| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,918,907 | 8,920,250 | +1,343 | 0.02 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 5,400,000 | 5,424,444 | +24,444 | 2.80 | 2.39 | -0.42 | buy |
| BlackRock, Inc. | 4,770,951 | 5,100,284 | +329,333 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,609,857 | 4,764,779 | +1,154,922 | 0.03 | 0.04 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,169,114 | 4,538,691 | +369,577 | 1.20 | 1.38 | +0.18 | buy |
| JANUS HENDERSON GROUP PLC | 3,943,885 | 4,084,034 | +140,149 | 0.07 | 0.08 | +0.01 | buy |
| Capital International Investors | 3,181,493 | 3,414,959 | +233,466 | 0.02 | 0.02 | +0.00 | buy |
| Polar Capital Holdings Plc | 2,546,766 | 2,465,694 | -81,072 | 0.49 | 0.51 | +0.01 | sell |
| BRAIDWELL LP | 3,605,029 | 1,825,076 | -1,779,953 | 4.29 | 2.62 | -1.68 | sell |
| Commodore Capital LP | 2,700,000 | 1,800,000 | -900,000 | 5.29 | 5.37 | +0.08 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,654,417 | 1,593,814 | -60,603 | 0.02 | 0.02 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,399,033 | 1,494,032 | +94,999 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,466,467 | 1,492,550 | +26,083 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 959,098 | 1,321,213 | +362,115 | 0.03 | 0.04 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 1,135,235 | 1,292,055 | +156,820 | 0.03 | 0.03 | +0.01 | buy |
| Holocene Advisors, LP | 1,976,553 | 1,282,081 | -694,472 | 0.18 | 0.12 | -0.06 | sell |
| Affinity Asset Advisors, LLC | 1,400,000 | 1,250,000 | -150,000 | 5.23 | 4.03 | -1.20 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,206,066 | 1,226,771 | +20,705 | 0.20 | 0.23 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 670,257 | 1,060,221 | +389,964 | 0.07 | 0.05 | -0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 977,435 | 952,679 | -24,756 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 41,692 | 862,300 | +820,608 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 812,761 | 812,761 | 0 | 1.28 | 1.09 | -0.19 | hold |
| First Turn Management, LLC | 799,743 | 799,743 | 0 | 4.82 | 4.10 | -0.73 | hold |
| Rock Springs Capital Management LP | 851,744 | 787,788 | -63,956 | 2.00 | 1.81 | -0.19 | sell |
| FRANKLIN RESOURCES INC | 695,900 | 758,059 | +62,159 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 579,145 | 750,291 | +171,146 | 0.04 | 0.05 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 720,659 | 696,047 | -24,612 | 0.00 | 0.00 | +0.00 | sell |
| Fiera Capital Corp | 519,999 | 686,056 | +166,057 | 0.07 | 0.10 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 835,100 | 685,100 | -150,000 | 0.05 | 0.05 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 659,257 | 680,473 | +21,216 | 0.01 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 232,500 | 672,237 | +439,737 | 0.02 | 0.05 | +0.03 | buy |
| VANGUARD GROUP INC | 851,386 | 664,641 | -186,745 | 0.00 | 0.00 | -0.00 | sell |
| Capital World Investors | 655,737 | 655,737 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,384,007 | 635,056 | -748,951 | 0.04 | 0.02 | -0.02 | sell |
| Pictet Asset Management Holding SA | 1,262,579 | 625,985 | -636,594 | 0.05 | 0.03 | -0.02 | sell |
| LOOMIS SAYLES & CO L P | 640,626 | 612,032 | -28,594 | 0.03 | 0.03 | +0.00 | sell |
| BARCLAYS PLC | 111,300 | 600,964 | +489,664 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 1,100,000 | 600,000 | -500,000 | 2.00 | 0.99 | -1.02 | sell |
| Caligan Partners LP | 444,565 | 549,665 | +105,100 | 2.48 | 2.26 | -0.22 | buy |
| T. Rowe Price Investment Management, Inc. | 599,113 | 547,613 | -51,500 | 0.01 | 0.02 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 542,020 | 542,020 | 0 | 0.33 | 0.31 | -0.02 | hold |
| TimesSquare Capital Management, LLC | 556,800 | 532,740 | -24,060 | 0.32 | 0.36 | +0.04 | sell |
| MPM BioImpact LLC | 503,398 | 485,620 | -17,778 | 3.31 | 2.49 | -0.82 | sell |
| DIMENSIONAL FUND ADVISORS LP | 454,023 | 452,147 | -1,876 | 0.00 | 0.00 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 419,600 | 447,200 | +27,600 | 0.40 | 0.41 | +0.01 | buy |
| NORTHERN TRUST CORP | 498,147 | 438,714 | -59,433 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 436,743 | +436,743 | 0.00 | 0.03 | +0.03 | buy |
| Candriam S.C.A. | 396,636 | 417,402 | +20,766 | 0.08 | 0.09 | +0.01 | buy |
| Bank of New York Mellon Corp | 418,416 | 387,158 | -31,258 | 0.00 | 0.00 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 370,208 | 370,208 | 0 | 0.11 | 0.10 | -0.01 | hold |
| Deep Track Capital, LP | 1,200,000 | 366,435 | -833,565 | 1.34 | 0.37 | -0.97 | sell |
| STEMPOINT CAPITAL LP | 192,295 | 348,605 | +156,310 | 1.56 | 2.68 | +1.12 | buy |
| MORGAN STANLEY | 366,572 | 294,332 | -72,240 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 287,939 | 287,939 | 0 | 2.86 | 3.00 | +0.14 | hold |
| DnB Asset Management AS | 249,081 | 272,831 | +23,750 | 0.04 | 0.04 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 18,100 | 259,320 | +241,220 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 76,824 | 254,002 | +177,178 | 0.02 | 0.06 | +0.04 | buy |
| Nicholas Investment Partners, LP | 119,098 | 242,989 | +123,891 | 0.37 | 0.79 | +0.43 | buy |
| Iron Triangle Partners LP | 0 | 233,688 | +233,688 | 0.00 | 1.20 | +1.20 | buy |
| Eversept Partners, LP | 0 | 231,380 | +231,380 | 0.00 | 0.58 | +0.58 | buy |
| NAN FUNG TRINITY (HK) Ltd | 158,605 | 226,965 | +68,360 | 0.64 | 0.81 | +0.17 | buy |
| BANK OF AMERICA CORP /DE/ | 199,106 | 221,368 | +22,262 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 224,289 | 216,238 | -8,051 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 208,372 | 205,569 | -2,803 | 0.02 | 0.02 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 189,098 | 203,969 | +14,871 | 0.75 | 0.68 | -0.07 | buy |
| PERCEPTIVE ADVISORS LLC | 200,791 | 200,791 | 0 | 0.23 | 0.16 | -0.07 | hold |
| DEUTSCHE BANK AG\ | 112,951 | 190,233 | +77,282 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 188,747 | 189,059 | +312 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,708 | 186,705 | +14,997 | 0.01 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 172,354 | 178,747 | +6,393 | 0.01 | 0.01 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 174,851 | +174,851 | 0.00 | 0.24 | +0.24 | buy |
| Jain Global LLC | 252,379 | 173,882 | -78,497 | 0.13 | 0.08 | -0.06 | sell |
| MARSHALL WACE, LLP | 611,982 | 162,551 | -449,431 | 0.03 | 0.01 | -0.02 | sell |
| Foresite Capital Management IV, LLC | 160,000 | 160,000 | 0 | 3.52 | 3.12 | -0.40 | hold |
| Parkman Healthcare Partners LLC | 176,137 | 154,184 | -21,953 | 0.78 | 0.66 | -0.12 | sell |
| WELLS FARGO & COMPANY/MN | 115,221 | 152,297 | +37,076 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 140,000 | 140,000 | 0 | 0.11 | 0.13 | +0.02 | hold |
| Rhenman & Partners Asset Management AB | 81,000 | 139,000 | +58,000 | 0.36 | 0.58 | +0.22 | buy |
| Patient Square Capital LP | 0 | 136,500 | +136,500 | 0.00 | 1.31 | +1.31 | buy |
| Redmile Group, LLC | 0 | 133,882 | +133,882 | 0.00 | 0.44 | +0.44 | buy |
| HRT FINANCIAL LP | 0 | 129,800 | +129,800 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 54,255 | 123,189 | +68,934 | 0.04 | 0.09 | +0.05 | buy |
| Assenagon Asset Management S.A. | 0 | 119,186 | +119,186 | 0.00 | 0.01 | +0.01 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 94,935 | 116,088 | +21,153 | 0.04 | 0.05 | +0.01 | buy |
| Man Group plc | 23,119 | 114,826 | +91,707 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 126,400 | 114,000 | -12,400 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 97,567 | 109,544 | +11,977 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 96,519 | +96,519 | 0.00 | 0.60 | +0.60 | buy |
| Verition Fund Management LLC | 57,117 | 93,756 | +36,639 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 159,238 | 93,462 | -65,776 | 0.00 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 87,470 | 92,778 | +5,308 | 0.14 | 0.18 | +0.03 | buy |
| Atika Capital Management LLC | 38,000 | 92,506 | +54,506 | 0.13 | 0.58 | +0.45 | buy |
| RHUMBLINE ADVISERS | 106,791 | 90,143 | -16,648 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 120,545 | 89,757 | -30,788 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 69,892 | 86,220 | +16,328 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 322,456 | 84,360 | -238,096 | 0.03 | 0.01 | -0.02 | sell |
| RAYMOND JAMES FINANCIAL INC | 69,922 | 83,255 | +13,333 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 81,156 | 81,156 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 0 | 78,663 | +78,663 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 72,957 | +72,957 | 0.00 | 0.07 | +0.07 | buy |