| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 1,308,011 | 2,560,573 | +1,252,562 | 1.81 | 3.13 | +1.32 | buy |
| Commodore Capital LP | 2,167,793 | 2,754,266 | +586,473 | 6.24 | 7.33 | +1.09 | buy |
| Logos Global Management LP | 0 | 375,000 | +375,000 | 0.00 | 1.68 | +1.68 | buy |
| ORBIMED ADVISORS LLC | 550,000 | 862,362 | +312,362 | 0.43 | 0.67 | +0.23 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 347,351 | 643,546 | +296,195 | 0.08 | 0.12 | +0.04 | buy |
| SAMLYN CAPITAL, LLC | 396,196 | 639,685 | +243,489 | 0.30 | 0.43 | +0.13 | buy |
| Point72 Asset Management, L.P. | 275,859 | 482,022 | +206,163 | 0.03 | 0.06 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 154,038 | 357,178 | +203,140 | 0.08 | 0.15 | +0.07 | buy |
| Aberdeen Group plc | 32,036 | 212,502 | +180,466 | 0.00 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,671,917 | 1,839,555 | +167,638 | 0.14 | 0.13 | -0.00 | buy |
| FMR LLC | 6,601,830 | 6,768,173 | +166,343 | 0.02 | 0.02 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 837,387 | 994,227 | +156,840 | 5.86 | 6.11 | +0.24 | buy |
| Artal Group S.A. | 253,387 | 381,554 | +128,167 | 0.28 | 0.38 | +0.10 | buy |
| Vestal Point Capital, LP | 400,000 | 525,000 | +125,000 | 1.42 | 1.53 | +0.10 | buy |
| JANUS HENDERSON GROUP PLC | 941,569 | 1,045,257 | +103,688 | 0.02 | 0.02 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,321,740 | 4,419,472 | +97,732 | 1.85 | 1.67 | -0.19 | buy |
| MILLENNIUM MANAGEMENT LLC | 83,661 | 175,584 | +91,923 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 77,484 | 162,466 | +84,982 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 299,774 | 364,173 | +64,399 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 238,843 | 291,868 | +53,025 | 0.06 | 0.07 | +0.00 | buy |
| DnB Asset Management AS | 126,250 | 175,733 | +49,483 | 0.03 | 0.03 | +0.00 | buy |
| Avidity Partners Management LP | 710,000 | 754,000 | +44,000 | 1.09 | 1.25 | +0.16 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 43,093 | +43,093 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 40,376 | +40,376 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 542,289 | 578,865 | +36,576 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 56,400 | 92,900 | +36,500 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 36,621 | 71,654 | +35,033 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 35,000 | +35,000 | 0.00 | 0.13 | +0.13 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 201,274 | 233,335 | +32,061 | 0.02 | 0.02 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 30,196 | +30,196 | 0.00 | 0.19 | +0.19 | buy |
| CenterBook Partners LP | 0 | 29,153 | +29,153 | 0.00 | 0.07 | +0.07 | buy |
| DIMENSIONAL FUND ADVISORS LP | 410,207 | 436,460 | +26,253 | 0.00 | 0.00 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 24,060 | +24,060 | 0.00 | 0.08 | +0.08 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 3,225 | 24,116 | +20,891 | 0.02 | 0.07 | +0.05 | buy |
| TimesSquare Capital Management, LLC | 737,173 | 754,493 | +17,320 | 0.46 | 0.46 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,255,577 | 1,272,877 | +17,300 | 1.37 | 1.50 | +0.12 | buy |
| DEUTSCHE BANK AG\ | 38,711 | 53,711 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,468,446 | 1,483,166 | +14,720 | 0.02 | 0.02 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,426,339 | 1,439,903 | +13,564 | 0.04 | 0.04 | -0.00 | buy |
| Altium Capital Management LLC | 348,000 | 360,600 | +12,600 | 6.69 | 5.81 | -0.88 | buy |
| XTX Topco Ltd | 0 | 11,910 | +11,910 | 0.00 | 0.04 | +0.04 | buy |
| Tower Research Capital LLC (TRC) | 1,226 | 8,227 | +7,001 | 0.00 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 14,100 | 21,000 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,687 | +6,687 | 0.00 | 0.05 | +0.05 | buy |
| Fiera Capital Corp | 576,542 | 582,879 | +6,337 | 0.07 | 0.07 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 563,952 | 570,272 | +6,320 | 0.02 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 8,449 | 14,755 | +6,306 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 10,032 | 15,911 | +5,879 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 20,366 | 26,179 | +5,813 | 0.00 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 53,200 | 58,853 | +5,653 | 0.02 | 0.02 | -0.00 | buy |
| VANGUARD GROUP INC | 335,635 | 341,152 | +5,517 | 0.00 | 0.00 | -0.00 | buy |
| ASSETMARK, INC | 13,185 | 18,235 | +5,050 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 64,229 | 68,929 | +4,700 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 4,700 | +4,700 | 0.00 | 0.04 | +0.04 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 4,863 | 9,328 | +4,465 | 0.05 | 0.07 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 416,736 | 421,121 | +4,385 | 0.05 | 0.04 | -0.01 | buy |
| STATE STREET CORP | 242,640 | 246,812 | +4,172 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 65,637 | 69,000 | +3,363 | 0.06 | 0.05 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,321 | 11,616 | +3,295 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,513 | 29,293 | +2,780 | 0.03 | 0.03 | -0.00 | buy |
| Quarry LP | 1,300 | 4,000 | +2,700 | 0.02 | 0.07 | +0.04 | buy |
| Qube Research & Technologies Ltd | 45,286 | 47,842 | +2,556 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 123,800 | 126,100 | +2,300 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,253 | +2,253 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,680 | 4,840 | +2,160 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 46,079 | 48,166 | +2,087 | 0.05 | 0.04 | -0.02 | buy |
| Atika Capital Management LLC | 122,000 | 124,000 | +2,000 | 0.59 | 0.56 | -0.03 | buy |
| KBC Group NV | 0 | 1,962 | +1,962 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56,477 | 58,140 | +1,663 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 32,608 | 34,192 | +1,584 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 2,413 | 3,838 | +1,425 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 35,132 | 36,388 | +1,256 | 0.00 | 0.00 | -0.00 | buy |
| Orion Porfolio Solutions, LLC | 13,698 | 14,514 | +816 | 0.01 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 48,177 | 48,946 | +769 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 17,261 | 17,949 | +688 | 0.01 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 27 | 367 | +340 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 317 | +317 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,103 | 2,380 | +277 | 0.05 | 0.05 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 235 | +235 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 218 | +218 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 187,872 | 188,038 | +166 | 0.02 | 0.02 | -0.00 | buy |
| Ashton Thomas Private Wealth, LLC | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 55,010 | 55,120 | +110 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,977 | 14,078 | +101 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 25,157 | 25,232 | +75 | 0.01 | 0.01 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 30 | 64 | +34 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,311 | 18,335 | +24 | 0.05 | 0.06 | +0.01 | buy |
| Snowden Capital Advisors LLC | 5,499 | 5,511 | +12 | 0.01 | 0.01 | -0.00 | buy |
| CWM, LLC | 0 | 7 | +7 | 0.00 | 0.00 | 0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 5,374 | 5,380 | +6 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 16 | 21 | +5 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 35 | 38 | +3 | 0.00 | 0.00 | -0.00 | buy |
| BAMCO INC /NY/ | 100,100 | 100,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 21,500 | 21,500 | 0 | 0.17 | 0.14 | -0.03 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TD ASSET MANAGEMENT INC | 20,430 | 20,430 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 91,500 | 91,500 | 0 | 0.00 | 0.00 | -0.00 | hold |