| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,917,684 | 7,525,290 | +607,606 | 0.02 | 0.02 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 669,600 | 1,157,189 | +487,589 | 0.12 | 0.20 | +0.08 | buy |
| JPMORGAN CHASE & CO | 976,783 | 1,356,895 | +380,112 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 375,845 | +375,845 | 0.00 | 3.70 | +3.70 | buy |
| First Turn Management, LLC | 325,218 | 684,986 | +359,768 | 2.03 | 4.81 | +2.78 | buy |
| Saturn V Capital Management LP | 0 | 322,470 | +322,470 | 0.00 | 4.95 | +4.95 | buy |
| JANUS HENDERSON GROUP PLC | 2,552,392 | 2,866,755 | +314,363 | 0.05 | 0.06 | +0.01 | buy |
| Polar Capital Holdings Plc | 2,444,645 | 2,697,657 | +253,012 | 0.46 | 0.59 | +0.13 | buy |
| GREAT POINT PARTNERS LLC | 0 | 245,272 | +245,272 | 0.00 | 4.53 | +4.53 | buy |
| JENNISON ASSOCIATES LLC | 576,661 | 801,553 | +224,892 | 0.01 | 0.02 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 439,074 | 663,704 | +224,630 | 0.04 | 0.06 | +0.02 | buy |
| BRAIDWELL LP | 2,707,255 | 2,913,964 | +206,709 | 3.02 | 3.39 | +0.37 | buy |
| Deep Track Capital, LP | 0 | 169,132 | +169,132 | 0.00 | 0.25 | +0.25 | buy |
| Eversept Partners, LP | 0 | 155,540 | +155,540 | 0.00 | 0.63 | +0.63 | buy |
| MILLENNIUM MANAGEMENT LLC | 209,026 | 346,040 | +137,014 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 104,960 | 221,982 | +117,022 | 0.04 | 0.08 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 84,198 | 184,580 | +100,382 | 0.01 | 0.02 | +0.01 | buy |
| Neuberger Berman Group LLC | 0 | 92,961 | +92,961 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 778,293 | 848,850 | +70,557 | 0.46 | 0.48 | +0.03 | buy |
| BIT Capital GmbH | 0 | 53,928 | +53,928 | 0.00 | 0.19 | +0.19 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 52,097 | +52,097 | 0.00 | 0.38 | +0.38 | buy |
| Commodore Capital LP | 2,700,000 | 2,740,000 | +40,000 | 6.64 | 7.87 | +1.23 | buy |
| Woodline Partners LP | 0 | 39,938 | +39,938 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 911,420 | 947,877 | +36,457 | 0.66 | 0.77 | +0.11 | buy |
| Aberdeen Group plc | 248,311 | 283,899 | +35,588 | 0.02 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 165,800 | 197,212 | +31,412 | 0.98 | 1.10 | +0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 243,579 | 273,352 | +29,773 | 0.02 | 0.02 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 162,683 | 191,852 | +29,169 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 463,861 | 492,181 | +28,320 | 0.10 | 0.11 | +0.01 | buy |
| Assenagon Asset Management S.A. | 212,287 | 238,522 | +26,235 | 0.02 | 0.02 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 66,383 | 92,350 | +25,967 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 273,700 | 298,700 | +25,000 | 0.03 | 0.03 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 14,044 | 39,000 | +24,956 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 27,903 | 50,547 | +22,644 | 0.18 | 0.41 | +0.22 | buy |
| ROYAL BANK OF CANADA | 37,636 | 60,068 | +22,432 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 43,406 | 65,783 | +22,377 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 219,645 | 241,417 | +21,772 | 0.23 | 0.22 | -0.01 | buy |
| LORD, ABBETT & CO. LLC | 173,985 | 194,971 | +20,986 | 0.02 | 0.02 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,424,735 | 1,443,180 | +18,445 | 0.02 | 0.02 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 0 | 17,786 | +17,786 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 1,144,021 | 1,161,237 | +17,216 | 6.99 | 7.11 | +0.12 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,165 | 62,415 | +15,250 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 190,623 | 203,243 | +12,620 | 0.03 | 0.03 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 11,138 | +11,138 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 565,915 | 575,590 | +9,675 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 279,513 | 288,722 | +9,209 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 8,297 | +8,297 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 8,260 | +8,260 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 8,054 | +8,054 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 12,012 | 19,005 | +6,993 | 0.02 | 0.02 | -0.00 | buy |
| NEOS Investment Management LLC | 0 | 6,111 | +6,111 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 7,716 | 13,293 | +5,577 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 48,573 | 54,033 | +5,460 | 0.01 | 0.01 | +0.00 | buy |
| Vident Advisory, LLC | 0 | 5,413 | +5,413 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 5,363 | +5,363 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 55,120 | 60,406 | +5,286 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 56,989 | 61,648 | +4,659 | 0.02 | 0.02 | +0.00 | buy |
| Allianz Asset Management GmbH | 8,100 | 12,400 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| Elmwood Wealth Management, Inc. | 7,607 | 11,007 | +3,400 | 0.12 | 0.17 | +0.05 | buy |
| BARCLAYS PLC | 14,993 | 18,127 | +3,134 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16,089 | 19,083 | +2,994 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 16,408 | 19,274 | +2,866 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,648 | 6,448 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 2,569 | +2,569 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 2,000 | +2,000 | 0.00 | 0.02 | +0.02 | buy |
| ASSETMARK, INC | 19,670 | 21,585 | +1,915 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 48,063 | 49,818 | +1,755 | 0.08 | 0.09 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,572 | 16,166 | +1,594 | 0.06 | 0.06 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 13,582 | 15,150 | +1,568 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 191,658 | 193,004 | +1,346 | 0.96 | 1.01 | +0.04 | buy |
| Swiss National Bank | 125,300 | 126,600 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 5,000 | 6,100 | +1,100 | 0.11 | 0.14 | +0.03 | buy |
| KBC Group NV | 1,962 | 2,742 | +780 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 68,809 | 69,529 | +720 | 0.00 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 10,811 | 11,441 | +630 | 0.08 | 0.08 | +0.00 | buy |
| SIGNATUREFD, LLC | 237 | 571 | +334 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 18,472 | 18,666 | +194 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,960 | 5,140 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 89 | +89 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 381 | 466 | +85 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 14 | 58 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 64 | 99 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5,000 | 5,019 | +19 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 45 | 58 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Hexagon Capital Partners LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 36 | 37 | +1 | 0.00 | 0.00 | -0.00 | buy |
| BAMCO INC /NY/ | 100,100 | 100,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 15,911 | 15,911 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 21,500 | 21,500 | 0 | 0.14 | 0.13 | -0.01 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TD ASSET MANAGEMENT INC | 20,430 | 20,430 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 176,674 | 176,674 | 0 | 0.01 | 0.01 | -0.00 | hold |
| C M BIDWELL & ASSOCIATES LTD | 9 | 9 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 29 | 29 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGER MANAGEMENT, LLC | 146,800 | 146,800 | 0 | 2.89 | 3.09 | +0.20 | hold |
| BAKER BROS. ADVISORS LP | 993,679 | 993,679 | 0 | 0.41 | 0.42 | +0.01 | hold |
| Rathbones Group PLC | 23,666 | 23,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18,266 | 18,266 | 0 | 0.06 | 0.06 | +0.00 | hold |