| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,832,174 | 1,223,377 | +608,797 | 1.71 | 1.37 | 0.00 | sell |
| GREAT POINT PARTNERS LLC | 818,505 | 530,000 | +288,505 | 5.79 | 4.09 | 0.00 | sell |
| ALGERT GLOBAL LLC | 38,407 | 144,877 | +106,470 | 0.07 | 0.24 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000 | 670,000 | +80,000 | 0.06 | 0.06 | 0.00 | sell |
| Parkman Healthcare Partners LLC | 277,283 | 217,740 | +59,543 | 2.16 | 1.45 | 0.00 | sell |
| Granahan Investment Management, LLC | 276,012 | 236,753 | +39,259 | 0.30 | 0.28 | 0.00 | sell |
| Affinity Asset Advisors, LLC | 90,000 | 60,376 | +29,624 | 1.24 | 0.91 | 0.00 | sell |
| BAMCO INC /NY/ | 73,000 | 100,100 | +27,100 | 0.01 | 0.01 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 63,391 | 38,676 | +24,715 | 0.10 | 0.06 | 0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 77,740 | 94,490 | +16,750 | 0.14 | 0.16 | 0.00 | buy |
| Walleye Capital LLC | 105,332 | 89,704 | +15,628 | 0.08 | 0.07 | 0.00 | sell |
| CIBC WORLD MARKET INC. | 32,749 | 41,222 | +8,473 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 321,465 | 327,344 | +5,879 | 0.01 | 0.01 | 0.00 | buy |
| ALPS ADVISORS INC | 41,528 | 46,723 | +5,195 | 0.01 | 0.02 | 0.00 | buy |
| Elmwood Wealth Management, Inc. | 14,994 | 10,069 | +4,925 | 0.25 | 0.18 | 0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 14,598 | 14,515 | +83 | 0.02 | 0.02 | 0.00 | sell |
| Redmile Group, LLC | 1,325,832 | 1,120,476 | -205,356 | 2.06 | 1.66 | -0.40 | sell |
| SAMLYN CAPITAL, LLC | 1,158,994 | 939,909 | -219,085 | 0.76 | 0.63 | -0.13 | sell |