| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,169,114 | 4,538,691 | +369,577 | 1.20 | 1.38 | +0.18 | buy |
| Capital International Investors | 3,181,493 | 3,414,959 | +233,466 | 0.02 | 0.02 | +0.00 | buy |
| Aberdeen Group plc | 579,145 | 750,291 | +171,146 | 0.04 | 0.05 | +0.02 | buy |
| Fiera Capital Corp | 519,999 | 686,056 | +166,057 | 0.07 | 0.10 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 1,135,235 | 1,292,055 | +156,820 | 0.03 | 0.03 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 192,295 | 348,605 | +156,310 | 1.56 | 2.68 | +1.12 | buy |
| Nicholas Investment Partners, LP | 119,098 | 242,989 | +123,891 | 0.37 | 0.79 | +0.43 | buy |
| Caligan Partners LP | 444,565 | 549,665 | +105,100 | 2.48 | 2.26 | -0.22 | buy |
| NAN FUNG TRINITY (HK) Ltd | 158,605 | 226,965 | +68,360 | 0.64 | 0.81 | +0.17 | buy |
| Rhenman & Partners Asset Management AB | 81,000 | 139,000 | +58,000 | 0.36 | 0.58 | +0.22 | buy |
| Atika Capital Management LLC | 38,000 | 92,506 | +54,506 | 0.12 | 0.44 | +0.31 | buy |
| ORBIMED ADVISORS LLC | 419,600 | 447,200 | +27,600 | 0.40 | 0.41 | +0.01 | buy |
| ALPS ADVISORS INC | 37,300 | 63,302 | +26,002 | 0.01 | 0.02 | 0.00 | buy |
| Avoro Capital Advisors LLC | 5,400,000 | 5,424,444 | +24,444 | 2.80 | 2.39 | -0.41 | buy |
| DnB Asset Management AS | 249,081 | 272,831 | +23,750 | 0.04 | 0.04 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 659,257 | 680,473 | +21,216 | 0.01 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 396,636 | 417,402 | +20,766 | 0.08 | 0.09 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,206,066 | 1,226,771 | +20,705 | 0.20 | 0.23 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,708 | 186,705 | +14,997 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 189,098 | 203,969 | +14,871 | 0.75 | 0.68 | -0.07 | buy |
| Granahan Investment Management, LLC | 87,470 | 92,778 | +5,308 | 0.14 | 0.18 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 3,469 | 6,037 | +2,568 | 0.04 | 0.07 | +0.03 | buy |
| ProShare Advisors LLC | 15,740 | 17,279 | +1,539 | 0.00 | 0.00 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 11,218 | 10,053 | +1,165 | 0.04 | 0.04 | 0.00 | sell |
| ALTFEST L J & CO INC | 7,731 | 8,232 | +501 | 0.03 | 0.04 | +0.01 | buy |
| Cinctive Capital Management LP | 23,054 | 23,317 | +263 | 0.05 | 0.06 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,659 | 1,517 | -142 | 0.00 | 0.00 | -0.00 | sell |
| Elmwood Wealth Management, Inc. | 10,907 | 10,757 | -150 | 0.16 | 0.15 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,515 | 12,592 | -923 | 0.04 | 0.04 | -0.00 | sell |
| HighMark Wealth Management LLC | 26,100 | 23,000 | -3,100 | 0.46 | 0.42 | -0.04 | sell |
| TLS Advisors LLC | 32,956 | 18,858 | -14,098 | 4.02 | 0.81 | -3.21 | sell |
| J. Safra Sarasin Holding AG | 30,168 | 13,581 | -16,587 | 0.02 | 0.01 | -0.01 | sell |
| MPM BioImpact LLC | 503,398 | 485,620 | -17,778 | 3.31 | 2.49 | -0.82 | sell |
| Parkman Healthcare Partners LLC | 176,137 | 154,184 | -21,953 | 0.78 | 0.66 | -0.12 | sell |
| TimesSquare Capital Management, LLC | 556,800 | 532,740 | -24,060 | 100.00 | 0.36 | -99.64 | sell |
| LOOMIS SAYLES & CO L P | 640,626 | 612,032 | -28,594 | 0.03 | 0.03 | +0.00 | sell |
| Neo Ivy Capital Management | 49,838 | 7,477 | -42,361 | 0.49 | 0.05 | -0.43 | sell |
| T. Rowe Price Investment Management, Inc. | 599,113 | 547,613 | -51,500 | 0.01 | 0.02 | +0.00 | sell |
| Rock Springs Capital Management LP | 851,744 | 787,788 | -63,956 | 2.00 | 1.81 | -0.19 | sell |
| Polar Capital Holdings Plc | 2,546,766 | 2,465,694 | -81,072 | 0.49 | 0.51 | +0.01 | sell |
| Affinity Asset Advisors, LLC | 1,400,000 | 1,250,000 | -150,000 | 5.23 | 4.03 | -1.20 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 835,100 | 685,100 | -150,000 | 0.05 | 0.05 | -0.01 | sell |
| Vestal Point Capital, LP | 1,100,000 | 600,000 | -500,000 | 2.00 | 0.99 | -1.02 | sell |
| Holocene Advisors, LP | 1,976,553 | 1,282,081 | -694,472 | 0.18 | 0.12 | -0.06 | sell |
| Deep Track Capital, LP | 1,200,000 | 366,435 | -833,565 | 1.34 | 0.37 | -0.97 | sell |
| Commodore Capital LP | 2,700,000 | 1,800,000 | -900,000 | 5.29 | 5.37 | +0.08 | sell |
| BRAIDWELL LP | 3,605,029 | 1,825,076 | -1,779,953 | 4.29 | 2.62 | -1.68 | sell |