| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,045,257 | 2,552,392 | +1,507,135 | 0.02 | 0.05 | 0.00 | buy |
| SAMLYN CAPITAL, LLC | 639,685 | 1,020,206 | +380,521 | 0.42 | 0.61 | +0.19 | buy |
| Vestal Point Capital, LP | 525,000 | 825,000 | +300,000 | 1.53 | 2.56 | +1.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,839,555 | 2,083,972 | +244,417 | 0.13 | 0.14 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,419,472 | 4,595,721 | +176,249 | 1.67 | 1.55 | -0.11 | buy |
| Affinity Asset Advisors, LLC | 994,227 | 1,144,021 | +149,794 | 6.11 | 6.99 | +0.88 | buy |
| BRAIDWELL LP | 2,560,573 | 2,707,255 | +146,682 | 3.13 | 3.02 | -0.11 | buy |
| Capital International Investors | 2,475,859 | 2,581,172 | +105,313 | 0.02 | 0.02 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 357,178 | 262,631 | +94,547 | 0.16 | 0.11 | 0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 91,500 | 176,674 | +85,174 | 0.00 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 754,000 | 818,000 | +64,000 | 1.25 | 1.64 | +0.39 | buy |
| T. Rowe Price Investment Management, Inc. | 1,439,903 | 1,503,808 | +63,905 | 0.04 | 0.04 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 862,362 | 911,420 | +49,058 | 0.67 | 0.66 | -0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 195,129 | 243,579 | +48,450 | 0.02 | 0.02 | 0.00 | buy |
| LOOMIS SAYLES & CO L P | 660,258 | 707,222 | +46,964 | 0.04 | 0.04 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,272,877 | 1,316,477 | +43,600 | 1.49 | 1.69 | +0.19 | buy |
| Ally Bridge Group (NY) LLC | 169,369 | 211,791 | +42,422 | 3.93 | 4.46 | +0.53 | buy |
| ALGERT GLOBAL LLC | 183,205 | 219,645 | +36,440 | 0.25 | 0.23 | 0.00 | buy |
| Aberdeen Group plc | 212,502 | 248,311 | +35,809 | 0.02 | 0.02 | +0.00 | buy |
| PFM Health Sciences, LP | 150,554 | 179,878 | +29,324 | 0.29 | 0.40 | +0.11 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 643,546 | 669,600 | +26,054 | 0.12 | 0.12 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 24,116 | 48,063 | +23,947 | 0.07 | 0.08 | 0.00 | buy |
| TimesSquare Capital Management, LLC | 754,493 | 778,293 | +23,800 | 0.46 | 0.46 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 4,700 | 27,903 | +23,203 | 0.04 | 0.18 | +0.15 | buy |
| BNP Paribas Asset Management Holding S.A. | 421,121 | 439,074 | +17,953 | 0.04 | 0.04 | +0.00 | buy |
| DnB Asset Management AS | 175,733 | 190,623 | +14,890 | 0.03 | 0.03 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 6,687 | 19,744 | +13,057 | 0.05 | 0.17 | +0.12 | buy |
| Y-Intercept (Hong Kong) Ltd | 14,550 | 24,557 | +10,007 | 0.03 | 0.06 | 0.00 | buy |
| JENNISON ASSOCIATES LLC | 570,272 | 576,661 | +6,389 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,868 | 14,572 | +5,704 | 0.05 | 0.06 | +0.01 | buy |
| Atika Capital Management LLC | 124,000 | 126,000 | +2,000 | 0.47 | 0.51 | +0.03 | buy |
| HighVista Strategies LLC | 72,715 | 73,762 | +1,047 | 1.04 | 1.00 | -0.03 | buy |
| Advisors Asset Management, Inc. | 13,099 | 13,592 | +493 | 0.01 | 0.01 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,380 | 2,425 | +45 | 0.05 | 0.04 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,335 | 18,266 | -69 | 0.06 | 0.06 | -0.00 | sell |
| Elmwood Wealth Management, Inc. | 7,943 | 7,607 | -336 | 0.14 | 0.12 | -0.01 | sell |
| ALPS ADVISORS INC | 58,853 | 56,989 | -1,864 | 0.02 | 0.02 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 9,328 | 7,370 | -1,958 | 0.07 | 0.06 | -0.01 | sell |
| Bellevue Group AG | 10,200 | 8,200 | -2,000 | 0.01 | 0.01 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 291,868 | 288,843 | -3,025 | 0.07 | 0.06 | -0.01 | sell |
| Nebula Research & Development LLC | 30,196 | 24,265 | -5,931 | 0.19 | 0.11 | -0.08 | sell |
| First Turn Management, LLC | 339,876 | 325,218 | -14,658 | 2.16 | 2.03 | -0.13 | sell |
| LORD, ABBETT & CO. LLC | 190,033 | 173,985 | -16,048 | 0.02 | 0.02 | -0.00 | sell |
| CIBC WORLD MARKET INC. | 36,385 | 19,835 | -16,550 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 209,290 | 191,658 | -17,632 | 1.11 | 0.96 | -0.15 | sell |
| Granahan Investment Management, LLC | 226,166 | 200,877 | -25,289 | 0.35 | 0.31 | -0.04 | sell |
| Fiera Capital Corp | 582,879 | 554,200 | -28,679 | 0.07 | 0.07 | -0.00 | sell |
| Commodore Capital LP | 2,754,266 | 2,700,000 | -54,266 | 7.33 | 6.64 | -0.69 | sell |
| Candriam S.C.A. | 521,836 | 463,861 | -57,975 | 0.12 | 0.10 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 583,256 | 524,930 | -58,326 | 0.55 | 0.44 | -0.11 | sell |
| Polar Capital Holdings Plc | 2,536,058 | 2,444,645 | -91,413 | 0.58 | 0.46 | -0.12 | sell |
| First Light Asset Management, LLC | 1,306,260 | 1,181,662 | -124,598 | 4.46 | 3.87 | -0.59 | sell |