| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 2,709,875 | 3,605,029 | +895,154 | 3.20 | 3.86 | +0.66 | buy |
| Commodore Capital LP | 2,325,000 | 3,025,000 | +700,000 | 5.75 | 6.68 | +0.94 | buy |
| Vestal Point Capital, LP | 1,300,000 | 2,000,000 | +700,000 | 3.11 | 3.30 | +0.18 | buy |
| Deep Track Capital, LP | 1,000,000 | 1,350,000 | +350,000 | 1.09 | 1.36 | +0.27 | buy |
| JANUS HENDERSON GROUP PLC | 3,325,093 | 3,577,735 | +252,642 | 0.06 | 0.06 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 127,548 | 259,503 | +131,955 | 0.82 | 1.32 | +0.50 | buy |
| Aberdeen Group plc | 404,154 | 521,492 | +117,338 | 0.03 | 0.03 | +0.00 | buy |
| Capital International Investors | 3,088,730 | 3,181,549 | +92,819 | 0.02 | 0.02 | -0.00 | buy |
| Polar Capital Holdings Plc | 2,623,039 | 2,703,256 | +80,217 | 0.54 | 0.44 | -0.09 | buy |
| Siren, L.L.C. | 732,761 | 812,761 | +80,000 | 1.39 | 1.32 | -0.07 | buy |
| Granahan Investment Management, LLC | 183,808 | 240,038 | +56,230 | 0.31 | 0.31 | -0.00 | buy |
| Saturn V Capital Management LP | 413,711 | 468,364 | +54,653 | 7.00 | 5.94 | -1.06 | buy |
| J. Safra Sarasin Holding AG | 30,573 | 82,048 | +51,475 | 0.02 | 0.04 | +0.03 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 55,000 | 90,000 | +35,000 | 0.04 | 0.04 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 56,591 | 30,036 | +26,555 | 0.09 | 0.04 | 0.00 | sell |
| BAKER BROS. ADVISORS LP | 347,408 | 370,208 | +22,800 | 0.13 | 0.11 | -0.02 | buy |
| ALGERT GLOBAL LLC | 123,415 | 102,345 | +21,070 | 0.10 | 0.07 | 0.00 | sell |
| HighMark Wealth Management LLC | 6,100 | 26,100 | +20,000 | 0.12 | 0.40 | +0.28 | buy |
| MPM BioImpact LLC | 303,398 | 323,398 | +20,000 | 1.75 | 1.75 | +0.00 | buy |
| DAFNA Capital Management LLC | 273,739 | 287,939 | +14,200 | 2.60 | 2.49 | -0.12 | buy |
| ALPS ADVISORS INC | 55,332 | 41,380 | +13,952 | 0.01 | 0.01 | 0.00 | sell |
| Nebula Research & Development LLC | 46,561 | 60,223 | +13,662 | 0.14 | 0.16 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137,221 | 129,103 | +8,118 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 229,482 | 234,157 | +4,675 | 0.04 | 0.03 | -0.01 | buy |
| CenterBook Partners LP | 22,211 | 24,664 | +2,453 | 0.05 | 0.04 | -0.00 | buy |
| Advisors Asset Management, Inc. | 14,281 | 12,205 | +2,076 | 0.01 | 0.01 | 0.00 | sell |
| Fiera Capital Corp | 529,442 | 530,683 | +1,241 | 0.06 | 0.06 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 15,353 | 15,412 | +59 | 0.05 | 0.05 | -0.00 | buy |
| J.Safra Asset Management Corp | 84 | 87 | +3 | 0.00 | 0.00 | -0.00 | buy |
| Elmwood Wealth Management, Inc. | 11,007 | 10,824 | -183 | 0.15 | 0.13 | -0.02 | sell |
| Virtus Investment Advisers, LLC | 4,161 | 2,867 | -1,294 | 0.04 | 0.03 | -0.01 | sell |
| Knott David M Jr | 15,866 | 10,962 | -4,904 | 0.25 | 0.16 | -0.10 | sell |
| LOOMIS SAYLES & CO L P | 673,011 | 657,165 | -15,846 | 0.03 | 0.03 | -0.01 | sell |
| Nicholas Investment Partners, LP | 86,968 | 68,896 | -18,072 | 0.30 | 0.19 | -0.11 | sell |
| HighVista Strategies LLC | 66,788 | 45,620 | -21,168 | 0.86 | 0.52 | -0.34 | sell |
| First Turn Management, LLC | 683,451 | 660,617 | -22,834 | 4.62 | 3.86 | -0.76 | sell |
| Parkman Healthcare Partners LLC | 174,576 | 150,373 | -24,203 | 0.69 | 0.54 | -0.15 | sell |
| BAMCO INC /NY/ | 100,100 | 56,000 | -44,100 | 0.01 | 0.00 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 245,272 | 200,000 | -45,272 | 4.36 | 4.07 | -0.29 | sell |
| Candriam S.C.A. | 454,650 | 396,636 | -58,014 | 0.10 | 0.07 | -0.02 | sell |
| JENNISON ASSOCIATES LLC | 776,693 | 696,383 | -80,310 | 0.02 | 0.01 | -0.01 | sell |
| Avidity Partners Management LP | 229,000 | 107,891 | -121,109 | 1.58 | 0.68 | -0.91 | sell |
| PERCEPTIVE ADVISORS LLC | 325,324 | 200,791 | -124,533 | 0.39 | 0.23 | -0.15 | sell |
| TimesSquare Capital Management, LLC | 745,551 | 571,242 | -174,309 | 100.00 | 0.26 | -99.74 | sell |
| Affinity Asset Advisors, LLC | 1,328,175 | 1,100,000 | -228,175 | 6.98 | 5.09 | -1.88 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,391,370 | 1,152,605 | -238,765 | 0.23 | 0.15 | -0.08 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,584,859 | 4,335,648 | -249,211 | 1.48 | 1.09 | -0.40 | sell |
| Avoro Capital Advisors LLC | 5,741,666 | 5,400,000 | -341,666 | 3.01 | 2.96 | -0.05 | sell |
| First Light Asset Management, LLC | 627,904 | 188,367 | -439,537 | 2.41 | 0.76 | -1.64 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,914,749 | 1,290,100 | -624,649 | 0.12 | 0.07 | -0.05 | sell |
| T. Rowe Price Investment Management, Inc. | 796,986 | 76,943 | -720,043 | 0.02 | 0.00 | -0.02 | sell |
| Capital World Investors | 2,224,715 | 655,737 | -1,568,978 | 0.01 | 0.00 | -0.01 | sell |