| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 989,327 | 1,491,835 | +502,508 | 3.08 | 3.48 | +0.39 | buy |
| BRAIDWELL LP | 1,828,353 | 2,103,396 | +275,043 | 2.30 | 2.27 | -0.03 | buy |
| First Light Asset Management, LLC | 338,646 | 602,070 | +263,424 | 1.02 | 1.95 | +0.93 | buy |
| Affinity Asset Advisors, LLC | 60,376 | 300,438 | +240,062 | 0.91 | 3.35 | +2.44 | buy |
| Logos Global Management LP | 275,000 | 450,000 | +175,000 | 1.46 | 2.19 | +0.73 | buy |
| TimesSquare Capital Management, LLC | 426,925 | 590,575 | +163,650 | 0.24 | 0.31 | +0.08 | buy |
| Tri Locum Partners LP | 24,221 | 171,755 | +147,534 | 0.35 | 1.88 | +1.54 | buy |
| Capital International Investors | 2,321,991 | 2,446,820 | +124,829 | 0.02 | 0.02 | -0.00 | buy |
| Nicholas Investment Partners, LP | 791,118 | 854,447 | +63,329 | 2.08 | 2.18 | +0.10 | buy |
| JANUS HENDERSON GROUP PLC | 327,344 | 382,305 | +54,961 | 0.01 | 0.01 | 0.00 | buy |
| JENNISON ASSOCIATES LLC | 188,391 | 213,823 | +25,432 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 17,575 | 35,255 | +17,680 | 0.31 | 0.56 | +0.25 | buy |
| ALGERT GLOBAL LLC | 144,877 | 128,487 | +16,390 | 0.24 | 0.21 | 0.00 | sell |
| SAMLYN CAPITAL, LLC | 939,909 | 951,755 | +11,846 | 0.63 | 0.58 | -0.05 | buy |
| Fiera Capital Corp | 549,341 | 560,546 | +11,205 | 0.06 | 0.06 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 38,676 | 48,676 | +10,000 | 0.06 | 0.04 | 0.00 | buy |
| DnB Asset Management AS | 112,629 | 121,770 | +9,141 | 0.02 | 0.02 | -0.00 | buy |
| CIBC WORLD MARKET INC. | 41,222 | 45,372 | +4,150 | 0.01 | 0.01 | +0.00 | buy |
| NATIXIS | 7,000 | 10,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 833 | 1,651 | +818 | 0.01 | 0.02 | +0.01 | buy |
| ALPS ADVISORS INC | 46,723 | 47,349 | +626 | 0.02 | 0.01 | -0.00 | buy |
| Moran Wealth Management, LLC | 68,930 | 69,510 | +580 | 0.10 | 0.09 | -0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,472 | 15,758 | +286 | 0.05 | 0.05 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,552 | 2,324 | -228 | 0.06 | 0.05 | -0.01 | sell |
| Granahan Investment Management, LLC | 236,753 | 236,290 | -463 | 0.28 | 0.29 | +0.01 | sell |
| TLS Advisors LLC | 33,756 | 32,956 | -800 | 5.58 | 4.56 | -1.02 | sell |
| Parkman Healthcare Partners LLC | 217,740 | 216,644 | -1,096 | 1.45 | 1.36 | -0.10 | sell |
| ADVISORY RESEARCH INC | 44,422 | 38,326 | -6,096 | 0.22 | 0.18 | -0.04 | sell |
| Nan Fung Group Holdings Ltd | 114,380 | 106,680 | -7,700 | 2.81 | 2.95 | +0.14 | sell |
| Soleus Capital Management, L.P. | 66,000 | 52,000 | -14,000 | 0.28 | 0.18 | -0.10 | sell |
| Polar Capital Holdings Plc | 3,022,071 | 3,003,747 | -18,324 | 0.80 | 0.76 | -0.04 | sell |
| PFM Health Sciences, LP | 100,147 | 78,587 | -21,560 | 0.16 | 0.13 | -0.03 | sell |
| LOOMIS SAYLES & CO L P | 753,526 | 730,716 | -22,810 | 0.05 | 0.04 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 530,000 | 500,001 | -29,999 | 4.09 | 3.21 | -0.87 | sell |
| J. Goldman & Co LP | 48,041 | 17,775 | -30,266 | 0.11 | 0.03 | -0.08 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 99,756 | 53,996 | -45,760 | 1.30 | 0.69 | -0.61 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 670,000 | 550,000 | -120,000 | 0.06 | 0.04 | -0.01 | sell |
| Candriam S.C.A. | 705,884 | 569,884 | -136,000 | 0.20 | 0.14 | -0.06 | sell |
| ORBIMED ADVISORS LLC | 1,096,000 | 958,793 | -137,207 | 0.77 | 0.70 | -0.07 | sell |
| Woodline Partners LP | 290,400 | 143,451 | -146,949 | 0.13 | 0.06 | -0.08 | sell |
| Avidity Partners Management LP | 481,300 | 321,400 | -159,900 | 0.65 | 0.44 | -0.21 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,760,853 | 4,513,005 | -247,848 | 2.31 | 2.00 | -0.31 | sell |
| Holocene Advisors, LP | 712,478 | 178,470 | -534,008 | 0.12 | 0.03 | -0.09 | sell |
| PERCEPTIVE ADVISORS LLC | 1,223,377 | 617,500 | -605,877 | 1.37 | 0.71 | -0.66 | sell |
| Redmile Group, LLC | 1,120,476 | 419,568 | -700,908 | 1.66 | 0.68 | -0.97 | sell |
| LORD, ABBETT & CO. LLC | 1,958,540 | 1,149,168 | -809,372 | 0.26 | 0.15 | -0.11 | sell |