| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 2,036,125 | 5,365,327 | +3,329,202 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 1,809,475 | +1,809,475 | 0.00 | 0.14 | +0.14 | buy |
| STATE STREET CORP | 305,620 | 1,380,460 | +1,074,840 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 69,597 | 970,343 | +900,746 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 2,709,875 | 3,605,029 | +895,154 | 3.20 | 3.86 | +0.66 | buy |
| Commodore Capital LP | 2,325,000 | 3,025,000 | +700,000 | 5.75 | 6.68 | +0.94 | buy |
| Vestal Point Capital, LP | 1,300,000 | 2,000,000 | +700,000 | 3.11 | 3.30 | +0.18 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 679,857 | +679,857 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 234,056 | 882,835 | +648,779 | 0.01 | 0.02 | +0.02 | buy |
| FMR LLC | 8,287,499 | 8,884,363 | +596,864 | 0.02 | 0.02 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 542,020 | +542,020 | 0.00 | 0.31 | +0.31 | buy |
| VANGUARD GROUP INC | 336,514 | 873,228 | +536,714 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 81,024 | 489,940 | +408,916 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 1,000,000 | 1,350,000 | +350,000 | 1.09 | 1.36 | +0.27 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 63,568 | 404,384 | +340,816 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 758,145 | 1,020,254 | +262,109 | 0.03 | 0.04 | +0.00 | buy |
| MORGAN STANLEY | 129,491 | 387,596 | +258,105 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 3,325,093 | 3,577,735 | +252,642 | 0.06 | 0.05 | -0.01 | buy |
| Nuveen, LLC | 0 | 228,567 | +228,567 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 222,352 | +222,352 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 136,569 | 358,432 | +221,863 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 241,206 | 436,974 | +195,768 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 192,242 | +192,242 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,329,386 | 1,518,527 | +189,141 | 0.02 | 0.02 | -0.00 | buy |
| Bank of New York Mellon Corp | 251,147 | 436,020 | +184,873 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 491,120 | 666,466 | +175,346 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 214,860 | 379,988 | +165,128 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management IV, LLC | 0 | 160,000 | +160,000 | 0.00 | 4.05 | +4.05 | buy |
| Foresite Capital Management VI LLC | 0 | 160,000 | +160,000 | 0.00 | 2.82 | +2.82 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 158,605 | +158,605 | 0.00 | 0.59 | +0.59 | buy |
| BARCLAYS PLC | 19,270 | 152,770 | +133,500 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 127,548 | 259,503 | +131,955 | 0.82 | 1.32 | +0.50 | buy |
| GOLDMAN SACHS GROUP INC | 442,732 | 561,800 | +119,068 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 404,154 | 521,492 | +117,338 | 0.03 | 0.03 | +0.00 | buy |
| RHUMBLINE ADVISERS | 29 | 109,700 | +109,671 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 44,852 | 147,411 | +102,559 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 100,940 | +100,940 | 0.00 | 0.29 | +0.29 | buy |
| Capital International Investors | 3,088,730 | 3,181,549 | +92,819 | 0.02 | 0.02 | -0.00 | buy |
| ROYAL BANK OF CANADA | 59,366 | 147,226 | +87,860 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 2,623,039 | 2,703,256 | +80,217 | 0.54 | 0.44 | -0.09 | buy |
| Siren, L.L.C. | 732,761 | 812,761 | +80,000 | 1.39 | 1.32 | -0.07 | buy |
| Soleus Capital Management, L.P. | 0 | 78,800 | +78,800 | 0.00 | 0.17 | +0.17 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 97,149 | 174,850 | +77,701 | 0.01 | 0.01 | +0.00 | buy |
| Man Group plc | 0 | 62,348 | +62,348 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 183,808 | 240,038 | +56,230 | 0.31 | 0.31 | -0.00 | buy |
| Saturn V Capital Management LP | 413,711 | 468,364 | +54,653 | 7.00 | 5.94 | -1.06 | buy |
| J. Safra Sarasin Holding AG | 30,573 | 82,048 | +51,475 | 0.02 | 0.04 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 53,711 | 104,534 | +50,823 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 105,333 | 153,058 | +47,725 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 48,763 | 95,568 | +46,805 | 0.02 | 0.03 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 65,912 | 112,562 | +46,650 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 45,547 | +45,547 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 43,676 | +43,676 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 43,380 | +43,380 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 41,648 | +41,648 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 37,935 | +37,935 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 55,000 | 90,000 | +35,000 | 0.06 | 0.06 | -0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 34,312 | +34,312 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 7,029 | 36,290 | +29,261 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 26,079 | +26,079 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 25,300 | +25,300 | 0.00 | 0.02 | +0.02 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 24,814 | +24,814 | 0.00 | 0.03 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 142,372 | 166,472 | +24,100 | 0.01 | 0.01 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 347,408 | 370,208 | +22,800 | 0.13 | 0.11 | -0.02 | buy |
| Legal & General Group Plc | 60,406 | 81,792 | +21,386 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 303,398 | 323,398 | +20,000 | 1.75 | 1.75 | +0.00 | buy |
| HighMark Wealth Management LLC | 6,100 | 26,100 | +20,000 | 0.12 | 0.40 | +0.28 | buy |
| ProShare Advisors LLC | 0 | 18,448 | +18,448 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 103,624 | 122,026 | +18,402 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 17,358 | +17,358 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 16,991 | +16,991 | 0.00 | 0.01 | +0.01 | buy |
| PEAK6 LLC | 0 | 15,000 | +15,000 | 0.00 | 0.02 | +0.02 | buy |
| OXFORD ASSET MANAGEMENT LLP | 6,174 | 21,138 | +14,964 | 0.10 | 0.22 | +0.12 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,210 | 17,844 | +14,634 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 273,739 | 287,939 | +14,200 | 2.60 | 2.49 | -0.12 | buy |
| Nebula Research & Development LLC | 46,561 | 60,223 | +13,662 | 0.14 | 0.16 | +0.02 | buy |
| SEI INVESTMENTS CO | 9,404 | 22,723 | +13,319 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 48,065 | 59,465 | +11,400 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 50,417 | 61,772 | +11,355 | 0.01 | 0.01 | -0.00 | buy |
| SG Americas Securities, LLC | 8,655 | 19,177 | +10,522 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 9,363 | +9,363 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 39,000 | 47,755 | +8,755 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 7,758 | +7,758 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 50 | 5,357 | +5,307 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,956 | 23,866 | +4,910 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,492 | 60,233 | +4,741 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 229,482 | 234,157 | +4,675 | 0.04 | 0.03 | -0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 4,653 | +4,653 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 2,595 | +2,595 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 22,211 | 24,664 | +2,453 | 0.05 | 0.04 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 63,385 | 65,214 | +1,829 | 0.00 | 0.00 | -0.00 | buy |
| ASSETMARK, INC | 19,934 | 21,250 | +1,316 | 0.00 | 0.00 | -0.00 | buy |
| L1 Capital Pty Ltd | 0 | 1,296 | +1,296 | 0.00 | 0.00 | +0.00 | buy |
| Fiera Capital Corp | 529,442 | 530,683 | +1,241 | 0.06 | 0.06 | -0.01 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 0 | 1,015 | +1,015 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 784 | +784 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 689 | +689 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 185 | 661 | +476 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,561 | 2,964 | +403 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 18,579 | 18,956 | +377 | 0.00 | 0.00 | -0.00 | buy |