| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| First Light Asset Management, LLC | 602,070 | 1,645,490 | +1,043,420 | 1.95 | 6.10 | +4.14 | buy |
| Avoro Capital Advisors LLC | 4,900,000 | 5,666,666 | +766,666 | 2.61 | 3.61 | +0.99 | buy |
| Paradigm Biocapital Advisors LP | 1,491,835 | 2,127,400 | +635,565 | 3.48 | 4.59 | +1.12 | buy |
| JANUS HENDERSON GROUP PLC | 382,305 | 966,065 | +583,760 | 0.01 | 0.03 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | 1,048,725 | +498,725 | 0.04 | 0.10 | +0.06 | buy |
| Avidity Partners Management LP | 321,400 | 815,993 | +494,593 | 0.44 | 1.44 | +1.00 | buy |
| PERCEPTIVE ADVISORS LLC | 617,500 | 1,100,748 | +483,248 | 0.70 | 1.13 | +0.43 | buy |
| Capital World Investors | 2,274,974 | 2,681,537 | +406,563 | 0.02 | 0.02 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 213,823 | 566,396 | +352,573 | 0.01 | 0.02 | +0.01 | buy |
| Commodore Capital LP | 1,845,000 | 2,167,793 | +322,793 | 7.37 | 8.72 | +1.36 | buy |
| BAKER BROS. ADVISORS LP | 751,639 | 993,679 | +242,040 | 0.15 | 0.52 | +0.37 | buy |
| TimesSquare Capital Management, LLC | 590,575 | 793,954 | +203,379 | 0.31 | 0.54 | +0.22 | buy |
| ExodusPoint Capital Management, LP | 359,838 | 165,267 | +194,571 | 0.16 | 0.10 | 0.00 | sell |
| Affinity Asset Advisors, LLC | 300,438 | 460,000 | +159,562 | 3.35 | 4.22 | +0.87 | buy |
| PFM Health Sciences, LP | 78,587 | 192,856 | +114,269 | 0.13 | 0.53 | +0.41 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 53,996 | 163,168 | +109,172 | 0.69 | 2.32 | +1.63 | buy |
| GREAT POINT PARTNERS LLC | 500,001 | 600,000 | +99,999 | 3.11 | 4.71 | +1.60 | buy |
| ALGERT GLOBAL LLC | 128,487 | 217,320 | +88,833 | 0.21 | 0.41 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 216,644 | 294,788 | +78,144 | 1.36 | 1.92 | +0.56 | buy |
| Rock Springs Capital Management LP | 1,178,002 | 1,255,577 | +77,575 | 1.08 | 1.42 | +0.35 | buy |
| Granahan Investment Management, LLC | 236,290 | 302,581 | +66,291 | 0.29 | 0.46 | +0.17 | buy |
| Polar Capital Holdings Plc | 3,003,747 | 3,066,628 | +62,881 | 0.76 | 0.87 | +0.11 | buy |
| Altium Capital Management LLC | 228,000 | 290,535 | +62,535 | 4.51 | 9.22 | +4.72 | buy |
| Tri Locum Partners LP | 171,755 | 225,564 | +53,809 | 1.88 | 5.10 | +3.22 | buy |
| Woodline Partners LP | 143,451 | 196,453 | +53,002 | 0.06 | 0.10 | +0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 48,676 | 14,676 | +34,000 | 0.04 | 0.05 | 0.00 | sell |
| HighVista Strategies LLC | 35,255 | 51,801 | +16,546 | 0.56 | 0.87 | +0.31 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,758 | 32,196 | +16,438 | 0.05 | 0.13 | +0.08 | buy |
| Erste Asset Management GmbH | 35,000 | 50,000 | +15,000 | 0.02 | 0.03 | +0.01 | buy |
| Capital International Investors | 2,446,820 | 2,455,683 | +8,863 | 0.02 | 0.03 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,651 | 8,546 | +6,895 | 0.02 | 0.08 | +0.06 | buy |
| Soleus Capital Management, L.P. | 52,000 | 58,000 | +6,000 | 0.18 | 0.30 | +0.12 | buy |
| DnB Asset Management AS | 121,770 | 126,375 | +4,605 | 0.02 | 0.03 | +0.01 | buy |
| Quarry LP | 4,500 | 1,000 | +3,500 | 0.10 | 0.02 | 0.00 | sell |
| ALPS ADVISORS INC | 47,349 | 50,780 | +3,431 | 0.01 | 0.02 | +0.00 | buy |
| NATIXIS | 10,000 | 7,000 | +3,000 | 0.00 | 0.00 | 0.00 | sell |
| Advisors Asset Management, Inc. | 10,188 | 10,416 | +228 | 0.01 | 0.01 | 0.00 | buy |
| Headlands Technologies LLC | 27 | 23 | -4 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,324 | 2,245 | -79 | 0.05 | 0.07 | +0.02 | sell |
| Bellevue Group AG | 23,900 | 22,000 | -1,900 | 0.01 | 0.02 | +0.00 | sell |
| DAFNA Capital Management LLC | 280,538 | 276,739 | -3,799 | 2.98 | 3.05 | +0.07 | sell |
| CIBC WORLD MARKET INC. | 45,372 | 37,892 | -7,480 | 0.01 | 0.00 | -0.00 | sell |
| Fiera Capital Corp | 560,546 | 553,030 | -7,516 | 0.06 | 0.08 | +0.02 | sell |
| LOOMIS SAYLES & CO L P | 730,716 | 708,295 | -22,421 | 0.04 | 0.05 | +0.01 | sell |
| Ally Bridge Group (NY) LLC | 266,961 | 241,961 | -25,000 | 10.70 | 6.64 | -4.06 | sell |
| Candriam S.C.A. | 569,884 | 530,884 | -39,000 | 0.14 | 0.17 | +0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,513,005 | 4,345,180 | -167,825 | 2.00 | 2.41 | +0.41 | sell |
| Logos Global Management LP | 450,000 | 150,000 | -300,000 | 2.19 | 0.77 | -1.42 | sell |
| ORBIMED ADVISORS LLC | 958,793 | 550,000 | -408,793 | 0.70 | 0.51 | -0.20 | sell |
| LORD, ABBETT & CO. LLC | 1,149,168 | 717,972 | -431,196 | 0.15 | 0.12 | -0.03 | sell |
| BRAIDWELL LP | 2,103,396 | 1,647,311 | -456,085 | 2.27 | 2.79 | +0.52 | sell |
| SAMLYN CAPITAL, LLC | 951,755 | 421,155 | -530,600 | 0.53 | 0.39 | -0.15 | sell |
| Nicholas Investment Partners, LP | 854,447 | 87,752 | -766,695 | 2.18 | 0.47 | -1.71 | sell |
| BVF INC/IL | 1,827,958 | 890,072 | -937,886 | 1.68 | 1.03 | -0.66 | sell |