| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,884,363 | 8,918,907 | +34,544 | 0.02 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 5,400,000 | 5,400,000 | 0 | 2.96 | 2.80 | -0.16 | hold |
| BlackRock, Inc. | 5,365,327 | 4,770,951 | -594,376 | 0.00 | 0.00 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,335,648 | 4,169,114 | -166,534 | 1.09 | 1.20 | +0.11 | sell |
| JANUS HENDERSON GROUP PLC | 3,577,735 | 3,943,885 | +366,150 | 0.05 | 0.07 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,174,761 | 3,609,857 | +1,435,096 | 0.01 | 0.03 | +0.01 | buy |
| BRAIDWELL LP | 3,605,029 | 3,605,029 | 0 | 3.86 | 4.29 | +0.44 | hold |
| Capital International Investors | 3,181,549 | 3,181,493 | -56 | 0.02 | 0.02 | +0.00 | sell |
| Commodore Capital LP | 3,025,000 | 2,700,000 | -325,000 | 6.68 | 5.29 | -1.39 | sell |
| Polar Capital Holdings Plc | 2,703,256 | 2,546,766 | -156,490 | 0.44 | 0.49 | +0.05 | sell |
| Holocene Advisors, LP | 1,809,475 | 1,976,553 | +167,078 | 0.14 | 0.18 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,518,527 | 1,654,417 | +135,890 | 0.02 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 1,380,460 | 1,466,467 | +86,007 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,100,000 | 1,400,000 | +300,000 | 5.09 | 5.23 | +0.14 | buy |
| JPMORGAN CHASE & CO | 1,256,581 | 1,399,033 | +142,452 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 882,835 | 1,384,007 | +501,172 | 0.02 | 0.04 | +0.02 | buy |
| Pictet Asset Management Holding SA | 1,474,449 | 1,262,579 | -211,870 | 0.05 | 0.05 | +0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,152,605 | 1,206,066 | +53,461 | 0.15 | 0.20 | +0.05 | buy |
| Deep Track Capital, LP | 1,350,000 | 1,200,000 | -150,000 | 1.36 | 1.34 | -0.01 | sell |
| JENNISON ASSOCIATES LLC | 696,383 | 1,135,235 | +438,852 | 0.01 | 0.03 | +0.01 | buy |
| Vestal Point Capital, LP | 2,000,000 | 1,100,000 | -900,000 | 3.30 | 2.00 | -1.29 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 970,343 | 977,435 | +7,092 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 120,045 | 959,098 | +839,053 | 0.00 | 0.03 | +0.03 | buy |
| Rock Springs Capital Management LP | 931,681 | 851,744 | -79,937 | 1.82 | 2.00 | +0.18 | sell |
| VANGUARD GROUP INC | 873,228 | 851,386 | -21,842 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,290,100 | 835,100 | -455,000 | 0.07 | 0.05 | -0.01 | sell |
| Siren, L.L.C. | 812,761 | 812,761 | 0 | 1.32 | 1.28 | -0.04 | hold |
| First Turn Management, LLC | 660,617 | 799,743 | +139,126 | 3.86 | 4.82 | +0.96 | buy |
| GOLDMAN SACHS GROUP INC | 561,800 | 720,659 | +158,859 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 666,466 | 695,900 | +29,434 | 0.01 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 661,082 | 670,257 | +9,175 | 0.05 | 0.07 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 679,857 | 659,257 | -20,600 | 0.01 | 0.01 | +0.00 | sell |
| Capital World Investors | 655,737 | 655,737 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOOMIS SAYLES & CO L P | 657,165 | 640,626 | -16,539 | 0.03 | 0.03 | +0.00 | sell |
| MARSHALL WACE, LLP | 1,020,254 | 611,982 | -408,272 | 0.04 | 0.03 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 76,943 | 599,113 | +522,170 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 521,492 | 579,145 | +57,653 | 0.03 | 0.04 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 571,242 | 556,800 | -14,442 | 0.26 | 0.32 | +0.06 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 542,020 | 542,020 | 0 | 0.31 | 0.33 | +0.03 | hold |
| Fiera Capital Corp | 530,683 | 519,999 | -10,684 | 0.06 | 0.07 | +0.01 | sell |
| Saturn V Capital Management LP | 468,364 | 503,701 | +35,337 | 5.94 | 4.44 | -1.51 | buy |
| MPM BioImpact LLC | 323,398 | 503,398 | +180,000 | 1.75 | 3.31 | +1.55 | buy |
| NORTHERN TRUST CORP | 489,940 | 498,147 | +8,207 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 379,988 | 454,023 | +74,035 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 0 | 444,565 | +444,565 | 0.00 | 2.48 | +2.48 | buy |
| ORBIMED ADVISORS LLC | 947,877 | 419,600 | -528,277 | 0.75 | 0.40 | -0.34 | sell |
| Bank of New York Mellon Corp | 436,020 | 418,416 | -17,604 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 396,636 | 396,636 | 0 | 0.07 | 0.08 | +0.01 | hold |
| BAKER BROS. ADVISORS LP | 370,208 | 370,208 | 0 | 0.11 | 0.11 | -0.01 | hold |
| MORGAN STANLEY | 387,596 | 366,572 | -21,024 | 0.00 | 0.00 | +0.00 | sell |
| Tri Locum Partners LP | 0 | 366,102 | +366,102 | 0.00 | 3.38 | +3.38 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 68,869 | 322,456 | +253,587 | 0.00 | 0.03 | +0.02 | buy |
| DAFNA Capital Management LLC | 287,939 | 287,939 | 0 | 2.49 | 2.86 | +0.37 | hold |
| Jain Global LLC | 0 | 252,379 | +252,379 | 0.00 | 0.13 | +0.13 | buy |
| DnB Asset Management AS | 234,157 | 249,081 | +14,924 | 0.03 | 0.04 | +0.01 | buy |
| FEDERATED HERMES, INC. | 232,500 | 232,500 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Nuveen, LLC | 228,567 | 224,289 | -4,278 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 174,850 | 208,372 | +33,522 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 200,791 | 200,791 | 0 | 0.24 | 0.23 | -0.00 | hold |
| GREAT POINT PARTNERS LLC | 200,000 | 200,000 | 0 | 4.07 | 3.35 | -0.72 | hold |
| BANK OF AMERICA CORP /DE/ | 358,432 | 199,106 | -159,326 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 192,295 | +192,295 | 0.00 | 1.56 | +1.56 | buy |
| ADAR1 Capital Management, LLC | 259,503 | 189,098 | -70,405 | 1.32 | 0.75 | -0.57 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 192,242 | 188,747 | -3,495 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 150,373 | 176,137 | +25,764 | 0.54 | 0.78 | +0.23 | buy |
| Neuberger Berman Group LLC | 147,411 | 172,354 | +24,943 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 166,472 | 171,708 | +5,236 | 0.01 | 0.01 | +0.00 | buy |
| Foresite Capital Management IV, LLC | 160,000 | 160,000 | 0 | 4.05 | 3.52 | -0.53 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 17,844 | 159,238 | +141,394 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 158,605 | 158,605 | 0 | 0.59 | 0.64 | +0.04 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 90,000 | 140,000 | +50,000 | 0.06 | 0.11 | +0.06 | buy |
| Swiss National Bank | 124,300 | 126,400 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 147,226 | 120,545 | -26,681 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 68,896 | 119,098 | +50,202 | 0.19 | 0.37 | +0.17 | buy |
| WELLS FARGO & COMPANY/MN | 112,562 | 115,221 | +2,659 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 104,534 | 112,951 | +8,417 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 152,770 | 111,300 | -41,470 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 109,700 | 106,791 | -2,909 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 153,058 | 106,744 | -46,314 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 122,026 | 97,567 | -24,459 | 0.00 | 0.00 | -0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 95,568 | 94,935 | -633 | 0.03 | 0.04 | +0.01 | sell |
| JANE STREET GROUP, LLC | 43,676 | 89,879 | +46,203 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 240,038 | 87,470 | -152,568 | 0.31 | 0.14 | -0.16 | sell |
| HighVista Strategies LLC | 45,620 | 82,190 | +36,570 | 0.52 | 0.81 | +0.28 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 129,103 | 81,156 | -47,947 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 35,000 | 81,000 | +46,000 | 0.14 | 0.36 | +0.22 | buy |
| Legal & General Group Plc | 81,792 | 79,848 | -1,944 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 76,824 | +76,824 | 0.00 | 0.02 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 65,214 | 69,922 | +4,708 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 52,136 | 69,892 | +17,756 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 59,465 | 60,858 | +1,393 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,233 | 60,237 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 57,117 | +57,117 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 59,598 | 56,064 | -3,534 | 0.00 | 0.00 | +0.00 | sell |
| State of New Jersey Common Pension Fund D | 61,772 | 55,711 | -6,061 | 0.01 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 102,345 | 54,255 | -48,090 | 0.07 | 0.04 | -0.03 | sell |
| Avidity Partners Management LP | 107,891 | 53,400 | -54,491 | 0.68 | 0.49 | -0.19 | sell |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Neo Ivy Capital Management | 0 | 49,838 | +49,838 | 0.00 | 0.49 | +0.49 | buy |
| D. E. Shaw & Co., Inc. | 141,783 | 48,455 | -93,328 | 0.00 | 0.00 | -0.00 | sell |