| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 6,917,684 | 7,525,290 | +607,606 | 0.02 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 5,666,666 | 5,666,666 | 0 | 3.25 | 3.14 | -0.11 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,595,721 | 4,520,595 | -75,126 | 1.55 | 1.46 | -0.09 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,843,447 | 3,777,611 | -65,836 | 0.03 | 0.03 | +0.00 | sell |
| BRAIDWELL LP | 2,707,255 | 2,913,964 | +206,709 | 3.02 | 3.39 | +0.37 | buy |
| JANUS HENDERSON GROUP PLC | 2,552,392 | 2,866,755 | +314,363 | 0.05 | 0.06 | +0.01 | buy |
| Commodore Capital LP | 2,700,000 | 2,740,000 | +40,000 | 6.64 | 7.87 | +1.23 | buy |
| Polar Capital Holdings Plc | 2,444,645 | 2,697,657 | +253,012 | 0.46 | 0.59 | +0.13 | buy |
| Capital International Investors | 2,581,172 | 2,547,210 | -33,962 | 0.02 | 0.02 | -0.00 | sell |
| Capital World Investors | 2,681,537 | 2,294,537 | -387,000 | 0.02 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 2,105,562 | 2,105,236 | -326 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,083,972 | 1,863,473 | -220,499 | 0.14 | 0.13 | -0.02 | sell |
| Pictet Asset Management Holding SA | 1,528,814 | 1,496,511 | -32,303 | 0.07 | 0.06 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,424,735 | 1,443,180 | +18,445 | 0.02 | 0.02 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,503,808 | 1,437,831 | -65,977 | 0.04 | 0.03 | -0.00 | sell |
| JPMORGAN CHASE & CO | 976,783 | 1,356,895 | +380,112 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,316,477 | 1,251,859 | -64,618 | 1.69 | 1.87 | +0.18 | sell |
| Affinity Asset Advisors, LLC | 1,144,021 | 1,161,237 | +17,216 | 6.99 | 7.11 | +0.12 | buy |
| First Light Asset Management, LLC | 1,181,662 | 1,160,580 | -21,082 | 3.87 | 4.35 | +0.48 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 669,600 | 1,157,189 | +487,589 | 0.12 | 0.20 | +0.08 | buy |
| SAMLYN CAPITAL, LLC | 1,020,206 | 1,017,838 | -2,368 | 0.65 | 0.63 | -0.01 | sell |
| BAKER BROS. ADVISORS LP | 993,679 | 993,679 | 0 | 0.41 | 0.42 | +0.01 | hold |
| ORBIMED ADVISORS LLC | 911,420 | 947,877 | +36,457 | 0.66 | 0.77 | +0.11 | buy |
| MARSHALL WACE, LLP | 1,195,480 | 899,718 | -295,762 | 0.06 | 0.04 | -0.02 | sell |
| TimesSquare Capital Management, LLC | 778,293 | 848,850 | +70,557 | 0.46 | 0.48 | +0.03 | buy |
| Vestal Point Capital, LP | 825,000 | 810,000 | -15,000 | 2.56 | 1.88 | -0.68 | sell |
| JENNISON ASSOCIATES LLC | 576,661 | 801,553 | +224,892 | 0.01 | 0.02 | +0.00 | buy |
| Siren, L.L.C. | 743,769 | 743,769 | 0 | 1.47 | 1.29 | -0.18 | hold |
| LOOMIS SAYLES & CO L P | 707,222 | 687,145 | -20,077 | 0.04 | 0.03 | -0.00 | sell |
| First Turn Management, LLC | 325,218 | 684,986 | +359,768 | 2.03 | 4.81 | +2.78 | buy |
| BNP Paribas Asset Management Holding S.A. | 439,074 | 663,704 | +224,630 | 0.04 | 0.06 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 565,915 | 575,590 | +9,675 | 0.01 | 0.01 | -0.00 | buy |
| FEDERATED HERMES, INC. | 736,200 | 558,500 | -177,700 | 0.06 | 0.05 | -0.02 | sell |
| Fiera Capital Corp | 554,200 | 535,887 | -18,313 | 0.07 | 0.07 | +0.00 | sell |
| Candriam S.C.A. | 463,861 | 492,181 | +28,320 | 0.10 | 0.11 | +0.01 | buy |
| Avidity Partners Management LP | 818,000 | 474,000 | -344,000 | 1.64 | 1.85 | +0.21 | sell |
| GOLDMAN SACHS GROUP INC | 459,625 | 410,246 | -49,379 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 375,845 | +375,845 | 0.00 | 3.70 | +3.70 | buy |
| MILLENNIUM MANAGEMENT LLC | 209,026 | 346,040 | +137,014 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 344,365 | 342,779 | -1,586 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 722,504 | 327,303 | -395,201 | 0.03 | 0.01 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 524,930 | 325,324 | -199,606 | 0.44 | 0.36 | -0.09 | sell |
| Saturn V Capital Management LP | 0 | 322,470 | +322,470 | 0.00 | 4.95 | +4.95 | buy |
| TWO SIGMA ADVISERS, LP | 273,700 | 298,700 | +25,000 | 0.03 | 0.03 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 288,843 | 288,843 | 0 | 0.06 | 0.04 | -0.02 | hold |
| STATE STREET CORP | 279,513 | 288,722 | +9,209 | 0.00 | 0.00 | -0.00 | buy |
| Altium Capital Management LLC | 360,600 | 288,000 | -72,600 | 4.23 | 3.52 | -0.71 | sell |
| Aberdeen Group plc | 248,311 | 283,899 | +35,588 | 0.02 | 0.02 | +0.00 | buy |
| DAFNA Capital Management LLC | 273,739 | 273,739 | 0 | 2.55 | 2.73 | +0.18 | hold |
| TWO SIGMA INVESTMENTS, LP | 243,579 | 273,352 | +29,773 | 0.02 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 299,865 | 259,970 | -39,895 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 0 | 245,272 | +245,272 | 0.00 | 4.53 | +4.53 | buy |
| ALGERT GLOBAL LLC | 219,645 | 241,417 | +21,772 | 0.23 | 0.22 | -0.01 | buy |
| Assenagon Asset Management S.A. | 212,287 | 238,522 | +26,235 | 0.02 | 0.02 | -0.00 | buy |
| Walleye Capital LLC | 104,960 | 221,982 | +117,022 | 0.04 | 0.08 | +0.04 | buy |
| Russell Investments Group, Ltd. | 223,614 | 213,696 | -9,918 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 215,822 | 209,554 | -6,268 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 190,623 | 203,243 | +12,620 | 0.03 | 0.03 | +0.00 | buy |
| MPM BioImpact LLC | 165,800 | 197,212 | +31,412 | 0.98 | 1.10 | +0.12 | buy |
| LORD, ABBETT & CO. LLC | 173,985 | 194,971 | +20,986 | 0.02 | 0.02 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 191,658 | 193,004 | +1,346 | 0.96 | 1.01 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 162,683 | 191,852 | +29,169 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 188,090 | 187,796 | -294 | 0.02 | 0.02 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 84,198 | 184,580 | +100,382 | 0.01 | 0.02 | +0.01 | buy |
| Granahan Investment Management, LLC | 200,877 | 182,333 | -18,544 | 0.31 | 0.30 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 176,674 | 176,674 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Deep Track Capital, LP | 0 | 169,132 | +169,132 | 0.00 | 0.25 | +0.25 | buy |
| Eversept Partners, LP | 0 | 155,540 | +155,540 | 0.00 | 0.63 | +0.63 | buy |
| BRIDGER MANAGEMENT, LLC | 146,800 | 146,800 | 0 | 2.89 | 3.09 | +0.20 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 132,521 | 132,521 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ally Bridge Group (NY) LLC | 211,791 | 129,291 | -82,500 | 4.46 | 4.35 | -0.12 | sell |
| Swiss National Bank | 125,300 | 126,600 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 179,878 | 116,998 | -62,880 | 0.41 | 0.35 | -0.06 | sell |
| BANK OF AMERICA CORP /DE/ | 127,456 | 106,906 | -20,550 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 106,680 | 106,680 | 0 | 3.62 | 3.58 | -0.04 | hold |
| BAMCO INC /NY/ | 100,100 | 100,100 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 100,982 | 96,584 | -4,398 | 0.01 | 0.01 | -0.00 | sell |
| Neuberger Berman Group LLC | 0 | 92,961 | +92,961 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 66,383 | 92,350 | +25,967 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 204,892 | 86,973 | -117,919 | 0.01 | 0.00 | -0.01 | sell |
| Atika Capital Management LLC | 126,000 | 72,600 | -53,400 | 0.53 | 0.37 | -0.16 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 68,809 | 69,529 | +720 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 262,631 | 68,884 | -193,747 | 0.11 | 0.03 | -0.08 | sell |
| MORGAN STANLEY | 239,942 | 68,062 | -171,880 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 73,762 | 66,788 | -6,974 | 1.00 | 0.97 | -0.03 | sell |
| NORTHERN TRUST CORP | 43,406 | 65,783 | +22,377 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,165 | 62,415 | +15,250 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 107,187 | 62,052 | -45,135 | 1.31 | 0.69 | -0.62 | sell |
| ALPS ADVISORS INC | 56,989 | 61,648 | +4,659 | 0.02 | 0.02 | +0.00 | buy |
| Legal & General Group Plc | 55,120 | 60,406 | +5,286 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 37,636 | 60,068 | +22,432 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 60,456 | 59,520 | -936 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56,004 | 55,492 | -512 | 0.00 | 0.00 | -0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 55,000 | 55,000 | 0 | 0.06 | 0.04 | -0.02 | hold |
| State of New Jersey Common Pension Fund D | 48,573 | 54,033 | +5,460 | 0.01 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 0 | 53,928 | +53,928 | 0.00 | 0.19 | +0.19 | buy |
| DEUTSCHE BANK AG\ | 53,711 | 53,711 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 52,097 | +52,097 | 0.00 | 0.38 | +0.38 | buy |
| ADAR1 Capital Management, LLC | 27,903 | 50,547 | +22,644 | 0.18 | 0.41 | +0.22 | buy |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.02 | 0.02 | +0.00 | hold |