| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 110,758 | 445,052 | +334,294 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 194,167 | 445,615 | +251,448 | 0.04 | 0.05 | +0.02 | buy |
| MORGAN STANLEY | 0 | 135,754 | +135,754 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 95,615 | +95,615 | 0.00 | 1.42 | +1.42 | buy |
| Clio Asset Management LLC | 0 | 91,508 | +91,508 | 0.00 | 1.62 | +1.62 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 94,199 | 173,986 | +79,787 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 12,062 | 82,011 | +69,949 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 19,053 | 85,329 | +66,276 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 56,290 | +56,290 | 0.00 | 0.04 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 15,258 | 66,858 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 269,837 | 314,989 | +45,152 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 0 | 43,149 | +43,149 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 16,635 | 54,503 | +37,868 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 690,012 | 722,400 | +32,388 | 0.88 | 0.65 | -0.23 | buy |
| VANGUARD GROUP INC | 138,433 | 163,809 | +25,376 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 21,013 | +21,013 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 30,345 | 49,077 | +18,732 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 17,701 | +17,701 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 0 | 13,662 | +13,662 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 13,542 | +13,542 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 63 | 12,179 | +12,116 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 9,956 | +9,956 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 8,905 | +8,905 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 6,066 | +6,066 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,900 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4,630 | +4,630 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 4,260 | +4,260 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 3,750 | +3,750 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 3,665 | +3,665 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 3,245 | +3,245 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 71,514 | 74,516 | +3,002 | 0.02 | 0.02 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 1,639 | +1,639 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 755 | +755 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 428 | +428 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 234 | +234 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 192 | +192 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,246 | 2,426 | +180 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| Vermillion & White Wealth Management Group, LLC | 0 | 88 | +88 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| BVF INC/IL | 696,555 | 696,555 | 0 | 0.79 | 0.56 | -0.23 | hold |
| DELTEC ASSET MANAGEMENT LLC | 12,500 | 12,500 | 0 | 0.08 | 0.05 | -0.02 | hold |
| DAFNA Capital Management LLC | 43,348 | 43,348 | 0 | 0.34 | 0.27 | -0.07 | hold |
| Nantahala Capital Management, LLC | 250,062 | 250,062 | 0 | 0.58 | 0.40 | -0.18 | hold |
| AWM Investment Company, Inc. | 69,416 | 69,416 | 0 | 0.27 | 0.18 | -0.09 | hold |
| Allworth Financial LP | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 714,463 | 714,463 | 0 | 0.81 | 0.61 | -0.20 | hold |
| Truvestments Capital LLC | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cresset Asset Management, LLC | 20,911 | 20,911 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Spire Wealth Management | 2,516 | 2,516 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 312 | 132 | -180 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 18,872 | 17,500 | -1,372 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 48,664 | 43,994 | -4,670 | 0.03 | 0.03 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 8,176 | 0 | -8,176 | 0.00 | 0.00 | -0.00 | sell |
| Strid Group, LLC | 29,219 | 18,166 | -11,053 | 0.13 | 0.06 | -0.07 | sell |
| Blue Owl Capital Holdings LP | 140,259 | 125,259 | -15,000 | 1.27 | 0.91 | -0.35 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 114,388 | 17,384 | -97,004 | 0.01 | 0.00 | -0.00 | sell |
| ADAMS STREET PARTNERS LLC | 409,666 | 298,986 | -110,680 | 10.15 | 4.75 | -5.40 | sell |
| Opaleye Management Inc. | 172,357 | 0 | -172,357 | 1.07 | 0.00 | -1.07 | sell |
| Samsara BioCapital, LLC | 679,486 | 339,743 | -339,743 | 3.39 | 1.57 | -1.83 | sell |