| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 2,174,761 | 3,609,857 | +1,435,096 | 0.01 | 0.03 | +0.01 | buy |
| CITADEL ADVISORS LLC | 120,045 | 959,098 | +839,053 | 0.00 | 0.03 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 76,943 | 599,113 | +522,170 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 882,835 | 1,384,007 | +501,172 | 0.02 | 0.04 | +0.02 | buy |
| Caligan Partners LP | 0 | 444,565 | +444,565 | 0.00 | 2.48 | +2.48 | buy |
| JENNISON ASSOCIATES LLC | 696,383 | 1,135,235 | +438,852 | 0.01 | 0.03 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 3,577,735 | 3,943,885 | +366,150 | 0.05 | 0.07 | +0.02 | buy |
| Tri Locum Partners LP | 0 | 366,102 | +366,102 | 0.00 | 3.38 | +3.38 | buy |
| Affinity Asset Advisors, LLC | 1,100,000 | 1,400,000 | +300,000 | 5.09 | 5.23 | +0.14 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 68,869 | 322,456 | +253,587 | 0.00 | 0.03 | +0.02 | buy |
| Jain Global LLC | 0 | 252,379 | +252,379 | 0.00 | 0.13 | +0.13 | buy |
| STEMPOINT CAPITAL LP | 0 | 192,295 | +192,295 | 0.00 | 1.56 | +1.56 | buy |
| MPM BioImpact LLC | 323,398 | 503,398 | +180,000 | 1.75 | 3.31 | +1.55 | buy |
| Holocene Advisors, LP | 1,809,475 | 1,976,553 | +167,078 | 0.14 | 0.18 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 561,800 | 720,659 | +158,859 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,256,581 | 1,399,033 | +142,452 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,844 | 159,238 | +141,394 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 660,617 | 799,743 | +139,126 | 3.86 | 4.82 | +0.96 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,518,527 | 1,654,417 | +135,890 | 0.02 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 1,380,460 | 1,466,467 | +86,007 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 76,824 | +76,824 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 379,988 | 454,023 | +74,035 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 521,492 | 579,145 | +57,653 | 0.03 | 0.04 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 57,117 | +57,117 | 0.00 | 0.01 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,152,605 | 1,206,066 | +53,461 | 0.15 | 0.20 | +0.05 | buy |
| Nicholas Investment Partners, LP | 68,896 | 119,098 | +50,202 | 0.19 | 0.37 | +0.17 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 90,000 | 140,000 | +50,000 | 0.06 | 0.11 | +0.06 | buy |
| Neo Ivy Capital Management | 0 | 49,838 | +49,838 | 0.00 | 0.49 | +0.49 | buy |
| JANE STREET GROUP, LLC | 43,676 | 89,879 | +46,203 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 35,000 | 81,000 | +46,000 | 0.14 | 0.36 | +0.22 | buy |
| Atika Capital Management LLC | 0 | 38,000 | +38,000 | 0.00 | 0.13 | +0.13 | buy |
| HighVista Strategies LLC | 45,620 | 82,190 | +36,570 | 0.52 | 0.81 | +0.28 | buy |
| Saturn V Capital Management LP | 468,364 | 503,701 | +35,337 | 5.94 | 4.44 | -1.51 | buy |
| FMR LLC | 8,884,363 | 8,918,907 | +34,544 | 0.02 | 0.02 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 174,850 | 208,372 | +33,522 | 0.01 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 666,466 | 695,900 | +29,434 | 0.01 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 28,859 | +28,859 | 0.00 | 0.03 | +0.03 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 28,669 | +28,669 | 0.00 | 0.09 | +0.09 | buy |
| Parkman Healthcare Partners LLC | 150,373 | 176,137 | +25,764 | 0.54 | 0.78 | +0.23 | buy |
| Neuberger Berman Group LLC | 147,411 | 172,354 | +24,943 | 0.00 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 23,054 | +23,054 | 0.00 | 0.05 | +0.05 | buy |
| SANDERS MORRIS HARRIS LLC | 0 | 21,500 | +21,500 | 0.00 | 0.11 | +0.11 | buy |
| Russell Investments Group, Ltd. | 52,136 | 69,892 | +17,756 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 16,230 | +16,230 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 16,101 | +16,101 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 234,157 | 249,081 | +14,924 | 0.03 | 0.04 | +0.01 | buy |
| Quantinno Capital Management LP | 0 | 13,371 | +13,371 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 13,210 | +13,210 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 9,273 | +9,273 | 0.00 | 0.02 | +0.02 | buy |
| BNP Paribas Asset Management Holding S.A. | 661,082 | 670,257 | +9,175 | 0.05 | 0.07 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 104,534 | 112,951 | +8,417 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 489,940 | 498,147 | +8,207 | 0.00 | 0.00 | +0.00 | buy |
| ALTFEST L J & CO INC | 0 | 7,731 | +7,731 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 970,343 | 977,435 | +7,092 | 0.00 | 0.00 | +0.00 | buy |
| PenderFund Capital Management Ltd. | 0 | 6,850 | +6,850 | 0.00 | 0.05 | +0.05 | buy |
| Freestone Grove Partners LP | 0 | 6,748 | +6,748 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 6,322 | +6,322 | 0.00 | 0.06 | +0.06 | buy |
| XPONANCE, INC. | 0 | 5,967 | +5,967 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 5,818 | +5,818 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 166,472 | 171,708 | +5,236 | 0.01 | 0.01 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 5,028 | +5,028 | 0.00 | 0.08 | +0.08 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 65,214 | 69,922 | +4,708 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,935 | 41,692 | +3,757 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 17,358 | 21,032 | +3,674 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 112,562 | 115,221 | +2,659 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,462 | 5,899 | +2,437 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 10,538 | 12,652 | +2,114 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 124,300 | 126,400 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 23,866 | 25,589 | +1,723 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 59,465 | 60,858 | +1,393 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 21,250 | 22,566 | +1,316 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 21,138 | 22,162 | +1,024 | 0.22 | 0.29 | +0.08 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 959 | +959 | 0.00 | 0.02 | +0.02 | buy |
| State of Wyoming | 541 | 1,151 | +610 | 0.00 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 2,867 | 3,469 | +602 | 0.03 | 0.04 | +0.01 | buy |
| Quarry LP | 2,000 | 2,500 | +500 | 0.01 | 0.02 | +0.01 | buy |
| Arizona State Retirement System | 18,956 | 19,290 | +334 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 689 | 924 | +235 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 14 | 185 | +171 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 17,424 | 17,564 | +140 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 119 | +119 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 237 | 335 | +98 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 35 | 126 | +91 | 0.00 | 0.00 | +0.00 | buy |
| Elmwood Wealth Management, Inc. | 10,824 | 10,907 | +83 | 0.13 | 0.16 | +0.02 | buy |
| Farther Finance Advisors, LLC | 784 | 846 | +62 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 1,865 | 1,908 | +43 | 0.00 | 0.00 | +0.00 | buy |
| Rossby Financial, LCC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 347 | 386 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,964 | 2,981 | +17 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 26 | 40 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 135 | 147 | +12 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,233 | 60,237 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| Orion Porfolio Solutions, LLC | 14,916 | 14,918 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Tortoise Investment Management, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 542,020 | 542,020 | 0 | 0.31 | 0.33 | +0.03 | hold |