| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,045,257 | 2,552,392 | +1,507,135 | 0.02 | 0.05 | +0.03 | buy |
| JPMORGAN CHASE & CO | 71,654 | 976,783 | +905,129 | 0.00 | 0.00 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 639,685 | 1,020,206 | +380,521 | 0.43 | 0.65 | +0.22 | buy |
| Vestal Point Capital, LP | 525,000 | 825,000 | +300,000 | 1.53 | 2.56 | +1.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,839,555 | 2,083,972 | +244,417 | 0.13 | 0.14 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,419,472 | 4,595,721 | +176,249 | 1.67 | 1.55 | -0.11 | buy |
| MPM BioImpact LLC | 0 | 165,800 | +165,800 | 0.00 | 0.98 | +0.98 | buy |
| Affinity Asset Advisors, LLC | 994,227 | 1,144,021 | +149,794 | 6.11 | 6.99 | +0.88 | buy |
| FMR LLC | 6,768,173 | 6,917,684 | +149,511 | 0.02 | 0.02 | -0.00 | buy |
| BRAIDWELL LP | 2,560,573 | 2,707,255 | +146,682 | 3.13 | 3.02 | -0.11 | buy |
| Assenagon Asset Management S.A. | 73,602 | 212,287 | +138,685 | 0.01 | 0.02 | +0.01 | buy |
| Capital International Investors | 2,475,859 | 2,581,172 | +105,313 | 0.02 | 0.02 | -0.00 | buy |
| Walleye Capital LLC | 0 | 104,960 | +104,960 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 364,173 | 459,625 | +95,452 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 91,500 | 176,674 | +85,174 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 66,383 | +66,383 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 208,900 | 273,700 | +64,800 | 0.02 | 0.03 | +0.01 | buy |
| Avidity Partners Management LP | 754,000 | 818,000 | +64,000 | 1.25 | 1.64 | +0.39 | buy |
| T. Rowe Price Investment Management, Inc. | 1,439,903 | 1,503,808 | +63,905 | 0.04 | 0.04 | +0.00 | buy |
| Russell Investments Group, Ltd. | 162,850 | 223,614 | +60,764 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,479,491 | 1,528,814 | +49,323 | 0.07 | 0.07 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 862,362 | 911,420 | +49,058 | 0.67 | 0.66 | -0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 195,129 | 243,579 | +48,450 | 0.02 | 0.02 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 660,258 | 707,222 | +46,964 | 0.04 | 0.04 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,272,877 | 1,316,477 | +43,600 | 1.50 | 1.69 | +0.19 | buy |
| D. E. Shaw & Co., Inc. | 161,722 | 204,892 | +43,170 | 0.01 | 0.01 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 169,369 | 211,791 | +42,422 | 3.93 | 4.46 | +0.53 | buy |
| ALGERT GLOBAL LLC | 183,205 | 219,645 | +36,440 | 0.24 | 0.23 | -0.01 | buy |
| Aberdeen Group plc | 212,502 | 248,311 | +35,809 | 0.02 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 175,584 | 209,026 | +33,442 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 246,812 | 279,513 | +32,701 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 6,478 | 37,308 | +30,830 | 0.02 | 0.11 | +0.09 | buy |
| PFM Health Sciences, LP | 150,554 | 179,878 | +29,324 | 0.32 | 0.41 | +0.09 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 643,546 | 669,600 | +26,054 | 0.12 | 0.12 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 24,116 | 48,063 | +23,947 | 0.07 | 0.08 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 754,493 | 778,293 | +23,800 | 0.46 | 0.46 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 4,700 | 27,903 | +23,203 | 0.04 | 0.18 | +0.15 | buy |
| BNP Paribas Asset Management Holding S.A. | 421,121 | 439,074 | +17,953 | 0.04 | 0.04 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,828,221 | 3,843,447 | +15,226 | 0.03 | 0.03 | -0.00 | buy |
| DnB Asset Management AS | 175,733 | 190,623 | +14,890 | 0.03 | 0.03 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 14,658 | +14,658 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 1,090 | 14,993 | +13,903 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 6,687 | 19,744 | +13,057 | 0.05 | 0.17 | +0.12 | buy |
| Brevan Howard Capital Management LP | 0 | 12,012 | +12,012 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 25,232 | 36,687 | +11,455 | 0.01 | 0.02 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 89,800 | 100,982 | +11,182 | 0.01 | 0.01 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 10,811 | +10,811 | 0.00 | 0.08 | +0.08 | buy |
| Y-Intercept (Hong Kong) Ltd | 14,550 | 24,557 | +10,007 | 0.03 | 0.06 | +0.03 | buy |
| Vestcor Inc | 0 | 8,300 | +8,300 | 0.00 | 0.01 | +0.01 | buy |
| NATIXIS ADVISORS, LLC | 19,594 | 27,158 | +7,564 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 7,504 | +7,504 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 570,272 | 576,661 | +6,389 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,868 | 14,572 | +5,704 | 0.05 | 0.06 | +0.01 | buy |
| VANGUARD GROUP INC | 341,152 | 344,365 | +3,213 | 0.00 | 0.00 | -0.00 | buy |
| nVerses Capital, LLC | 0 | 2,600 | +2,600 | 0.00 | 0.05 | +0.05 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 14,078 | 16,089 | +2,011 | 0.00 | 0.00 | -0.00 | buy |
| Atika Capital Management LLC | 124,000 | 126,000 | +2,000 | 0.56 | 0.53 | -0.03 | buy |
| Handelsbanken Fonder AB | 21,000 | 22,700 | +1,700 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 734,555 | 736,200 | +1,645 | 0.07 | 0.06 | -0.00 | buy |
| ASSETMARK, INC | 18,235 | 19,670 | +1,435 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,067 | 60,456 | +1,389 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 36,388 | 37,636 | +1,248 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 238,772 | 239,942 | +1,170 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 72,715 | 73,762 | +1,047 | 1.04 | 1.00 | -0.03 | buy |
| UBS Group AG | 12,578 | 13,290 | +712 | 0.00 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 367 | 1,008 | +641 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 17,949 | 18,472 | +523 | 0.00 | 0.00 | -0.00 | buy |
| Advisors Asset Management, Inc. | 13,099 | 13,592 | +493 | 0.01 | 0.01 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,253 | 2,740 | +487 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 71 | 418 | +347 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 294 | 544 | +250 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 162,466 | 162,683 | +217 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,840 | 4,960 | +120 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 129 | 237 | +108 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 4 | 104 | +100 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| WOLFF WIESE MAGANA LLC | 0 | 61 | +61 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 188,038 | 188,090 | +52 | 0.02 | 0.02 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,380 | 2,425 | +45 | 0.05 | 0.04 | -0.00 | buy |
| Daiwa Securities Group Inc. | 252 | 288 | +36 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 21 | 45 | +24 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 38 | 59 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 15 | 27 | +12 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 7 | 14 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 5 | 12 | +7 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 100,100 | 100,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 15,911 | 15,911 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 21,500 | 21,500 | 0 | 0.14 | 0.14 | +0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TD ASSET MANAGEMENT INC | 20,430 | 20,430 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 47,165 | 47,165 | 0 | 0.00 | 0.00 | +0.00 | hold |
| C M BIDWELL & ASSOCIATES LTD | 9 | 9 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5,000 | 5,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 146,800 | 146,800 | 0 | 2.95 | 2.89 | -0.05 | hold |
| BAKER BROS. ADVISORS LP | 993,679 | 993,679 | 0 | 0.50 | 0.41 | -0.09 | hold |
| WHITTIER TRUST CO OF NEVADA INC | 36 | 36 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 23,666 | 23,666 | 0 | 0.01 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 273,739 | 273,739 | 0 | 2.55 | 2.55 | -0.00 | hold |