| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 1,728,108 | 4,162,654 | +2,434,546 | 0.01 | 0.04 | +0.02 | buy |
| FMR LLC | 4,252,866 | 5,655,922 | +1,403,056 | 0.01 | 0.02 | +0.01 | buy |
| First Light Asset Management, LLC | 602,070 | 1,645,490 | +1,043,420 | 1.95 | 6.10 | +4.14 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 891,149 | +891,149 | 0.00 | 0.03 | +0.03 | buy |
| Avoro Capital Advisors LLC | 4,900,000 | 5,666,666 | +766,666 | 2.61 | 3.61 | +0.99 | buy |
| Paradigm Biocapital Advisors LP | 1,491,835 | 2,127,400 | +635,565 | 3.48 | 4.59 | +1.12 | buy |
| JANUS HENDERSON GROUP PLC | 382,305 | 966,065 | +583,760 | 0.01 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 723,524 | 1,266,844 | +543,320 | 0.03 | 0.06 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | 1,048,725 | +498,725 | 0.04 | 0.10 | +0.06 | buy |
| Avidity Partners Management LP | 321,400 | 815,993 | +494,593 | 0.44 | 1.44 | +1.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,084,337 | 1,574,568 | +490,231 | 0.02 | 0.03 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 617,500 | 1,100,748 | +483,248 | 0.71 | 1.13 | +0.42 | buy |
| Capital World Investors | 2,274,974 | 2,681,537 | +406,563 | 0.02 | 0.02 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 213,823 | 566,396 | +352,573 | 0.01 | 0.02 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 346,596 | +346,596 | 0.00 | 0.04 | +0.04 | buy |
| Commodore Capital LP | 1,845,000 | 2,167,793 | +322,793 | 7.37 | 8.72 | +1.36 | buy |
| TWO SIGMA INVESTMENTS, LP | 80,633 | 340,015 | +259,382 | 0.01 | 0.04 | +0.03 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 255,432 | +255,432 | 0.00 | 2.75 | +2.75 | buy |
| BAKER BROS. ADVISORS LP | 751,639 | 993,679 | +242,040 | 0.15 | 0.52 | +0.37 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 237,495 | +237,495 | 0.00 | 0.06 | +0.06 | buy |
| TimesSquare Capital Management, LLC | 590,575 | 793,954 | +203,379 | 0.31 | 0.54 | +0.22 | buy |
| TWO SIGMA ADVISERS, LP | 64,900 | 252,700 | +187,800 | 0.01 | 0.03 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 300,438 | 460,000 | +159,562 | 3.35 | 4.22 | +0.87 | buy |
| BRIDGER MANAGEMENT, LLC | 0 | 146,800 | +146,800 | 0.00 | 2.59 | +2.59 | buy |
| FRANKLIN RESOURCES INC | 172,612 | 293,825 | +121,213 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 255,368 | 376,302 | +120,934 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 78,587 | 192,856 | +114,269 | 0.13 | 0.53 | +0.40 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 53,996 | 163,168 | +109,172 | 0.69 | 2.32 | +1.63 | buy |
| BARCLAYS PLC | 9,521 | 111,990 | +102,469 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,938,779 | 2,040,400 | +101,621 | 0.08 | 0.10 | +0.02 | buy |
| GREAT POINT PARTNERS LLC | 500,001 | 600,000 | +99,999 | 3.21 | 4.71 | +1.50 | buy |
| Atika Capital Management LLC | 0 | 93,234 | +93,234 | 0.00 | 0.61 | +0.61 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 91,500 | +91,500 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 128,487 | 217,320 | +88,833 | 0.21 | 0.40 | +0.20 | buy |
| Parkman Healthcare Partners LLC | 216,644 | 294,788 | +78,144 | 1.36 | 1.92 | +0.56 | buy |
| Rock Springs Capital Management LP | 1,178,002 | 1,255,577 | +77,575 | 1.08 | 1.43 | +0.35 | buy |
| Laurion Capital Management LP | 0 | 75,000 | +75,000 | 0.00 | 0.12 | +0.12 | buy |
| Granahan Investment Management, LLC | 236,290 | 302,581 | +66,291 | 0.29 | 0.46 | +0.17 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 65,000 | +65,000 | 0.00 | 0.07 | +0.07 | buy |
| Polar Capital Holdings Plc | 3,003,747 | 3,066,628 | +62,881 | 0.76 | 0.87 | +0.11 | buy |
| Altium Capital Management LLC | 228,000 | 290,535 | +62,535 | 4.51 | 9.22 | +4.72 | buy |
| VANGUARD GROUP INC | 266,826 | 323,495 | +56,669 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 11,088 | 66,723 | +55,635 | 0.01 | 0.05 | +0.04 | buy |
| Tri Locum Partners LP | 171,755 | 225,564 | +53,809 | 1.88 | 5.10 | +3.22 | buy |
| Woodline Partners LP | 143,451 | 196,453 | +53,002 | 0.06 | 0.10 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 52,951 | +52,951 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 35,210 | 83,069 | +47,859 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 40,547 | 84,153 | +43,606 | 0.00 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 43,221 | +43,221 | 0.00 | 0.03 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 40,256 | +40,256 | 0.00 | 0.06 | +0.06 | buy |
| Aberdeen Group plc | 0 | 32,036 | +32,036 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 27,000 | 59,000 | +32,000 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 27,775 | +27,775 | 0.00 | 0.09 | +0.09 | buy |
| Cinctive Capital Management LP | 0 | 27,600 | +27,600 | 0.00 | 0.09 | +0.09 | buy |
| UBS Group AG | 5,882 | 30,943 | +25,061 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 24,000 | +24,000 | 0.00 | 0.04 | +0.04 | buy |
| DekaBank Deutsche Girozentrale | 20,000 | 39,000 | +19,000 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 17,973 | +17,973 | 0.00 | 0.07 | +0.07 | buy |
| SIMPLEX TRADING, LLC | 10,735 | 28,387 | +17,652 | 0.01 | 0.04 | +0.03 | buy |
| HighVista Strategies LLC | 35,255 | 51,801 | +16,546 | 0.56 | 0.87 | +0.31 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,758 | 32,196 | +16,438 | 0.05 | 0.13 | +0.08 | buy |
| TD ASSET MANAGEMENT INC | 0 | 16,230 | +16,230 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 15,851 | +15,851 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 15,247 | +15,247 | 0.00 | 0.12 | +0.12 | buy |
| Erste Asset Management GmbH | 35,000 | 50,000 | +15,000 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 212,370 | 227,040 | +14,670 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 111,700 | 123,800 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,950 | 55,987 | +11,037 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 21,900 | 32,600 | +10,700 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 123,967 | 133,412 | +9,445 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 44,713 | 53,649 | +8,936 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 27,121 | 36,055 | +8,934 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Investors | 2,446,820 | 2,455,683 | +8,863 | 0.02 | 0.03 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 8,861 | +8,861 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 68,801 | 77,484 | +8,683 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 8,253 | +8,253 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 8,043 | +8,043 | 0.00 | 0.07 | +0.07 | buy |
| OMERS ADMINISTRATION Corp | 0 | 7,700 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 7,281 | +7,281 | 0.00 | 0.10 | +0.10 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 7,199 | +7,199 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 7,006 | +7,006 | 0.00 | 0.09 | +0.09 | buy |
| China Universal Asset Management Co., Ltd. | 1,651 | 8,546 | +6,895 | 0.02 | 0.08 | +0.06 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 6,595 | +6,595 | 0.00 | 0.08 | +0.08 | buy |
| State of New Jersey Common Pension Fund D | 64,454 | 71,013 | +6,559 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 55,945 | 62,073 | +6,128 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 52,000 | 58,000 | +6,000 | 0.18 | 0.30 | +0.12 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 184,632 | 190,312 | +5,680 | 0.01 | 0.01 | +0.00 | buy |
| Vident Advisory, LLC | 0 | 5,292 | +5,292 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 24,479 | 29,390 | +4,911 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 169,388 | 174,286 | +4,898 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 4,721 | +4,721 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 121,770 | 126,375 | +4,605 | 0.02 | 0.03 | +0.01 | buy |
| Allianz Asset Management GmbH | 13,200 | 17,400 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 15,300 | 19,500 | +4,200 | 0.02 | 0.02 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,623 | 15,584 | +3,961 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 47,349 | 50,780 | +3,431 | 0.01 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 716,303 | 719,718 | +3,415 | 0.01 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 14,478 | 17,552 | +3,074 | 0.00 | 0.01 | +0.00 | buy |
| ASSETMARK, INC | 7,103 | 9,938 | +2,835 | 0.00 | 0.00 | +0.00 | buy |