| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 892,400 | 1,153,496 | +261,096 | 2.33 | 3.90 | +1.57 | buy |
| First Light Asset Management, LLC | 709,141 | 980,758 | +271,617 | 5.67 | 10.96 | +5.28 | buy |
| BVF INC/IL | 879,009 | 960,989 | +81,980 | 3.10 | 3.82 | +0.72 | buy |
| Frazier Life Sciences Management, L.P. | 722,400 | 882,400 | +160,000 | 2.03 | 2.83 | +0.80 | buy |
| BlackRock, Inc. | 559,065 | 686,853 | +127,788 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 387,483 | 640,611 | +253,128 | 0.02 | 0.05 | +0.03 | buy |
| STATE STREET CORP | 420,462 | 458,999 | +38,537 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 368,038 | 433,015 | +64,977 | 0.06 | 0.09 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,090 | 402,564 | +398,474 | 0.00 | 0.01 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 374,035 | +374,035 | 0.00 | 0.48 | +0.48 | buy |
| Woodline Partners LP | 300,536 | 317,517 | +16,981 | 0.12 | 0.15 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 269,027 | 262,835 | -6,192 | 0.01 | 0.01 | +0.00 | sell |
| Siren, L.L.C. | 75,000 | 257,485 | +182,485 | 0.23 | 0.89 | +0.66 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 101,748 | 233,248 | +131,500 | 0.17 | 0.48 | +0.31 | buy |
| FMR LLC | 231,760 | 215,808 | -15,952 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 205,745 | 206,404 | +659 | 2.46 | 1.99 | -0.48 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 178,992 | 205,609 | +26,617 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 0 | 195,030 | +195,030 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 98,935 | 194,179 | +95,244 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 211,553 | 193,796 | -17,757 | 0.03 | 0.04 | +0.01 | sell |
| Alyeska Investment Group, L.P. | 0 | 179,922 | +179,922 | 0.00 | 0.06 | +0.06 | buy |
| EMERALD ADVISERS, LLC | 0 | 161,500 | +161,500 | 0.00 | 0.64 | +0.64 | buy |
| First Turn Management, LLC | 0 | 148,093 | +148,093 | 0.00 | 2.06 | +2.06 | buy |
| ORBIMED ADVISORS LLC | 0 | 134,600 | +134,600 | 0.00 | 0.37 | +0.37 | buy |
| MORGAN STANLEY | 220,662 | 127,987 | -92,675 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 105,820 | +105,820 | 0.00 | 0.64 | +0.64 | buy |
| UBS Group AG | 36,505 | 104,537 | +68,032 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 108,880 | 96,726 | -12,154 | 0.02 | 0.02 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,480 | 93,646 | +90,166 | 0.00 | 0.01 | +0.01 | buy |
| Clio Asset Management LLC | 91,642 | 90,757 | -885 | 7.45 | 9.48 | +2.03 | sell |
| APIS CAPITAL ADVISORS, LLC | 0 | 89,000 | +89,000 | 0.00 | 1.71 | +1.71 | buy |
| Point72 Asset Management, L.P. | 77,297 | 88,160 | +10,863 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 0 | 81,081 | +81,081 | 0.00 | 0.02 | +0.02 | buy |
| Avidity Partners Management LP | 19,300 | 70,000 | +50,700 | 0.58 | 1.77 | +1.18 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 47,681 | 69,901 | +22,220 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 69,416 | 69,416 | 0 | 0.70 | 0.96 | +0.26 | hold |
| Ikarian Capital, LLC | 0 | 64,626 | +64,626 | 0.00 | 1.15 | +1.15 | buy |
| NORTHERN TRUST CORP | 54,490 | 64,371 | +9,881 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.50 | +0.50 | buy |
| Clearbridge Investments, LLC | 60,628 | 59,410 | -1,218 | 0.01 | 0.01 | +0.00 | sell |
| Neuberger Berman Group LLC | 44,901 | 49,103 | +4,202 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 54,273 | 48,527 | -5,746 | 0.00 | 0.00 | +0.00 | sell |
| Lisanti Capital Growth, LLC | 41,470 | 41,445 | -25 | 1.03 | 1.30 | +0.27 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 39,964 | +39,964 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 39,223 | +39,223 | 0.00 | 0.01 | +0.01 | buy |
| Samsara BioCapital, LLC | 104,817 | 38,432 | -66,385 | 1.13 | 0.47 | -0.67 | sell |
| BANK OF AMERICA CORP /DE/ | 30,272 | 37,972 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 36,639 | +36,639 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 22,403 | 34,040 | +11,637 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 30,010 | 31,507 | +1,497 | 0.03 | 0.04 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 40,259 | 31,259 | -9,000 | 1.30 | 1.05 | -0.25 | sell |
| Informed Momentum Co LLC | 0 | 29,328 | +29,328 | 0.00 | 0.42 | +0.42 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 470 | 27,781 | +27,311 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 27,603 | +27,603 | 0.00 | 0.25 | +0.25 | buy |
| RAYMOND JAMES FINANCIAL INC | 22,264 | 25,446 | +3,182 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 24,008 | +24,008 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,633 | 22,970 | +1,337 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 22,746 | +22,746 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 150,026 | 21,236 | -128,790 | 0.06 | 0.01 | -0.05 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,315 | 21,142 | +3,827 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 19,576 | 20,834 | +1,258 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,636 | 20,472 | +17,836 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 20,277 | +20,277 | 0.00 | 0.03 | +0.03 | buy |
| BlueCrest Capital Management Ltd | 0 | 20,000 | +20,000 | 0.00 | 0.23 | +0.23 | buy |
| FIFTH THIRD BANCORP | 0 | 19,947 | +19,947 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 14,200 | 19,400 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 18,962 | +18,962 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 18,808 | +18,808 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 16,264 | 18,041 | +1,777 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 22,530 | 17,970 | -4,560 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 2,270 | 17,907 | +15,637 | 0.00 | 0.00 | +0.00 | buy |
| Arete Wealth Advisors, LLC | 0 | 17,470 | +17,470 | 0.00 | 0.05 | +0.05 | buy |
| SEI INVESTMENTS CO | 11,719 | 16,663 | +4,944 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 11,385 | 16,023 | +4,638 | 0.10 | 0.18 | +0.08 | buy |
| Rafferty Asset Management, LLC | 15,734 | 14,590 | -1,144 | 0.01 | 0.01 | +0.00 | sell |
| F/m Investments LLC | 0 | 13,839 | +13,839 | 0.00 | 0.11 | +0.11 | buy |
| Russell Investments Group, Ltd. | 1,229 | 13,527 | +12,298 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 13,067 | +13,067 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 11,429 | 11,860 | +431 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 14,124 | 11,403 | -2,721 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 9,716 | 11,132 | +1,416 | 0.01 | 0.01 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 9,804 | +9,804 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 8,636 | 9,129 | +493 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 8,232 | +8,232 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 6,594 | 7,784 | +1,190 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 0 | 7,758 | +7,758 | 0.00 | 0.05 | +0.05 | buy |
| Virtu Financial LLC | 0 | 7,726 | +7,726 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 5,849 | 7,446 | +1,597 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,919 | 6,895 | -24 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 0 | 6,743 | +6,743 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 6,652 | +6,652 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 5,813 | 6,498 | +685 | 0.02 | 0.03 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 4,513 | 5,929 | +1,416 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 5,903 | +5,903 | 0.00 | 0.20 | +0.20 | buy |
| ASPIRIANT, LLC | 5,852 | 5,852 | 0 | 0.02 | 0.02 | +0.00 | hold |
| XTX Topco Ltd | 4,103 | 5,828 | +1,725 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,928 | 5,824 | -5,104 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 5,006 | 5,519 | +513 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 5,152 | +5,152 | 0.00 | 0.00 | +0.00 | buy |