| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | 269,837 | +269,837 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 194,167 | +194,167 | 0.00 | 0.04 | +0.04 | buy |
| Opaleye Management Inc. | 0 | 172,357 | +172,357 | 0.00 | 1.07 | +1.07 | buy |
| VANGUARD GROUP INC | 11,342 | 138,433 | +127,091 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 114,388 | +114,388 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 12,938 | 110,758 | +97,820 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 14,270 | 94,199 | +79,929 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 71,514 | +71,514 | 0.00 | 0.02 | +0.02 | buy |
| AWM Investment Company, Inc. | 0 | 69,416 | +69,416 | 0.00 | 0.27 | +0.27 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 48,664 | +48,664 | 0.00 | 0.03 | +0.03 | buy |
| Frazier Life Sciences Management, L.P. | 653,892 | 690,012 | +36,120 | 0.33 | 0.88 | +0.56 | buy |
| MARSHALL WACE, LLP | 0 | 30,345 | +30,345 | 0.00 | 0.00 | +0.00 | buy |
| Strid Group, LLC | 0 | 29,219 | +29,219 | 0.00 | 0.13 | +0.13 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 19,053 | +19,053 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 16,635 | +16,635 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 12,062 | +12,062 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 8,176 | +8,176 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 13,211 | 18,872 | +5,661 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 0 | 2,516 | +2,516 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,108 | 2,246 | +1,138 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 696,555 | 696,555 | 0 | 0.28 | 0.79 | +0.51 | hold |
| ADAMS STREET PARTNERS LLC | 409,666 | 409,666 | 0 | 4.36 | 10.15 | +5.79 | hold |
| DELTEC ASSET MANAGEMENT LLC | 12,500 | 12,500 | 0 | 0.03 | 0.08 | +0.05 | hold |
| Nantahala Capital Management, LLC | 250,062 | 250,062 | 0 | 0.21 | 0.58 | +0.37 | hold |
| Allworth Financial LP | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 714,463 | 714,463 | 0 | 0.32 | 0.81 | +0.49 | hold |
| Samsara BioCapital, LLC | 679,486 | 679,486 | 0 | 1.12 | 3.39 | +2.27 | hold |
| Truvestments Capital LLC | 14 | 14 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cresset Asset Management, LLC | 20,911 | 20,911 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 63 | 63 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 312 | 312 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 138 | 0 | -138 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 175 | 0 | -175 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,549 | 0 | -1,549 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 21,371 | 15,258 | -6,113 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 71,452 | 43,348 | -28,104 | 0.22 | 0.34 | +0.13 | sell |
| BML Capital Management, LLC | 42,130 | 0 | -42,130 | 0.31 | 0.00 | -0.31 | sell |
| Blue Owl Capital Holdings LP | 250,062 | 140,259 | -109,803 | 0.69 | 1.27 | +0.57 | sell |
| ADAR1 Capital Management, LLC | 144,641 | 0 | -144,641 | 0.36 | 0.00 | -0.36 | sell |