| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,818,491 | 9,647,998 | -1,170,493 | 0.03 | 0.03 | -0.01 | sell |
| BlackRock, Inc. | 5,640,118 | 7,522,482 | +1,882,364 | 0.01 | 0.01 | +0.00 | buy |
| Avoro Capital Advisors LLC | 5,777,777 | 5,777,777 | 0 | 3.31 | 3.13 | -0.18 | hold |
| Polar Capital Holdings Plc | 4,405,312 | 4,570,556 | +165,244 | 1.12 | 0.78 | -0.34 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,491,653 | 4,418,557 | -73,096 | 1.92 | 1.55 | -0.37 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,329,591 | 3,248,219 | +1,918,628 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,923,610 | 2,617,360 | +693,750 | 0.01 | 0.01 | +0.00 | buy |
| Capital International Investors | 2,674,727 | 2,361,639 | -313,088 | 0.04 | 0.03 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 951,955 | 2,168,581 | +1,216,626 | 0.04 | 0.09 | +0.05 | buy |
| STATE STREET CORP | 1,720,533 | 1,969,629 | +249,096 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 606,085 | 1,642,848 | +1,036,763 | 0.03 | 0.07 | +0.05 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,615,696 | 1,615,696 | 0 | 1.11 | 1.02 | -0.09 | hold |
| Affinity Asset Advisors, LLC | 1,675,000 | 1,595,000 | -80,000 | 5.71 | 4.71 | -1.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,403,297 | 1,562,276 | +158,979 | 0.02 | 0.03 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,401,483 | 1,507,294 | +105,811 | 0.34 | 0.30 | -0.04 | buy |
| FRANKLIN RESOURCES INC | 1,280,577 | 1,437,712 | +157,135 | 0.02 | 0.02 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,829,641 | 1,425,492 | -3,404,149 | 0.05 | 0.01 | -0.04 | sell |
| CITADEL ADVISORS LLC | 2,652,990 | 1,401,242 | -1,251,748 | 0.11 | 0.05 | -0.06 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,092,932 | 1,370,114 | +277,182 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 1,318,564 | 1,318,564 | 0 | 2.13 | 1.62 | -0.51 | hold |
| BNP Paribas Asset Management Holding S.A. | 1,342,028 | 1,290,731 | -51,297 | 0.09 | 0.08 | -0.01 | sell |
| Pictet Asset Management Holding SA | 679,709 | 1,187,723 | +508,014 | 0.04 | 0.07 | +0.03 | buy |
| BRAIDWELL LP | 1,338,452 | 1,131,452 | -207,000 | 2.60 | 2.53 | -0.07 | sell |
| Nuveen, LLC | 250,036 | 993,126 | +743,090 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 59,103 | 903,458 | +844,355 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,059,971 | 892,471 | -167,500 | 1.34 | 1.02 | -0.32 | sell |
| Caligan Partners LP | 1,393,027 | 889,944 | -503,083 | 5.73 | 2.59 | -3.14 | sell |
| AMERICAN CENTURY COMPANIES INC | 679,314 | 884,319 | +205,005 | 0.02 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 972,237 | 883,737 | -88,500 | 0.09 | 0.08 | -0.02 | sell |
| Capital World Investors | 840,072 | 862,775 | +22,703 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 769,875 | 773,625 | +3,750 | 0.01 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 639,900 | 700,000 | +60,100 | 1.04 | 0.99 | -0.05 | buy |
| Alyeska Investment Group, L.P. | 1,299,469 | 697,692 | -601,777 | 0.21 | 0.11 | -0.11 | sell |
| MARSHALL WACE, LLP | 0 | 689,342 | +689,342 | 0.00 | 0.04 | +0.04 | buy |
| Rock Springs Capital Management LP | 763,020 | 683,907 | -79,113 | 2.62 | 2.01 | -0.60 | sell |
| NORTHERN TRUST CORP | 527,783 | 671,566 | +143,783 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 664,031 | +664,031 | 0.00 | 0.12 | +0.12 | buy |
| First Turn Management, LLC | 786,844 | 600,200 | -186,644 | 5.11 | 3.88 | -1.24 | sell |
| TUDOR INVESTMENT CORP ET AL | 495,591 | 545,387 | +49,796 | 0.16 | 0.14 | -0.02 | buy |
| LOOMIS SAYLES & CO L P | 564,897 | 527,273 | -37,624 | 0.04 | 0.04 | -0.00 | sell |
| Octagon Capital Advisors LP | 490,000 | 490,000 | 0 | 3.15 | 2.71 | -0.44 | hold |
| Novo Holdings A/S | 485,438 | 485,438 | 0 | 2.29 | 1.70 | -0.59 | hold |
| Candriam S.C.A. | 476,494 | 462,768 | -13,726 | 0.14 | 0.13 | -0.02 | sell |
| TimesSquare Capital Management, LLC | 359,293 | 451,593 | +92,300 | 0.35 | 0.40 | +0.05 | buy |
| Logos Global Management LP | 450,000 | 450,000 | 0 | 1.35 | 1.17 | -0.18 | hold |
| Bank of New York Mellon Corp | 396,138 | 421,518 | +25,380 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 264,200 | 419,773 | +155,573 | 0.23 | 0.30 | +0.07 | buy |
| Aberdeen Group plc | 609,929 | 408,736 | -201,193 | 0.06 | 0.03 | -0.02 | sell |
| MORGAN STANLEY | 473,759 | 406,257 | -67,502 | 0.00 | 0.00 | -0.00 | sell |
| Fiera Capital Corp | 709,529 | 405,638 | -303,891 | 0.14 | 0.09 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 265,267 | 404,067 | +138,800 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 497,035 | 397,379 | -99,656 | 3.00 | 2.46 | -0.53 | sell |
| Nicholas Investment Partners, LP | 247,101 | 395,844 | +148,743 | 1.04 | 1.35 | +0.31 | buy |
| MILLENNIUM MANAGEMENT LLC | 201,785 | 376,777 | +174,992 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 375,166 | 374,748 | -418 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 370,208 | 370,208 | 0 | 0.12 | 0.11 | -0.01 | hold |
| AMERIPRISE FINANCIAL INC | 78,905 | 318,548 | +239,643 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 310,617 | +310,617 | 0.00 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 470,000 | 300,000 | -170,000 | 0.04 | 0.03 | -0.02 | sell |
| Soleus Capital Management, L.P. | 292,000 | 267,000 | -25,000 | 0.69 | 0.56 | -0.13 | sell |
| Jump Financial, LLC | 155,776 | 260,730 | +104,954 | 0.13 | 0.14 | +0.01 | buy |
| DAFNA Capital Management LLC | 250,772 | 250,772 | 0 | 3.32 | 2.89 | -0.43 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 249,473 | +249,473 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 189,080 | 249,473 | +60,393 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 254,483 | 248,821 | -5,662 | 0.03 | 0.03 | -0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 247,765 | 247,765 | 0 | 1.58 | 1.48 | -0.11 | hold |
| Duquesne Family Office LLC | 238,600 | 238,600 | 0 | 0.47 | 0.33 | -0.14 | hold |
| Allspring Global Investments Holdings, LLC | 246,306 | 234,412 | -11,894 | 0.02 | 0.02 | -0.00 | sell |
| Redmile Group, LLC | 262,674 | 229,374 | -33,300 | 1.01 | 0.93 | -0.08 | sell |
| Schonfeld Strategic Advisors LLC | 324,722 | 227,330 | -97,392 | 0.15 | 0.07 | -0.08 | sell |
| D. E. Shaw & Co., Inc. | 18,940 | 223,922 | +204,982 | 0.00 | 0.01 | +0.01 | buy |
| Patient Square Capital LP | 227,000 | 220,000 | -7,000 | 2.34 | 2.06 | -0.28 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 188,505 | 210,471 | +21,966 | 0.02 | 0.02 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,318,814 | 208,060 | -1,110,754 | 0.05 | 0.01 | -0.05 | sell |
| Neuberger Berman Group LLC | 130,438 | 206,604 | +76,166 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 67,361 | 202,455 | +135,094 | 0.03 | 0.08 | +0.05 | buy |
| DnB Asset Management AS | 181,085 | 200,451 | +19,366 | 0.04 | 0.03 | -0.00 | buy |
| Integral Health Asset Management, LLC | 200,000 | 200,000 | 0 | 0.62 | 0.50 | -0.12 | hold |
| Eversept Partners, LP | 129,574 | 196,532 | +66,958 | 0.50 | 0.65 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 233,905 | 193,407 | -40,498 | 0.03 | 0.02 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 162,682 | 191,126 | +28,444 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 300,500 | 187,110 | -113,390 | 0.03 | 0.02 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 197,759 | 186,821 | -10,938 | 1.36 | 1.26 | -0.10 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 270,412 | 183,343 | -87,069 | 0.36 | 0.21 | -0.16 | sell |
| WELLS FARGO & COMPANY/MN | 115,652 | 173,945 | +58,293 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 228,899 | 166,550 | -62,349 | 0.80 | 0.47 | -0.33 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 143,136 | 164,894 | +21,758 | 0.31 | 0.32 | +0.01 | buy |
| Swiss National Bank | 157,700 | 162,700 | +5,000 | 0.01 | 0.01 | -0.00 | buy |
| Foresite Capital Management IV, LLC | 160,000 | 160,000 | 0 | 3.92 | 3.33 | -0.60 | hold |
| Woodline Partners LP | 150,302 | 155,302 | +5,000 | 0.03 | 0.03 | -0.00 | buy |
| HSBC HOLDINGS PLC | 121,558 | 151,474 | +29,916 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 129,399 | 148,451 | +19,052 | 0.01 | 0.01 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 18,468 | 133,059 | +114,591 | 0.02 | 0.13 | +0.11 | buy |
| Point72 Asset Management, L.P. | 0 | 130,378 | +130,378 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 104,478 | 129,443 | +24,965 | 0.29 | 0.28 | -0.02 | buy |
| KBC Group NV | 129,010 | 129,010 | 0 | 0.02 | 0.02 | -0.00 | hold |
| RHUMBLINE ADVISERS | 101,785 | 123,398 | +21,613 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 81,156 | 121,819 | +40,663 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 114,381 | 119,251 | +4,870 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 112,869 | +112,869 | 0.00 | 0.01 | +0.01 | buy |