| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,287,499 | 8,884,363 | +596,864 | 0.02 | 0.02 | -0.00 | buy |
| Avoro Capital Advisors LLC | 5,741,666 | 5,400,000 | -341,666 | 3.01 | 2.96 | -0.05 | sell |
| BlackRock, Inc. | 2,036,125 | 5,365,327 | +3,329,202 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,584,859 | 4,335,648 | -249,211 | 1.48 | 1.09 | -0.40 | sell |
| BRAIDWELL LP | 2,709,875 | 3,605,029 | +895,154 | 3.20 | 3.86 | +0.66 | buy |
| JANUS HENDERSON GROUP PLC | 3,325,093 | 3,577,735 | +252,642 | 0.06 | 0.05 | -0.01 | buy |
| Capital International Investors | 3,088,730 | 3,181,549 | +92,819 | 0.02 | 0.02 | -0.00 | buy |
| Commodore Capital LP | 2,325,000 | 3,025,000 | +700,000 | 5.75 | 6.68 | +0.94 | buy |
| Polar Capital Holdings Plc | 2,623,039 | 2,703,256 | +80,217 | 0.54 | 0.44 | -0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,789,197 | 2,174,761 | -1,614,436 | 0.02 | 0.01 | -0.01 | sell |
| Vestal Point Capital, LP | 1,300,000 | 2,000,000 | +700,000 | 3.11 | 3.30 | +0.18 | buy |
| Holocene Advisors, LP | 0 | 1,809,475 | +1,809,475 | 0.00 | 0.14 | +0.14 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,329,386 | 1,518,527 | +189,141 | 0.02 | 0.02 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,477,617 | 1,474,449 | -3,168 | 0.06 | 0.05 | -0.01 | sell |
| STATE STREET CORP | 305,620 | 1,380,460 | +1,074,840 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 1,000,000 | 1,350,000 | +350,000 | 1.09 | 1.36 | +0.27 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,914,749 | 1,290,100 | -624,649 | 0.12 | 0.07 | -0.05 | sell |
| JPMORGAN CHASE & CO | 1,357,602 | 1,256,581 | -101,021 | 0.00 | 0.00 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,391,370 | 1,152,605 | -238,765 | 0.23 | 0.15 | -0.08 | sell |
| Affinity Asset Advisors, LLC | 1,328,175 | 1,100,000 | -228,175 | 6.98 | 5.09 | -1.88 | sell |
| MARSHALL WACE, LLP | 758,145 | 1,020,254 | +262,109 | 0.03 | 0.04 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 69,597 | 970,343 | +900,746 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 947,877 | 947,877 | 0 | 0.76 | 0.75 | -0.02 | hold |
| Rock Springs Capital Management LP | 931,681 | 931,681 | 0 | 1.79 | 1.82 | +0.03 | hold |
| MILLENNIUM MANAGEMENT LLC | 234,056 | 882,835 | +648,779 | 0.01 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 336,514 | 873,228 | +536,714 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 732,761 | 812,761 | +80,000 | 1.39 | 1.32 | -0.07 | buy |
| JENNISON ASSOCIATES LLC | 776,693 | 696,383 | -80,310 | 0.02 | 0.01 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 679,857 | +679,857 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 491,120 | 666,466 | +175,346 | 0.00 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 703,795 | 661,082 | -42,713 | 0.06 | 0.05 | -0.01 | sell |
| First Turn Management, LLC | 683,451 | 660,617 | -22,834 | 4.62 | 3.86 | -0.76 | sell |
| LOOMIS SAYLES & CO L P | 673,011 | 657,165 | -15,846 | 0.03 | 0.03 | -0.01 | sell |
| Capital World Investors | 2,224,715 | 655,737 | -1,568,978 | 0.01 | 0.00 | -0.01 | sell |
| TimesSquare Capital Management, LLC | 745,551 | 571,242 | -174,309 | 0.40 | 0.26 | -0.14 | sell |
| GOLDMAN SACHS GROUP INC | 442,732 | 561,800 | +119,068 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 542,020 | +542,020 | 0.00 | 0.31 | +0.31 | buy |
| Fiera Capital Corp | 529,442 | 530,683 | +1,241 | 0.06 | 0.06 | -0.01 | buy |
| Aberdeen Group plc | 404,154 | 521,492 | +117,338 | 0.03 | 0.03 | +0.00 | buy |
| NORTHERN TRUST CORP | 81,024 | 489,940 | +408,916 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 413,711 | 468,364 | +54,653 | 7.00 | 5.94 | -1.06 | buy |
| Assenagon Asset Management S.A. | 241,206 | 436,974 | +195,768 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 251,147 | 436,020 | +184,873 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 63,568 | 404,384 | +340,816 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 454,650 | 396,636 | -58,014 | 0.10 | 0.07 | -0.02 | sell |
| MORGAN STANLEY | 129,491 | 387,596 | +258,105 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 214,860 | 379,988 | +165,128 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 347,408 | 370,208 | +22,800 | 0.13 | 0.11 | -0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 136,569 | 358,432 | +221,863 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 303,398 | 323,398 | +20,000 | 1.75 | 1.75 | +0.00 | buy |
| DAFNA Capital Management LLC | 273,739 | 287,939 | +14,200 | 2.60 | 2.49 | -0.12 | buy |
| ADAR1 Capital Management, LLC | 127,548 | 259,503 | +131,955 | 0.82 | 1.32 | +0.50 | buy |
| Granahan Investment Management, LLC | 183,808 | 240,038 | +56,230 | 0.31 | 0.31 | -0.00 | buy |
| DnB Asset Management AS | 229,482 | 234,157 | +4,675 | 0.04 | 0.03 | -0.01 | buy |
| FEDERATED HERMES, INC. | 232,500 | 232,500 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Nuveen, LLC | 0 | 228,567 | +228,567 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 222,352 | +222,352 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 325,324 | 200,791 | -124,533 | 0.39 | 0.24 | -0.15 | sell |
| GREAT POINT PARTNERS LLC | 245,272 | 200,000 | -45,272 | 4.47 | 4.07 | -0.40 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 192,242 | +192,242 | 0.00 | 0.00 | +0.00 | buy |
| First Light Asset Management, LLC | 627,904 | 188,367 | -439,537 | 2.41 | 0.76 | -1.64 | sell |
| AXA S.A. | 175,350 | 175,632 | +282 | 0.02 | 0.02 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 97,149 | 174,850 | +77,701 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 142,372 | 166,472 | +24,100 | 0.01 | 0.01 | -0.00 | buy |
| Foresite Capital Management IV, LLC | 0 | 160,000 | +160,000 | 0.00 | 4.05 | +4.05 | buy |
| Foresite Capital Management VI LLC | 0 | 160,000 | +160,000 | 0.00 | 2.82 | +2.82 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 158,605 | +158,605 | 0.00 | 0.59 | +0.59 | buy |
| UBS Group AG | 105,333 | 153,058 | +47,725 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 19,270 | 152,770 | +133,500 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 174,576 | 150,373 | -24,203 | 0.69 | 0.54 | -0.15 | sell |
| Neuberger Berman Group LLC | 44,852 | 147,411 | +102,559 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 59,366 | 147,226 | +87,860 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 152,188 | 141,783 | -10,405 | 0.01 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137,221 | 129,103 | -8,118 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 125,600 | 124,300 | -1,300 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 103,624 | 122,026 | +18,402 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 687,088 | 120,045 | -567,043 | 0.02 | 0.00 | -0.02 | sell |
| WELLS FARGO & COMPANY/MN | 65,912 | 112,562 | +46,650 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 29 | 109,700 | +109,671 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 229,000 | 107,891 | -121,109 | 1.58 | 0.68 | -0.91 | sell |
| DEUTSCHE BANK AG\ | 53,711 | 104,534 | +50,823 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 123,415 | 102,345 | -21,070 | 0.10 | 0.07 | -0.04 | sell |
| Caption Management, LLC | 0 | 100,940 | +100,940 | 0.00 | 0.29 | +0.29 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 48,763 | 95,568 | +46,805 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 298,800 | 95,300 | -203,500 | 0.02 | 0.01 | -0.02 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 55,000 | 90,000 | +35,000 | 0.06 | 0.06 | -0.01 | buy |
| J. Safra Sarasin Holding AG | 30,573 | 82,048 | +51,475 | 0.02 | 0.04 | +0.03 | buy |
| Legal & General Group Plc | 60,406 | 81,792 | +21,386 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 78,800 | +78,800 | 0.00 | 0.17 | +0.17 | buy |
| T. Rowe Price Investment Management, Inc. | 796,986 | 76,943 | -720,043 | 0.02 | 0.00 | -0.02 | sell |
| Nicholas Investment Partners, LP | 86,968 | 68,896 | -18,072 | 0.30 | 0.19 | -0.11 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 267,142 | 68,869 | -198,273 | 0.02 | 0.00 | -0.02 | sell |
| RAYMOND JAMES FINANCIAL INC | 63,385 | 65,214 | +1,829 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 62,348 | +62,348 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 50,417 | 61,772 | +11,355 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,492 | 60,233 | +4,741 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 46,561 | 60,223 | +13,662 | 0.14 | 0.16 | +0.02 | buy |
| Invesco Ltd. | 205,763 | 59,598 | -146,165 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 48,065 | 59,465 | +11,400 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 100,100 | 56,000 | -44,100 | 0.01 | 0.00 | -0.01 | sell |