| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 669,600 | 1,157,189 | +487,589 | 0.12 | 0.20 | +0.08 | buy |
| First Turn Management, LLC | 325,218 | 684,986 | +359,768 | 2.03 | 4.81 | +2.78 | buy |
| JANUS HENDERSON GROUP PLC | 2,552,392 | 2,866,755 | +314,363 | 0.05 | 0.06 | 0.00 | buy |
| Polar Capital Holdings Plc | 2,444,645 | 2,697,657 | +253,012 | 0.46 | 0.59 | +0.13 | buy |
| JENNISON ASSOCIATES LLC | 576,661 | 801,553 | +224,892 | 0.01 | 0.02 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 439,074 | 663,704 | +224,630 | 0.04 | 0.06 | +0.02 | buy |
| BRAIDWELL LP | 2,707,255 | 2,913,964 | +206,709 | 3.02 | 3.39 | +0.37 | buy |
| ExodusPoint Capital Management, LP | 262,631 | 68,884 | +193,747 | 0.11 | 0.03 | 0.00 | sell |
| TimesSquare Capital Management, LLC | 778,293 | 848,850 | +70,557 | 0.46 | 100.00 | +99.54 | buy |
| Commodore Capital LP | 2,700,000 | 2,740,000 | +40,000 | 6.64 | 7.87 | +1.23 | buy |
| ORBIMED ADVISORS LLC | 911,420 | 947,877 | +36,457 | 0.66 | 0.77 | +0.11 | buy |
| Aberdeen Group plc | 248,311 | 283,899 | +35,588 | 0.02 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 165,800 | 197,212 | +31,412 | 0.98 | 1.10 | +0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 243,579 | 273,352 | +29,773 | 0.02 | 0.03 | 0.00 | buy |
| Candriam S.C.A. | 463,861 | 492,181 | +28,320 | 0.10 | 0.11 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 27,903 | 50,547 | +22,644 | 0.18 | 0.41 | +0.22 | buy |
| ALGERT GLOBAL LLC | 219,645 | 241,417 | +21,772 | 0.23 | 0.22 | 0.00 | buy |
| LORD, ABBETT & CO. LLC | 173,985 | 194,971 | +20,986 | 0.02 | 0.02 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,144,021 | 1,161,237 | +17,216 | 6.99 | 7.11 | +0.12 | buy |
| DnB Asset Management AS | 190,623 | 203,243 | +12,620 | 0.03 | 0.03 | +0.00 | buy |
| Brevan Howard Capital Management LP | 12,012 | 19,005 | +6,993 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 56,989 | 61,648 | +4,659 | 0.02 | 0.02 | +0.00 | buy |
| Elmwood Wealth Management, Inc. | 7,607 | 11,007 | +3,400 | 0.12 | 0.17 | +0.05 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 48,063 | 49,818 | +1,755 | 0.08 | 0.09 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,572 | 16,166 | +1,594 | 0.06 | 0.06 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 191,658 | 193,004 | +1,346 | 0.96 | 1.01 | +0.04 | buy |
| HighMark Wealth Management LLC | 5,000 | 6,100 | +1,100 | 0.11 | 0.14 | +0.03 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 10,811 | 11,441 | +630 | 0.08 | 0.08 | +0.00 | buy |
| Advisors Asset Management, Inc. | 13,592 | 13,048 | +544 | 0.01 | 0.01 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,425 | 1,802 | -623 | 0.04 | 0.03 | -0.02 | sell |
| SAMLYN CAPITAL, LLC | 1,020,206 | 1,017,838 | -2,368 | 0.61 | 0.60 | -0.01 | sell |
| Nebula Research & Development LLC | 24,265 | 20,360 | -3,905 | 0.11 | 0.09 | -0.02 | sell |
| HighVista Strategies LLC | 73,762 | 66,788 | -6,974 | 1.00 | 0.97 | -0.03 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 19,744 | 8,621 | -11,123 | 0.17 | 0.06 | -0.11 | sell |
| Vestal Point Capital, LP | 825,000 | 810,000 | -15,000 | 2.56 | 1.88 | -0.68 | sell |
| Fiera Capital Corp | 554,200 | 535,887 | -18,313 | 0.07 | 0.07 | +0.00 | sell |
| Granahan Investment Management, LLC | 200,877 | 182,333 | -18,544 | 0.31 | 0.30 | -0.01 | sell |
| LOOMIS SAYLES & CO L P | 707,222 | 687,145 | -20,077 | 0.04 | 0.03 | -0.00 | sell |
| First Light Asset Management, LLC | 1,181,662 | 1,160,580 | -21,082 | 3.87 | 4.35 | +0.48 | sell |
| Candriam S.C.A. | 521,836 | 492,181 | -29,655 | 0.12 | 0.11 | -0.01 | sell |
| Capital International Investors | 2,581,172 | 2,547,210 | -33,962 | 0.02 | 0.02 | -0.00 | sell |
| Ikarian Capital, LLC | 107,187 | 62,052 | -45,135 | 1.31 | 0.69 | -0.62 | sell |
| Atika Capital Management LLC | 126,000 | 72,600 | -53,400 | 0.51 | 0.30 | -0.21 | sell |
| PFM Health Sciences, LP | 179,878 | 116,998 | -62,880 | 0.40 | 0.28 | -0.12 | sell |
| Rock Springs Capital Management LP | 1,316,477 | 1,251,859 | -64,618 | 1.69 | 1.87 | +0.18 | sell |
| T. Rowe Price Investment Management, Inc. | 1,503,808 | 1,437,831 | -65,977 | 0.04 | 0.03 | -0.00 | sell |
| Altium Capital Management LLC | 360,600 | 288,000 | -72,600 | 4.23 | 3.52 | -0.71 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,595,721 | 4,520,595 | -75,126 | 1.55 | 1.46 | -0.09 | sell |
| Ally Bridge Group (NY) LLC | 211,791 | 129,291 | -82,500 | 4.46 | 4.35 | -0.12 | sell |
| PERCEPTIVE ADVISORS LLC | 524,930 | 325,324 | -199,606 | 0.44 | 0.35 | -0.09 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,083,972 | 1,863,473 | -220,499 | 0.14 | 0.13 | -0.02 | sell |
| Avidity Partners Management LP | 818,000 | 474,000 | -344,000 | 1.64 | 1.85 | +0.21 | sell |
| Capital World Investors | 2,681,537 | 2,294,537 | -387,000 | 0.02 | 0.01 | -0.00 | sell |