| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 1,308,011 | 2,560,573 | +1,252,562 | 1.81 | 3.13 | +1.32 | buy |
| Commodore Capital LP | 2,167,793 | 2,754,266 | +586,473 | 6.24 | 7.33 | +1.09 | buy |
| ORBIMED ADVISORS LLC | 550,000 | 862,362 | +312,362 | 0.43 | 0.67 | +0.23 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 347,351 | 643,546 | +296,195 | 0.08 | 0.12 | +0.04 | buy |
| SAMLYN CAPITAL, LLC | 396,196 | 639,685 | +243,489 | 0.29 | 0.42 | +0.13 | buy |
| ExodusPoint Capital Management, LP | 154,038 | 357,178 | +203,140 | 0.08 | 0.16 | 0.00 | buy |
| Aberdeen Group plc | 32,036 | 212,502 | +180,466 | 0.00 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,671,917 | 1,839,555 | +167,638 | 0.14 | 0.13 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 837,387 | 994,227 | +156,840 | 4.46 | 4.47 | +0.01 | buy |
| Artal Group S.A. | 253,387 | 381,554 | +128,167 | 0.28 | 0.38 | +0.10 | buy |
| Vestal Point Capital, LP | 400,000 | 525,000 | +125,000 | 1.42 | 1.53 | +0.10 | buy |
| JANUS HENDERSON GROUP PLC | 941,569 | 1,045,257 | +103,688 | 0.02 | 0.02 | 0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,321,740 | 4,419,472 | +97,732 | 1.85 | 1.67 | -0.19 | buy |
| TWO SIGMA INVESTMENTS, LP | 274,626 | 195,129 | +79,497 | 0.03 | 0.02 | 0.00 | sell |
| Alyeska Investment Group, L.P. | 238,843 | 291,868 | +53,025 | 0.06 | 0.07 | +0.00 | buy |
| DnB Asset Management AS | 126,250 | 175,733 | +49,483 | 0.03 | 0.03 | +0.00 | buy |
| Avidity Partners Management LP | 710,000 | 754,000 | +44,000 | 1.09 | 1.25 | +0.16 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 201,274 | 233,335 | +32,061 | 0.02 | 0.02 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 3,225 | 24,116 | +20,891 | 0.02 | 0.07 | +0.05 | buy |
| TimesSquare Capital Management, LLC | 737,173 | 754,493 | +17,320 | 0.46 | 0.46 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,255,577 | 1,272,877 | +17,300 | 1.37 | 1.49 | +0.12 | buy |
| T. Rowe Price Investment Management, Inc. | 1,426,339 | 1,439,903 | +13,564 | 0.04 | 0.04 | -0.00 | buy |
| Altium Capital Management LLC | 348,000 | 360,600 | +12,600 | 6.69 | 5.81 | -0.88 | buy |
| Fiera Capital Corp | 576,542 | 582,879 | +6,337 | 0.07 | 0.07 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 563,952 | 570,272 | +6,320 | 0.02 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 53,200 | 58,853 | +5,653 | 0.02 | 0.02 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 4,863 | 9,328 | +4,465 | 0.05 | 0.07 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 416,736 | 421,121 | +4,385 | 0.05 | 0.04 | -0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 18,305 | 14,550 | +3,755 | 0.06 | 0.03 | 0.00 | sell |
| Quarry LP | 1,300 | 4,000 | +2,700 | 0.02 | 0.07 | 0.00 | buy |
| Atika Capital Management LLC | 122,000 | 124,000 | +2,000 | 0.52 | 0.47 | -0.04 | buy |
| ALGERT GLOBAL LLC | 184,015 | 183,205 | +810 | 0.31 | 0.25 | 0.00 | sell |
| Advisors Asset Management, Inc. | 13,717 | 13,099 | +618 | 0.01 | 0.01 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,103 | 2,380 | +277 | 0.05 | 0.05 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,311 | 18,335 | +24 | 0.06 | 0.06 | +0.01 | buy |
| CIBC WORLD MARKET INC. | 37,320 | 36,385 | -935 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 23,866 | 20,866 | -3,000 | 0.36 | 0.32 | -0.04 | sell |
| Bellevue Group AG | 14,100 | 10,200 | -3,900 | 0.01 | 0.01 | -0.00 | sell |
| EntryPoint Capital, LLC | 4,541 | 26 | -4,515 | 0.18 | 0.00 | -0.17 | sell |
| China Universal Asset Management Co., Ltd. | 14,520 | 8,868 | -5,652 | 0.08 | 0.05 | -0.03 | sell |
| TWINBEECH CAPITAL LP | 98,042 | 88,711 | -9,331 | 0.09 | 0.07 | -0.02 | sell |
| Cinctive Capital Management LP | 31,770 | 20,520 | -11,250 | 0.07 | 0.04 | -0.03 | sell |
| First Light Asset Management, LLC | 1,320,172 | 1,306,260 | -13,912 | 4.35 | 4.46 | +0.11 | sell |
| Parkman Healthcare Partners LLC | 223,942 | 209,290 | -14,652 | 1.18 | 1.09 | -0.09 | sell |
| Granahan Investment Management, LLC | 244,080 | 226,166 | -17,914 | 0.37 | 0.35 | -0.02 | sell |
| LOOMIS SAYLES & CO L P | 686,510 | 660,258 | -26,252 | 0.04 | 0.04 | -0.01 | sell |
| Candriam S.C.A. | 560,884 | 521,836 | -39,048 | 0.15 | 0.12 | -0.03 | sell |
| BOONE CAPITAL MANAGEMENT LLC | 291,403 | 250,460 | -40,943 | 2.54 | 2.55 | +0.01 | sell |
| Laurion Capital Management LP | 239,126 | 171,195 | -67,931 | 0.09 | 0.08 | -0.01 | sell |
| Polar Capital Holdings Plc | 2,612,108 | 2,536,058 | -76,050 | 0.59 | 0.58 | -0.01 | sell |
| Tri Locum Partners LP | 207,465 | 101,959 | -105,506 | 3.10 | 1.01 | -2.09 | sell |
| Ally Bridge Group (NY) LLC | 309,369 | 169,369 | -140,000 | 7.40 | 3.93 | -3.47 | sell |
| PERCEPTIVE ADVISORS LLC | 892,208 | 583,256 | -308,952 | 0.67 | 0.55 | -0.12 | sell |
| First Turn Management, LLC | 680,389 | 339,876 | -340,513 | 4.38 | 2.16 | -2.23 | sell |
| Paradigm Biocapital Advisors LP | 2,484,874 | 2,043,280 | -441,594 | 3.77 | 3.05 | -0.72 | sell |
| LORD, ABBETT & CO. LLC | 895,196 | 190,033 | -705,163 | 0.12 | 0.02 | -0.10 | sell |