro Capital Advisors LLC | 5,424,444 | 5,777,777 | +353,333 | 2.39 | 3.31 | +0.92 | buy |
| BlackRock, Inc. | 5,100,284 | 5,640,118 | +539,834 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,764,779 | 4,829,641 | +64,862 | 0.04 | 0.05 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,538,691 | 4,491,653 | -47,038 | 1.38 | 1.92 | +0.54 | sell |
| Polar Capital Holdings Plc | 2,465,694 | 4,405,312 | +1,939,618 | 0.51 | 1.12 | +0.61 | buy |
| JANUS HENDERSON GROUP PLC | 4,084,034 | 4,175,982 | +91,948 | 0.08 | 0.12 | +0.03 | buy |
| Capital International Investors | 3,414,959 | 2,674,727 | -740,232 | 0.02 | 0.04 | +0.01 | sell |
| CITADEL ADVISORS LLC | 1,321,213 | 2,652,990 | +1,331,777 | 0.04 | 0.11 | +0.07 | buy |
| JPMORGAN CHASE & CO | 1,494,032 | 1,923,610 | +429,578 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,492,550 | 1,720,533 | +227,983 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,250,000 | 1,675,000 | +425,000 | 4.03 | 5.71 | +1.69 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 542,020 | 1,615,696 | +1,073,676 | 0.31 | 1.11 | +0.80 | buy |
| Holocene Advisors, LP | 1,282,081 | 1,518,686 | +236,605 | 0.12 | 0.21 | +0.09 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,593,814 | 1,403,297 | -190,517 | 0.02 | 0.02 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,226,771 | 1,401,483 | +174,712 | 0.23 | 0.34 | +0.11 | buy |
| Caligan Partners LP | 549,665 | 1,393,027 | +843,362 | 2.26 | 5.73 | +3.47 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,060,221 | 1,342,028 | +281,807 | 0.05 | 0.09 | +0.04 | buy |
| BRAIDWELL LP | 1,825,076 | 1,338,452 | -486,624 | 2.62 | 2.60 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 862,300 | 1,329,591 | +467,291 | 0.00 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,292,055 | 1,318,814 | +26,759 | 0.03 | 0.05 | +0.02 | buy |
| Siren, L.L.C. | 812,761 | 1,318,564 | +505,803 | 1.09 | 2.13 | +1.04 | buy |
| Alyeska Investment Group, L.P. | 0 | 1,299,469 | +1,299,469 | 0.00 | 0.21 | +0.21 | buy |
| FRANKLIN RESOURCES INC | 758,059 | 1,280,577 | +522,518 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 952,679 | 1,092,932 | +140,253 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 447,200 | 1,059,971 | +612,771 | 0.41 | 1.34 | +0.93 | buy |
| FEDERATED HERMES, INC. | 672,237 | 972,237 | +300,000 | 0.05 | 0.09 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 547,613 | 951,955 | +404,342 | 0.02 | 0.04 | +0.02 | buy |
| Capital World Investors | 655,737 | 840,072 | +184,335 | 0.00 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 1,800,000 | 825,000 | -975,000 | 5.37 | 2.78 | -2.59 | sell |
| First Turn Management, LLC | 799,743 | 786,844 | -12,899 | 4.10 | 5.11 | +1.02 | sell |
| GOLDMAN SACHS GROUP INC | 696,047 | 769,875 | +73,828 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 787,788 | 763,020 | -24,768 | 1.81 | 2.62 | +0.80 | sell |
| Fiera Capital Corp | 686,056 | 709,529 | +23,473 | 0.10 | 0.14 | +0.04 | buy |
| Pictet Asset Management Holding SA | 625,985 | 679,709 | +53,724 | 0.03 | 0.04 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 680,473 | 679,314 | -1,159 | 0.02 | 0.02 | +0.01 | sell |
| Vestal Point Capital, LP | 600,000 | 639,900 | +39,900 | 0.99 | 1.04 | +0.05 | buy |
| Aberdeen Group plc | 750,291 | 609,929 | -140,362 | 0.05 | 0.06 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 436,743 | 606,085 | +169,342 | 0.03 | 0.03 | +0.00 | buy |
| MPM BioImpact LLC | 485,620 | 588,706 | +103,086 | 2.49 | 2.64 | +0.15 | buy |
| LOOMIS SAYLES & CO L P | 612,032 | 564,897 | -47,135 | 0.03 | 0.04 | +0.01 | sell |
| NORTHERN TRUST CORP | 438,714 | 527,783 | +89,069 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 154,184 | 497,035 | +342,851 | 0.66 | 3.00 | +2.34 | buy |
| TUDOR INVESTMENT CORP ET AL | 254,002 | 495,591 | +241,589 | 0.06 | 0.16 | +0.09 | buy |
| Octagon Capital Advisors LP | 0 | 490,000 | +490,000 | 0.00 | 3.15 | +3.15 | buy |
| Novo Holdings A/S | 0 | 485,438 | +485,438 | 0.00 | 2.29 | +2.29 | buy |
| Candriam S.C.A. | 417,402 | 476,494 | +59,092 | 0.09 | 0.14 | +0.05 | buy |
| MORGAN STANLEY | 294,332 | 473,759 | +179,427 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 685,100 | 470,000 | -215,100 | 0.05 | 0.04 | -0.00 | sell |
| Logos Global Management LP | 0 | 450,000 | +450,000 | 0.00 | 1.35 | +1.35 | buy |
| Bank of New York Mellon Corp | 387,158 | 396,138 | +8,980 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 236 | 375,166 | +374,930 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 370,208 | 370,208 | 0 | 0.10 | 0.12 | +0.03 | hold |
| TimesSquare Capital Management, LLC | 532,740 | 359,293 | -173,447 | 0.36 | 0.35 | -0.01 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 324,722 | +324,722 | 0.00 | 0.15 | +0.15 | buy |
| Sofinnova Investments, Inc. | 59,900 | 305,216 | +245,316 | 0.12 | 0.89 | +0.77 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 300,500 | +300,500 | 0.00 | 0.03 | +0.03 | buy |
| Soleus Capital Management, L.P. | 0 | 292,000 | +292,000 | 0.00 | 0.69 | +0.69 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 35,681 | 270,412 | +234,731 | 0.04 | 0.36 | +0.32 | buy |
| BANK OF AMERICA CORP /DE/ | 221,368 | 265,267 | +43,899 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 123,189 | 264,200 | +141,011 | 0.09 | 0.23 | +0.15 | buy |
| Redmile Group, LLC | 133,882 | 262,674 | +128,792 | 0.44 | 1.01 | +0.57 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 205,569 | 254,483 | +48,914 | 0.02 | 0.03 | +0.01 | buy |
| DAFNA Capital Management LLC | 287,939 | 250,772 | -37,167 | 3.00 | 3.32 | +0.32 | sell |
| Nuveen, LLC | 216,238 | 250,036 | +33,798 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 226,965 | 247,765 | +20,800 | 0.81 | 1.58 | +0.78 | buy |
| Nicholas Investment Partners, LP | 242,989 | 247,101 | +4,112 | 0.79 | 1.04 | +0.24 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 246,306 | +246,306 | 0.00 | 0.02 | +0.02 | buy |
| Duquesne Family Office LLC | 0 | 238,600 | +238,600 | 0.00 | 0.47 | +0.47 | buy |
| BARCLAYS PLC | 600,964 | 238,209 | -362,755 | 0.01 | 0.00 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 84,360 | 233,905 | +149,545 | 0.01 | 0.03 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 203,969 | 228,899 | +24,930 | 0.68 | 0.80 | +0.12 | buy |
| Patient Square Capital LP | 136,500 | 227,000 | +90,500 | 1.31 | 2.34 | +1.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 635,056 | 201,785 | -433,271 | 0.02 | 0.01 | -0.01 | sell |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.62 | +0.62 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 197,759 | +197,759 | 0.00 | 1.36 | +1.36 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189,059 | 189,080 | +21 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 186,705 | 188,505 | +1,800 | 0.01 | 0.02 | +0.00 | buy |
| DnB Asset Management AS | 272,831 | 181,085 | -91,746 | 0.04 | 0.04 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,319 | 177,137 | +168,818 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 173,425 | +173,425 | 0.00 | 0.10 | +0.10 | buy |
| DEUTSCHE BANK AG\ | 190,233 | 162,682 | -27,551 | 0.00 | 0.00 | +0.00 | sell |
| Foresite Capital Management IV, LLC | 160,000 | 160,000 | 0 | 3.12 | 3.92 | +0.80 | hold |
| Swiss National Bank | 114,000 | 157,700 | +43,700 | 0.00 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 30,987 | 155,776 | +124,789 | 0.02 | 0.13 | +0.12 | buy |
| Woodline Partners LP | 0 | 150,302 | +150,302 | 0.00 | 0.03 | +0.03 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 174,851 | 143,136 | -31,715 | 0.24 | 0.31 | +0.07 | sell |
| STEMPOINT CAPITAL LP | 348,605 | 140,755 | -207,850 | 2.68 | 1.57 | -1.11 | sell |
| Neuberger Berman Group LLC | 178,747 | 130,438 | -48,309 | 0.01 | 0.01 | -0.00 | sell |
| HRT FINANCIAL LP | 129,800 | 129,800 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Eversept Partners, LP | 231,380 | 129,574 | -101,806 | 0.58 | 0.50 | -0.08 | sell |
| Russell Investments Group, Ltd. | 86,220 | 129,399 | +43,179 | 0.00 | 0.01 | +0.00 | buy |
| KBC Group NV | 2,780 | 129,010 | +126,230 | 0.00 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 127,000 | +127,000 | 0.00 | 1.27 | +1.27 | buy |
| HSBC HOLDINGS PLC | 0 | 121,558 | +121,558 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 152,297 | 115,652 | -36,645 | 0.00 | 0.00 | +0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 116,088 | 115,594 | -494 | 0.05 | 0.08 | +0.02 | sell |
| SEI INVESTMENTS CO | 43,858 | 114,381 | +70,523 | 0.00 | 0.01 | +0.00 | buy |
| Granahan Investment Management, LLC | 92,778 | 104,478 | +11,700 | 0.18 | 0.29 | +0.12 | buy |
| RHUMBLINE ADVISERS | 90,143 | 101,785 | +11,642 | 0.00 | 0.01 | +0.00 | buy |